3RQ7A

Polo-like kinase 1 polo box domain in complex with a c6h5(ch2)8-derivatized peptide inhibitor
Total Genus 63
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
63
sequence length
222
structure length
212
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGAPRLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Serine/threonine-protein kinase PLK1
total genus 63
structure length 212
sequence length 222
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2011-04-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3rq7A02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3rq7A01
1Q4OA 4RCPA 4LKMA 1Q4KA 4RS6A 4X9WA 3P2WA 5DMSA 2OJXA 4YYPA 3FVHA 4WHKA 3RQ7A 4E67A 4HCOA 3HIHA 3P36A 3Q1IA 4WHHA 3C5LA 5DNJA 4HABA 4X9VA 4J7BB 4HY2A 4E9CA 4WHLA 4H5XA 3P2ZA 5LHZA 3P34A 1UMWA 4O9WA 4X9RA 4LKLA 4E9DA 3BZIA 3HIKA 4O56A 3P35A 4DFWA 4H71A 4XB0A 5J19A 4O6WA 2N19A 5DMVC 2OGQA 3P37A
chains in the Genus database with same CATH superfamily
4RCPA 3LXQA 4CXKA 2I9XA 3P2WA 3KDRA 2VKZG 2OJXA 3FVHA 4WHKA 1E1ZP 3LM3A 4N7VA 2QZUA 3P37A 4N9JA 4CYRA 4G7NA 1A87A 5DNJA 4J7BB 5LHZA 2IA9A 3P34A 3BZIA 3P35A 1N2LA 1Q4OA 2E50A 2I9ZA 1N2KA 3GYWA 1E2TA 1E33P 4HCOA 1F32A 3P36A 4NKBA 4HABA 4H5XA 3P2ZA 3FS3A 4X9RA 4XB0A 1P49A 4E67A 4FDIA 1HDHA 4FDJA 4LKMA 1Q4KA 4RS6A 5DAYA 3HFDA 4CXUA 1FSUA 3HIHA 3C5LA 4HY2A 2UV8G 1UMWA 4N7ZA 3GYVA 3HIKA 4DFWA 5J19A 4H71A 4O6WA 2N19A 5DMVC 1E3CP 1AUKA 4X9WA 5DMSA 4YYPA 3RQ7A 5AJ9A 3Q1IA 4WHHA 4X9VA 1F34B 4CYSA 4E9CA 4WHLA 4LKLA 4NK7A 4CXSA 4E9DA 1E2SP 4O56A 3ED4A 2OGQA 3HMJG 4O9WA
chains in the Genus database with same CATH topology
1Q4OA 4RCPA 4LKMA 1Q4KA 4RS6A 4X9WA 3P2WA 5DMSA 2OJXA 4YYPA 3FVHA 4WHKA 3RQ7A 4E67A 4HCOA 3HIHA 3P36A 3Q1IA 4WHHA 3C5LA 5DNJA 4HABA 4X9VA 4J7BB 4HY2A 4E9CA 4WHLA 4H5XA 3P2ZA 5LHZA 3P34A 1UMWA 4O9WA 4X9RA 4LKLA 4E9DA 3BZIA 3HIKA 4O56A 3P35A 4DFWA 4H71A 4XB0A 5J19A 4O6WA 2N19A 5DMVC 2OGQA 3P37A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q4O A;  4RCP A;  4LKM A;  1Q4K A;  4RS6 A;  4X9W A;  3P2W A;  5DMS A;  2OJX A;  4YYP A;  3FVH A;  4WHK A;  3RQ7 A;  4E67 A;  4HCO A;  3HIH A;  3P36 A;  3Q1I A;  4WHH A;  3C5L A;  5DNJ A;  4HAB A;  4X9V A;  4J7B B;  4HY2 A;  4E9C A;  4WHL A;  4H5X A;  3P2Z A;  5LHZ A;  3P34 A;  1UMW A;  4O9W A;  4X9R A;  4LKL A;  4E9D A;  3BZI A;  3HIK A;  4O56 A;  3P35 A;  4DFW A;  4H71 A;  4XB0 A;  5J19 A;  4O6W A;  2N19 A;  5DMV C;  2OGQ A;  3P37 A; 
#chains in the Genus database with same CATH topology
 4RCP A;  3LXQ A;  4CXK A;  2I9X A;  3P2W A;  3KDR A;  2VKZ G;  2OJX A;  3FVH A;  4WHK A;  1E1Z P;  3LM3 A;  4N7V A;  2QZU A;  3P37 A;  4N9J A;  4CYR A;  4G7N A;  1A87 A;  5DNJ A;  4J7B B;  5LHZ A;  2IA9 A;  3P34 A;  3BZI A;  3P35 A;  1N2L A;  1Q4O A;  2E50 A;  2I9Z A;  1N2K A;  3GYW A;  1E2T A;  1E33 P;  4HCO A;  1F32 A;  3P36 A;  4NKB A;  4HAB A;  4H5X A;  3P2Z A;  3FS3 A;  4X9R A;  4XB0 A;  1P49 A;  4E67 A;  4FDI A;  1HDH A;  4FDJ A;  4LKM A;  1Q4K A;  4RS6 A;  5DAY A;  3HFD A;  4CXU A;  1FSU A;  3HIH A;  3C5L A;  4HY2 A;  2UV8 G;  1UMW A;  4N7Z A;  3GYV A;  3HIK A;  4DFW A;  5J19 A;  4H71 A;  4O6W A;  2N19 A;  5DMV C;  1E3C P;  1AUK A;  4X9W A;  5DMS A;  4YYP A;  3RQ7 A;  5AJ9 A;  3Q1I A;  4WHH A;  4X9V A;  1F34 B;  4CYS A;  4E9C A;  4WHL A;  4LKL A;  4NK7 A;  4CXS A;  4E9D A;  1E2S P;  4O56 A;  3ED4 A;  2OGQ A;  3HMJ G;  4O9W A; 
#chains in the Genus database with same CATH homology
 1Q4O A;  4RCP A;  4LKM A;  1Q4K A;  4RS6 A;  4X9W A;  3P2W A;  5DMS A;  2OJX A;  4YYP A;  3FVH A;  4WHK A;  3RQ7 A;  4E67 A;  4HCO A;  3HIH A;  3P36 A;  3Q1I A;  4WHH A;  3C5L A;  5DNJ A;  4HAB A;  4X9V A;  4J7B B;  4HY2 A;  4E9C A;  4WHL A;  4H5X A;  3P2Z A;  5LHZ A;  3P34 A;  1UMW A;  4O9W A;  4X9R A;  4LKL A;  4E9D A;  3BZI A;  3HIK A;  4O56 A;  3P35 A;  4DFW A;  4H71 A;  4XB0 A;  5J19 A;  4O6W A;  2N19 A;  5DMV C;  2OGQ A;  3P37 A; 
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