4X9WA

Plk-1 polo-box domain in complex with bioactive imidazolium-containing phosphopeptide macrocycle 4c
Total Genus 70
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
226
structure length
226
Chain Sequence
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSAS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 70
structure length 226
sequence length 226
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2014-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4x9wA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4x9wA01
4X9WA 4YYPA 4E9DA 3P2WA 4H71A 4X9RA 4RCPA 3HIHA 3Q1IA 4HY2A 4X9VA 4O56A 1Q4OA 3P36A 4WHHA 2OJXA 4H5XA 2N19A 4WHLA 4XB0A 4LKMA 5DNJA 3BZIA 3P35A 4WHKA 4E9CA 5J19A 4O9WA 5DMVC 4HABA 4O6WA 2OGQA 4RS6A 4E67A 3C5LA 3RQ7A 4J7BB 1UMWA 3P34A 4DFWA 3HIKA 3P2ZA 4LKLA 3P37A 5LHZA 4HCOA 1Q4KA 3FVHA 5DMSA
chains in the Genus database with same CATH superfamily
4E9DA 1E3CP 4H71A 1A87A 2UV8G 4RCPA 3Q1IA 2QZUA 4X9VA 5DNJA 3P35A 3GYVA 4HABA 1UMWA 4N9JA 3P2ZA 3HMJG 3FS3A 4X9WA 4YYPA 3P2WA 3KDRA 1N2KA 4X9RA 3GYWA 3HIHA 2IA9A 4O56A 1Q4OA 2OJXA 4H5XA 2N19A 4FDIA 5DAYA 3LM3A 4LKMA 4CXUA 3ED4A 4N7VA 4CYSA 4G7NA 4LKLA 3P37A 1E33P 4CYRA 2I9XA 1N2LA 1Q4KA 3FVHA 5LHZA 1P49A 4NK7A 1AUKA 1F34B 4WHHA 4WHLA 4FDJA 2E50A 1E2SP 4O6WA 4RS6A 2I9ZA 3RQ7A 4J7BB 4CXKA 1FSUA 2VKZG 1F32A 4HCOA 5AJ9A 4DFWA 1HDHA 4HY2A 1E1ZP 3HFDA 3P36A 1E2TA 4XB0A 3BZIA 4WHKA 4E9CA 5J19A 3LXQA 4O9WA 5DMVC 4N7ZA 2OGQA 4E67A 3C5LA 3P34A 3HIKA 4NKBA 4CXSA 5DMSA
chains in the Genus database with same CATH topology
4X9WA 4YYPA 4E9DA 3P2WA 4H71A 4X9RA 4RCPA 3HIHA 3Q1IA 4HY2A 4X9VA 4O56A 1Q4OA 3P36A 4WHHA 2OJXA 4H5XA 2N19A 4WHLA 4XB0A 4LKMA 5DNJA 3BZIA 3P35A 4WHKA 4E9CA 5J19A 4O9WA 5DMVC 4HABA 4O6WA 2OGQA 4RS6A 4E67A 3C5LA 3RQ7A 4J7BB 1UMWA 3P34A 4DFWA 3HIKA 3P2ZA 4LKLA 3P37A 5LHZA 4HCOA 1Q4KA 3FVHA 5DMSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X9W A;  4YYP A;  4E9D A;  3P2W A;  4H71 A;  4X9R A;  4RCP A;  3HIH A;  3Q1I A;  4HY2 A;  4X9V A;  4O56 A;  1Q4O A;  3P36 A;  4WHH A;  2OJX A;  4H5X A;  2N19 A;  4WHL A;  4XB0 A;  4LKM A;  5DNJ A;  3BZI A;  3P35 A;  4WHK A;  4E9C A;  5J19 A;  4O9W A;  5DMV C;  4HAB A;  4O6W A;  2OGQ A;  4RS6 A;  4E67 A;  3C5L A;  3RQ7 A;  4J7B B;  1UMW A;  3P34 A;  4DFW A;  3HIK A;  3P2Z A;  4LKL A;  3P37 A;  5LHZ A;  4HCO A;  1Q4K A;  3FVH A;  5DMS A; 
#chains in the Genus database with same CATH topology
 4E9D A;  1E3C P;  4H71 A;  1A87 A;  2UV8 G;  4RCP A;  3Q1I A;  2QZU A;  4X9V A;  5DNJ A;  3P35 A;  3GYV A;  4HAB A;  1UMW A;  4N9J A;  3P2Z A;  3HMJ G;  3FS3 A;  4X9W A;  4YYP A;  3P2W A;  3KDR A;  1N2K A;  4X9R A;  3GYW A;  3HIH A;  2IA9 A;  4O56 A;  1Q4O A;  2OJX A;  4H5X A;  2N19 A;  4FDI A;  5DAY A;  3LM3 A;  4LKM A;  4CXU A;  3ED4 A;  4N7V A;  4CYS A;  4G7N A;  4LKL A;  3P37 A;  1E33 P;  4CYR A;  2I9X A;  1N2L A;  1Q4K A;  3FVH A;  5LHZ A;  1P49 A;  4NK7 A;  1AUK A;  1F34 B;  4WHH A;  4WHL A;  4FDJ A;  2E50 A;  1E2S P;  4O6W A;  4RS6 A;  2I9Z A;  3RQ7 A;  4J7B B;  4CXK A;  1FSU A;  2VKZ G;  1F32 A;  4HCO A;  5AJ9 A;  4DFW A;  1HDH A;  4HY2 A;  1E1Z P;  3HFD A;  3P36 A;  1E2T A;  4XB0 A;  3BZI A;  4WHK A;  4E9C A;  5J19 A;  3LXQ A;  4O9W A;  5DMV C;  4N7Z A;  2OGQ A;  4E67 A;  3C5L A;  3P34 A;  3HIK A;  4NKB A;  4CXS A;  5DMS A; 
#chains in the Genus database with same CATH homology
 4X9W A;  4YYP A;  4E9D A;  3P2W A;  4H71 A;  4X9R A;  4RCP A;  3HIH A;  3Q1I A;  4HY2 A;  4X9V A;  4O56 A;  1Q4O A;  3P36 A;  4WHH A;  2OJX A;  4H5X A;  2N19 A;  4WHL A;  4XB0 A;  4LKM A;  5DNJ A;  3BZI A;  3P35 A;  4WHK A;  4E9C A;  5J19 A;  4O9W A;  5DMV C;  4HAB A;  4O6W A;  2OGQ A;  4RS6 A;  4E67 A;  3C5L A;  3RQ7 A;  4J7B B;  1UMW A;  3P34 A;  4DFW A;  3HIK A;  3P2Z A;  4LKL A;  3P37 A;  5LHZ A;  4HCO A;  1Q4K A;  3FVH A;  5DMS A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...