4RCPA

Crystal structure of plk1 polo-box domain in complex with pl-2
Total Genus 76
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
228
structure length
223
Chain Sequence
b'CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNR'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 76
structure length 223
sequence length 228
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2014-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4rcpA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4rcpA01
4E9CA 4HY2A 4RCPA 4O56A 4O9WA 4WHLA 4H71A 5LHZA 4HCOA 4XB0A 3P2ZA 4E9DA 1Q4OA 2OGQA 3RQ7A 4HABA 4E67A 3Q1IA 3P2WA 4LKLA 2N19A 1Q4KA 5DMVC 5J19A 3FVHA 3C5LA 4O6WA 2OJXA 3P34A 4YYPA 4X9VA 5DNJA 4DFWA 1UMWA 3P37A 4LKMA 4WHKA 4X9RA 4H5XA 4RS6A 4WHHA 3HIKA 3P35A 4J7BB 5DMSA 3HIHA 4X9WA 3P36A 3BZIA
chains in the Genus database with same CATH superfamily
4E9CA 4FDJA 1HDHA 2VKZG 2IA9A 4XB0A 2OGQA 3LM3A 1E1ZP 3P2WA 4LKLA 2N19A 3FVHA 2QZUA 1E3CP 4X9VA 1N2KA 5DNJA 3P37A 3HMJG 4H5XA 4CXKA 3P35A 4CYRA 3HIHA 2I9ZA 4HY2A 4RCPA 3KDRA 4NK7A 4O56A 4WHLA 4E9DA 1A87A 1Q4KA 3C5LA 2OJXA 3P34A 1UMWA 5AJ9A 4J7BB 5DAYA 5DMSA 1F34B 3GYWA 3P2ZA 1Q4OA 4E67A 3Q1IA 5DMVC 5J19A 4CXSA 4CYSA 4O6WA 3HFDA 1E33P 4DFWA 4WHKA 4FDIA 4N7ZA 4RS6A 3HIKA 3ED4A 1AUKA 4X9WA 3GYVA 3P36A 3BZIA 2I9XA 4NKBA 4G7NA 4O9WA 4H71A 5LHZA 4HCOA 3RQ7A 4HABA 1E2TA 4N9JA 2UV8G 1P49A 3LXQA 4N7VA 4CXUA 4YYPA 4LKMA 3FS3A 1FSUA 4X9RA 1N2LA 4WHHA 2E50A 1E2SP 1F32A
chains in the Genus database with same CATH topology
4E9CA 4HY2A 4RCPA 4O56A 4O9WA 4WHLA 4H71A 5LHZA 4HCOA 4XB0A 3P2ZA 4E9DA 1Q4OA 2OGQA 3RQ7A 4HABA 4E67A 3Q1IA 3P2WA 4LKLA 2N19A 1Q4KA 5DMVC 5J19A 3FVHA 3C5LA 4O6WA 2OJXA 3P34A 4YYPA 4X9VA 5DNJA 4DFWA 1UMWA 3P37A 4LKMA 4WHKA 4X9RA 4H5XA 4RS6A 4WHHA 3HIKA 3P35A 4J7BB 5DMSA 3HIHA 4X9WA 3P36A 3BZIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4E9C A;  4HY2 A;  4RCP A;  4O56 A;  4O9W A;  4WHL A;  4H71 A;  5LHZ A;  4HCO A;  4XB0 A;  3P2Z A;  4E9D A;  1Q4O A;  2OGQ A;  3RQ7 A;  4HAB A;  4E67 A;  3Q1I A;  3P2W A;  4LKL A;  2N19 A;  1Q4K A;  5DMV C;  5J19 A;  3FVH A;  3C5L A;  4O6W A;  2OJX A;  3P34 A;  4YYP A;  4X9V A;  5DNJ A;  4DFW A;  1UMW A;  3P37 A;  4LKM A;  4WHK A;  4X9R A;  4H5X A;  4RS6 A;  4WHH A;  3HIK A;  3P35 A;  4J7B B;  5DMS A;  3HIH A;  4X9W A;  3P36 A;  3BZI A; 
#chains in the Genus database with same CATH topology
 4E9C A;  4FDJ A;  1HDH A;  2VKZ G;  2IA9 A;  4XB0 A;  2OGQ A;  3LM3 A;  1E1Z P;  3P2W A;  4LKL A;  2N19 A;  3FVH A;  2QZU A;  1E3C P;  4X9V A;  1N2K A;  5DNJ A;  3P37 A;  3HMJ G;  4H5X A;  4CXK A;  3P35 A;  4CYR A;  3HIH A;  2I9Z A;  4HY2 A;  4RCP A;  3KDR A;  4NK7 A;  4O56 A;  4WHL A;  4E9D A;  1A87 A;  1Q4K A;  3C5L A;  2OJX A;  3P34 A;  1UMW A;  5AJ9 A;  4J7B B;  5DAY A;  5DMS A;  1F34 B;  3GYW A;  3P2Z A;  1Q4O A;  4E67 A;  3Q1I A;  5DMV C;  5J19 A;  4CXS A;  4CYS A;  4O6W A;  3HFD A;  1E33 P;  4DFW A;  4WHK A;  4FDI A;  4N7Z A;  4RS6 A;  3HIK A;  3ED4 A;  1AUK A;  4X9W A;  3GYV A;  3P36 A;  3BZI A;  2I9X A;  4NKB A;  4G7N A;  4O9W A;  4H71 A;  5LHZ A;  4HCO A;  3RQ7 A;  4HAB A;  1E2T A;  4N9J A;  2UV8 G;  1P49 A;  3LXQ A;  4N7V A;  4CXU A;  4YYP A;  4LKM A;  3FS3 A;  1FSU A;  4X9R A;  1N2L A;  4WHH A;  2E50 A;  1E2S P;  1F32 A; 
#chains in the Genus database with same CATH homology
 4E9C A;  4HY2 A;  4RCP A;  4O56 A;  4O9W A;  4WHL A;  4H71 A;  5LHZ A;  4HCO A;  4XB0 A;  3P2Z A;  4E9D A;  1Q4O A;  2OGQ A;  3RQ7 A;  4HAB A;  4E67 A;  3Q1I A;  3P2W A;  4LKL A;  2N19 A;  1Q4K A;  5DMV C;  5J19 A;  3FVH A;  3C5L A;  4O6W A;  2OJX A;  3P34 A;  4YYP A;  4X9V A;  5DNJ A;  4DFW A;  1UMW A;  3P37 A;  4LKM A;  4WHK A;  4X9R A;  4H5X A;  4RS6 A;  4WHH A;  3HIK A;  3P35 A;  4J7B B;  5DMS A;  3HIH A;  4X9W A;  3P36 A;  3BZI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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