5DMSA

Mouse polo-box domain and emi2 (169-177)
Total Genus 76
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
226
structure length
226
Chain Sequence
EAIECHLSDLLQQLTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLNYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGTVQINFFQDHTKLILCPLMAAVTYINEKRDFQTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization.
pubmed doi rcsb
source organism Mus musculus
molecule tags Transferase/metal binding protein
molecule keywords Serine/threonine-protein kinase PLK1
total genus 76
structure length 226
sequence length 226
chains with identical sequence C
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2015-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 5dmsA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 5dmsA01
1Q4KA 4RCPA 4X9WA 4E9DA 4O56A 5LHZA 4HY2A 4H5XA 4X9RA 5DMSA 4RS6A 4XB0A 3P2ZA 4WHLA 3P37A 3P2WA 3P36A 3P35A 3RQ7A 4O6WA 4X9VA 2N19A 3C5LA 4LKLA 4DFWA 3HIKA 4HCOA 4LKMA 1UMWA 5DMVC 4WHKA 4E9CA 1Q4OA 4HABA 5DNJA 3FVHA 4H71A 4E67A 3HIHA 4WHHA 4YYPA 3BZIA 3P34A 3Q1IA 2OGQA 4J7BB 2OJXA 4O9WA 5J19A
chains in the Genus database with same CATH superfamily
1Q4KA 4X9WA 5LHZA 4FDJA 2E50A 4H5XA 3P2ZA 1F32A 3P37A 4CXUA 4X9VA 1F34B 4DFWA 2QZUA 1P49A 4WHKA 1N2LA 1FSUA 4CXKA 3HIHA 4J7BB 4CYSA 4CYRA 5J19A 1E1ZP 1HDHA 4N9JA 3HFDA 4G7NA 4LKLA 3HIKA 4HCOA 4N7VA 4LKMA 5DMVC 1Q4OA 5DNJA 1A87A 1E3CP 3KDRA 3P34A 3Q1IA 4N7ZA 3ED4A 2OGQA 1N2KA 4NKBA 1AUKA 4RCPA 4NK7A 5DMSA 4WHLA 3P36A 3P35A 3C5LA 3GYVA 5DAYA 1E33P 1UMWA 2IA9A 3FS3A 2VKZG 4E9CA 4FDIA 1E2TA 4HABA 3LM3A 4YYPA 2OJXA 4E9DA 4O56A 2I9ZA 5AJ9A 4HY2A 4X9RA 4RS6A 4XB0A 3P2WA 3RQ7A 3HMJG 1E2SP 2UV8G 4O6WA 2N19A 4CXSA 3LXQA 3FVHA 4H71A 2I9XA 4E67A 4WHHA 3GYWA 3BZIA 4O9WA
chains in the Genus database with same CATH topology
1Q4KA 4RCPA 4X9WA 4E9DA 4O56A 5LHZA 4HY2A 4H5XA 4X9RA 5DMSA 4RS6A 4XB0A 3P2ZA 4WHLA 3P37A 3P2WA 3P36A 3P35A 3RQ7A 4O6WA 4X9VA 2N19A 3C5LA 4LKLA 4DFWA 3HIKA 4HCOA 4LKMA 1UMWA 5DMVC 4WHKA 4E9CA 1Q4OA 4HABA 5DNJA 3FVHA 4H71A 4E67A 3HIHA 4WHHA 4YYPA 3BZIA 3P34A 3Q1IA 2OGQA 4J7BB 2OJXA 4O9WA 5J19A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q4K A;  4RCP A;  4X9W A;  4E9D A;  4O56 A;  5LHZ A;  4HY2 A;  4H5X A;  4X9R A;  5DMS A;  4RS6 A;  4XB0 A;  3P2Z A;  4WHL A;  3P37 A;  3P2W A;  3P36 A;  3P35 A;  3RQ7 A;  4O6W A;  4X9V A;  2N19 A;  3C5L A;  4LKL A;  4DFW A;  3HIK A;  4HCO A;  4LKM A;  1UMW A;  5DMV C;  4WHK A;  4E9C A;  1Q4O A;  4HAB A;  5DNJ A;  3FVH A;  4H71 A;  4E67 A;  3HIH A;  4WHH A;  4YYP A;  3BZI A;  3P34 A;  3Q1I A;  2OGQ A;  4J7B B;  2OJX A;  4O9W A;  5J19 A; 
#chains in the Genus database with same CATH topology
 1Q4K A;  4X9W A;  5LHZ A;  4FDJ A;  2E50 A;  4H5X A;  3P2Z A;  1F32 A;  3P37 A;  4CXU A;  4X9V A;  1F34 B;  4DFW A;  2QZU A;  1P49 A;  4WHK A;  1N2L A;  1FSU A;  4CXK A;  3HIH A;  4J7B B;  4CYS A;  4CYR A;  5J19 A;  1E1Z P;  1HDH A;  4N9J A;  3HFD A;  4G7N A;  4LKL A;  3HIK A;  4HCO A;  4N7V A;  4LKM A;  5DMV C;  1Q4O A;  5DNJ A;  1A87 A;  1E3C P;  3KDR A;  3P34 A;  3Q1I A;  4N7Z A;  3ED4 A;  2OGQ A;  1N2K A;  4NKB A;  1AUK A;  4RCP A;  4NK7 A;  5DMS A;  4WHL A;  3P36 A;  3P35 A;  3C5L A;  3GYV A;  5DAY A;  1E33 P;  1UMW A;  2IA9 A;  3FS3 A;  2VKZ G;  4E9C A;  4FDI A;  1E2T A;  4HAB A;  3LM3 A;  4YYP A;  2OJX A;  4E9D A;  4O56 A;  2I9Z A;  5AJ9 A;  4HY2 A;  4X9R A;  4RS6 A;  4XB0 A;  3P2W A;  3RQ7 A;  3HMJ G;  1E2S P;  2UV8 G;  4O6W A;  2N19 A;  4CXS A;  3LXQ A;  3FVH A;  4H71 A;  2I9X A;  4E67 A;  4WHH A;  3GYW A;  3BZI A;  4O9W A; 
#chains in the Genus database with same CATH homology
 1Q4K A;  4RCP A;  4X9W A;  4E9D A;  4O56 A;  5LHZ A;  4HY2 A;  4H5X A;  4X9R A;  5DMS A;  4RS6 A;  4XB0 A;  3P2Z A;  4WHL A;  3P37 A;  3P2W A;  3P36 A;  3P35 A;  3RQ7 A;  4O6W A;  4X9V A;  2N19 A;  3C5L A;  4LKL A;  4DFW A;  3HIK A;  4HCO A;  4LKM A;  1UMW A;  5DMV C;  4WHK A;  4E9C A;  1Q4O A;  4HAB A;  5DNJ A;  3FVH A;  4H71 A;  4E67 A;  3HIH A;  4WHH A;  4YYP A;  3BZI A;  3P34 A;  3Q1I A;  2OGQ A;  4J7B B;  2OJX A;  4O9W A;  5J19 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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