4N7VA

Crystal structure of human plk4 cryptic polo box (cpb) in complex with a cep152 n-terminal fragment
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
222
structure length
222
Chain Sequence
TLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Cell cycle
molecule keywords Serine/threonine-protein kinase PLK4
publication title Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.
pubmed doi rcsb
source organism Homo sapiens
total genus 52
structure length 222
sequence length 222
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-10-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF18190 Plk4_PB1 Polo-like Kinase 4 Polo Box 1
A PF18409 Plk4_PB2 Polo-like Kinase 4 Polo Box 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.120 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n7vA01
3.30.1120.130 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n7vA02
4N7VA 4N9JA 4G7NA 4N7ZA 4NKBA 4NK7A
chains in the Genus database with same CATH superfamily
4O6WA 1Q4KA 5J19A 1A87A 4CXKA 4N7VA 3HIKA 4FDJA 4CXUA 2QZUA 4E67A 1E2TA 4H5XA 1N2LA 2VKZG 1F34B 3LXQA 4G7NA 4N7ZA 3P2ZA 4HABA 4YYPA 4LKMA 4NK7A 4H71A 2I9ZA 4RCPA 4HCOA 3FVHA 4X9RA 1E33P 4CYRA 4E9CA 2IA9A 4WHHA 3C5LA 3P36A 5DMVC 4HY2A 3LM3A 3HIHA 2I9XA 1E1ZP 4DFWA 3BZIA 2OJXA 1FSUA 4CYSA 3Q1IA 3GYWA 5DMSA 3KDRA 3RQ7A 3HMJG 4WHKA 5AJ9A 3FS3A 1P49A 4J7BB 4N9JA 4E9DA 3HFDA 1E3CP 3P34A 3P2WA 4X9WA 1E2SP 1UMWA 4O9WA 2OGQA 1HDHA 1F32A 1AUKA 2UV8G 3P35A 4XB0A 4NKBA 2E50A 4RS6A 5DNJA 4LKLA 2N19A 4FDIA 3ED4A 3GYVA 1N2KA 5LHZA 1Q4OA 4X9VA 4WHLA 5DAYA 3P37A 4O56A 4CXSA
chains in the Genus database with same CATH topology
1AUKA 3GYWA 2UV8G 3KDRA 1E33P 4CYRA 4NKBA 2E50A 4CXKA 3HMJG 4FDIA 4N7VA 5AJ9A 3ED4A 3GYVA 1N2KA 3FS3A 4FDJA 4CXUA 1P49A 2QZUA 1E2TA 3LM3A 1N2LA 2VKZG 4N9JA 3LXQA 4G7NA 4N7ZA 3HFDA 1E1ZP 1E3CP 5DAYA 1FSUA 4CYSA 1E2SP 1HDHA 4CXSA 4NK7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4N7V A;  4N9J A;  4G7N A;  4N7Z A;  4NKB A;  4NK7 A; 
#chains in the Genus database with same CATH topology
 4O6W A;  1Q4K A;  5J19 A;  1A87 A;  4CXK A;  4N7V A;  3HIK A;  4FDJ A;  4CXU A;  2QZU A;  4E67 A;  1E2T A;  4H5X A;  1N2L A;  2VKZ G;  1F34 B;  3LXQ A;  4G7N A;  4N7Z A;  3P2Z A;  4HAB A;  4YYP A;  4LKM A;  4NK7 A;  4H71 A;  2I9Z A;  4RCP A;  4HCO A;  3FVH A;  4X9R A;  1E33 P;  4CYR A;  4E9C A;  2IA9 A;  4WHH A;  3C5L A;  3P36 A;  5DMV C;  4HY2 A;  3LM3 A;  3HIH A;  2I9X A;  1E1Z P;  4DFW A;  3BZI A;  2OJX A;  1FSU A;  4CYS A;  3Q1I A;  3GYW A;  5DMS A;  3KDR A;  3RQ7 A;  3HMJ G;  4WHK A;  5AJ9 A;  3FS3 A;  1P49 A;  4J7B B;  4N9J A;  4E9D A;  3HFD A;  1E3C P;  3P34 A;  3P2W A;  4X9W A;  1E2S P;  1UMW A;  4O9W A;  2OGQ A;  1HDH A;  1F32 A;  1AUK A;  2UV8 G;  3P35 A;  4XB0 A;  4NKB A;  2E50 A;  4RS6 A;  5DNJ A;  4LKL A;  2N19 A;  4FDI A;  3ED4 A;  3GYV A;  1N2K A;  5LHZ A;  1Q4O A;  4X9V A;  4WHL A;  5DAY A;  3P37 A;  4O56 A;  4CXS A; 
#chains in the Genus database with same CATH homology
 1AUK A;  3GYW A;  2UV8 G;  3KDR A;  1E33 P;  4CYR A;  4NKB A;  2E50 A;  4CXK A;  3HMJ G;  4FDI A;  4N7V A;  5AJ9 A;  3ED4 A;  3GYV A;  1N2K A;  3FS3 A;  4FDJ A;  4CXU A;  1P49 A;  2QZU A;  1E2T A;  3LM3 A;  1N2L A;  2VKZ G;  4N9J A;  3LXQ A;  4G7N A;  4N7Z A;  3HFD A;  1E1Z P;  1E3C P;  5DAY A;  1FSU A;  4CYS A;  1E2S P;  1HDH A;  4CXS A;  4NK7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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