4DFWA

Oxime-based post solid-phase peptide diversification: identification of high affinity polo-like kinase 1 (plk1) polo-box domain binding peptides
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
221
structure length
219
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
pubmed rcsb
molecule tags Transcription/antagonist
source organism Homo sapiens
molecule keywords Serine/threonine-protein kinase PLK1
total genus 68
structure length 219
sequence length 221
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-01-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4dfwA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4dfwA01
1Q4OA 4DFWA 4H71A 4RCPA 4HY2A 1Q4KA 3HIKA 3C5LA 4J7BB 4RS6A 4E9CA 5LHZA 4E9DA 3P35A 4O6WA 3P2ZA 4X9VA 4HABA 3P36A 4O56A 3BZIA 4E67A 4XB0A 4HCOA 5DMVC 3P37A 4X9WA 2OJXA 4WHLA 4YYPA 4LKLA 3FVHA 5DMSA 4X9RA 4LKMA 3RQ7A 3Q1IA 4H5XA 3P34A 2N19A 2OGQA 4WHHA 5DNJA 4O9WA 5J19A 3P2WA 3HIHA 4WHKA 1UMWA
chains in the Genus database with same CATH superfamily
1Q4OA 4HY2A 3HIKA 3HMJG 4J7BB 4O6WA 3P36A 3LM3A 4CXKA 4E67A 5DMVC 3P37A 4WHLA 4LKLA 3FVHA 1A87A 5DMSA 3RQ7A 4WHHA 2N19A 3GYWA 3HFDA 3HIHA 4CXSA 1UMWA 2I9ZA 2QZUA 2VKZG 1Q4KA 3C5LA 4E9DA 3P35A 4HABA 1E1ZP 3LXQA 5DAYA 1E2TA 1FSUA 4HCOA 2OJXA 4N9JA 1HDHA 3Q1IA 3P34A 4N7VA 4CXUA 4G7NA 3P2WA 4FDJA 1E3CP 4RS6A 2E50A 4X9VA 3KDRA 4CYRA 2IA9A 3FS3A 3BZIA 4XB0A 1N2LA 1E33P 4X9WA 1AUKA 1N2KA 4YYPA 4LKMA 4H5XA 5DNJA 2OGQA 3GYVA 4O9WA 4NKBA 4WHKA 5AJ9A 2I9XA 2UV8G 4DFWA 4H71A 1F32A 4RCPA 4FDIA 4NK7A 4E9CA 5LHZA 4N7ZA 3P2ZA 1E2SP 1P49A 1F34B 4O56A 4X9RA 4CYSA 3ED4A 5J19A
chains in the Genus database with same CATH topology
1Q4OA 4DFWA 4H71A 4RCPA 4HY2A 1Q4KA 3HIKA 3C5LA 4J7BB 4RS6A 4E9CA 5LHZA 4E9DA 3P35A 4O6WA 3P2ZA 4X9VA 4HABA 3P36A 4O56A 3BZIA 4E67A 4XB0A 4HCOA 5DMVC 3P37A 4X9WA 2OJXA 4WHLA 4YYPA 4LKLA 3FVHA 5DMSA 4X9RA 4LKMA 3RQ7A 3Q1IA 4H5XA 3P34A 2N19A 2OGQA 4WHHA 5DNJA 4O9WA 5J19A 3P2WA 3HIHA 4WHKA 1UMWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q4O A;  4DFW A;  4H71 A;  4RCP A;  4HY2 A;  1Q4K A;  3HIK A;  3C5L A;  4J7B B;  4RS6 A;  4E9C A;  5LHZ A;  4E9D A;  3P35 A;  4O6W A;  3P2Z A;  4X9V A;  4HAB A;  3P36 A;  4O56 A;  3BZI A;  4E67 A;  4XB0 A;  4HCO A;  5DMV C;  3P37 A;  4X9W A;  2OJX A;  4WHL A;  4YYP A;  4LKL A;  3FVH A;  5DMS A;  4X9R A;  4LKM A;  3RQ7 A;  3Q1I A;  4H5X A;  3P34 A;  2N19 A;  2OGQ A;  4WHH A;  5DNJ A;  4O9W A;  5J19 A;  3P2W A;  3HIH A;  4WHK A;  1UMW A; 
#chains in the Genus database with same CATH topology
 1Q4O A;  4HY2 A;  3HIK A;  3HMJ G;  4J7B B;  4O6W A;  3P36 A;  3LM3 A;  4CXK A;  4E67 A;  5DMV C;  3P37 A;  4WHL A;  4LKL A;  3FVH A;  1A87 A;  5DMS A;  3RQ7 A;  4WHH A;  2N19 A;  3GYW A;  3HFD A;  3HIH A;  4CXS A;  1UMW A;  2I9Z A;  2QZU A;  2VKZ G;  1Q4K A;  3C5L A;  4E9D A;  3P35 A;  4HAB A;  1E1Z P;  3LXQ A;  5DAY A;  1E2T A;  1FSU A;  4HCO A;  2OJX A;  4N9J A;  1HDH A;  3Q1I A;  3P34 A;  4N7V A;  4CXU A;  4G7N A;  3P2W A;  4FDJ A;  1E3C P;  4RS6 A;  2E50 A;  4X9V A;  3KDR A;  4CYR A;  2IA9 A;  3FS3 A;  3BZI A;  4XB0 A;  1N2L A;  1E33 P;  4X9W A;  1AUK A;  1N2K A;  4YYP A;  4LKM A;  4H5X A;  5DNJ A;  2OGQ A;  3GYV A;  4O9W A;  4NKB A;  4WHK A;  5AJ9 A;  2I9X A;  2UV8 G;  4DFW A;  4H71 A;  1F32 A;  4RCP A;  4FDI A;  4NK7 A;  4E9C A;  5LHZ A;  4N7Z A;  3P2Z A;  1E2S P;  1P49 A;  1F34 B;  4O56 A;  4X9R A;  4CYS A;  3ED4 A;  5J19 A; 
#chains in the Genus database with same CATH homology
 1Q4O A;  4DFW A;  4H71 A;  4RCP A;  4HY2 A;  1Q4K A;  3HIK A;  3C5L A;  4J7B B;  4RS6 A;  4E9C A;  5LHZ A;  4E9D A;  3P35 A;  4O6W A;  3P2Z A;  4X9V A;  4HAB A;  3P36 A;  4O56 A;  3BZI A;  4E67 A;  4XB0 A;  4HCO A;  5DMV C;  3P37 A;  4X9W A;  2OJX A;  4WHL A;  4YYP A;  4LKL A;  3FVH A;  5DMS A;  4X9R A;  4LKM A;  3RQ7 A;  3Q1I A;  4H5X A;  3P34 A;  2N19 A;  2OGQ A;  4WHH A;  5DNJ A;  4O9W A;  5J19 A;  3P2W A;  3HIH A;  4WHK A;  1UMW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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