4LKMA

Crystal structure of plk1 polo-box domain in complex with pl-74
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
231
structure length
226
Chain Sequence
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
publication title Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1
pubmed doi rcsb
source organism Homo sapiens
total genus 75
structure length 226
sequence length 231
chains with identical sequence C
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-07-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4lkmA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4lkmA01
4X9RA 4O56A 4J7BB 3BZIA 3HIHA 4LKLA 2OGQA 3C5LA 4HABA 3P2ZA 3RQ7A 4RCPA 3P34A 4E9DA 5DMVC 3HIKA 3P37A 4LKMA 4RS6A 4DFWA 4E67A 3Q1IA 1Q4OA 3P36A 4X9VA 5J19A 3FVHA 2N19A 4WHLA 4XB0A 3P35A 4HCOA 4WHKA 4HY2A 1UMWA 4WHHA 5DNJA 1Q4KA 4E9CA 4O6WA 4X9WA 2OJXA 5DMSA 4O9WA 4H71A 5LHZA 4YYPA 4H5XA 3P2WA
chains in the Genus database with same CATH superfamily
1N2KA 4O56A 4J7BB 2OGQA 2I9XA 1FSUA 4RCPA 4E9DA 3HIKA 4E67A 2UV8G 2VKZG 3FVHA 4G7NA 1F34B 4FDIA 4HCOA 4CXSA 1UMWA 3HMJG 1AUKA 1Q4KA 4E9CA 1E2TA 4X9WA 2OJXA 3LM3A 5LHZA 2N19A 4CXKA 5AJ9A 1P49A 4LKLA 3C5LA 1E33P 4CXUA 4N7ZA 4N7VA 3P37A 4NKBA 4RS6A 1E3CP 2I9ZA 1Q4OA 1F32A 2QZUA 4WHKA 3ED4A 4HY2A 1E2SP 4H71A 4H5XA 1N2LA 4N9JA 3HIHA 4FDJA 1HDHA 5DMVC 4DFWA 3KDRA 5J19A 4WHLA 4WHHA 3LXQA 3FS3A 4O6WA 5DMSA 4O9WA 2IA9A 1E1ZP 4X9RA 3BZIA 4HABA 3HFDA 3P2ZA 3RQ7A 3P34A 2E50A 1A87A 4LKMA 3Q1IA 4CYRA 3P36A 4X9VA 4NK7A 4CYSA 4XB0A 3GYVA 3P35A 5DAYA 3GYWA 5DNJA 4YYPA 3P2WA
chains in the Genus database with same CATH topology
4X9RA 4O56A 4J7BB 3BZIA 3HIHA 4LKLA 2OGQA 3C5LA 4HABA 3P2ZA 3RQ7A 4RCPA 3P34A 4E9DA 5DMVC 3HIKA 3P37A 4LKMA 4RS6A 4DFWA 4E67A 3Q1IA 1Q4OA 3P36A 4X9VA 5J19A 3FVHA 2N19A 4WHLA 4XB0A 3P35A 4HCOA 4WHKA 4HY2A 1UMWA 4WHHA 5DNJA 1Q4KA 4E9CA 4O6WA 4X9WA 2OJXA 5DMSA 4O9WA 4H71A 5LHZA 4YYPA 4H5XA 3P2WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X9R A;  4O56 A;  4J7B B;  3BZI A;  3HIH A;  4LKL A;  2OGQ A;  3C5L A;  4HAB A;  3P2Z A;  3RQ7 A;  4RCP A;  3P34 A;  4E9D A;  5DMV C;  3HIK A;  3P37 A;  4LKM A;  4RS6 A;  4DFW A;  4E67 A;  3Q1I A;  1Q4O A;  3P36 A;  4X9V A;  5J19 A;  3FVH A;  2N19 A;  4WHL A;  4XB0 A;  3P35 A;  4HCO A;  4WHK A;  4HY2 A;  1UMW A;  4WHH A;  5DNJ A;  1Q4K A;  4E9C A;  4O6W A;  4X9W A;  2OJX A;  5DMS A;  4O9W A;  4H71 A;  5LHZ A;  4YYP A;  4H5X A;  3P2W A; 
#chains in the Genus database with same CATH topology
 1N2K A;  4O56 A;  4J7B B;  2OGQ A;  2I9X A;  1FSU A;  4RCP A;  4E9D A;  3HIK A;  4E67 A;  2UV8 G;  2VKZ G;  3FVH A;  4G7N A;  1F34 B;  4FDI A;  4HCO A;  4CXS A;  1UMW A;  3HMJ G;  1AUK A;  1Q4K A;  4E9C A;  1E2T A;  4X9W A;  2OJX A;  3LM3 A;  5LHZ A;  2N19 A;  4CXK A;  5AJ9 A;  1P49 A;  4LKL A;  3C5L A;  1E33 P;  4CXU A;  4N7Z A;  4N7V A;  3P37 A;  4NKB A;  4RS6 A;  1E3C P;  2I9Z A;  1Q4O A;  1F32 A;  2QZU A;  4WHK A;  3ED4 A;  4HY2 A;  1E2S P;  4H71 A;  4H5X A;  1N2L A;  4N9J A;  3HIH A;  4FDJ A;  1HDH A;  5DMV C;  4DFW A;  3KDR A;  5J19 A;  4WHL A;  4WHH A;  3LXQ A;  3FS3 A;  4O6W A;  5DMS A;  4O9W A;  2IA9 A;  1E1Z P;  4X9R A;  3BZI A;  4HAB A;  3HFD A;  3P2Z A;  3RQ7 A;  3P34 A;  2E50 A;  1A87 A;  4LKM A;  3Q1I A;  4CYR A;  3P36 A;  4X9V A;  4NK7 A;  4CYS A;  4XB0 A;  3GYV A;  3P35 A;  5DAY A;  3GYW A;  5DNJ A;  4YYP A;  3P2W A; 
#chains in the Genus database with same CATH homology
 4X9R A;  4O56 A;  4J7B B;  3BZI A;  3HIH A;  4LKL A;  2OGQ A;  3C5L A;  4HAB A;  3P2Z A;  3RQ7 A;  4RCP A;  3P34 A;  4E9D A;  5DMV C;  3HIK A;  3P37 A;  4LKM A;  4RS6 A;  4DFW A;  4E67 A;  3Q1I A;  1Q4O A;  3P36 A;  4X9V A;  5J19 A;  3FVH A;  2N19 A;  4WHL A;  4XB0 A;  3P35 A;  4HCO A;  4WHK A;  4HY2 A;  1UMW A;  4WHH A;  5DNJ A;  1Q4K A;  4E9C A;  4O6W A;  4X9W A;  2OJX A;  5DMS A;  4O9W A;  4H71 A;  5LHZ A;  4YYP A;  4H5X A;  3P2W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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