4O6WA

Peptide-based inhibitors of plk1 polo-box domain
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
222
structure length
217
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPRERLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 74
structure length 217
sequence length 222
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-12-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4o6wA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4o6wA01
3Q1IA 5J19A 3P2WA 4XB0A 4RS6A 4YYPA 4LKMA 4J7BB 4WHHA 4E9CA 5DMVC 4HCOA 3HIHA 2OGQA 4O56A 1Q4KA 3P2ZA 4X9RA 5LHZA 3RQ7A 3P35A 4E9DA 3P34A 4H5XA 3P37A 2OJXA 1UMWA 4HABA 4E67A 3P36A 4O6WA 3C5LA 1Q4OA 4H71A 4X9WA 4HY2A 3HIKA 4WHLA 4WHKA 4DFWA 5DNJA 4LKLA 4X9VA 3FVHA 2N19A 4RCPA 5DMSA 3BZIA 4O9WA
chains in the Genus database with same CATH superfamily
2I9ZA 4N7ZA 1F32A 4YYPA 3GYWA 3KDRA 4NK7A 1N2LA 1HDHA 3P2ZA 3P34A 1F34B 4H5XA 4CXUA 4E67A 4H71A 5DAYA 1P49A 4CYSA 5DNJA 2IA9A 3FVHA 4N7VA 3GYVA 4NKBA 3P2WA 4CXKA 1E2SP 2QZUA 4FDJA 5DMVC 4HCOA 3RQ7A 4O56A 1Q4KA 4X9RA 3HMJG 4HABA 1E2TA 4X9WA 3ED4A 3HIKA 4WHKA 4LKLA 4CYRA 1E33P 5DMSA 3Q1IA 5J19A 4RS6A 1E1ZP 4LKMA 4J7BB 4WHHA 4E9CA 2OGQA 4G7NA 3C5LA 4HY2A 4WHLA 4DFWA 1N2KA 3LXQA 4RCPA 4CXSA 1FSUA 3BZIA 1A87A 4O9WA 4XB0A 2UV8G 1AUKA 3HIHA 5LHZA 3P35A 2VKZG 4E9DA 3FS3A 3P37A 2OJXA 1UMWA 3P36A 4O6WA 1Q4OA 4N9JA 4FDIA 3HFDA 4X9VA 2I9XA 1E3CP 2N19A 3LM3A 2E50A 5AJ9A
chains in the Genus database with same CATH topology
3Q1IA 5J19A 3P2WA 4XB0A 4RS6A 4YYPA 4LKMA 4J7BB 4WHHA 4E9CA 5DMVC 4HCOA 3HIHA 2OGQA 4O56A 1Q4KA 3P2ZA 4X9RA 5LHZA 3RQ7A 3P35A 4E9DA 3P34A 4H5XA 3P37A 2OJXA 1UMWA 4HABA 4E67A 3P36A 4O6WA 3C5LA 1Q4OA 4H71A 4X9WA 4HY2A 3HIKA 4WHLA 4WHKA 4DFWA 5DNJA 4LKLA 4X9VA 3FVHA 2N19A 4RCPA 5DMSA 3BZIA 4O9WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q1I A;  5J19 A;  3P2W A;  4XB0 A;  4RS6 A;  4YYP A;  4LKM A;  4J7B B;  4WHH A;  4E9C A;  5DMV C;  4HCO A;  3HIH A;  2OGQ A;  4O56 A;  1Q4K A;  3P2Z A;  4X9R A;  5LHZ A;  3RQ7 A;  3P35 A;  4E9D A;  3P34 A;  4H5X A;  3P37 A;  2OJX A;  1UMW A;  4HAB A;  4E67 A;  3P36 A;  4O6W A;  3C5L A;  1Q4O A;  4H71 A;  4X9W A;  4HY2 A;  3HIK A;  4WHL A;  4WHK A;  4DFW A;  5DNJ A;  4LKL A;  4X9V A;  3FVH A;  2N19 A;  4RCP A;  5DMS A;  3BZI A;  4O9W A; 
#chains in the Genus database with same CATH topology
 2I9Z A;  4N7Z A;  1F32 A;  4YYP A;  3GYW A;  3KDR A;  4NK7 A;  1N2L A;  1HDH A;  3P2Z A;  3P34 A;  1F34 B;  4H5X A;  4CXU A;  4E67 A;  4H71 A;  5DAY A;  1P49 A;  4CYS A;  5DNJ A;  2IA9 A;  3FVH A;  4N7V A;  3GYV A;  4NKB A;  3P2W A;  4CXK A;  1E2S P;  2QZU A;  4FDJ A;  5DMV C;  4HCO A;  3RQ7 A;  4O56 A;  1Q4K A;  4X9R A;  3HMJ G;  4HAB A;  1E2T A;  4X9W A;  3ED4 A;  3HIK A;  4WHK A;  4LKL A;  4CYR A;  1E33 P;  5DMS A;  3Q1I A;  5J19 A;  4RS6 A;  1E1Z P;  4LKM A;  4J7B B;  4WHH A;  4E9C A;  2OGQ A;  4G7N A;  3C5L A;  4HY2 A;  4WHL A;  4DFW A;  1N2K A;  3LXQ A;  4RCP A;  4CXS A;  1FSU A;  3BZI A;  1A87 A;  4O9W A;  4XB0 A;  2UV8 G;  1AUK A;  3HIH A;  5LHZ A;  3P35 A;  2VKZ G;  4E9D A;  3FS3 A;  3P37 A;  2OJX A;  1UMW A;  3P36 A;  4O6W A;  1Q4O A;  4N9J A;  4FDI A;  3HFD A;  4X9V A;  2I9X A;  1E3C P;  2N19 A;  3LM3 A;  2E50 A;  5AJ9 A; 
#chains in the Genus database with same CATH homology
 3Q1I A;  5J19 A;  3P2W A;  4XB0 A;  4RS6 A;  4YYP A;  4LKM A;  4J7B B;  4WHH A;  4E9C A;  5DMV C;  4HCO A;  3HIH A;  2OGQ A;  4O56 A;  1Q4K A;  3P2Z A;  4X9R A;  5LHZ A;  3RQ7 A;  3P35 A;  4E9D A;  3P34 A;  4H5X A;  3P37 A;  2OJX A;  1UMW A;  4HAB A;  4E67 A;  3P36 A;  4O6W A;  3C5L A;  1Q4O A;  4H71 A;  4X9W A;  4HY2 A;  3HIK A;  4WHL A;  4WHK A;  4DFW A;  5DNJ A;  4LKL A;  4X9V A;  3FVH A;  2N19 A;  4RCP A;  5DMS A;  3BZI A;  4O9W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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