4WHKA

A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1
Total Genus 71
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
220
structure length
220
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 71
structure length 220
sequence length 220
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2014-09-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4whkA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4whkA01
1Q4OA 4HCOA 5LHZA 4X9WA 4LKLA 3P2WA 4WHKA 2OGQA 4RCPA 3BZIA 3C5LA 4XB0A 3P35A 3FVHA 4WHLA 1Q4KA 4RS6A 4H5XA 4E9DA 4HY2A 3P36A 4J7BB 4X9VA 4H71A 2N19A 2OJXA 3P34A 4E67A 3HIHA 4E9CA 4YYPA 4DFWA 5DMVC 3P2ZA 5J19A 3HIKA 3P37A 3Q1IA 4O9WA 3RQ7A 5DMSA 4O56A 5DNJA 4LKMA 4HABA 4X9RA 4WHHA 4O6WA 1UMWA
chains in the Genus database with same CATH superfamily
4LKLA 3LXQA 3P2WA 4WHKA 1N2KA 4RCPA 4FDJA 3FVHA 1E3CP 4WHLA 1N2LA 1AUKA 2I9ZA 4CXSA 4E9CA 4DFWA 1E1ZP 2I9XA 4HABA 4X9RA 4NK7A 1P49A 2IA9A 2VKZG 1E33P 1A87A 2OGQA 3BZIA 3C5LA 4E9DA 4H71A 2N19A 3P34A 4E67A 4CXUA 5DMVC 3HIKA 4O9WA 1E2SP 4CYSA 4LKMA 4CXKA 1E2TA 4N7VA 2E50A 5LHZA 4X9WA 3KDRA 2UV8G 3P35A 4H5XA 1HDHA 3P36A 4G7NA 2OJXA 4NKBA 3GYWA 4YYPA 3GYVA 5J19A 3P37A 2QZUA 1F34B 5DNJA 1F32A 4WHHA 4O6WA 4O56A 1UMWA 4CYRA 1Q4OA 4HCOA 4FDIA 4XB0A 3LM3A 3HMJG 5AJ9A 1Q4KA 4RS6A 4HY2A 3HFDA 4J7BB 4X9VA 3FS3A 3HIHA 1FSUA 3P2ZA 4N9JA 3Q1IA 4N7ZA 3ED4A 3RQ7A 5DMSA 5DAYA
chains in the Genus database with same CATH topology
1Q4OA 4HCOA 5LHZA 4X9WA 4LKLA 3P2WA 4WHKA 2OGQA 4RCPA 3BZIA 3C5LA 4XB0A 3P35A 3FVHA 4WHLA 1Q4KA 4RS6A 4H5XA 4E9DA 4HY2A 3P36A 4J7BB 4X9VA 4H71A 2N19A 2OJXA 3P34A 4E67A 3HIHA 4E9CA 4YYPA 4DFWA 5DMVC 3P2ZA 5J19A 3HIKA 3P37A 3Q1IA 4O9WA 3RQ7A 5DMSA 4O56A 5DNJA 4LKMA 4HABA 4X9RA 4WHHA 4O6WA 1UMWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q4O A;  4HCO A;  5LHZ A;  4X9W A;  4LKL A;  3P2W A;  4WHK A;  2OGQ A;  4RCP A;  3BZI A;  3C5L A;  4XB0 A;  3P35 A;  3FVH A;  4WHL A;  1Q4K A;  4RS6 A;  4H5X A;  4E9D A;  4HY2 A;  3P36 A;  4J7B B;  4X9V A;  4H71 A;  2N19 A;  2OJX A;  3P34 A;  4E67 A;  3HIH A;  4E9C A;  4YYP A;  4DFW A;  5DMV C;  3P2Z A;  5J19 A;  3HIK A;  3P37 A;  3Q1I A;  4O9W A;  3RQ7 A;  5DMS A;  4O56 A;  5DNJ A;  4LKM A;  4HAB A;  4X9R A;  4WHH A;  4O6W A;  1UMW A; 
#chains in the Genus database with same CATH topology
 4LKL A;  3LXQ A;  3P2W A;  4WHK A;  1N2K A;  4RCP A;  4FDJ A;  3FVH A;  1E3C P;  4WHL A;  1N2L A;  1AUK A;  2I9Z A;  4CXS A;  4E9C A;  4DFW A;  1E1Z P;  2I9X A;  4HAB A;  4X9R A;  4NK7 A;  1P49 A;  2IA9 A;  2VKZ G;  1E33 P;  1A87 A;  2OGQ A;  3BZI A;  3C5L A;  4E9D A;  4H71 A;  2N19 A;  3P34 A;  4E67 A;  4CXU A;  5DMV C;  3HIK A;  4O9W A;  1E2S P;  4CYS A;  4LKM A;  4CXK A;  1E2T A;  4N7V A;  2E50 A;  5LHZ A;  4X9W A;  3KDR A;  2UV8 G;  3P35 A;  4H5X A;  1HDH A;  3P36 A;  4G7N A;  2OJX A;  4NKB A;  3GYW A;  4YYP A;  3GYV A;  5J19 A;  3P37 A;  2QZU A;  1F34 B;  5DNJ A;  1F32 A;  4WHH A;  4O6W A;  4O56 A;  1UMW A;  4CYR A;  1Q4O A;  4HCO A;  4FDI A;  4XB0 A;  3LM3 A;  3HMJ G;  5AJ9 A;  1Q4K A;  4RS6 A;  4HY2 A;  3HFD A;  4J7B B;  4X9V A;  3FS3 A;  3HIH A;  1FSU A;  3P2Z A;  4N9J A;  3Q1I A;  4N7Z A;  3ED4 A;  3RQ7 A;  5DMS A;  5DAY A; 
#chains in the Genus database with same CATH homology
 1Q4O A;  4HCO A;  5LHZ A;  4X9W A;  4LKL A;  3P2W A;  4WHK A;  2OGQ A;  4RCP A;  3BZI A;  3C5L A;  4XB0 A;  3P35 A;  3FVH A;  4WHL A;  1Q4K A;  4RS6 A;  4H5X A;  4E9D A;  4HY2 A;  3P36 A;  4J7B B;  4X9V A;  4H71 A;  2N19 A;  2OJX A;  3P34 A;  4E67 A;  3HIH A;  4E9C A;  4YYP A;  4DFW A;  5DMV C;  3P2Z A;  5J19 A;  3HIK A;  3P37 A;  3Q1I A;  4O9W A;  3RQ7 A;  5DMS A;  4O56 A;  5DNJ A;  4LKM A;  4HAB A;  4X9R A;  4WHH A;  4O6W A;  1UMW A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...