4HCOA

Human plk1-pbd in complex with thymoquinone at the phophopeptide binding site
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
221
structure length
220
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDLARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
publication title Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
pubmed doi rcsb
source organism Homo sapiens
total genus 66
structure length 220
sequence length 221
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-10-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4hcoA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4hcoA01
3P37A 4RS6A 4H71A 4J7BB 3Q1IA 4H5XA 4XB0A 3P2WA 3BZIA 4HY2A 3P36A 1Q4KA 3FVHA 5DMVC 5DMSA 3C5LA 4E9CA 4DFWA 2OGQA 4HCOA 4E67A 3HIHA 4LKLA 5DNJA 4X9WA 3P34A 4WHLA 4O56A 4X9VA 2OJXA 4HABA 5LHZA 1UMWA 3HIKA 3P2ZA 4YYPA 4O6WA 2N19A 5J19A 1Q4OA 3RQ7A 4E9DA 3P35A 4WHHA 4LKMA 4WHKA 4RCPA 4X9RA 4O9WA
chains in the Genus database with same CATH superfamily
3HMJG 3P37A 3P2WA 3P36A 3FVHA 5DNJA 4X9WA 1F32A 3ED4A 4G7NA 1N2KA 2QZUA 4N7ZA 2I9ZA 1Q4OA 3RQ7A 4E9DA 4WHHA 3LM3A 2I9XA 1E3CP 1E2TA 4XB0A 3BZIA 4HY2A 3GYVA 5DMVC 5DMSA 2OGQA 3KDRA 4E67A 4LKLA 4WHLA 1E2SP 4O56A 4X9VA 5AJ9A 2E50A 1UMWA 4O6WA 4FDJA 3LXQA 4CXUA 1F34B 3P35A 4X9RA 4O9WA 4NK7A 4CYRA 1N2LA 1E33P 3GYWA 4N7VA 1Q4KA 3C5LA 4CYSA 3HIHA 1HDHA 3FS3A 2UV8G 1AUKA 4CXSA 2VKZG 4HABA 3HIKA 3P2ZA 4N9JA 5DAYA 1A87A 5J19A 4LKMA 4RCPA 2IA9A 4RS6A 4FDIA 4H71A 3Q1IA 4J7BB 4H5XA 4NKBA 4E9CA 4DFWA 4HCOA 1E1ZP 3P34A 1FSUA 3HFDA 2OJXA 5LHZA 4CXKA 4YYPA 2N19A 1P49A 4WHKA
chains in the Genus database with same CATH topology
3P37A 4RS6A 4H71A 4J7BB 3Q1IA 4H5XA 4XB0A 3P2WA 3BZIA 4HY2A 3P36A 1Q4KA 3FVHA 5DMVC 5DMSA 3C5LA 4E9CA 4DFWA 2OGQA 4HCOA 4E67A 3HIHA 4LKLA 5DNJA 4X9WA 3P34A 4WHLA 4O56A 4X9VA 2OJXA 4HABA 5LHZA 1UMWA 3HIKA 3P2ZA 4YYPA 4O6WA 2N19A 5J19A 1Q4OA 3RQ7A 4E9DA 3P35A 4WHHA 4LKMA 4WHKA 4RCPA 4X9RA 4O9WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3P37 A;  4RS6 A;  4H71 A;  4J7B B;  3Q1I A;  4H5X A;  4XB0 A;  3P2W A;  3BZI A;  4HY2 A;  3P36 A;  1Q4K A;  3FVH A;  5DMV C;  5DMS A;  3C5L A;  4E9C A;  4DFW A;  2OGQ A;  4HCO A;  4E67 A;  3HIH A;  4LKL A;  5DNJ A;  4X9W A;  3P34 A;  4WHL A;  4O56 A;  4X9V A;  2OJX A;  4HAB A;  5LHZ A;  1UMW A;  3HIK A;  3P2Z A;  4YYP A;  4O6W A;  2N19 A;  5J19 A;  1Q4O A;  3RQ7 A;  4E9D A;  3P35 A;  4WHH A;  4LKM A;  4WHK A;  4RCP A;  4X9R A;  4O9W A; 
#chains in the Genus database with same CATH topology
 3HMJ G;  3P37 A;  3P2W A;  3P36 A;  3FVH A;  5DNJ A;  4X9W A;  1F32 A;  3ED4 A;  4G7N A;  1N2K A;  2QZU A;  4N7Z A;  2I9Z A;  1Q4O A;  3RQ7 A;  4E9D A;  4WHH A;  3LM3 A;  2I9X A;  1E3C P;  1E2T A;  4XB0 A;  3BZI A;  4HY2 A;  3GYV A;  5DMV C;  5DMS A;  2OGQ A;  3KDR A;  4E67 A;  4LKL A;  4WHL A;  1E2S P;  4O56 A;  4X9V A;  5AJ9 A;  2E50 A;  1UMW A;  4O6W A;  4FDJ A;  3LXQ A;  4CXU A;  1F34 B;  3P35 A;  4X9R A;  4O9W A;  4NK7 A;  4CYR A;  1N2L A;  1E33 P;  3GYW A;  4N7V A;  1Q4K A;  3C5L A;  4CYS A;  3HIH A;  1HDH A;  3FS3 A;  2UV8 G;  1AUK A;  4CXS A;  2VKZ G;  4HAB A;  3HIK A;  3P2Z A;  4N9J A;  5DAY A;  1A87 A;  5J19 A;  4LKM A;  4RCP A;  2IA9 A;  4RS6 A;  4FDI A;  4H71 A;  3Q1I A;  4J7B B;  4H5X A;  4NKB A;  4E9C A;  4DFW A;  4HCO A;  1E1Z P;  3P34 A;  1FSU A;  3HFD A;  2OJX A;  5LHZ A;  4CXK A;  4YYP A;  2N19 A;  1P49 A;  4WHK A; 
#chains in the Genus database with same CATH homology
 3P37 A;  4RS6 A;  4H71 A;  4J7B B;  3Q1I A;  4H5X A;  4XB0 A;  3P2W A;  3BZI A;  4HY2 A;  3P36 A;  1Q4K A;  3FVH A;  5DMV C;  5DMS A;  3C5L A;  4E9C A;  4DFW A;  2OGQ A;  4HCO A;  4E67 A;  3HIH A;  4LKL A;  5DNJ A;  4X9W A;  3P34 A;  4WHL A;  4O56 A;  4X9V A;  2OJX A;  4HAB A;  5LHZ A;  1UMW A;  3HIK A;  3P2Z A;  4YYP A;  4O6W A;  2N19 A;  5J19 A;  1Q4O A;  3RQ7 A;  4E9D A;  3P35 A;  4WHH A;  4LKM A;  4WHK A;  4RCP A;  4X9R A;  4O9W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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