4HCOA

Human plk1-pbd in complex with thymoquinone at the phophopeptide binding site
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
221
structure length
220
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDLARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 66
structure length 220
sequence length 221
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-10-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4hcoA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4hcoA01
4J7BB 5J19A 3HIKA 4YYPA 2OGQA 3FVHA 4RS6A 3P36A 4H71A 3RQ7A 3P2WA 4O9WA 1Q4OA 4WHHA 1Q4KA 4H5XA 5DMVC 2OJXA 3BZIA 2N19A 3C5LA 3Q1IA 4HY2A 4E9DA 4RCPA 5DMSA 4E67A 4LKLA 4E9CA 3HIHA 4X9RA 4LKMA 4DFWA 1UMWA 3P34A 4O6WA 5DNJA 4HABA 4X9VA 3P35A 3P37A 4X9WA 3P2ZA 4WHLA 4XB0A 4HCOA 5LHZA 4WHKA 4O56A
chains in the Genus database with same CATH superfamily
4CXSA 3HIKA 4YYPA 4RS6A 1HDHA 4CYSA 2I9XA 1N2LA 4WHHA 4CYRA 3ED4A 4FDJA 3C5LA 4N7ZA 3FS3A 4E9CA 1E3CP 1F34B 1N2KA 4FDIA 4X9WA 4XB0A 4HCOA 3KDRA 5LHZA 4CXKA 1AUKA 2OGQA 4N9JA 4O9WA 1F32A 1Q4OA 1P49A 4NK7A 5DMVC 2OJXA 3Q1IA 4LKLA 2QZUA 3HIHA 4X9RA 4DFWA 1UMWA 4X9VA 3P35A 4WHLA 2UV8G 4G7NA 4J7BB 5J19A 4N7VA 4NKBA 2VKZG 3GYVA 2E50A 2I9ZA 3GYWA 4HY2A 4RCPA 3LXQA 4HABA 2IA9A 3P2ZA 4WHKA 3FVHA 1FSUA 3P36A 4H71A 3RQ7A 3P2WA 1E2TA 1Q4KA 4H5XA 3LM3A 3BZIA 2N19A 4E9DA 1E33P 3HFDA 5DMSA 4E67A 4CXUA 4LKMA 4O6WA 3P34A 5DNJA 3HMJG 5AJ9A 1E1ZP 3P37A 1A87A 1E2SP 4O56A 5DAYA
chains in the Genus database with same CATH topology
4J7BB 5J19A 3HIKA 4YYPA 2OGQA 3FVHA 4RS6A 3P36A 4H71A 3RQ7A 3P2WA 4O9WA 1Q4OA 4WHHA 1Q4KA 4H5XA 5DMVC 2OJXA 3BZIA 2N19A 3C5LA 3Q1IA 4HY2A 4E9DA 4RCPA 5DMSA 4E67A 4LKLA 4E9CA 3HIHA 4X9RA 4LKMA 4DFWA 1UMWA 3P34A 4O6WA 5DNJA 4HABA 4X9VA 3P35A 3P37A 4X9WA 3P2ZA 4WHLA 4XB0A 4HCOA 5LHZA 4WHKA 4O56A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J7B B;  5J19 A;  3HIK A;  4YYP A;  2OGQ A;  3FVH A;  4RS6 A;  3P36 A;  4H71 A;  3RQ7 A;  3P2W A;  4O9W A;  1Q4O A;  4WHH A;  1Q4K A;  4H5X A;  5DMV C;  2OJX A;  3BZI A;  2N19 A;  3C5L A;  3Q1I A;  4HY2 A;  4E9D A;  4RCP A;  5DMS A;  4E67 A;  4LKL A;  4E9C A;  3HIH A;  4X9R A;  4LKM A;  4DFW A;  1UMW A;  3P34 A;  4O6W A;  5DNJ A;  4HAB A;  4X9V A;  3P35 A;  3P37 A;  4X9W A;  3P2Z A;  4WHL A;  4XB0 A;  4HCO A;  5LHZ A;  4WHK A;  4O56 A; 
#chains in the Genus database with same CATH topology
 4CXS A;  3HIK A;  4YYP A;  4RS6 A;  1HDH A;  4CYS A;  2I9X A;  1N2L A;  4WHH A;  4CYR A;  3ED4 A;  4FDJ A;  3C5L A;  4N7Z A;  3FS3 A;  4E9C A;  1E3C P;  1F34 B;  1N2K A;  4FDI A;  4X9W A;  4XB0 A;  4HCO A;  3KDR A;  5LHZ A;  4CXK A;  1AUK A;  2OGQ A;  4N9J A;  4O9W A;  1F32 A;  1Q4O A;  1P49 A;  4NK7 A;  5DMV C;  2OJX A;  3Q1I A;  4LKL A;  2QZU A;  3HIH A;  4X9R A;  4DFW A;  1UMW A;  4X9V A;  3P35 A;  4WHL A;  2UV8 G;  4G7N A;  4J7B B;  5J19 A;  4N7V A;  4NKB A;  2VKZ G;  3GYV A;  2E50 A;  2I9Z A;  3GYW A;  4HY2 A;  4RCP A;  3LXQ A;  4HAB A;  2IA9 A;  3P2Z A;  4WHK A;  3FVH A;  1FSU A;  3P36 A;  4H71 A;  3RQ7 A;  3P2W A;  1E2T A;  1Q4K A;  4H5X A;  3LM3 A;  3BZI A;  2N19 A;  4E9D A;  1E33 P;  3HFD A;  5DMS A;  4E67 A;  4CXU A;  4LKM A;  4O6W A;  3P34 A;  5DNJ A;  3HMJ G;  5AJ9 A;  1E1Z P;  3P37 A;  1A87 A;  1E2S P;  4O56 A;  5DAY A; 
#chains in the Genus database with same CATH homology
 4J7B B;  5J19 A;  3HIK A;  4YYP A;  2OGQ A;  3FVH A;  4RS6 A;  3P36 A;  4H71 A;  3RQ7 A;  3P2W A;  4O9W A;  1Q4O A;  4WHH A;  1Q4K A;  4H5X A;  5DMV C;  2OJX A;  3BZI A;  2N19 A;  3C5L A;  3Q1I A;  4HY2 A;  4E9D A;  4RCP A;  5DMS A;  4E67 A;  4LKL A;  4E9C A;  3HIH A;  4X9R A;  4LKM A;  4DFW A;  1UMW A;  3P34 A;  4O6W A;  5DNJ A;  4HAB A;  4X9V A;  3P35 A;  3P37 A;  4X9W A;  3P2Z A;  4WHL A;  4XB0 A;  4HCO A;  5LHZ A;  4WHK A;  4O56 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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