4HCOA

Human plk1-pbd in complex with thymoquinone at the phophopeptide binding site
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
221
structure length
220
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDLARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 66
structure length 220
sequence length 221
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-10-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4hcoA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4hcoA01
3C5LA 2N19A 4WHKA 5DMSA 4O9WA 3P2ZA 5DNJA 4HABA 4XB0A 4LKLA 3P34A 4HCOA 3P37A 4RCPA 4DFWA 4E9DA 3HIKA 1Q4OA 3BZIA 4H71A 3P36A 4WHHA 4X9VA 5LHZA 4X9RA 3FVHA 4YYPA 5J19A 4E9CA 4J7BB 3Q1IA 2OJXA 3RQ7A 4E67A 1Q4KA 3P35A 4H5XA 4RS6A 1UMWA 4O56A 4X9WA 4LKMA 5DMVC 2OGQA 3HIHA 4HY2A 4WHLA 3P2WA 4O6WA
chains in the Genus database with same CATH superfamily
2N19A 4WHKA 3P2ZA 3KDRA 4XB0A 1E1ZP 3P34A 4CXUA 1Q4OA 4N7VA 2I9XA 4X9VA 1A87A 2OJXA 2QZUA 3RQ7A 1F34B 3P35A 3FS3A 4X9WA 4WHLA 3P2WA 2I9ZA 4O6WA 3C5LA 3LM3A 1F32A 5DMSA 4FDIA 3LXQA 5DNJA 4RCPA 3P37A 4DFWA 4H71A 4WHHA 2IA9A 1E33P 1HDHA 3GYVA 4E67A 4N7ZA 1UMWA 1FSUA 5DAYA 5DMVC 2OGQA 4N9JA 4CXSA 4O9WA 1AUKA 4NKBA 2VKZG 1P49A 4G7NA 3BZIA 4YYPA 5J19A 3HMJG 4E9CA 4J7BB 3Q1IA 4H5XA 2E50A 4LKMA 4NK7A 1E3CP 4HCOA 1N2KA 3HIHA 1E2SP 1E2TA 1N2LA 4CYSA 4HABA 4LKLA 2UV8G 4E9DA 3ED4A 4CYRA 3HIKA 3P36A 3GYWA 5LHZA 4X9RA 3FVHA 4FDJA 3HFDA 5AJ9A 1Q4KA 4CXKA 4RS6A 4O56A 4HY2A
chains in the Genus database with same CATH topology
3C5LA 2N19A 4WHKA 5DMSA 4O9WA 3P2ZA 5DNJA 4HABA 4XB0A 4LKLA 3P34A 4HCOA 3P37A 4RCPA 4DFWA 4E9DA 3HIKA 1Q4OA 3BZIA 4H71A 3P36A 4WHHA 4X9VA 5LHZA 4X9RA 3FVHA 4YYPA 5J19A 4E9CA 4J7BB 3Q1IA 2OJXA 3RQ7A 4E67A 1Q4KA 3P35A 4H5XA 4RS6A 1UMWA 4O56A 4X9WA 4LKMA 5DMVC 2OGQA 3HIHA 4HY2A 4WHLA 3P2WA 4O6WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C5L A;  2N19 A;  4WHK A;  5DMS A;  4O9W A;  3P2Z A;  5DNJ A;  4HAB A;  4XB0 A;  4LKL A;  3P34 A;  4HCO A;  3P37 A;  4RCP A;  4DFW A;  4E9D A;  3HIK A;  1Q4O A;  3BZI A;  4H71 A;  3P36 A;  4WHH A;  4X9V A;  5LHZ A;  4X9R A;  3FVH A;  4YYP A;  5J19 A;  4E9C A;  4J7B B;  3Q1I A;  2OJX A;  3RQ7 A;  4E67 A;  1Q4K A;  3P35 A;  4H5X A;  4RS6 A;  1UMW A;  4O56 A;  4X9W A;  4LKM A;  5DMV C;  2OGQ A;  3HIH A;  4HY2 A;  4WHL A;  3P2W A;  4O6W A; 
#chains in the Genus database with same CATH topology
 2N19 A;  4WHK A;  3P2Z A;  3KDR A;  4XB0 A;  1E1Z P;  3P34 A;  4CXU A;  1Q4O A;  4N7V A;  2I9X A;  4X9V A;  1A87 A;  2OJX A;  2QZU A;  3RQ7 A;  1F34 B;  3P35 A;  3FS3 A;  4X9W A;  4WHL A;  3P2W A;  2I9Z A;  4O6W A;  3C5L A;  3LM3 A;  1F32 A;  5DMS A;  4FDI A;  3LXQ A;  5DNJ A;  4RCP A;  3P37 A;  4DFW A;  4H71 A;  4WHH A;  2IA9 A;  1E33 P;  1HDH A;  3GYV A;  4E67 A;  4N7Z A;  1UMW A;  1FSU A;  5DAY A;  5DMV C;  2OGQ A;  4N9J A;  4CXS A;  4O9W A;  1AUK A;  4NKB A;  2VKZ G;  1P49 A;  4G7N A;  3BZI A;  4YYP A;  5J19 A;  3HMJ G;  4E9C A;  4J7B B;  3Q1I A;  4H5X A;  2E50 A;  4LKM A;  4NK7 A;  1E3C P;  4HCO A;  1N2K A;  3HIH A;  1E2S P;  1E2T A;  1N2L A;  4CYS A;  4HAB A;  4LKL A;  2UV8 G;  4E9D A;  3ED4 A;  4CYR A;  3HIK A;  3P36 A;  3GYW A;  5LHZ A;  4X9R A;  3FVH A;  4FDJ A;  3HFD A;  5AJ9 A;  1Q4K A;  4CXK A;  4RS6 A;  4O56 A;  4HY2 A; 
#chains in the Genus database with same CATH homology
 3C5L A;  2N19 A;  4WHK A;  5DMS A;  4O9W A;  3P2Z A;  5DNJ A;  4HAB A;  4XB0 A;  4LKL A;  3P34 A;  4HCO A;  3P37 A;  4RCP A;  4DFW A;  4E9D A;  3HIK A;  1Q4O A;  3BZI A;  4H71 A;  3P36 A;  4WHH A;  4X9V A;  5LHZ A;  4X9R A;  3FVH A;  4YYP A;  5J19 A;  4E9C A;  4J7B B;  3Q1I A;  2OJX A;  3RQ7 A;  4E67 A;  1Q4K A;  3P35 A;  4H5X A;  4RS6 A;  1UMW A;  4O56 A;  4X9W A;  4LKM A;  5DMV C;  2OGQ A;  3HIH A;  4HY2 A;  4WHL A;  3P2W A;  4O6W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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