4E9DA

The structure of the polo-box domain (pbd) of polo-like kinase 1 (plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized dpplhspta peptide
Total Genus 58
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
222
structure length
222
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
total genus 58
structure length 222
sequence length 222
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-03-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9dA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9dA01
4X9VA 4E9DA 4YYPA 4X9RA 2N19A 4X9WA 4E67A 4LKLA 3P35A 5J19A 2OGQA 2OJXA 3BZIA 4XB0A 4DFWA 1UMWA 3P2WA 4H71A 4H5XA 4HCOA 3P2ZA 4RCPA 4HY2A 3P37A 4WHKA 5DMSA 5DMVC 3FVHA 3C5LA 3P36A 5LHZA 5DNJA 4RS6A 4O6WA 3HIHA 4LKMA 1Q4OA 3Q1IA 3RQ7A 3P34A 3HIKA 4E9CA 1Q4KA 4HABA 4O9WA 4WHHA 4O56A 4J7BB 4WHLA
chains in the Genus database with same CATH superfamily
4E67A 4FDIA 2OGQA 2I9XA 2E50A 4CYRA 4DFWA 4H5XA 2VKZG 3LXQA 5DMSA 3P36A 4NKBA 3HMJG 4NK7A 3Q1IA 4CXSA 2UV8G 3P34A 2I9ZA 1FSUA 4YYPA 2N19A 4X9WA 1N2LA 3P35A 5J19A 2OJXA 1E33P 3BZIA 3KDRA 4CXUA 1UMWA 4H71A 4HY2A 3P37A 1F32A 5DNJA 1A87A 3LM3A 1E1ZP 3HIHA 4CXKA 4G7NA 1Q4OA 3RQ7A 1E3CP 4O9WA 4WHHA 4O56A 1E2TA 4J7BB 4X9VA 4E9DA 4X9RA 2IA9A 5DAYA 5AJ9A 4XB0A 3P2WA 4N9JA 1HDHA 1N2KA 4N7VA 3GYVA 3FVHA 1P49A 5LHZA 4RS6A 4LKMA 4FDJA 4N7ZA 3HFDA 1AUKA 2QZUA 4WHKA 4WHLA 1F34B 4LKLA 3GYWA 3ED4A 3FS3A 4HCOA 3P2ZA 4RCPA 4CYSA 1E2SP 5DMVC 3C5LA 4O6WA 3HIKA 1Q4KA 4HABA 4E9CA
chains in the Genus database with same CATH topology
4X9VA 4E9DA 4YYPA 4X9RA 2N19A 4X9WA 4E67A 4LKLA 3P35A 5J19A 2OGQA 2OJXA 3BZIA 4XB0A 4DFWA 1UMWA 3P2WA 4H71A 4H5XA 4HCOA 3P2ZA 4RCPA 4HY2A 3P37A 4WHKA 5DMSA 5DMVC 3FVHA 3C5LA 3P36A 5LHZA 5DNJA 4RS6A 4O6WA 3HIHA 4LKMA 1Q4OA 3Q1IA 3RQ7A 3P34A 3HIKA 4E9CA 1Q4KA 4HABA 4O9WA 4WHHA 4O56A 4J7BB 4WHLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X9V A;  4E9D A;  4YYP A;  4X9R A;  2N19 A;  4X9W A;  4E67 A;  4LKL A;  3P35 A;  5J19 A;  2OGQ A;  2OJX A;  3BZI A;  4XB0 A;  4DFW A;  1UMW A;  3P2W A;  4H71 A;  4H5X A;  4HCO A;  3P2Z A;  4RCP A;  4HY2 A;  3P37 A;  4WHK A;  5DMS A;  5DMV C;  3FVH A;  3C5L A;  3P36 A;  5LHZ A;  5DNJ A;  4RS6 A;  4O6W A;  3HIH A;  4LKM A;  1Q4O A;  3Q1I A;  3RQ7 A;  3P34 A;  3HIK A;  4E9C A;  1Q4K A;  4HAB A;  4O9W A;  4WHH A;  4O56 A;  4J7B B;  4WHL A; 
#chains in the Genus database with same CATH topology
 4E67 A;  4FDI A;  2OGQ A;  2I9X A;  2E50 A;  4CYR A;  4DFW A;  4H5X A;  2VKZ G;  3LXQ A;  5DMS A;  3P36 A;  4NKB A;  3HMJ G;  4NK7 A;  3Q1I A;  4CXS A;  2UV8 G;  3P34 A;  2I9Z A;  1FSU A;  4YYP A;  2N19 A;  4X9W A;  1N2L A;  3P35 A;  5J19 A;  2OJX A;  1E33 P;  3BZI A;  3KDR A;  4CXU A;  1UMW A;  4H71 A;  4HY2 A;  3P37 A;  1F32 A;  5DNJ A;  1A87 A;  3LM3 A;  1E1Z P;  3HIH A;  4CXK A;  4G7N A;  1Q4O A;  3RQ7 A;  1E3C P;  4O9W A;  4WHH A;  4O56 A;  1E2T A;  4J7B B;  4X9V A;  4E9D A;  4X9R A;  2IA9 A;  5DAY A;  5AJ9 A;  4XB0 A;  3P2W A;  4N9J A;  1HDH A;  1N2K A;  4N7V A;  3GYV A;  3FVH A;  1P49 A;  5LHZ A;  4RS6 A;  4LKM A;  4FDJ A;  4N7Z A;  3HFD A;  1AUK A;  2QZU A;  4WHK A;  4WHL A;  1F34 B;  4LKL A;  3GYW A;  3ED4 A;  3FS3 A;  4HCO A;  3P2Z A;  4RCP A;  4CYS A;  1E2S P;  5DMV C;  3C5L A;  4O6W A;  3HIK A;  1Q4K A;  4HAB A;  4E9C A; 
#chains in the Genus database with same CATH homology
 4X9V A;  4E9D A;  4YYP A;  4X9R A;  2N19 A;  4X9W A;  4E67 A;  4LKL A;  3P35 A;  5J19 A;  2OGQ A;  2OJX A;  3BZI A;  4XB0 A;  4DFW A;  1UMW A;  3P2W A;  4H71 A;  4H5X A;  4HCO A;  3P2Z A;  4RCP A;  4HY2 A;  3P37 A;  4WHK A;  5DMS A;  5DMV C;  3FVH A;  3C5L A;  3P36 A;  5LHZ A;  5DNJ A;  4RS6 A;  4O6W A;  3HIH A;  4LKM A;  1Q4O A;  3Q1I A;  3RQ7 A;  3P34 A;  3HIK A;  4E9C A;  1Q4K A;  4HAB A;  4O9W A;  4WHH A;  4O56 A;  4J7B B;  4WHL A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...