4N7VA

Crystal structure of human plk4 cryptic polo box (cpb) in complex with a cep152 n-terminal fragment
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
222
structure length
222
Chain Sequence
TLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords Serine/threonine-protein kinase PLK4
total genus 52
structure length 222
sequence length 222
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-10-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF18190 Plk4_PB1 Polo-like Kinase 4 Polo Box 1
A PF18409 Plk4_PB2 Polo-like Kinase 4 Polo Box 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.120 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n7vA01
3.30.1120.130 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n7vA02
4N7ZA 4N9JA 4N7VA 4NKBA 4NK7A 4G7NA
chains in the Genus database with same CATH superfamily
3GYVA 4X9VA 1F32A 4HABA 4RCPA 1E2TA 3P37A 1Q4KA 4X9WA 2I9XA 1N2LA 3ED4A 2UV8G 3FVHA 4E67A 4RS6A 4N7ZA 2OGQA 4XB0A 5J19A 4N9JA 4J7BB 5AJ9A 1HDHA 4O6WA 1Q4OA 3HMJG 1E33P 3RQ7A 2I9ZA 4WHKA 4HY2A 3P35A 4WHHA 4G7NA 4E9DA 3GYWA 3HFDA 4CXKA 4WHLA 2VKZG 1P49A 4CYRA 4CXSA 5DMSA 1A87A 2OJXA 4E9CA 4CYSA 4YYPA 3KDRA 4H71A 3HIHA 4HCOA 3LXQA 4N7VA 1N2KA 3P2ZA 1E3CP 1FSUA 3Q1IA 3FS3A 1F34B 3C5LA 5LHZA 3P2WA 3P34A 5DNJA 1UMWA 3LM3A 4X9RA 3P36A 4LKMA 4CXUA 2N19A 4LKLA 2E50A 3HIKA 1E2SP 5DMVC 4DFWA 2IA9A 1E1ZP 4FDJA 4O56A 4FDIA 5DAYA 1AUKA 2QZUA 4H5XA 3BZIA 4NKBA 4O9WA 4NK7A
chains in the Genus database with same CATH topology
3GYVA 1E33P 3KDRA 1E2TA 4CXUA 4G7NA 3LXQA 2E50A 4N7VA 1N2KA 3ED4A 1E2SP 1E3CP 1N2LA 2UV8G 1FSUA 3GYWA 3HFDA 3FS3A 4CXKA 4N7ZA 1E1ZP 4FDJA 2VKZG 1P49A 4FDIA 4N9JA 4CYRA 5DAYA 3LM3A 5AJ9A 1AUKA 2QZUA 4CXSA 1HDHA 4NKBA 4NK7A 4CYSA 3HMJG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4N7Z A;  4N9J A;  4N7V A;  4NKB A;  4NK7 A;  4G7N A; 
#chains in the Genus database with same CATH topology
 3GYV A;  4X9V A;  1F32 A;  4HAB A;  4RCP A;  1E2T A;  3P37 A;  1Q4K A;  4X9W A;  2I9X A;  1N2L A;  3ED4 A;  2UV8 G;  3FVH A;  4E67 A;  4RS6 A;  4N7Z A;  2OGQ A;  4XB0 A;  5J19 A;  4N9J A;  4J7B B;  5AJ9 A;  1HDH A;  4O6W A;  1Q4O A;  3HMJ G;  1E33 P;  3RQ7 A;  2I9Z A;  4WHK A;  4HY2 A;  3P35 A;  4WHH A;  4G7N A;  4E9D A;  3GYW A;  3HFD A;  4CXK A;  4WHL A;  2VKZ G;  1P49 A;  4CYR A;  4CXS A;  5DMS A;  1A87 A;  2OJX A;  4E9C A;  4CYS A;  4YYP A;  3KDR A;  4H71 A;  3HIH A;  4HCO A;  3LXQ A;  4N7V A;  1N2K A;  3P2Z A;  1E3C P;  1FSU A;  3Q1I A;  3FS3 A;  1F34 B;  3C5L A;  5LHZ A;  3P2W A;  3P34 A;  5DNJ A;  1UMW A;  3LM3 A;  4X9R A;  3P36 A;  4LKM A;  4CXU A;  2N19 A;  4LKL A;  2E50 A;  3HIK A;  1E2S P;  5DMV C;  4DFW A;  2IA9 A;  1E1Z P;  4FDJ A;  4O56 A;  4FDI A;  5DAY A;  1AUK A;  2QZU A;  4H5X A;  3BZI A;  4NKB A;  4O9W A;  4NK7 A; 
#chains in the Genus database with same CATH homology
 3GYV A;  1E33 P;  3KDR A;  1E2T A;  4CXU A;  4G7N A;  3LXQ A;  2E50 A;  4N7V A;  1N2K A;  3ED4 A;  1E2S P;  1E3C P;  1N2L A;  2UV8 G;  1FSU A;  3GYW A;  3HFD A;  3FS3 A;  4CXK A;  4N7Z A;  1E1Z P;  4FDJ A;  2VKZ G;  1P49 A;  4FDI A;  4N9J A;  4CYR A;  5DAY A;  3LM3 A;  5AJ9 A;  1AUK A;  2QZU A;  4CXS A;  1HDH A;  4NKB A;  4NK7 A;  4CYS A;  3HMJ G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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