4DFWA

Oxime-based post solid-phase peptide diversification: identification of high affinity polo-like kinase 1 (plk1) polo-box domain binding peptides
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
221
structure length
219
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
pubmed rcsb
source organism Homo sapiens
molecule tags Transcription/antagonist
total genus 68
structure length 219
sequence length 221
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-01-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4dfwA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4dfwA01
4H71A 4E9CA 4LKLA 4YYPA 1Q4OA 4WHKA 3HIKA 4HABA 5DNJA 5DMSA 3P2ZA 4HCOA 2OGQA 3Q1IA 3P37A 4RCPA 2N19A 4O9WA 2OJXA 3BZIA 3P35A 4XB0A 4HY2A 4WHLA 3P36A 3HIHA 4WHHA 4O6WA 5J19A 3P34A 4E9DA 5DMVC 4J7BB 4X9VA 4DFWA 4X9WA 4X9RA 4LKMA 4E67A 1Q4KA 4H5XA 1UMWA 3FVHA 3C5LA 3RQ7A 5LHZA 4RS6A 3P2WA 4O56A
chains in the Genus database with same CATH superfamily
4H71A 1Q4OA 1N2KA 1HDHA 5DMSA 4CYRA 4HCOA 3P37A 2QZUA 2N19A 4FDIA 4O9WA 3BZIA 3P35A 4XB0A 4HY2A 4WHLA 2UV8G 5DMVC 4X9WA 4X9RA 1E2TA 3C5LA 4NKBA 3P2WA 2E50A 4O56A 4YYPA 4E9CA 5DAYA 4CXUA 3LM3A 4G7NA 3GYVA 2OGQA 3Q1IA 4N7ZA 4WHHA 4N9JA 5J19A 3HMJG 3KDRA 3P34A 4E9DA 4FDJA 4DFWA 4N7VA 4E67A 4NK7A 4H5XA 2I9XA 4CYSA 3LXQA 4LKLA 1A87A 1N2LA 4WHKA 1F34B 1P49A 1E33P 5DNJA 3P2ZA 2IA9A 3P36A 3HIHA 4O6WA 1FSUA 4CXSA 3GYWA 1E3CP 1AUKA 4RS6A 2I9ZA 3HIKA 3ED4A 4HABA 2VKZG 5AJ9A 1E2SP 4CXKA 4RCPA 1F32A 2OJXA 1E1ZP 4J7BB 4X9VA 4LKMA 1Q4KA 1UMWA 3FVHA 3RQ7A 3FS3A 3HFDA 5LHZA
chains in the Genus database with same CATH topology
4H71A 4E9CA 4LKLA 4YYPA 1Q4OA 4WHKA 3HIKA 4HABA 5DNJA 5DMSA 3P2ZA 4HCOA 2OGQA 3Q1IA 3P37A 4RCPA 2N19A 4O9WA 2OJXA 3BZIA 3P35A 4XB0A 4HY2A 4WHLA 3P36A 3HIHA 4WHHA 4O6WA 5J19A 3P34A 4E9DA 5DMVC 4J7BB 4X9VA 4DFWA 4X9WA 4X9RA 4LKMA 4E67A 1Q4KA 4H5XA 1UMWA 3FVHA 3C5LA 3RQ7A 5LHZA 4RS6A 3P2WA 4O56A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H71 A;  4E9C A;  4LKL A;  4YYP A;  1Q4O A;  4WHK A;  3HIK A;  4HAB A;  5DNJ A;  5DMS A;  3P2Z A;  4HCO A;  2OGQ A;  3Q1I A;  3P37 A;  4RCP A;  2N19 A;  4O9W A;  2OJX A;  3BZI A;  3P35 A;  4XB0 A;  4HY2 A;  4WHL A;  3P36 A;  3HIH A;  4WHH A;  4O6W A;  5J19 A;  3P34 A;  4E9D A;  5DMV C;  4J7B B;  4X9V A;  4DFW A;  4X9W A;  4X9R A;  4LKM A;  4E67 A;  1Q4K A;  4H5X A;  1UMW A;  3FVH A;  3C5L A;  3RQ7 A;  5LHZ A;  4RS6 A;  3P2W A;  4O56 A; 
#chains in the Genus database with same CATH topology
 4H71 A;  1Q4O A;  1N2K A;  1HDH A;  5DMS A;  4CYR A;  4HCO A;  3P37 A;  2QZU A;  2N19 A;  4FDI A;  4O9W A;  3BZI A;  3P35 A;  4XB0 A;  4HY2 A;  4WHL A;  2UV8 G;  5DMV C;  4X9W A;  4X9R A;  1E2T A;  3C5L A;  4NKB A;  3P2W A;  2E50 A;  4O56 A;  4YYP A;  4E9C A;  5DAY A;  4CXU A;  3LM3 A;  4G7N A;  3GYV A;  2OGQ A;  3Q1I A;  4N7Z A;  4WHH A;  4N9J A;  5J19 A;  3HMJ G;  3KDR A;  3P34 A;  4E9D A;  4FDJ A;  4DFW A;  4N7V A;  4E67 A;  4NK7 A;  4H5X A;  2I9X A;  4CYS A;  3LXQ A;  4LKL A;  1A87 A;  1N2L A;  4WHK A;  1F34 B;  1P49 A;  1E33 P;  5DNJ A;  3P2Z A;  2IA9 A;  3P36 A;  3HIH A;  4O6W A;  1FSU A;  4CXS A;  3GYW A;  1E3C P;  1AUK A;  4RS6 A;  2I9Z A;  3HIK A;  3ED4 A;  4HAB A;  2VKZ G;  5AJ9 A;  1E2S P;  4CXK A;  4RCP A;  1F32 A;  2OJX A;  1E1Z P;  4J7B B;  4X9V A;  4LKM A;  1Q4K A;  1UMW A;  3FVH A;  3RQ7 A;  3FS3 A;  3HFD A;  5LHZ A; 
#chains in the Genus database with same CATH homology
 4H71 A;  4E9C A;  4LKL A;  4YYP A;  1Q4O A;  4WHK A;  3HIK A;  4HAB A;  5DNJ A;  5DMS A;  3P2Z A;  4HCO A;  2OGQ A;  3Q1I A;  3P37 A;  4RCP A;  2N19 A;  4O9W A;  2OJX A;  3BZI A;  3P35 A;  4XB0 A;  4HY2 A;  4WHL A;  3P36 A;  3HIH A;  4WHH A;  4O6W A;  5J19 A;  3P34 A;  4E9D A;  5DMV C;  4J7B B;  4X9V A;  4DFW A;  4X9W A;  4X9R A;  4LKM A;  4E67 A;  1Q4K A;  4H5X A;  1UMW A;  3FVH A;  3C5L A;  3RQ7 A;  5LHZ A;  4RS6 A;  3P2W A;  4O56 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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