4N9JA

Crystal structure of the cryptic polo box domain of human plk4
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
222
structure length
222
Chain Sequence
b'TLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKP'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK4
publication title Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 60
structure length 222
sequence length 222
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF18190 Plk4_PB1 Polo-like Kinase 4 Polo Box 1
A PF18409 Plk4_PB2 Polo-like Kinase 4 Polo Box 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.120 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n9jA01
3.30.1120.130 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4n9jA02
4N7ZA 4N9JA 4NK7A 4NKBA 4N7VA 4G7NA
chains in the Genus database with same CATH superfamily
2OJXA 1E33P 1P49A 3HIKA 4O6WA 4WHHA 3BZIA 1AUKA 3FS3A 3P36A 4G7NA 4X9VA 4CYSA 4CXSA 4HCOA 3P35A 3HMJG 2QZUA 1Q4KA 1F34B 4NK7A 4YYPA 3HFDA 4E9DA 4DFWA 3ED4A 4HABA 2VKZG 3Q1IA 4H5XA 4X9RA 5LHZA 4CXUA 1F32A 2I9ZA 1N2KA 4H71A 1A87A 4CXKA 4NKBA 1E2SP 3C5LA 3HIHA 4N9JA 2UV8G 3KDRA 4XB0A 1E2TA 4X9WA 3FVHA 4O9WA 4O56A 3LM3A 4WHKA 3LXQA 4RS6A 4J7BB 1UMWA 4E9CA 4CYRA 1E1ZP 4RCPA 5J19A 1FSUA 3RQ7A 1N2LA 3P2WA 3GYWA 1Q4OA 5DMVC 1E3CP 2I9XA 3P37A 3P2ZA 5DNJA 5DMSA 4LKMA 2N19A 3GYVA 5AJ9A 4WHLA 4HY2A 2IA9A 4FDJA 5DAYA 4N7VA 4N7ZA 4FDIA 4LKLA 4E67A 2E50A 1HDHA 2OGQA 3P34A
chains in the Genus database with same CATH topology
3LM3A 1N2LA 3GYWA 3HFDA 3LXQA 3ED4A 1E33P 1P49A 1E3CP 1AUKA 3FS3A 2VKZG 3GYVA 4CXUA 4G7NA 5AJ9A 4CYRA 4CYSA 1N2KA 4CXSA 4CXKA 4FDJA 4NKBA 4N7VA 1E2SP 4N7ZA 4FDIA 5DAYA 4N9JA 2UV8G 1E1ZP 2QZUA 3KDRA 3HMJG 2E50A 1FSUA 1HDHA 1E2TA 4NK7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4N7Z A;  4N9J A;  4NK7 A;  4NKB A;  4N7V A;  4G7N A; 
#chains in the Genus database with same CATH topology
 2OJX A;  1E33 P;  1P49 A;  3HIK A;  4O6W A;  4WHH A;  3BZI A;  1AUK A;  3FS3 A;  3P36 A;  4G7N A;  4X9V A;  4CYS A;  4CXS A;  4HCO A;  3P35 A;  3HMJ G;  2QZU A;  1Q4K A;  1F34 B;  4NK7 A;  4YYP A;  3HFD A;  4E9D A;  4DFW A;  3ED4 A;  4HAB A;  2VKZ G;  3Q1I A;  4H5X A;  4X9R A;  5LHZ A;  4CXU A;  1F32 A;  2I9Z A;  1N2K A;  4H71 A;  1A87 A;  4CXK A;  4NKB A;  1E2S P;  3C5L A;  3HIH A;  4N9J A;  2UV8 G;  3KDR A;  4XB0 A;  1E2T A;  4X9W A;  3FVH A;  4O9W A;  4O56 A;  3LM3 A;  4WHK A;  3LXQ A;  4RS6 A;  4J7B B;  1UMW A;  4E9C A;  4CYR A;  1E1Z P;  4RCP A;  5J19 A;  1FSU A;  3RQ7 A;  1N2L A;  3P2W A;  3GYW A;  1Q4O A;  5DMV C;  1E3C P;  2I9X A;  3P37 A;  3P2Z A;  5DNJ A;  5DMS A;  4LKM A;  2N19 A;  3GYV A;  5AJ9 A;  4WHL A;  4HY2 A;  2IA9 A;  4FDJ A;  5DAY A;  4N7V A;  4N7Z A;  4FDI A;  4LKL A;  4E67 A;  2E50 A;  1HDH A;  2OGQ A;  3P34 A; 
#chains in the Genus database with same CATH homology
 3LM3 A;  1N2L A;  3GYW A;  3HFD A;  3LXQ A;  3ED4 A;  1E33 P;  1P49 A;  1E3C P;  1AUK A;  3FS3 A;  2VKZ G;  3GYV A;  4CXU A;  4G7N A;  5AJ9 A;  4CYR A;  4CYS A;  1N2K A;  4CXS A;  4CXK A;  4FDJ A;  4NKB A;  4N7V A;  1E2S P;  4N7Z A;  4FDI A;  5DAY A;  4N9J A;  2UV8 G;  1E1Z P;  2QZU A;  3KDR A;  3HMJ G;  2E50 A;  1FSU A;  1HDH A;  1E2T A;  4NK7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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