5DMVC

Polo-box domain of mouse polo-like kinase 1 complexed with emi2 (146-177)
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
230
structure length
230
Chain Sequence
CHLSDLLQQLTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLNYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGTVQINFFQDHTKLILCPLMAAVTYINEKRDFQTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/metal binding protein
molecule keywords Serine/threonine-protein kinase PLK1
publication title Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization.
pubmed doi rcsb
source organism Mus musculus
total genus 72
structure length 230
sequence length 230
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2015-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 5dmvC02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 5dmvC01
1UMWA 4RCPA 4LKLA 4WHKA 2N19A 3BZIA 3HIKA 4HCOA 4WHLA 4J7BB 5DNJA 3P2WA 3P34A 2OGQA 3P36A 4O9WA 5J19A 4RS6A 3FVHA 4HY2A 4X9VA 3P2ZA 3RQ7A 3Q1IA 3P35A 4E67A 4E9CA 5DMVC 4E9DA 4WHHA 5LHZA 4HABA 3P37A 3HIHA 4O6WA 4X9RA 2OJXA 4DFWA 4LKMA 4O56A 4H71A 3C5LA 4H5XA 4YYPA 4XB0A 4X9WA 1Q4KA 1Q4OA 5DMSA
chains in the Genus database with same CATH superfamily
1UMWA 4LKLA 4FDIA 2VKZG 3FS3A 4J7BB 4CXUA 4CYRA 3P34A 2OGQA 4N7ZA 3P36A 4WHHA 3HFDA 3LXQA 1F32A 3HIHA 4N9JA 4YYPA 4H5XA 4XB0A 1A87A 1FSUA 1Q4OA 4WHKA 3HMJG 1N2LA 5AJ9A 1E1ZP 5DNJA 4CXKA 2I9ZA 2UV8G 2I9XA 4CYSA 3ED4A 3FVHA 4X9VA 3P35A 4E67A 5DMVC 4E9DA 4G7NA 4O6WA 4X9RA 1F34B 4H71A 3GYVA 5DMSA 1HDHA 2N19A 1E33P 3LM3A 4NK7A 4HCOA 4WHLA 3P2WA 4FDJA 4O9WA 4RS6A 3Q1IA 4E9CA 3KDRA 1E2TA 3P37A 4N7VA 3C5LA 1E2SP 2E50A 1Q4KA 4NKBA 4RCPA 3BZIA 2IA9A 3HIKA 4CXSA 3GYWA 5DAYA 5J19A 4HY2A 3RQ7A 3P2ZA 5LHZA 1N2KA 4HABA 1AUKA 1E3CP 1P49A 2OJXA 4DFWA 4LKMA 4O56A 2QZUA 4X9WA
chains in the Genus database with same CATH topology
1UMWA 4RCPA 4LKLA 4WHKA 2N19A 3BZIA 3HIKA 4HCOA 4WHLA 4J7BB 5DNJA 3P2WA 3P34A 2OGQA 3P36A 4O9WA 5J19A 4RS6A 3FVHA 4HY2A 4X9VA 3P2ZA 3RQ7A 3Q1IA 3P35A 4E67A 4E9CA 5DMVC 4E9DA 4WHHA 5LHZA 4HABA 3P37A 3HIHA 4O6WA 4X9RA 2OJXA 4DFWA 4LKMA 4O56A 4H71A 3C5LA 4H5XA 4YYPA 4XB0A 4X9WA 1Q4KA 1Q4OA 5DMSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1UMW A;  4RCP A;  4LKL A;  4WHK A;  2N19 A;  3BZI A;  3HIK A;  4HCO A;  4WHL A;  4J7B B;  5DNJ A;  3P2W A;  3P34 A;  2OGQ A;  3P36 A;  4O9W A;  5J19 A;  4RS6 A;  3FVH A;  4HY2 A;  4X9V A;  3P2Z A;  3RQ7 A;  3Q1I A;  3P35 A;  4E67 A;  4E9C A;  5DMV C;  4E9D A;  4WHH A;  5LHZ A;  4HAB A;  3P37 A;  3HIH A;  4O6W A;  4X9R A;  2OJX A;  4DFW A;  4LKM A;  4O56 A;  4H71 A;  3C5L A;  4H5X A;  4YYP A;  4XB0 A;  4X9W A;  1Q4K A;  1Q4O A;  5DMS A; 
#chains in the Genus database with same CATH topology
 1UMW A;  4LKL A;  4FDI A;  2VKZ G;  3FS3 A;  4J7B B;  4CXU A;  4CYR A;  3P34 A;  2OGQ A;  4N7Z A;  3P36 A;  4WHH A;  3HFD A;  3LXQ A;  1F32 A;  3HIH A;  4N9J A;  4YYP A;  4H5X A;  4XB0 A;  1A87 A;  1FSU A;  1Q4O A;  4WHK A;  3HMJ G;  1N2L A;  5AJ9 A;  1E1Z P;  5DNJ A;  4CXK A;  2I9Z A;  2UV8 G;  2I9X A;  4CYS A;  3ED4 A;  3FVH A;  4X9V A;  3P35 A;  4E67 A;  5DMV C;  4E9D A;  4G7N A;  4O6W A;  4X9R A;  1F34 B;  4H71 A;  3GYV A;  5DMS A;  1HDH A;  2N19 A;  1E33 P;  3LM3 A;  4NK7 A;  4HCO A;  4WHL A;  3P2W A;  4FDJ A;  4O9W A;  4RS6 A;  3Q1I A;  4E9C A;  3KDR A;  1E2T A;  3P37 A;  4N7V A;  3C5L A;  1E2S P;  2E50 A;  1Q4K A;  4NKB A;  4RCP A;  3BZI A;  2IA9 A;  3HIK A;  4CXS A;  3GYW A;  5DAY A;  5J19 A;  4HY2 A;  3RQ7 A;  3P2Z A;  5LHZ A;  1N2K A;  4HAB A;  1AUK A;  1E3C P;  1P49 A;  2OJX A;  4DFW A;  4LKM A;  4O56 A;  2QZU A;  4X9W A; 
#chains in the Genus database with same CATH homology
 1UMW A;  4RCP A;  4LKL A;  4WHK A;  2N19 A;  3BZI A;  3HIK A;  4HCO A;  4WHL A;  4J7B B;  5DNJ A;  3P2W A;  3P34 A;  2OGQ A;  3P36 A;  4O9W A;  5J19 A;  4RS6 A;  3FVH A;  4HY2 A;  4X9V A;  3P2Z A;  3RQ7 A;  3Q1I A;  3P35 A;  4E67 A;  4E9C A;  5DMV C;  4E9D A;  4WHH A;  5LHZ A;  4HAB A;  3P37 A;  3HIH A;  4O6W A;  4X9R A;  2OJX A;  4DFW A;  4LKM A;  4O56 A;  4H71 A;  3C5L A;  4H5X A;  4YYP A;  4XB0 A;  4X9W A;  1Q4K A;  1Q4O A;  5DMS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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