4N9JA

Crystal structure of the cryptic polo box domain of human plk4
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
222
structure length
222
Chain Sequence
TLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK4
publication title Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 60
structure length 222
sequence length 222
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF18190 Plk4_PB1 Polo-like Kinase 4 Polo Box 1
A PF18409 Plk4_PB2 Polo-like Kinase 4 Polo Box 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.120 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n9jA01
3.30.1120.130 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n9jA02
4NK7A 4N7VA 4G7NA 4N9JA 4N7ZA 4NKBA
chains in the Genus database with same CATH superfamily
3GYVA 4X9WA 4X9RA 4O6WA 4CYSA 1E1ZP 4NKBA 4DFWA 1A87A 3BZIA 4XB0A 5DNJA 1E33P 4LKMA 3C5LA 5DMVC 3RQ7A 3P34A 3FVHA 4O56A 3P36A 1N2LA 4FDIA 4YYPA 2I9XA 4WHLA 4N9JA 5DAYA 4LKLA 3FS3A 3P2WA 4NK7A 2OJXA 4N7VA 2QZUA 4E9DA 4O9WA 1E3CP 4CYRA 1UMWA 3GYWA 1E2SP 4WHHA 4G7NA 2IA9A 1P49A 3KDRA 1FSUA 4E67A 4H5XA 2I9ZA 3LM3A 4HCOA 3HFDA 2E50A 3Q1IA 5AJ9A 4RCPA 4X9VA 4WHKA 4FDJA 3HIKA 3HMJG 1Q4KA 1Q4OA 3P2ZA 3P35A 5DMSA 4E9CA 4HY2A 5J19A 4H71A 4CXSA 2OGQA 3ED4A 2VKZG 4CXKA 3LXQA 1HDHA 4RS6A 1F34B 4N7ZA 1F32A 3P37A 1E2TA 4CXUA 3HIHA 1AUKA 1N2KA 4J7BB 2UV8G 4HABA 5LHZA 2N19A
chains in the Genus database with same CATH topology
3GYVA 3HFDA 4NK7A 4N7VA 3LXQA 2E50A 2QZUA 1HDHA 1E3CP 4CYSA 1E1ZP 4N7ZA 4NKBA 5AJ9A 1E2TA 4FDJA 4CXUA 4CYRA 1AUKA 1N2KA 1E33P 3HMJG 2UV8G 3GYWA 1E2SP 1N2LA 4G7NA 1P49A 4FDIA 3KDRA 1FSUA 4CXKA 4CXSA 3ED4A 2VKZG 4N9JA 5DAYA 3LM3A 3FS3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NK7 A;  4N7V A;  4G7N A;  4N9J A;  4N7Z A;  4NKB A; 
#chains in the Genus database with same CATH topology
 3GYV A;  4X9W A;  4X9R A;  4O6W A;  4CYS A;  1E1Z P;  4NKB A;  4DFW A;  1A87 A;  3BZI A;  4XB0 A;  5DNJ A;  1E33 P;  4LKM A;  3C5L A;  5DMV C;  3RQ7 A;  3P34 A;  3FVH A;  4O56 A;  3P36 A;  1N2L A;  4FDI A;  4YYP A;  2I9X A;  4WHL A;  4N9J A;  5DAY A;  4LKL A;  3FS3 A;  3P2W A;  4NK7 A;  2OJX A;  4N7V A;  2QZU A;  4E9D A;  4O9W A;  1E3C P;  4CYR A;  1UMW A;  3GYW A;  1E2S P;  4WHH A;  4G7N A;  2IA9 A;  1P49 A;  3KDR A;  1FSU A;  4E67 A;  4H5X A;  2I9Z A;  3LM3 A;  4HCO A;  3HFD A;  2E50 A;  3Q1I A;  5AJ9 A;  4RCP A;  4X9V A;  4WHK A;  4FDJ A;  3HIK A;  3HMJ G;  1Q4K A;  1Q4O A;  3P2Z A;  3P35 A;  5DMS A;  4E9C A;  4HY2 A;  5J19 A;  4H71 A;  4CXS A;  2OGQ A;  3ED4 A;  2VKZ G;  4CXK A;  3LXQ A;  1HDH A;  4RS6 A;  1F34 B;  4N7Z A;  1F32 A;  3P37 A;  1E2T A;  4CXU A;  3HIH A;  1AUK A;  1N2K A;  4J7B B;  2UV8 G;  4HAB A;  5LHZ A;  2N19 A; 
#chains in the Genus database with same CATH homology
 3GYV A;  3HFD A;  4NK7 A;  4N7V A;  3LXQ A;  2E50 A;  2QZU A;  1HDH A;  1E3C P;  4CYS A;  1E1Z P;  4N7Z A;  4NKB A;  5AJ9 A;  1E2T A;  4FDJ A;  4CXU A;  4CYR A;  1AUK A;  1N2K A;  1E33 P;  3HMJ G;  2UV8 G;  3GYW A;  1E2S P;  1N2L A;  4G7N A;  1P49 A;  4FDI A;  3KDR A;  1FSU A;  4CXK A;  4CXS A;  3ED4 A;  2VKZ G;  4N9J A;  5DAY A;  3LM3 A;  3FS3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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