4O6WA

Peptide-based inhibitors of plk1 polo-box domain
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
222
structure length
217
Chain Sequence
b'HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPRERLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 74
structure length 217
sequence length 222
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-12-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4o6wA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4o6wA01
2OGQA 4XB0A 3HIKA 4O6WA 4E9DA 3P37A 3FVHA 4J7BB 4WHKA 5J19A 4X9RA 5DNJA 4H5XA 5LHZA 2N19A 4E9CA 4LKMA 1Q4OA 5DMSA 3P35A 4WHLA 3Q1IA 5DMVC 4O9WA 4LKLA 2OJXA 3P2ZA 4E67A 1Q4KA 3P34A 3RQ7A 4DFWA 3BZIA 3C5LA 3HIHA 4O56A 4RS6A 4HY2A 4HABA 4X9VA 4H71A 1UMWA 4HCOA 4X9WA 4YYPA 3P36A 4RCPA 3P2WA 4WHHA
chains in the Genus database with same CATH superfamily
1N2LA 2OGQA 2QZUA 4E9DA 3P37A 4NK7A 4J7BB 3GYWA 5DNJA 4H5XA 5DMSA 5AJ9A 1E1ZP 1A87A 3P2ZA 1Q4KA 1HDHA 4CYRA 3P34A 2I9ZA 3BZIA 3HIHA 3KDRA 1UMWA 4X9WA 4CXKA 4YYPA 3P36A 4RCPA 3P2WA 5J19A 4X9RA 4CXUA 4CYSA 2N19A 3HMJG 1Q4OA 4N7VA 3P35A 2VKZG 5DMVC 2OJXA 3LM3A 4N7ZA 3RQ7A 4FDJA 3C5LA 4RS6A 3FS3A 4G7NA 3HIKA 4O6WA 1E2TA 4NKBA 5LHZA 4E9CA 4LKMA 1E33P 1E3CP 1FSUA 4LKLA 4DFWA 1N2KA 4H71A 4HCOA 3GYVA 4FDIA 1F32A 4WHHA 4CXSA 4N9JA 4XB0A 2IA9A 3FVHA 4WHKA 1F34B 4WHLA 3Q1IA 2E50A 3HFDA 4O9WA 5DAYA 3ED4A 4E67A 2I9XA 3LXQA 4O56A 1P49A 4HY2A 4HABA 4X9VA 2UV8G 1E2SP 1AUKA
chains in the Genus database with same CATH topology
2OGQA 4XB0A 3HIKA 4O6WA 4E9DA 3P37A 3FVHA 4J7BB 4WHKA 5J19A 4X9RA 5DNJA 4H5XA 5LHZA 2N19A 4E9CA 4LKMA 1Q4OA 5DMSA 3P35A 4WHLA 3Q1IA 5DMVC 4O9WA 4LKLA 2OJXA 3P2ZA 4E67A 1Q4KA 3P34A 3RQ7A 4DFWA 3BZIA 3C5LA 3HIHA 4O56A 4RS6A 4HY2A 4HABA 4X9VA 4H71A 1UMWA 4HCOA 4X9WA 4YYPA 3P36A 4RCPA 3P2WA 4WHHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OGQ A;  4XB0 A;  3HIK A;  4O6W A;  4E9D A;  3P37 A;  3FVH A;  4J7B B;  4WHK A;  5J19 A;  4X9R A;  5DNJ A;  4H5X A;  5LHZ A;  2N19 A;  4E9C A;  4LKM A;  1Q4O A;  5DMS A;  3P35 A;  4WHL A;  3Q1I A;  5DMV C;  4O9W A;  4LKL A;  2OJX A;  3P2Z A;  4E67 A;  1Q4K A;  3P34 A;  3RQ7 A;  4DFW A;  3BZI A;  3C5L A;  3HIH A;  4O56 A;  4RS6 A;  4HY2 A;  4HAB A;  4X9V A;  4H71 A;  1UMW A;  4HCO A;  4X9W A;  4YYP A;  3P36 A;  4RCP A;  3P2W A;  4WHH A; 
#chains in the Genus database with same CATH topology
 1N2L A;  2OGQ A;  2QZU A;  4E9D A;  3P37 A;  4NK7 A;  4J7B B;  3GYW A;  5DNJ A;  4H5X A;  5DMS A;  5AJ9 A;  1E1Z P;  1A87 A;  3P2Z A;  1Q4K A;  1HDH A;  4CYR A;  3P34 A;  2I9Z A;  3BZI A;  3HIH A;  3KDR A;  1UMW A;  4X9W A;  4CXK A;  4YYP A;  3P36 A;  4RCP A;  3P2W A;  5J19 A;  4X9R A;  4CXU A;  4CYS A;  2N19 A;  3HMJ G;  1Q4O A;  4N7V A;  3P35 A;  2VKZ G;  5DMV C;  2OJX A;  3LM3 A;  4N7Z A;  3RQ7 A;  4FDJ A;  3C5L A;  4RS6 A;  3FS3 A;  4G7N A;  3HIK A;  4O6W A;  1E2T A;  4NKB A;  5LHZ A;  4E9C A;  4LKM A;  1E33 P;  1E3C P;  1FSU A;  4LKL A;  4DFW A;  1N2K A;  4H71 A;  4HCO A;  3GYV A;  4FDI A;  1F32 A;  4WHH A;  4CXS A;  4N9J A;  4XB0 A;  2IA9 A;  3FVH A;  4WHK A;  1F34 B;  4WHL A;  3Q1I A;  2E50 A;  3HFD A;  4O9W A;  5DAY A;  3ED4 A;  4E67 A;  2I9X A;  3LXQ A;  4O56 A;  1P49 A;  4HY2 A;  4HAB A;  4X9V A;  2UV8 G;  1E2S P;  1AUK A; 
#chains in the Genus database with same CATH homology
 2OGQ A;  4XB0 A;  3HIK A;  4O6W A;  4E9D A;  3P37 A;  3FVH A;  4J7B B;  4WHK A;  5J19 A;  4X9R A;  5DNJ A;  4H5X A;  5LHZ A;  2N19 A;  4E9C A;  4LKM A;  1Q4O A;  5DMS A;  3P35 A;  4WHL A;  3Q1I A;  5DMV C;  4O9W A;  4LKL A;  2OJX A;  3P2Z A;  4E67 A;  1Q4K A;  3P34 A;  3RQ7 A;  4DFW A;  3BZI A;  3C5L A;  3HIH A;  4O56 A;  4RS6 A;  4HY2 A;  4HAB A;  4X9V A;  4H71 A;  1UMW A;  4HCO A;  4X9W A;  4YYP A;  3P36 A;  4RCP A;  3P2W A;  4WHH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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