4RCPA

Crystal structure of plk1 polo-box domain in complex with pl-2
Total Genus 76
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
228
structure length
223
Chain Sequence
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
publication title A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
source organism Homo sapiens
total genus 76
structure length 223
sequence length 228
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2014-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4rcpA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4rcpA01
1Q4OA 4HABA 4O56A 4DFWA 4RCPA 4E9CA 4WHHA 3C5LA 4YYPA 4X9WA 4WHLA 5DMSA 4LKMA 3BZIA 3FVHA 4XB0A 4E67A 3RQ7A 4X9RA 5J19A 4X9VA 4J7BB 4H71A 4LKLA 4O6WA 4E9DA 5LHZA 4O9WA 3P2WA 4HY2A 1UMWA 3P2ZA 3P37A 5DNJA 3HIKA 2OJXA 1Q4KA 5DMVC 3HIHA 3P34A 2OGQA 3P36A 4H5XA 4HCOA 4RS6A 3P35A 3Q1IA 4WHKA 2N19A
chains in the Genus database with same CATH superfamily
2I9ZA 2UV8G 4RCPA 3LM3A 1FSUA 4YYPA 3FVHA 4XB0A 3HMJG 3RQ7A 4O6WA 4HY2A 1E3CP 4H5XA 4HCOA 4N7ZA 2VKZG 2QZUA 4O56A 1E33P 2E50A 4DFWA 4CYRA 4WHHA 3HFDA 4X9WA 1AUKA 4LKMA 3GYWA 3FS3A 5DAYA 4N9JA 3ED4A 4G7NA 1E1ZP 1N2KA 4LKLA 1N2LA 1E2SP 4O9WA 3P2WA 4CXKA 3HIKA 5DMVC 3HIHA 4CXSA 4RS6A 4NK7A 3Q1IA 2N19A 1Q4OA 1F32A 3C5LA 4FDIA 3BZIA 3LXQA 3P35A 5J19A 1P49A 2IA9A 4E9DA 1A87A 1F34B 1UMWA 3P37A 4CXUA 3P34A 3P36A 4CYSA 4HABA 1E2TA 4E9CA 4WHLA 5DMSA 4FDJA 4E67A 3KDRA 4X9RA 4X9VA 1HDHA 4J7BB 4H71A 4N7VA 5LHZA 5DNJA 3P2ZA 2OJXA 3GYVA 1Q4KA 2OGQA 2I9XA 4NKBA 5AJ9A 4WHKA
chains in the Genus database with same CATH topology
1Q4OA 4HABA 4O56A 4DFWA 4RCPA 4E9CA 4WHHA 3C5LA 4YYPA 4X9WA 4WHLA 5DMSA 4LKMA 3BZIA 3FVHA 4XB0A 4E67A 3RQ7A 4X9RA 5J19A 4X9VA 4J7BB 4H71A 4LKLA 4O6WA 4E9DA 5LHZA 4O9WA 3P2WA 4HY2A 1UMWA 3P2ZA 3P37A 5DNJA 3HIKA 2OJXA 1Q4KA 5DMVC 3HIHA 3P34A 2OGQA 3P36A 4H5XA 4HCOA 4RS6A 3P35A 3Q1IA 4WHKA 2N19A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q4O A;  4HAB A;  4O56 A;  4DFW A;  4RCP A;  4E9C A;  4WHH A;  3C5L A;  4YYP A;  4X9W A;  4WHL A;  5DMS A;  4LKM A;  3BZI A;  3FVH A;  4XB0 A;  4E67 A;  3RQ7 A;  4X9R A;  5J19 A;  4X9V A;  4J7B B;  4H71 A;  4LKL A;  4O6W A;  4E9D A;  5LHZ A;  4O9W A;  3P2W A;  4HY2 A;  1UMW A;  3P2Z A;  3P37 A;  5DNJ A;  3HIK A;  2OJX A;  1Q4K A;  5DMV C;  3HIH A;  3P34 A;  2OGQ A;  3P36 A;  4H5X A;  4HCO A;  4RS6 A;  3P35 A;  3Q1I A;  4WHK A;  2N19 A; 
#chains in the Genus database with same CATH topology
 2I9Z A;  2UV8 G;  4RCP A;  3LM3 A;  1FSU A;  4YYP A;  3FVH A;  4XB0 A;  3HMJ G;  3RQ7 A;  4O6W A;  4HY2 A;  1E3C P;  4H5X A;  4HCO A;  4N7Z A;  2VKZ G;  2QZU A;  4O56 A;  1E33 P;  2E50 A;  4DFW A;  4CYR A;  4WHH A;  3HFD A;  4X9W A;  1AUK A;  4LKM A;  3GYW A;  3FS3 A;  5DAY A;  4N9J A;  3ED4 A;  4G7N A;  1E1Z P;  1N2K A;  4LKL A;  1N2L A;  1E2S P;  4O9W A;  3P2W A;  4CXK A;  3HIK A;  5DMV C;  3HIH A;  4CXS A;  4RS6 A;  4NK7 A;  3Q1I A;  2N19 A;  1Q4O A;  1F32 A;  3C5L A;  4FDI A;  3BZI A;  3LXQ A;  3P35 A;  5J19 A;  1P49 A;  2IA9 A;  4E9D A;  1A87 A;  1F34 B;  1UMW A;  3P37 A;  4CXU A;  3P34 A;  3P36 A;  4CYS A;  4HAB A;  1E2T A;  4E9C A;  4WHL A;  5DMS A;  4FDJ A;  4E67 A;  3KDR A;  4X9R A;  4X9V A;  1HDH A;  4J7B B;  4H71 A;  4N7V A;  5LHZ A;  5DNJ A;  3P2Z A;  2OJX A;  3GYV A;  1Q4K A;  2OGQ A;  2I9X A;  4NKB A;  5AJ9 A;  4WHK A; 
#chains in the Genus database with same CATH homology
 1Q4O A;  4HAB A;  4O56 A;  4DFW A;  4RCP A;  4E9C A;  4WHH A;  3C5L A;  4YYP A;  4X9W A;  4WHL A;  5DMS A;  4LKM A;  3BZI A;  3FVH A;  4XB0 A;  4E67 A;  3RQ7 A;  4X9R A;  5J19 A;  4X9V A;  4J7B B;  4H71 A;  4LKL A;  4O6W A;  4E9D A;  5LHZ A;  4O9W A;  3P2W A;  4HY2 A;  1UMW A;  3P2Z A;  3P37 A;  5DNJ A;  3HIK A;  2OJX A;  1Q4K A;  5DMV C;  3HIH A;  3P34 A;  2OGQ A;  3P36 A;  4H5X A;  4HCO A;  4RS6 A;  3P35 A;  3Q1I A;  4WHK A;  2N19 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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