4O56A

Structure of plk1 in complex with peptide
Total Genus 76
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
244
structure length
244
Chain Sequence
LGSPGIQGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/peptide
molecule keywords Serine/threonine-protein kinase PLK1
publication title Integration of Charge-dipole Interaction and Intramolecular Hydrogen Bond in Ligand Design for the Polo-Box Domain of Polo-like Kinase 1
rcsb
source organism Homo sapiens
total genus 76
structure length 244
sequence length 244
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-12-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4o56A02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4o56A01
5DNJA 4YYPA 3P35A 4X9RA 4LKMA 5LHZA 4WHLA 3HIKA 4O56A 5DMVC 3C5LA 4HABA 4E9DA 1Q4KA 4X9VA 4XB0A 4J7BB 3P34A 4RCPA 2N19A 4H5XA 1UMWA 3P2WA 4HY2A 4WHKA 4O9WA 3P37A 2OGQA 4E67A 3BZIA 3FVHA 3P2ZA 4HCOA 4RS6A 2OJXA 3HIHA 1Q4OA 3Q1IA 4LKLA 4X9WA 4H71A 5DMSA 4E9CA 5J19A 4DFWA 4WHHA 3P36A 3RQ7A 4O6WA
chains in the Genus database with same CATH superfamily
1N2LA 3KDRA 2VKZG 4X9RA 4LKMA 5LHZA 3HIKA 4O56A 4E9DA 4HABA 2IA9A 4J7BB 2N19A 1F32A 4CXKA 2OGQA 5AJ9A 3P2ZA 4HCOA 4G7NA 3HFDA 4LKLA 3GYWA 1E3CP 4E9CA 1A87A 3LXQA 3RQ7A 4O6WA 1E2TA 3ED4A 5DAYA 4NKBA 1HDHA 4WHLA 3HMJG 1Q4KA 1F34B 4O9WA 4CYRA 2I9XA 3P37A 3HIHA 1Q4OA 1E2SP 4X9WA 4H71A 4FDIA 4CYSA 2UV8G 4CXSA 5DNJA 4YYPA 1E33P 3P35A 5DMVC 2I9ZA 4X9VA 3FS3A 3P34A 4RCPA 4N7VA 3BZIA 3Q1IA 4NK7A 2E50A 5DMSA 4CXUA 5J19A 4DFWA 4WHHA 1AUKA 3P36A 1P49A 1E1ZP 4N9JA 3C5LA 4XB0A 1N2KA 1FSUA 2QZUA 4N7ZA 1UMWA 4H5XA 3P2WA 4HY2A 4WHKA 4FDJA 4E67A 3FVHA 4RS6A 2OJXA 3GYVA 3LM3A
chains in the Genus database with same CATH topology
5DNJA 4YYPA 3P35A 4X9RA 4LKMA 5LHZA 4WHLA 3HIKA 4O56A 5DMVC 3C5LA 4HABA 4E9DA 1Q4KA 4X9VA 4XB0A 4J7BB 3P34A 4RCPA 2N19A 4H5XA 1UMWA 3P2WA 4HY2A 4WHKA 4O9WA 3P37A 2OGQA 4E67A 3BZIA 3FVHA 3P2ZA 4HCOA 4RS6A 2OJXA 3HIHA 1Q4OA 3Q1IA 4LKLA 4X9WA 4H71A 5DMSA 4E9CA 5J19A 4DFWA 4WHHA 3P36A 3RQ7A 4O6WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DNJ A;  4YYP A;  3P35 A;  4X9R A;  4LKM A;  5LHZ A;  4WHL A;  3HIK A;  4O56 A;  5DMV C;  3C5L A;  4HAB A;  4E9D A;  1Q4K A;  4X9V A;  4XB0 A;  4J7B B;  3P34 A;  4RCP A;  2N19 A;  4H5X A;  1UMW A;  3P2W A;  4HY2 A;  4WHK A;  4O9W A;  3P37 A;  2OGQ A;  4E67 A;  3BZI A;  3FVH A;  3P2Z A;  4HCO A;  4RS6 A;  2OJX A;  3HIH A;  1Q4O A;  3Q1I A;  4LKL A;  4X9W A;  4H71 A;  5DMS A;  4E9C A;  5J19 A;  4DFW A;  4WHH A;  3P36 A;  3RQ7 A;  4O6W A; 
#chains in the Genus database with same CATH topology
 1N2L A;  3KDR A;  2VKZ G;  4X9R A;  4LKM A;  5LHZ A;  3HIK A;  4O56 A;  4E9D A;  4HAB A;  2IA9 A;  4J7B B;  2N19 A;  1F32 A;  4CXK A;  2OGQ A;  5AJ9 A;  3P2Z A;  4HCO A;  4G7N A;  3HFD A;  4LKL A;  3GYW A;  1E3C P;  4E9C A;  1A87 A;  3LXQ A;  3RQ7 A;  4O6W A;  1E2T A;  3ED4 A;  5DAY A;  4NKB A;  1HDH A;  4WHL A;  3HMJ G;  1Q4K A;  1F34 B;  4O9W A;  4CYR A;  2I9X A;  3P37 A;  3HIH A;  1Q4O A;  1E2S P;  4X9W A;  4H71 A;  4FDI A;  4CYS A;  2UV8 G;  4CXS A;  5DNJ A;  4YYP A;  1E33 P;  3P35 A;  5DMV C;  2I9Z A;  4X9V A;  3FS3 A;  3P34 A;  4RCP A;  4N7V A;  3BZI A;  3Q1I A;  4NK7 A;  2E50 A;  5DMS A;  4CXU A;  5J19 A;  4DFW A;  4WHH A;  1AUK A;  3P36 A;  1P49 A;  1E1Z P;  4N9J A;  3C5L A;  4XB0 A;  1N2K A;  1FSU A;  2QZU A;  4N7Z A;  1UMW A;  4H5X A;  3P2W A;  4HY2 A;  4WHK A;  4FDJ A;  4E67 A;  3FVH A;  4RS6 A;  2OJX A;  3GYV A;  3LM3 A; 
#chains in the Genus database with same CATH homology
 5DNJ A;  4YYP A;  3P35 A;  4X9R A;  4LKM A;  5LHZ A;  4WHL A;  3HIK A;  4O56 A;  5DMV C;  3C5L A;  4HAB A;  4E9D A;  1Q4K A;  4X9V A;  4XB0 A;  4J7B B;  3P34 A;  4RCP A;  2N19 A;  4H5X A;  1UMW A;  3P2W A;  4HY2 A;  4WHK A;  4O9W A;  3P37 A;  2OGQ A;  4E67 A;  3BZI A;  3FVH A;  3P2Z A;  4HCO A;  4RS6 A;  2OJX A;  3HIH A;  1Q4O A;  3Q1I A;  4LKL A;  4X9W A;  4H71 A;  5DMS A;  4E9C A;  5J19 A;  4DFW A;  4WHH A;  3P36 A;  3RQ7 A;  4O6W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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