4X9WA

Plk-1 polo-box domain in complex with bioactive imidazolium-containing phosphopeptide macrocycle 4c
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
226
structure length
226
Chain Sequence
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSAS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
total genus 70
structure length 226
sequence length 226
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2014-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4x9wA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4x9wA01
5DMSA 3RQ7A 5DNJA 3P36A 4LKMA 3P34A 4E9DA 2N19A 4DFWA 4WHKA 4HABA 2OJXA 1Q4OA 4HCOA 4O9WA 4WHLA 1Q4KA 3P35A 4X9WA 4X9RA 4H71A 4RS6A 3C5LA 4E9CA 5LHZA 5DMVC 3HIKA 4O56A 4WHHA 5J19A 3P37A 3P2WA 4RCPA 1UMWA 4LKLA 3P2ZA 4X9VA 4YYPA 4E67A 4H5XA 4XB0A 3Q1IA 4O6WA 2OGQA 3HIHA 4HY2A 4J7BB 3FVHA 3BZIA
chains in the Genus database with same CATH superfamily
3RQ7A 5DNJA 4E9DA 3ED4A 2OJXA 4CYRA 4O9WA 4FDIA 2E50A 1E33P 2QZUA 4H71A 3LM3A 1P49A 4RCPA 4CXSA 1UMWA 4LKLA 3LXQA 1E2SP 4X9VA 1AUKA 4H5XA 4O6WA 3HIHA 4N7VA 3FVHA 4N9JA 1E1ZP 1Q4KA 3P35A 3GYWA 3C5LA 1F34B 4CXUA 4O56A 3P37A 1F32A 4G7NA 2I9ZA 2OGQA 4FDJA 3BZIA 4NK7A 4LKMA 2N19A 1N2LA 4WHKA 4HABA 1E2TA 4WHLA 5LHZA 3HIKA 3GYVA 4WHHA 5J19A 3P2WA 2I9XA 1FSUA 5AJ9A 4YYPA 3Q1IA 4HY2A 4J7BB 4CYSA 2UV8G 3HMJG 4CXKA 5DMSA 2VKZG 3KDRA 1N2KA 3P36A 3P34A 5DAYA 4DFWA 4NKBA 2IA9A 1Q4OA 4HCOA 4N7ZA 3HFDA 4X9WA 4X9RA 4RS6A 4E9CA 1A87A 5DMVC 1E3CP 3P2ZA 4E67A 4XB0A 1HDHA 3FS3A
chains in the Genus database with same CATH topology
5DMSA 3RQ7A 5DNJA 3P36A 4LKMA 3P34A 4E9DA 2N19A 4DFWA 4WHKA 4HABA 2OJXA 1Q4OA 4HCOA 4O9WA 4WHLA 1Q4KA 3P35A 4X9WA 4X9RA 4H71A 4RS6A 3C5LA 4E9CA 5LHZA 5DMVC 3HIKA 4O56A 4WHHA 5J19A 3P37A 3P2WA 4RCPA 1UMWA 4LKLA 3P2ZA 4X9VA 4YYPA 4E67A 4H5XA 4XB0A 3Q1IA 4O6WA 2OGQA 3HIHA 4HY2A 4J7BB 3FVHA 3BZIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DMS A;  3RQ7 A;  5DNJ A;  3P36 A;  4LKM A;  3P34 A;  4E9D A;  2N19 A;  4DFW A;  4WHK A;  4HAB A;  2OJX A;  1Q4O A;  4HCO A;  4O9W A;  4WHL A;  1Q4K A;  3P35 A;  4X9W A;  4X9R A;  4H71 A;  4RS6 A;  3C5L A;  4E9C A;  5LHZ A;  5DMV C;  3HIK A;  4O56 A;  4WHH A;  5J19 A;  3P37 A;  3P2W A;  4RCP A;  1UMW A;  4LKL A;  3P2Z A;  4X9V A;  4YYP A;  4E67 A;  4H5X A;  4XB0 A;  3Q1I A;  4O6W A;  2OGQ A;  3HIH A;  4HY2 A;  4J7B B;  3FVH A;  3BZI A; 
#chains in the Genus database with same CATH topology
 3RQ7 A;  5DNJ A;  4E9D A;  3ED4 A;  2OJX A;  4CYR A;  4O9W A;  4FDI A;  2E50 A;  1E33 P;  2QZU A;  4H71 A;  3LM3 A;  1P49 A;  4RCP A;  4CXS A;  1UMW A;  4LKL A;  3LXQ A;  1E2S P;  4X9V A;  1AUK A;  4H5X A;  4O6W A;  3HIH A;  4N7V A;  3FVH A;  4N9J A;  1E1Z P;  1Q4K A;  3P35 A;  3GYW A;  3C5L A;  1F34 B;  4CXU A;  4O56 A;  3P37 A;  1F32 A;  4G7N A;  2I9Z A;  2OGQ A;  4FDJ A;  3BZI A;  4NK7 A;  4LKM A;  2N19 A;  1N2L A;  4WHK A;  4HAB A;  1E2T A;  4WHL A;  5LHZ A;  3HIK A;  3GYV A;  4WHH A;  5J19 A;  3P2W A;  2I9X A;  1FSU A;  5AJ9 A;  4YYP A;  3Q1I A;  4HY2 A;  4J7B B;  4CYS A;  2UV8 G;  3HMJ G;  4CXK A;  5DMS A;  2VKZ G;  3KDR A;  1N2K A;  3P36 A;  3P34 A;  5DAY A;  4DFW A;  4NKB A;  2IA9 A;  1Q4O A;  4HCO A;  4N7Z A;  3HFD A;  4X9W A;  4X9R A;  4RS6 A;  4E9C A;  1A87 A;  5DMV C;  1E3C P;  3P2Z A;  4E67 A;  4XB0 A;  1HDH A;  3FS3 A; 
#chains in the Genus database with same CATH homology
 5DMS A;  3RQ7 A;  5DNJ A;  3P36 A;  4LKM A;  3P34 A;  4E9D A;  2N19 A;  4DFW A;  4WHK A;  4HAB A;  2OJX A;  1Q4O A;  4HCO A;  4O9W A;  4WHL A;  1Q4K A;  3P35 A;  4X9W A;  4X9R A;  4H71 A;  4RS6 A;  3C5L A;  4E9C A;  5LHZ A;  5DMV C;  3HIK A;  4O56 A;  4WHH A;  5J19 A;  3P37 A;  3P2W A;  4RCP A;  1UMW A;  4LKL A;  3P2Z A;  4X9V A;  4YYP A;  4E67 A;  4H5X A;  4XB0 A;  3Q1I A;  4O6W A;  2OGQ A;  3HIH A;  4HY2 A;  4J7B B;  3FVH A;  3BZI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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