4N7VA

Crystal structure of human plk4 cryptic polo box (cpb) in complex with a cep152 n-terminal fragment
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
222
structure length
222
Chain Sequence
TLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK4
publication title Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 52
structure length 222
sequence length 222
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-10-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF18190 Plk4_PB1 Polo-like Kinase 4 Polo Box 1
A PF18409 Plk4_PB2 Polo-like Kinase 4 Polo Box 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.120 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n7vA01
3.30.1120.130 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n7vA02
4G7NA 4N7ZA 4NK7A 4N9JA 4NKBA 4N7VA
chains in the Genus database with same CATH superfamily
4LKLA 3HIKA 4H71A 3GYWA 3P36A 1A87A 4CXSA 3P37A 2IA9A 1F34B 1Q4KA 4N9JA 5DMSA 4E67A 5DAYA 3C5LA 1P49A 4CYRA 1E1ZP 1E33P 3Q1IA 4RCPA 4XB0A 3HMJG 4E9CA 4CYSA 1E2SP 4WHLA 2N19A 3P34A 3FVHA 4RS6A 3HFDA 4HABA 2OJXA 2VKZG 4X9RA 1N2KA 5J19A 1AUKA 4O56A 3LXQA 4O6WA 4E9DA 1E3CP 2UV8G 4J7BB 3KDRA 3ED4A 4NK7A 3LM3A 4CXKA 2OGQA 4N7VA 3P2WA 3BZIA 5DMVC 4FDJA 4WHKA 1HDHA 1UMWA 4LKMA 1FSUA 4H5XA 4HY2A 3GYVA 3P35A 3HIHA 3P2ZA 1F32A 4X9VA 4O9WA 4G7NA 4N7ZA 5LHZA 2I9XA 4HCOA 4X9WA 2E50A 4CXUA 1N2LA 3FS3A 1E2TA 5AJ9A 4YYPA 4WHHA 4DFWA 1Q4OA 2QZUA 2I9ZA 5DNJA 4NKBA 4FDIA 3RQ7A
chains in the Genus database with same CATH topology
3ED4A 4NK7A 3HMJG 3LM3A 4CXKA 4CYSA 3GYWA 4G7NA 1E2SP 4N7ZA 4CXSA 2E50A 3HFDA 4N7VA 4CXUA 2VKZG 1N2LA 1N2KA 4N9JA 3FS3A 1E2TA 1AUKA 5AJ9A 3LXQA 5DAYA 4FDJA 1HDHA 1P49A 4CYRA 1E1ZP 1E33P 2QZUA 1E3CP 1FSUA 4NKBA 3GYVA 2UV8G 4FDIA 3KDRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4G7N A;  4N7Z A;  4NK7 A;  4N9J A;  4NKB A;  4N7V A; 
#chains in the Genus database with same CATH topology
 4LKL A;  3HIK A;  4H71 A;  3GYW A;  3P36 A;  1A87 A;  4CXS A;  3P37 A;  2IA9 A;  1F34 B;  1Q4K A;  4N9J A;  5DMS A;  4E67 A;  5DAY A;  3C5L A;  1P49 A;  4CYR A;  1E1Z P;  1E33 P;  3Q1I A;  4RCP A;  4XB0 A;  3HMJ G;  4E9C A;  4CYS A;  1E2S P;  4WHL A;  2N19 A;  3P34 A;  3FVH A;  4RS6 A;  3HFD A;  4HAB A;  2OJX A;  2VKZ G;  4X9R A;  1N2K A;  5J19 A;  1AUK A;  4O56 A;  3LXQ A;  4O6W A;  4E9D A;  1E3C P;  2UV8 G;  4J7B B;  3KDR A;  3ED4 A;  4NK7 A;  3LM3 A;  4CXK A;  2OGQ A;  4N7V A;  3P2W A;  3BZI A;  5DMV C;  4FDJ A;  4WHK A;  1HDH A;  1UMW A;  4LKM A;  1FSU A;  4H5X A;  4HY2 A;  3GYV A;  3P35 A;  3HIH A;  3P2Z A;  1F32 A;  4X9V A;  4O9W A;  4G7N A;  4N7Z A;  5LHZ A;  2I9X A;  4HCO A;  4X9W A;  2E50 A;  4CXU A;  1N2L A;  3FS3 A;  1E2T A;  5AJ9 A;  4YYP A;  4WHH A;  4DFW A;  1Q4O A;  2QZU A;  2I9Z A;  5DNJ A;  4NKB A;  4FDI A;  3RQ7 A; 
#chains in the Genus database with same CATH homology
 3ED4 A;  4NK7 A;  3HMJ G;  3LM3 A;  4CXK A;  4CYS A;  3GYW A;  4G7N A;  1E2S P;  4N7Z A;  4CXS A;  2E50 A;  3HFD A;  4N7V A;  4CXU A;  2VKZ G;  1N2L A;  1N2K A;  4N9J A;  3FS3 A;  1E2T A;  1AUK A;  5AJ9 A;  3LXQ A;  5DAY A;  4FDJ A;  1HDH A;  1P49 A;  4CYR A;  1E1Z P;  1E33 P;  2QZU A;  1E3C P;  1FSU A;  4NKB A;  3GYV A;  2UV8 G;  4FDI A;  3KDR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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