4E9DA

The structure of the polo-box domain (pbd) of polo-like kinase 1 (plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized dpplhspta peptide
Total Genus 58
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
222
structure length
222
Chain Sequence
b'HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 58
structure length 222
sequence length 222
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-03-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9dA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9dA01
2OGQA 4WHHA 5DMVC 3P37A 3P36A 4O9WA 3C5LA 4X9WA 3RQ7A 1UMWA 4O6WA 5J19A 4X9RA 3P34A 4WHLA 4X9VA 4J7BB 1Q4KA 4RCPA 4HABA 5DNJA 5DMSA 3P2ZA 4HY2A 3P2WA 3FVHA 2OJXA 3BZIA 4H5XA 4LKMA 1Q4OA 4DFWA 4LKLA 3HIHA 3HIKA 3Q1IA 4O56A 4E67A 4H71A 4E9DA 4WHKA 4RS6A 2N19A 4XB0A 4YYPA 4E9CA 5LHZA 3P35A 4HCOA
chains in the Genus database with same CATH superfamily
4O9WA 4NK7A 2I9XA 3GYVA 4X9RA 3P34A 2I9ZA 1Q4KA 1E1ZP 5DNJA 1HDHA 3P2ZA 4CYRA 3FVHA 4H5XA 1Q4OA 4G7NA 3GYWA 3HIKA 3Q1IA 3HFDA 4N7ZA 3LM3A 4O56A 2E50A 4RS6A 1P49A 4N7VA 4E9CA 5LHZA 4HCOA 1F34B 3ED4A 3C5LA 4NKBA 4J7BB 5DMSA 2VKZG 4E67A 4H71A 4FDIA 3LXQA 1E33P 4YYPA 1A87A 4LKMA 4CXUA 2OGQA 5DMVC 3P37A 3P36A 3KDRA 1F32A 3RQ7A 4WHLA 1FSUA 1N2KA 1AUKA 4HABA 4CXKA 3BZIA 4CYSA 1E3CP 4DFWA 1E2TA 4LKLA 4FDJA 3HIHA 2QZUA 4WHKA 4XB0A 4RCPA 4N9JA 4WHHA 4X9WA 2IA9A 1UMWA 4O6WA 5J19A 4X9VA 2UV8G 1N2LA 4HY2A 3P2WA 2OJXA 5AJ9A 3FS3A 3HMJG 5DAYA 4E9DA 4CXSA 1E2SP 2N19A 3P35A
chains in the Genus database with same CATH topology
2OGQA 4WHHA 5DMVC 3P37A 3P36A 4O9WA 3C5LA 4X9WA 3RQ7A 1UMWA 4O6WA 5J19A 4X9RA 3P34A 4WHLA 4X9VA 4J7BB 1Q4KA 4RCPA 4HABA 5DNJA 5DMSA 3P2ZA 4HY2A 3P2WA 3FVHA 2OJXA 3BZIA 4H5XA 4LKMA 1Q4OA 4DFWA 4LKLA 3HIHA 3HIKA 3Q1IA 4O56A 4E67A 4H71A 4E9DA 4WHKA 4RS6A 2N19A 4XB0A 4YYPA 4E9CA 5LHZA 3P35A 4HCOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OGQ A;  4WHH A;  5DMV C;  3P37 A;  3P36 A;  4O9W A;  3C5L A;  4X9W A;  3RQ7 A;  1UMW A;  4O6W A;  5J19 A;  4X9R A;  3P34 A;  4WHL A;  4X9V A;  4J7B B;  1Q4K A;  4RCP A;  4HAB A;  5DNJ A;  5DMS A;  3P2Z A;  4HY2 A;  3P2W A;  3FVH A;  2OJX A;  3BZI A;  4H5X A;  4LKM A;  1Q4O A;  4DFW A;  4LKL A;  3HIH A;  3HIK A;  3Q1I A;  4O56 A;  4E67 A;  4H71 A;  4E9D A;  4WHK A;  4RS6 A;  2N19 A;  4XB0 A;  4YYP A;  4E9C A;  5LHZ A;  3P35 A;  4HCO A; 
#chains in the Genus database with same CATH topology
 4O9W A;  4NK7 A;  2I9X A;  3GYV A;  4X9R A;  3P34 A;  2I9Z A;  1Q4K A;  1E1Z P;  5DNJ A;  1HDH A;  3P2Z A;  4CYR A;  3FVH A;  4H5X A;  1Q4O A;  4G7N A;  3GYW A;  3HIK A;  3Q1I A;  3HFD A;  4N7Z A;  3LM3 A;  4O56 A;  2E50 A;  4RS6 A;  1P49 A;  4N7V A;  4E9C A;  5LHZ A;  4HCO A;  1F34 B;  3ED4 A;  3C5L A;  4NKB A;  4J7B B;  5DMS A;  2VKZ G;  4E67 A;  4H71 A;  4FDI A;  3LXQ A;  1E33 P;  4YYP A;  1A87 A;  4LKM A;  4CXU A;  2OGQ A;  5DMV C;  3P37 A;  3P36 A;  3KDR A;  1F32 A;  3RQ7 A;  4WHL A;  1FSU A;  1N2K A;  1AUK A;  4HAB A;  4CXK A;  3BZI A;  4CYS A;  1E3C P;  4DFW A;  1E2T A;  4LKL A;  4FDJ A;  3HIH A;  2QZU A;  4WHK A;  4XB0 A;  4RCP A;  4N9J A;  4WHH A;  4X9W A;  2IA9 A;  1UMW A;  4O6W A;  5J19 A;  4X9V A;  2UV8 G;  1N2L A;  4HY2 A;  3P2W A;  2OJX A;  5AJ9 A;  3FS3 A;  3HMJ G;  5DAY A;  4E9D A;  4CXS A;  1E2S P;  2N19 A;  3P35 A; 
#chains in the Genus database with same CATH homology
 2OGQ A;  4WHH A;  5DMV C;  3P37 A;  3P36 A;  4O9W A;  3C5L A;  4X9W A;  3RQ7 A;  1UMW A;  4O6W A;  5J19 A;  4X9R A;  3P34 A;  4WHL A;  4X9V A;  4J7B B;  1Q4K A;  4RCP A;  4HAB A;  5DNJ A;  5DMS A;  3P2Z A;  4HY2 A;  3P2W A;  3FVH A;  2OJX A;  3BZI A;  4H5X A;  4LKM A;  1Q4O A;  4DFW A;  4LKL A;  3HIH A;  3HIK A;  3Q1I A;  4O56 A;  4E67 A;  4H71 A;  4E9D A;  4WHK A;  4RS6 A;  2N19 A;  4XB0 A;  4YYP A;  4E9C A;  5LHZ A;  3P35 A;  4HCO A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...