4X9WA

Plk-1 polo-box domain in complex with bioactive imidazolium-containing phosphopeptide macrocycle 4c
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
226
structure length
226
Chain Sequence
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSAS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
publication title Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
pubmed doi rcsb
source organism Homo sapiens
total genus 70
structure length 226
sequence length 226
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2014-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4x9wA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4x9wA01
3FVHA 3C5LA 4X9WA 4X9RA 3P34A 4WHKA 4DFWA 5DNJA 4E67A 4O56A 5LHZA 4XB0A 3HIHA 4YYPA 3P2ZA 4J7BB 1UMWA 2OJXA 3P35A 4HCOA 4HY2A 4RS6A 4WHLA 4E9CA 2OGQA 3Q1IA 5DMVC 4O9WA 4X9VA 1Q4OA 4LKMA 5J19A 3HIKA 4E9DA 4LKLA 3P37A 4O6WA 2N19A 4H71A 3P2WA 4WHHA 4HABA 4RCPA 3RQ7A 3BZIA 1Q4KA 5DMSA 4H5XA 3P36A
chains in the Genus database with same CATH superfamily
3FVHA 4X9WA 3HMJG 4DFWA 4FDJA 4XB0A 4J7BB 2OJXA 4HCOA 2IA9A 2UV8G 2QZUA 4LKMA 3P2WA 4RCPA 3LM3A 1Q4KA 5DMSA 4N7ZA 3C5LA 3P34A 5DNJA 4O56A 1HDHA 4YYPA 3P2ZA 4HY2A 5DAYA 4E9CA 2OGQA 3GYVA 1FSUA 5DMVC 4LKLA 4O6WA 4WHHA 4HABA 1E2TA 4CXSA 3BZIA 4NKBA 4X9RA 4NK7A 4G7NA 4E67A 3HIHA 1UMWA 1N2LA 4N7VA 1E3CP 1A87A 5AJ9A 1P49A 4CXUA 4O9WA 1Q4OA 4CYRA 3KDRA 3P37A 4CXKA 1F32A 4H71A 1E1ZP 1E33P 3GYWA 4H5XA 3HFDA 3LXQA 4WHKA 2E50A 2I9ZA 4N9JA 3ED4A 5LHZA 3P35A 4RS6A 4WHLA 1N2KA 3Q1IA 2VKZG 4X9VA 1AUKA 1F34B 3FS3A 5J19A 3HIKA 4E9DA 4FDIA 2N19A 4CYSA 3RQ7A 1E2SP 2I9XA 3P36A
chains in the Genus database with same CATH topology
3FVHA 3C5LA 4X9WA 4X9RA 3P34A 4WHKA 4DFWA 5DNJA 4E67A 4O56A 5LHZA 4XB0A 3HIHA 4YYPA 3P2ZA 4J7BB 1UMWA 2OJXA 3P35A 4HCOA 4HY2A 4RS6A 4WHLA 4E9CA 2OGQA 3Q1IA 5DMVC 4O9WA 4X9VA 1Q4OA 4LKMA 5J19A 3HIKA 4E9DA 4LKLA 3P37A 4O6WA 2N19A 4H71A 3P2WA 4WHHA 4HABA 4RCPA 3RQ7A 3BZIA 1Q4KA 5DMSA 4H5XA 3P36A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FVH A;  3C5L A;  4X9W A;  4X9R A;  3P34 A;  4WHK A;  4DFW A;  5DNJ A;  4E67 A;  4O56 A;  5LHZ A;  4XB0 A;  3HIH A;  4YYP A;  3P2Z A;  4J7B B;  1UMW A;  2OJX A;  3P35 A;  4HCO A;  4HY2 A;  4RS6 A;  4WHL A;  4E9C A;  2OGQ A;  3Q1I A;  5DMV C;  4O9W A;  4X9V A;  1Q4O A;  4LKM A;  5J19 A;  3HIK A;  4E9D A;  4LKL A;  3P37 A;  4O6W A;  2N19 A;  4H71 A;  3P2W A;  4WHH A;  4HAB A;  4RCP A;  3RQ7 A;  3BZI A;  1Q4K A;  5DMS A;  4H5X A;  3P36 A; 
#chains in the Genus database with same CATH topology
 3FVH A;  4X9W A;  3HMJ G;  4DFW A;  4FDJ A;  4XB0 A;  4J7B B;  2OJX A;  4HCO A;  2IA9 A;  2UV8 G;  2QZU A;  4LKM A;  3P2W A;  4RCP A;  3LM3 A;  1Q4K A;  5DMS A;  4N7Z A;  3C5L A;  3P34 A;  5DNJ A;  4O56 A;  1HDH A;  4YYP A;  3P2Z A;  4HY2 A;  5DAY A;  4E9C A;  2OGQ A;  3GYV A;  1FSU A;  5DMV C;  4LKL A;  4O6W A;  4WHH A;  4HAB A;  1E2T A;  4CXS A;  3BZI A;  4NKB A;  4X9R A;  4NK7 A;  4G7N A;  4E67 A;  3HIH A;  1UMW A;  1N2L A;  4N7V A;  1E3C P;  1A87 A;  5AJ9 A;  1P49 A;  4CXU A;  4O9W A;  1Q4O A;  4CYR A;  3KDR A;  3P37 A;  4CXK A;  1F32 A;  4H71 A;  1E1Z P;  1E33 P;  3GYW A;  4H5X A;  3HFD A;  3LXQ A;  4WHK A;  2E50 A;  2I9Z A;  4N9J A;  3ED4 A;  5LHZ A;  3P35 A;  4RS6 A;  4WHL A;  1N2K A;  3Q1I A;  2VKZ G;  4X9V A;  1AUK A;  1F34 B;  3FS3 A;  5J19 A;  3HIK A;  4E9D A;  4FDI A;  2N19 A;  4CYS A;  3RQ7 A;  1E2S P;  2I9X A;  3P36 A; 
#chains in the Genus database with same CATH homology
 3FVH A;  3C5L A;  4X9W A;  4X9R A;  3P34 A;  4WHK A;  4DFW A;  5DNJ A;  4E67 A;  4O56 A;  5LHZ A;  4XB0 A;  3HIH A;  4YYP A;  3P2Z A;  4J7B B;  1UMW A;  2OJX A;  3P35 A;  4HCO A;  4HY2 A;  4RS6 A;  4WHL A;  4E9C A;  2OGQ A;  3Q1I A;  5DMV C;  4O9W A;  4X9V A;  1Q4O A;  4LKM A;  5J19 A;  3HIK A;  4E9D A;  4LKL A;  3P37 A;  4O6W A;  2N19 A;  4H71 A;  3P2W A;  4WHH A;  4HAB A;  4RCP A;  3RQ7 A;  3BZI A;  1Q4K A;  5DMS A;  4H5X A;  3P36 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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