4N7VA

Crystal structure of human plk4 cryptic polo box (cpb) in complex with a cep152 n-terminal fragment
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
222
structure length
222
Chain Sequence
b'TLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKP'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK4
publication title Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 52
structure length 222
sequence length 222
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-10-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF18190 Plk4_PB1 Polo-like Kinase 4 Polo Box 1
A PF18409 Plk4_PB2 Polo-like Kinase 4 Polo Box 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.120 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n7vA01
3.30.1120.130 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n7vA02
4N7VA 4NKBA 4N7ZA 4NK7A 4G7NA 4N9JA
chains in the Genus database with same CATH superfamily
3P2WA 3RQ7A 1E2TA 3GYVA 4E67A 4N9JA 4LKMA 4X9VA 4X9RA 3P36A 1N2LA 4XB0A 2N19A 3P2ZA 3FS3A 4NKBA 4NK7A 3LM3A 1E33P 2OGQA 1F34B 4FDJA 3BZIA 4J7BB 3P34A 3GYWA 1AUKA 4O9WA 3HFDA 4CYRA 5AJ9A 2E50A 5J19A 5DMSA 4HABA 3LXQA 4HCOA 4CXUA 1HDHA 1P49A 5LHZA 4WHKA 4FDIA 4CYSA 4N7ZA 3ED4A 2UV8G 4H5XA 3KDRA 4G7NA 2I9XA 4RS6A 3P37A 2QZUA 3C5LA 4H71A 3P35A 5DMVC 3HIHA 4O56A 5DAYA 3FVHA 4HY2A 4X9WA 3HIKA 1A87A 4WHHA 2IA9A 1UMWA 4WHLA 4CXSA 2OJXA 2I9ZA 1Q4OA 3HMJG 4O6WA 3Q1IA 1E3CP 1Q4KA 4N7VA 1F32A 1E1ZP 4CXKA 1FSUA 4LKLA 4DFWA 4E9CA 4YYPA 2VKZG 1N2KA 4RCPA 5DNJA 4E9DA 1E2SP
chains in the Genus database with same CATH topology
3ED4A 3GYWA 2UV8G 4CXSA 1E2TA 1AUKA 3GYVA 3KDRA 4G7NA 4N9JA 3HFDA 4CYRA 2QZUA 3HMJG 1N2LA 5AJ9A 2E50A 1E3CP 4N7VA 3LXQA 3FS3A 4NKBA 5DAYA 1E1ZP 4NK7A 4CXUA 4CXKA 3LM3A 1FSUA 1HDHA 1P49A 1E33P 4FDJA 2VKZG 4FDIA 1N2KA 4CYSA 4N7ZA 1E2SP
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4N7V A;  4NKB A;  4N7Z A;  4NK7 A;  4G7N A;  4N9J A; 
#chains in the Genus database with same CATH topology
 3P2W A;  3RQ7 A;  1E2T A;  3GYV A;  4E67 A;  4N9J A;  4LKM A;  4X9V A;  4X9R A;  3P36 A;  1N2L A;  4XB0 A;  2N19 A;  3P2Z A;  3FS3 A;  4NKB A;  4NK7 A;  3LM3 A;  1E33 P;  2OGQ A;  1F34 B;  4FDJ A;  3BZI A;  4J7B B;  3P34 A;  3GYW A;  1AUK A;  4O9W A;  3HFD A;  4CYR A;  5AJ9 A;  2E50 A;  5J19 A;  5DMS A;  4HAB A;  3LXQ A;  4HCO A;  4CXU A;  1HDH A;  1P49 A;  5LHZ A;  4WHK A;  4FDI A;  4CYS A;  4N7Z A;  3ED4 A;  2UV8 G;  4H5X A;  3KDR A;  4G7N A;  2I9X A;  4RS6 A;  3P37 A;  2QZU A;  3C5L A;  4H71 A;  3P35 A;  5DMV C;  3HIH A;  4O56 A;  5DAY A;  3FVH A;  4HY2 A;  4X9W A;  3HIK A;  1A87 A;  4WHH A;  2IA9 A;  1UMW A;  4WHL A;  4CXS A;  2OJX A;  2I9Z A;  1Q4O A;  3HMJ G;  4O6W A;  3Q1I A;  1E3C P;  1Q4K A;  4N7V A;  1F32 A;  1E1Z P;  4CXK A;  1FSU A;  4LKL A;  4DFW A;  4E9C A;  4YYP A;  2VKZ G;  1N2K A;  4RCP A;  5DNJ A;  4E9D A;  1E2S P; 
#chains in the Genus database with same CATH homology
 3ED4 A;  3GYW A;  2UV8 G;  4CXS A;  1E2T A;  1AUK A;  3GYV A;  3KDR A;  4G7N A;  4N9J A;  3HFD A;  4CYR A;  2QZU A;  3HMJ G;  1N2L A;  5AJ9 A;  2E50 A;  1E3C P;  4N7V A;  3LXQ A;  3FS3 A;  4NKB A;  5DAY A;  1E1Z P;  4NK7 A;  4CXU A;  4CXK A;  3LM3 A;  1FSU A;  1HDH A;  1P49 A;  1E33 P;  4FDJ A;  2VKZ G;  4FDI A;  1N2K A;  4CYS A;  4N7Z A;  1E2S P; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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