4WHKA

A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
220
structure length
220
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
publication title A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
source organism Homo sapiens
total genus 71
structure length 220
sequence length 220
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2014-09-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4whkA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4whkA01
5LHZA 4RS6A 4X9WA 3RQ7A 1UMWA 4WHKA 5DNJA 3HIKA 2N19A 4X9VA 4LKMA 4O6WA 4RCPA 4WHLA 4DFWA 4E9DA 3HIHA 5J19A 3BZIA 4X9RA 4E9CA 5DMVC 4LKLA 3P36A 5DMSA 4HCOA 4H71A 4O9WA 3P2ZA 3P35A 4YYPA 3FVHA 4O56A 4E67A 4XB0A 3P2WA 2OJXA 1Q4OA 3Q1IA 3P37A 4H5XA 3C5LA 4WHHA 4HY2A 4HABA 4J7BB 1Q4KA 2OGQA 3P34A
chains in the Genus database with same CATH superfamily
5LHZA 1UMWA 2N19A 4FDJA 4E9DA 3HIHA 3BZIA 1N2KA 4CYSA 1A87A 4LKLA 4CXUA 1AUKA 3P2ZA 4CYRA 1FSUA 2E50A 2I9ZA 4X9WA 1E33P 3HIKA 4X9VA 3HFDA 4LKMA 4O6WA 4N9JA 5J19A 4H71A 4YYPA 2OJXA 4H5XA 3GYWA 4WHHA 1HDHA 4HABA 4N7VA 3HMJG 4RS6A 3RQ7A 1E2SP 5DNJA 1F34B 4WHLA 4FDIA 4DFWA 2I9XA 3FS3A 2UV8G 4X9RA 5DMVC 2QZUA 3P36A 5DMSA 4O9WA 1E3CP 3LM3A 4CXKA 4NKBA 4O56A 4E67A 4NK7A 3GYVA 4N7ZA 1Q4KA 4J7BB 5DAYA 3P34A 4WHKA 1F32A 4RCPA 1N2LA 4E9CA 1E2TA 4HCOA 5AJ9A 4G7NA 3ED4A 3KDRA 3P35A 2IA9A 3FVHA 1E1ZP 3LXQA 1P49A 4XB0A 3P2WA 1Q4OA 3Q1IA 3P37A 3C5LA 4CXSA 4HY2A 2OGQA 2VKZG
chains in the Genus database with same CATH topology
5LHZA 4RS6A 4X9WA 3RQ7A 1UMWA 4WHKA 5DNJA 3HIKA 2N19A 4X9VA 4LKMA 4O6WA 4RCPA 4WHLA 4DFWA 4E9DA 3HIHA 5J19A 3BZIA 4X9RA 4E9CA 5DMVC 4LKLA 3P36A 5DMSA 4HCOA 4H71A 4O9WA 3P2ZA 3P35A 4YYPA 3FVHA 4O56A 4E67A 4XB0A 3P2WA 2OJXA 1Q4OA 3Q1IA 3P37A 4H5XA 3C5LA 4WHHA 4HY2A 4HABA 4J7BB 1Q4KA 2OGQA 3P34A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LHZ A;  4RS6 A;  4X9W A;  3RQ7 A;  1UMW A;  4WHK A;  5DNJ A;  3HIK A;  2N19 A;  4X9V A;  4LKM A;  4O6W A;  4RCP A;  4WHL A;  4DFW A;  4E9D A;  3HIH A;  5J19 A;  3BZI A;  4X9R A;  4E9C A;  5DMV C;  4LKL A;  3P36 A;  5DMS A;  4HCO A;  4H71 A;  4O9W A;  3P2Z A;  3P35 A;  4YYP A;  3FVH A;  4O56 A;  4E67 A;  4XB0 A;  3P2W A;  2OJX A;  1Q4O A;  3Q1I A;  3P37 A;  4H5X A;  3C5L A;  4WHH A;  4HY2 A;  4HAB A;  4J7B B;  1Q4K A;  2OGQ A;  3P34 A; 
#chains in the Genus database with same CATH topology
 5LHZ A;  1UMW A;  2N19 A;  4FDJ A;  4E9D A;  3HIH A;  3BZI A;  1N2K A;  4CYS A;  1A87 A;  4LKL A;  4CXU A;  1AUK A;  3P2Z A;  4CYR A;  1FSU A;  2E50 A;  2I9Z A;  4X9W A;  1E33 P;  3HIK A;  4X9V A;  3HFD A;  4LKM A;  4O6W A;  4N9J A;  5J19 A;  4H71 A;  4YYP A;  2OJX A;  4H5X A;  3GYW A;  4WHH A;  1HDH A;  4HAB A;  4N7V A;  3HMJ G;  4RS6 A;  3RQ7 A;  1E2S P;  5DNJ A;  1F34 B;  4WHL A;  4FDI A;  4DFW A;  2I9X A;  3FS3 A;  2UV8 G;  4X9R A;  5DMV C;  2QZU A;  3P36 A;  5DMS A;  4O9W A;  1E3C P;  3LM3 A;  4CXK A;  4NKB A;  4O56 A;  4E67 A;  4NK7 A;  3GYV A;  4N7Z A;  1Q4K A;  4J7B B;  5DAY A;  3P34 A;  4WHK A;  1F32 A;  4RCP A;  1N2L A;  4E9C A;  1E2T A;  4HCO A;  5AJ9 A;  4G7N A;  3ED4 A;  3KDR A;  3P35 A;  2IA9 A;  3FVH A;  1E1Z P;  3LXQ A;  1P49 A;  4XB0 A;  3P2W A;  1Q4O A;  3Q1I A;  3P37 A;  3C5L A;  4CXS A;  4HY2 A;  2OGQ A;  2VKZ G; 
#chains in the Genus database with same CATH homology
 5LHZ A;  4RS6 A;  4X9W A;  3RQ7 A;  1UMW A;  4WHK A;  5DNJ A;  3HIK A;  2N19 A;  4X9V A;  4LKM A;  4O6W A;  4RCP A;  4WHL A;  4DFW A;  4E9D A;  3HIH A;  5J19 A;  3BZI A;  4X9R A;  4E9C A;  5DMV C;  4LKL A;  3P36 A;  5DMS A;  4HCO A;  4H71 A;  4O9W A;  3P2Z A;  3P35 A;  4YYP A;  3FVH A;  4O56 A;  4E67 A;  4XB0 A;  3P2W A;  2OJX A;  1Q4O A;  3Q1I A;  3P37 A;  4H5X A;  3C5L A;  4WHH A;  4HY2 A;  4HAB A;  4J7B B;  1Q4K A;  2OGQ A;  3P34 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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