4E9DA

The structure of the polo-box domain (pbd) of polo-like kinase 1 (plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized dpplhspta peptide
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
222
structure length
222
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
publication title High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
pubmed doi rcsb
source organism Homo sapiens
total genus 58
structure length 222
sequence length 222
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-03-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9dA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9dA01
4X9WA 4XB0A 4WHHA 4E9DA 4HY2A 4RCPA 1Q4KA 3P37A 4LKLA 4WHLA 4H5XA 4WHKA 4E9CA 5J19A 3C5LA 2OJXA 1Q4OA 4O56A 4LKMA 2OGQA 5DMVC 4O6WA 4H71A 3P2ZA 4X9RA 4X9VA 3P2WA 4RS6A 3RQ7A 4HCOA 4DFWA 5DNJA 3FVHA 3P35A 4E67A 3Q1IA 3P36A 4O9WA 3HIHA 2N19A 3P34A 1UMWA 4HABA 5DMSA 4J7BB 3BZIA 4YYPA 5LHZA 3HIKA
chains in the Genus database with same CATH superfamily
4CYRA 1AUKA 3P37A 4LKLA 4H5XA 4E9CA 2OJXA 4X9RA 3ED4A 3GYVA 3HMJG 3P2WA 4RS6A 2I9XA 4DFWA 5DNJA 4CXKA 3Q1IA 2IA9A 3P36A 4FDIA 4CYSA 4N7ZA 2VKZG 3HIHA 2N19A 1E2SP 4YYPA 1N2LA 4WHKA 2E50A 4WHHA 4E9DA 1Q4KA 4WHLA 5J19A 4LKMA 1E1ZP 5DMVC 3P2ZA 2QZUA 4X9VA 3RQ7A 4NKBA 3FVHA 4CXSA 3HFDA 4N9JA 1N2KA 4X9WA 4XB0A 5AJ9A 4RCPA 3GYWA 4O6WA 1E3CP 1E2TA 4HCOA 1HDHA 3P35A 4E67A 2UV8G 4O9WA 3P34A 5DMSA 3KDRA 3LXQA 4J7BB 3BZIA 3LM3A 5DAYA 1A87A 3HIKA 1E33P 4CXUA 4HY2A 4G7NA 4NK7A 3C5LA 1Q4OA 4O56A 1F34B 2OGQA 4H71A 4FDJA 3FS3A 2I9ZA 1UMWA 1P49A 4HABA 1F32A 1FSUA 4N7VA 5LHZA
chains in the Genus database with same CATH topology
4X9WA 4XB0A 4WHHA 4E9DA 4HY2A 4RCPA 1Q4KA 3P37A 4LKLA 4WHLA 4H5XA 4WHKA 4E9CA 5J19A 3C5LA 2OJXA 1Q4OA 4O56A 4LKMA 2OGQA 5DMVC 4O6WA 4H71A 3P2ZA 4X9RA 4X9VA 3P2WA 4RS6A 3RQ7A 4HCOA 4DFWA 5DNJA 3FVHA 3P35A 4E67A 3Q1IA 3P36A 4O9WA 3HIHA 2N19A 3P34A 1UMWA 4HABA 5DMSA 4J7BB 3BZIA 4YYPA 5LHZA 3HIKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X9W A;  4XB0 A;  4WHH A;  4E9D A;  4HY2 A;  4RCP A;  1Q4K A;  3P37 A;  4LKL A;  4WHL A;  4H5X A;  4WHK A;  4E9C A;  5J19 A;  3C5L A;  2OJX A;  1Q4O A;  4O56 A;  4LKM A;  2OGQ A;  5DMV C;  4O6W A;  4H71 A;  3P2Z A;  4X9R A;  4X9V A;  3P2W A;  4RS6 A;  3RQ7 A;  4HCO A;  4DFW A;  5DNJ A;  3FVH A;  3P35 A;  4E67 A;  3Q1I A;  3P36 A;  4O9W A;  3HIH A;  2N19 A;  3P34 A;  1UMW A;  4HAB A;  5DMS A;  4J7B B;  3BZI A;  4YYP A;  5LHZ A;  3HIK A; 
#chains in the Genus database with same CATH topology
 4CYR A;  1AUK A;  3P37 A;  4LKL A;  4H5X A;  4E9C A;  2OJX A;  4X9R A;  3ED4 A;  3GYV A;  3HMJ G;  3P2W A;  4RS6 A;  2I9X A;  4DFW A;  5DNJ A;  4CXK A;  3Q1I A;  2IA9 A;  3P36 A;  4FDI A;  4CYS A;  4N7Z A;  2VKZ G;  3HIH A;  2N19 A;  1E2S P;  4YYP A;  1N2L A;  4WHK A;  2E50 A;  4WHH A;  4E9D A;  1Q4K A;  4WHL A;  5J19 A;  4LKM A;  1E1Z P;  5DMV C;  3P2Z A;  2QZU A;  4X9V A;  3RQ7 A;  4NKB A;  3FVH A;  4CXS A;  3HFD A;  4N9J A;  1N2K A;  4X9W A;  4XB0 A;  5AJ9 A;  4RCP A;  3GYW A;  4O6W A;  1E3C P;  1E2T A;  4HCO A;  1HDH A;  3P35 A;  4E67 A;  2UV8 G;  4O9W A;  3P34 A;  5DMS A;  3KDR A;  3LXQ A;  4J7B B;  3BZI A;  3LM3 A;  5DAY A;  1A87 A;  3HIK A;  1E33 P;  4CXU A;  4HY2 A;  4G7N A;  4NK7 A;  3C5L A;  1Q4O A;  4O56 A;  1F34 B;  2OGQ A;  4H71 A;  4FDJ A;  3FS3 A;  2I9Z A;  1UMW A;  1P49 A;  4HAB A;  1F32 A;  1FSU A;  4N7V A;  5LHZ A; 
#chains in the Genus database with same CATH homology
 4X9W A;  4XB0 A;  4WHH A;  4E9D A;  4HY2 A;  4RCP A;  1Q4K A;  3P37 A;  4LKL A;  4WHL A;  4H5X A;  4WHK A;  4E9C A;  5J19 A;  3C5L A;  2OJX A;  1Q4O A;  4O56 A;  4LKM A;  2OGQ A;  5DMV C;  4O6W A;  4H71 A;  3P2Z A;  4X9R A;  4X9V A;  3P2W A;  4RS6 A;  3RQ7 A;  4HCO A;  4DFW A;  5DNJ A;  3FVH A;  3P35 A;  4E67 A;  3Q1I A;  3P36 A;  4O9W A;  3HIH A;  2N19 A;  3P34 A;  1UMW A;  4HAB A;  5DMS A;  4J7B B;  3BZI A;  4YYP A;  5LHZ A;  3HIK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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