4DFWA

Oxime-based post solid-phase peptide diversification: identification of high affinity polo-like kinase 1 (plk1) polo-box domain binding peptides
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
221
structure length
219
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription/antagonist
molecule keywords Serine/threonine-protein kinase PLK1
publication title Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
pubmed rcsb
source organism Homo sapiens
total genus 68
structure length 219
sequence length 221
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-01-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4dfwA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4dfwA01
4J7BB 5DMSA 4HY2A 3P36A 4O56A 5LHZA 1Q4KA 1UMWA 3P2ZA 4WHHA 4X9VA 4X9RA 4H5XA 2N19A 3P35A 3C5LA 4LKMA 4E67A 3HIKA 4O6WA 4RCPA 4WHKA 2OJXA 3RQ7A 1Q4OA 3FVHA 5J19A 5DNJA 3BZIA 4H71A 4LKLA 4HABA 3HIHA 4YYPA 4HCOA 3P2WA 5DMVC 3Q1IA 4E9DA 2OGQA 4RS6A 4O9WA 4X9WA 4WHLA 3P37A 4DFWA 4XB0A 3P34A 4E9CA
chains in the Genus database with same CATH superfamily
5DMSA 1E33P 1P49A 1HDHA 4FDJA 4WHHA 2VKZG 2N19A 3FS3A 1F32A 3P35A 4CXUA 4NK7A 3GYWA 4LKMA 2IA9A 4NKBA 4CYSA 1Q4OA 1E2SP 4N7VA 5DNJA 3BZIA 4H71A 4N9JA 5AJ9A 4N7ZA 2E50A 4X9WA 1F34B 3P36A 3HFDA 4H5XA 1E3CP 2I9ZA 3HIKA 3FVHA 3GYVA 4CYRA 4RS6A 4HABA 1N2LA 4FDIA 1Q4KA 1UMWA 4CXSA 1E2TA 4CXKA 3LM3A 4E67A 4O6WA 4RCPA 4WHKA 2OJXA 3RQ7A 1E1ZP 3KDRA 4G7NA 2QZUA 3HIHA 1FSUA 4HCOA 2UV8G 2OGQA 4WHLA 3P37A 4XB0A 3P2WA 1N2KA 4J7BB 3LXQA 4HY2A 5LHZA 4O56A 3ED4A 3P2ZA 4X9RA 4X9VA 3C5LA 2I9XA 5DAYA 1A87A 5J19A 3HMJG 4LKLA 4YYPA 5DMVC 1AUKA 3Q1IA 4E9DA 4O9WA 4DFWA 3P34A 4E9CA
chains in the Genus database with same CATH topology
4J7BB 5DMSA 4HY2A 3P36A 4O56A 5LHZA 1Q4KA 1UMWA 3P2ZA 4WHHA 4X9VA 4X9RA 4H5XA 2N19A 3P35A 3C5LA 4LKMA 4E67A 3HIKA 4O6WA 4RCPA 4WHKA 2OJXA 3RQ7A 1Q4OA 3FVHA 5J19A 5DNJA 3BZIA 4H71A 4LKLA 4HABA 3HIHA 4YYPA 4HCOA 3P2WA 5DMVC 3Q1IA 4E9DA 2OGQA 4RS6A 4O9WA 4X9WA 4WHLA 3P37A 4DFWA 4XB0A 3P34A 4E9CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J7B B;  5DMS A;  4HY2 A;  3P36 A;  4O56 A;  5LHZ A;  1Q4K A;  1UMW A;  3P2Z A;  4WHH A;  4X9V A;  4X9R A;  4H5X A;  2N19 A;  3P35 A;  3C5L A;  4LKM A;  4E67 A;  3HIK A;  4O6W A;  4RCP A;  4WHK A;  2OJX A;  3RQ7 A;  1Q4O A;  3FVH A;  5J19 A;  5DNJ A;  3BZI A;  4H71 A;  4LKL A;  4HAB A;  3HIH A;  4YYP A;  4HCO A;  3P2W A;  5DMV C;  3Q1I A;  4E9D A;  2OGQ A;  4RS6 A;  4O9W A;  4X9W A;  4WHL A;  3P37 A;  4DFW A;  4XB0 A;  3P34 A;  4E9C A; 
#chains in the Genus database with same CATH topology
 5DMS A;  1E33 P;  1P49 A;  1HDH A;  4FDJ A;  4WHH A;  2VKZ G;  2N19 A;  3FS3 A;  1F32 A;  3P35 A;  4CXU A;  4NK7 A;  3GYW A;  4LKM A;  2IA9 A;  4NKB A;  4CYS A;  1Q4O A;  1E2S P;  4N7V A;  5DNJ A;  3BZI A;  4H71 A;  4N9J A;  5AJ9 A;  4N7Z A;  2E50 A;  4X9W A;  1F34 B;  3P36 A;  3HFD A;  4H5X A;  1E3C P;  2I9Z A;  3HIK A;  3FVH A;  3GYV A;  4CYR A;  4RS6 A;  4HAB A;  1N2L A;  4FDI A;  1Q4K A;  1UMW A;  4CXS A;  1E2T A;  4CXK A;  3LM3 A;  4E67 A;  4O6W A;  4RCP A;  4WHK A;  2OJX A;  3RQ7 A;  1E1Z P;  3KDR A;  4G7N A;  2QZU A;  3HIH A;  1FSU A;  4HCO A;  2UV8 G;  2OGQ A;  4WHL A;  3P37 A;  4XB0 A;  3P2W A;  1N2K A;  4J7B B;  3LXQ A;  4HY2 A;  5LHZ A;  4O56 A;  3ED4 A;  3P2Z A;  4X9R A;  4X9V A;  3C5L A;  2I9X A;  5DAY A;  1A87 A;  5J19 A;  3HMJ G;  4LKL A;  4YYP A;  5DMV C;  1AUK A;  3Q1I A;  4E9D A;  4O9W A;  4DFW A;  3P34 A;  4E9C A; 
#chains in the Genus database with same CATH homology
 4J7B B;  5DMS A;  4HY2 A;  3P36 A;  4O56 A;  5LHZ A;  1Q4K A;  1UMW A;  3P2Z A;  4WHH A;  4X9V A;  4X9R A;  4H5X A;  2N19 A;  3P35 A;  3C5L A;  4LKM A;  4E67 A;  3HIK A;  4O6W A;  4RCP A;  4WHK A;  2OJX A;  3RQ7 A;  1Q4O A;  3FVH A;  5J19 A;  5DNJ A;  3BZI A;  4H71 A;  4LKL A;  4HAB A;  3HIH A;  4YYP A;  4HCO A;  3P2W A;  5DMV C;  3Q1I A;  4E9D A;  2OGQ A;  4RS6 A;  4O9W A;  4X9W A;  4WHL A;  3P37 A;  4DFW A;  4XB0 A;  3P34 A;  4E9C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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