4WHKA

A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
220
structure length
220
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
publication title A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
molecule keywords Serine/threonine-protein kinase PLK1
total genus 71
structure length 220
sequence length 220
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2014-09-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4whkA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4whkA01
5DMSA 1UMWA 3C5LA 5LHZA 5DMVC 4YYPA 4RCPA 4WHKA 3RQ7A 3P2WA 4LKMA 4O9WA 5J19A 2OJXA 4O56A 1Q4KA 4WHHA 4X9VA 4H5XA 1Q4OA 3P34A 4XB0A 4E67A 4LKLA 4HABA 3HIHA 2OGQA 4DFWA 3BZIA 3Q1IA 4WHLA 4E9DA 3P2ZA 4H71A 2N19A 4X9WA 3P35A 4E9CA 4O6WA 4J7BB 4HY2A 4RS6A 4HCOA 3P36A 5DNJA 3FVHA 3P37A 4X9RA 3HIKA
chains in the Genus database with same CATH superfamily
4CXUA 4N7VA 5LHZA 4YYPA 4WHKA 1E33P 3P2WA 4O9WA 5J19A 1HDHA 4H5XA 1N2KA 4LKLA 3HIHA 4N7ZA 1E2SP 3LXQA 1FSUA 1E3CP 4CXSA 4O6WA 3ED4A 1F32A 4HCOA 3FVHA 4X9RA 1UMWA 5DAYA 4LKMA 2IA9A 4X9VA 4G7NA 2UV8G 3HFDA 1Q4OA 4E67A 1P49A 3Q1IA 4H71A 2N19A 4J7BB 4N9JA 3GYWA 2VKZG 4CYRA 5DMSA 5DMVC 2E50A 4RCPA 3FS3A 3GYVA 1A87A 1E2TA 2OJXA 4CYSA 3P34A 1F34B 4DFWA 3BZIA 3P2ZA 4X9WA 3KDRA 3P35A 4E9CA 4FDIA 4HY2A 1N2LA 2QZUA 3C5LA 3LM3A 2I9XA 3RQ7A 3HMJG 4O56A 1Q4KA 4WHHA 4NK7A 5AJ9A 1AUKA 4XB0A 4NKBA 4HABA 2OGQA 4WHLA 4E9DA 4FDJA 4RS6A 1E1ZP 2I9ZA 3P36A 5DNJA 4CXKA 3P37A 3HIKA
chains in the Genus database with same CATH topology
5DMSA 1UMWA 3C5LA 5LHZA 5DMVC 4YYPA 4RCPA 4WHKA 3RQ7A 3P2WA 4LKMA 4O9WA 5J19A 2OJXA 4O56A 1Q4KA 4WHHA 4X9VA 4H5XA 1Q4OA 3P34A 4XB0A 4E67A 4LKLA 4HABA 3HIHA 2OGQA 4DFWA 3BZIA 3Q1IA 4WHLA 4E9DA 3P2ZA 4H71A 2N19A 4X9WA 3P35A 4E9CA 4O6WA 4J7BB 4HY2A 4RS6A 4HCOA 3P36A 5DNJA 3FVHA 3P37A 4X9RA 3HIKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DMS A;  1UMW A;  3C5L A;  5LHZ A;  5DMV C;  4YYP A;  4RCP A;  4WHK A;  3RQ7 A;  3P2W A;  4LKM A;  4O9W A;  5J19 A;  2OJX A;  4O56 A;  1Q4K A;  4WHH A;  4X9V A;  4H5X A;  1Q4O A;  3P34 A;  4XB0 A;  4E67 A;  4LKL A;  4HAB A;  3HIH A;  2OGQ A;  4DFW A;  3BZI A;  3Q1I A;  4WHL A;  4E9D A;  3P2Z A;  4H71 A;  2N19 A;  4X9W A;  3P35 A;  4E9C A;  4O6W A;  4J7B B;  4HY2 A;  4RS6 A;  4HCO A;  3P36 A;  5DNJ A;  3FVH A;  3P37 A;  4X9R A;  3HIK A; 
#chains in the Genus database with same CATH topology
 4CXU A;  4N7V A;  5LHZ A;  4YYP A;  4WHK A;  1E33 P;  3P2W A;  4O9W A;  5J19 A;  1HDH A;  4H5X A;  1N2K A;  4LKL A;  3HIH A;  4N7Z A;  1E2S P;  3LXQ A;  1FSU A;  1E3C P;  4CXS A;  4O6W A;  3ED4 A;  1F32 A;  4HCO A;  3FVH A;  4X9R A;  1UMW A;  5DAY A;  4LKM A;  2IA9 A;  4X9V A;  4G7N A;  2UV8 G;  3HFD A;  1Q4O A;  4E67 A;  1P49 A;  3Q1I A;  4H71 A;  2N19 A;  4J7B B;  4N9J A;  3GYW A;  2VKZ G;  4CYR A;  5DMS A;  5DMV C;  2E50 A;  4RCP A;  3FS3 A;  3GYV A;  1A87 A;  1E2T A;  2OJX A;  4CYS A;  3P34 A;  1F34 B;  4DFW A;  3BZI A;  3P2Z A;  4X9W A;  3KDR A;  3P35 A;  4E9C A;  4FDI A;  4HY2 A;  1N2L A;  2QZU A;  3C5L A;  3LM3 A;  2I9X A;  3RQ7 A;  3HMJ G;  4O56 A;  1Q4K A;  4WHH A;  4NK7 A;  5AJ9 A;  1AUK A;  4XB0 A;  4NKB A;  4HAB A;  2OGQ A;  4WHL A;  4E9D A;  4FDJ A;  4RS6 A;  1E1Z P;  2I9Z A;  3P36 A;  5DNJ A;  4CXK A;  3P37 A;  3HIK A; 
#chains in the Genus database with same CATH homology
 5DMS A;  1UMW A;  3C5L A;  5LHZ A;  5DMV C;  4YYP A;  4RCP A;  4WHK A;  3RQ7 A;  3P2W A;  4LKM A;  4O9W A;  5J19 A;  2OJX A;  4O56 A;  1Q4K A;  4WHH A;  4X9V A;  4H5X A;  1Q4O A;  3P34 A;  4XB0 A;  4E67 A;  4LKL A;  4HAB A;  3HIH A;  2OGQ A;  4DFW A;  3BZI A;  3Q1I A;  4WHL A;  4E9D A;  3P2Z A;  4H71 A;  2N19 A;  4X9W A;  3P35 A;  4E9C A;  4O6W A;  4J7B B;  4HY2 A;  4RS6 A;  4HCO A;  3P36 A;  5DNJ A;  3FVH A;  3P37 A;  4X9R A;  3HIK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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