4WHKA

A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
220
structure length
220
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
total genus 71
structure length 220
sequence length 220
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2014-09-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4whkA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4whkA01
1Q4OA 2OGQA 4X9VA 3C5LA 4O9WA 4LKMA 4J7BB 4RS6A 3FVHA 1UMWA 4XB0A 3BZIA 4H5XA 4YYPA 4H71A 4O56A 4WHKA 3P2ZA 1Q4KA 4WHHA 3HIHA 4HABA 4RCPA 4O6WA 4E9CA 3P34A 3P37A 3HIKA 5LHZA 3RQ7A 4LKLA 3P35A 4HCOA 3P36A 4E9DA 5J19A 4DFWA 4HY2A 4X9RA 4E67A 5DMVC 2N19A 3P2WA 4X9WA 2OJXA 5DNJA 4WHLA 3Q1IA 5DMSA
chains in the Genus database with same CATH superfamily
1FSUA 2OGQA 4LKMA 5DAYA 3LM3A 3KDRA 1UMWA 1E2TA 2UV8G 1P49A 2QZUA 1Q4KA 3HMJG 1E2SP 4HABA 4O6WA 3RQ7A 4N7ZA 1F32A 5J19A 1E33P 4E67A 5DMVC 3HFDA 4CXSA 2N19A 4G7NA 3GYWA 2OJXA 4O9WA 4FDJA 4N9JA 4XB0A 4H5XA 4O56A 3LXQA 5LHZA 3ED4A 4CYSA 4HCOA 3P36A 4E9DA 4N7VA 1A87A 2I9ZA 3GYVA 3P2WA 4X9WA 1E3CP 1F34B 4WHLA 3Q1IA 4NK7A 5DMSA 1Q4OA 4X9VA 3C5LA 4J7BB 4RS6A 3BZIA 4YYPA 3P2ZA 2E50A 4WHHA 2I9XA 4CXUA 4RCPA 5AJ9A 3P34A 3HIKA 3P37A 4HY2A 1AUKA 4X9RA 5DNJA 1HDHA 2IA9A 2VKZG 3FVHA 4H71A 4WHKA 3HIHA 1E1ZP 4CXKA 3FS3A 4E9CA 1N2LA 4LKLA 3P35A 1N2KA 4CYRA 4DFWA 4FDIA 4NKBA
chains in the Genus database with same CATH topology
1Q4OA 2OGQA 4X9VA 3C5LA 4O9WA 4LKMA 4J7BB 4RS6A 3FVHA 1UMWA 4XB0A 3BZIA 4H5XA 4YYPA 4H71A 4O56A 4WHKA 3P2ZA 1Q4KA 4WHHA 3HIHA 4HABA 4RCPA 4O6WA 4E9CA 3P34A 3P37A 3HIKA 5LHZA 3RQ7A 4LKLA 3P35A 4HCOA 3P36A 4E9DA 5J19A 4DFWA 4HY2A 4X9RA 4E67A 5DMVC 2N19A 3P2WA 4X9WA 2OJXA 5DNJA 4WHLA 3Q1IA 5DMSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q4O A;  2OGQ A;  4X9V A;  3C5L A;  4O9W A;  4LKM A;  4J7B B;  4RS6 A;  3FVH A;  1UMW A;  4XB0 A;  3BZI A;  4H5X A;  4YYP A;  4H71 A;  4O56 A;  4WHK A;  3P2Z A;  1Q4K A;  4WHH A;  3HIH A;  4HAB A;  4RCP A;  4O6W A;  4E9C A;  3P34 A;  3P37 A;  3HIK A;  5LHZ A;  3RQ7 A;  4LKL A;  3P35 A;  4HCO A;  3P36 A;  4E9D A;  5J19 A;  4DFW A;  4HY2 A;  4X9R A;  4E67 A;  5DMV C;  2N19 A;  3P2W A;  4X9W A;  2OJX A;  5DNJ A;  4WHL A;  3Q1I A;  5DMS A; 
#chains in the Genus database with same CATH topology
 1FSU A;  2OGQ A;  4LKM A;  5DAY A;  3LM3 A;  3KDR A;  1UMW A;  1E2T A;  2UV8 G;  1P49 A;  2QZU A;  1Q4K A;  3HMJ G;  1E2S P;  4HAB A;  4O6W A;  3RQ7 A;  4N7Z A;  1F32 A;  5J19 A;  1E33 P;  4E67 A;  5DMV C;  3HFD A;  4CXS A;  2N19 A;  4G7N A;  3GYW A;  2OJX A;  4O9W A;  4FDJ A;  4N9J A;  4XB0 A;  4H5X A;  4O56 A;  3LXQ A;  5LHZ A;  3ED4 A;  4CYS A;  4HCO A;  3P36 A;  4E9D A;  4N7V A;  1A87 A;  2I9Z A;  3GYV A;  3P2W A;  4X9W A;  1E3C P;  1F34 B;  4WHL A;  3Q1I A;  4NK7 A;  5DMS A;  1Q4O A;  4X9V A;  3C5L A;  4J7B B;  4RS6 A;  3BZI A;  4YYP A;  3P2Z A;  2E50 A;  4WHH A;  2I9X A;  4CXU A;  4RCP A;  5AJ9 A;  3P34 A;  3HIK A;  3P37 A;  4HY2 A;  1AUK A;  4X9R A;  5DNJ A;  1HDH A;  2IA9 A;  2VKZ G;  3FVH A;  4H71 A;  4WHK A;  3HIH A;  1E1Z P;  4CXK A;  3FS3 A;  4E9C A;  1N2L A;  4LKL A;  3P35 A;  1N2K A;  4CYR A;  4DFW A;  4FDI A;  4NKB A; 
#chains in the Genus database with same CATH homology
 1Q4O A;  2OGQ A;  4X9V A;  3C5L A;  4O9W A;  4LKM A;  4J7B B;  4RS6 A;  3FVH A;  1UMW A;  4XB0 A;  3BZI A;  4H5X A;  4YYP A;  4H71 A;  4O56 A;  4WHK A;  3P2Z A;  1Q4K A;  4WHH A;  3HIH A;  4HAB A;  4RCP A;  4O6W A;  4E9C A;  3P34 A;  3P37 A;  3HIK A;  5LHZ A;  3RQ7 A;  4LKL A;  3P35 A;  4HCO A;  3P36 A;  4E9D A;  5J19 A;  4DFW A;  4HY2 A;  4X9R A;  4E67 A;  5DMV C;  2N19 A;  3P2W A;  4X9W A;  2OJX A;  5DNJ A;  4WHL A;  3Q1I A;  5DMS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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