5DMVC

Polo-box domain of mouse polo-like kinase 1 complexed with emi2 (146-177)
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
230
structure length
230
Chain Sequence
CHLSDLLQQLTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLNYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGTVQINFFQDHTKLILCPLMAAVTYINEKRDFQTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization.
pubmed doi rcsb
source organism Mus musculus
molecule tags Transferase/metal binding protein
total genus 72
structure length 230
sequence length 230
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2015-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 5dmvC02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 5dmvC01
3BZIA 4H71A 5DMVC 3C5LA 1UMWA 5LHZA 4DFWA 5DNJA 4O56A 4E9DA 4LKLA 3HIKA 4HABA 3Q1IA 4WHLA 4RS6A 3RQ7A 1Q4OA 4O9WA 3P37A 3P36A 4WHKA 5DMSA 4X9VA 4LKMA 4H5XA 4E67A 4HCOA 4RCPA 5J19A 2OJXA 4X9WA 3P2ZA 4E9CA 3P35A 4YYPA 2N19A 4WHHA 4J7BB 4X9RA 3P2WA 3HIHA 4O6WA 3FVHA 2OGQA 4XB0A 1Q4KA 4HY2A 3P34A
chains in the Genus database with same CATH superfamily
3BZIA 2UV8G 1HDHA 1E2TA 4FDIA 1A87A 2IA9A 3RQ7A 3P36A 1FSUA 4HCOA 4CXKA 3HMJG 4X9WA 1E1ZP 3FVHA 4HY2A 5DMVC 3C5LA 5LHZA 4DFWA 3GYWA 1N2KA 4LKLA 3HIKA 3Q1IA 1Q4OA 4WHKA 4LKMA 3FS3A 4X9VA 4RCPA 1N2LA 3LM3A 2E50A 4E9CA 3ED4A 4N9JA 4WHHA 4G7NA 4J7BB 3HIHA 4O6WA 5DAYA 2I9ZA 4O56A 1E33P 4E9DA 5AJ9A 4CXSA 4NKBA 4WHLA 4RS6A 1F34B 4H5XA 3GYVA 5J19A 4N7VA 2OJXA 3P35A 2N19A 4X9RA 4N7ZA 3P2WA 4NK7A 1Q4KA 3P34A 1F32A 4H71A 4CYRA 1UMWA 3LXQA 5DNJA 4CYSA 1P49A 2VKZG 4HABA 1AUKA 4O9WA 3P37A 4CXUA 5DMSA 2QZUA 4E67A 1E3CP 3P2ZA 2I9XA 4YYPA 4FDJA 3HFDA 2OGQA 3KDRA 4XB0A 1E2SP
chains in the Genus database with same CATH topology
3BZIA 4H71A 5DMVC 3C5LA 1UMWA 5LHZA 4DFWA 5DNJA 4O56A 4E9DA 4LKLA 3HIKA 4HABA 3Q1IA 4WHLA 4RS6A 3RQ7A 1Q4OA 4O9WA 3P37A 3P36A 4WHKA 5DMSA 4X9VA 4LKMA 4H5XA 4E67A 4HCOA 4RCPA 5J19A 2OJXA 4X9WA 3P2ZA 4E9CA 3P35A 4YYPA 2N19A 4WHHA 4J7BB 4X9RA 3P2WA 3HIHA 4O6WA 3FVHA 2OGQA 4XB0A 1Q4KA 4HY2A 3P34A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BZI A;  4H71 A;  5DMV C;  3C5L A;  1UMW A;  5LHZ A;  4DFW A;  5DNJ A;  4O56 A;  4E9D A;  4LKL A;  3HIK A;  4HAB A;  3Q1I A;  4WHL A;  4RS6 A;  3RQ7 A;  1Q4O A;  4O9W A;  3P37 A;  3P36 A;  4WHK A;  5DMS A;  4X9V A;  4LKM A;  4H5X A;  4E67 A;  4HCO A;  4RCP A;  5J19 A;  2OJX A;  4X9W A;  3P2Z A;  4E9C A;  3P35 A;  4YYP A;  2N19 A;  4WHH A;  4J7B B;  4X9R A;  3P2W A;  3HIH A;  4O6W A;  3FVH A;  2OGQ A;  4XB0 A;  1Q4K A;  4HY2 A;  3P34 A; 
#chains in the Genus database with same CATH topology
 3BZI A;  2UV8 G;  1HDH A;  1E2T A;  4FDI A;  1A87 A;  2IA9 A;  3RQ7 A;  3P36 A;  1FSU A;  4HCO A;  4CXK A;  3HMJ G;  4X9W A;  1E1Z P;  3FVH A;  4HY2 A;  5DMV C;  3C5L A;  5LHZ A;  4DFW A;  3GYW A;  1N2K A;  4LKL A;  3HIK A;  3Q1I A;  1Q4O A;  4WHK A;  4LKM A;  3FS3 A;  4X9V A;  4RCP A;  1N2L A;  3LM3 A;  2E50 A;  4E9C A;  3ED4 A;  4N9J A;  4WHH A;  4G7N A;  4J7B B;  3HIH A;  4O6W A;  5DAY A;  2I9Z A;  4O56 A;  1E33 P;  4E9D A;  5AJ9 A;  4CXS A;  4NKB A;  4WHL A;  4RS6 A;  1F34 B;  4H5X A;  3GYV A;  5J19 A;  4N7V A;  2OJX A;  3P35 A;  2N19 A;  4X9R A;  4N7Z A;  3P2W A;  4NK7 A;  1Q4K A;  3P34 A;  1F32 A;  4H71 A;  4CYR A;  1UMW A;  3LXQ A;  5DNJ A;  4CYS A;  1P49 A;  2VKZ G;  4HAB A;  1AUK A;  4O9W A;  3P37 A;  4CXU A;  5DMS A;  2QZU A;  4E67 A;  1E3C P;  3P2Z A;  2I9X A;  4YYP A;  4FDJ A;  3HFD A;  2OGQ A;  3KDR A;  4XB0 A;  1E2S P; 
#chains in the Genus database with same CATH homology
 3BZI A;  4H71 A;  5DMV C;  3C5L A;  1UMW A;  5LHZ A;  4DFW A;  5DNJ A;  4O56 A;  4E9D A;  4LKL A;  3HIK A;  4HAB A;  3Q1I A;  4WHL A;  4RS6 A;  3RQ7 A;  1Q4O A;  4O9W A;  3P37 A;  3P36 A;  4WHK A;  5DMS A;  4X9V A;  4LKM A;  4H5X A;  4E67 A;  4HCO A;  4RCP A;  5J19 A;  2OJX A;  4X9W A;  3P2Z A;  4E9C A;  3P35 A;  4YYP A;  2N19 A;  4WHH A;  4J7B B;  4X9R A;  3P2W A;  3HIH A;  4O6W A;  3FVH A;  2OGQ A;  4XB0 A;  1Q4K A;  4HY2 A;  3P34 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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