3P37A

Polo-like kinase i polo-box domain in complex with fdpplhspta phosphopeptide from pbip1
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
224
structure length
224
Chain Sequence
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Serine/threonine-protein kinase PLK1
total genus 70
structure length 224
sequence length 224
chains with identical sequence B, C
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2010-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3p37A02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3p37A01
3Q1IA 4O6WA 4RCPA 2OJXA 4E9DA 3P35A 4X9VA 4E9CA 4X9WA 4E67A 4WHLA 5DMVC 3P2ZA 1Q4KA 3HIHA 5DNJA 3BZIA 4WHHA 3P34A 4HABA 4X9RA 3FVHA 4H71A 4HY2A 1UMWA 3P36A 4DFWA 4XB0A 2N19A 5J19A 4O9WA 4HCOA 4YYPA 4O56A 5LHZA 1Q4OA 3RQ7A 4RS6A 5DMSA 4H5XA 4LKLA 3C5LA 3P2WA 3HIKA 4LKMA 4J7BB 4WHKA 2OGQA 3P37A
chains in the Genus database with same CATH superfamily
3Q1IA 4O6WA 5DAYA 4CXKA 3BZIA 3P34A 3KDRA 4H71A 3P36A 3GYWA 5J19A 4FDJA 1F34B 2I9ZA 2QZUA 5LHZA 1E2SP 5DMSA 4N7ZA 3ED4A 3P2WA 4J7BB 1HDHA 2OGQA 4N7VA 1N2LA 4NKBA 2OJXA 4E9DA 5DMVC 1AUKA 1A87A 3FS3A 4G7NA 4CYRA 3HIHA 4CYSA 4WHHA 3LM3A 3FVHA 3HMJG 1UMWA 2N19A 5AJ9A 4RS6A 4CXSA 4H5XA 3HIKA 2E50A 1N2KA 3P37A 4RCPA 4NK7A 1F32A 3P35A 4WHLA 4HABA 2VKZG 4O9WA 4HCOA 4YYPA 3LXQA 1E1ZP 3HFDA 4LKMA 1FSUA 2I9XA 4X9VA 4X9WA 2IA9A 4E67A 2UV8G 3P2ZA 1E33P 1Q4KA 5DNJA 4X9RA 4HY2A 4DFWA 4XB0A 3GYVA 4O56A 4N9JA 1Q4OA 4FDIA 4CXUA 3RQ7A 4LKLA 1E2TA 1E3CP 3C5LA 4WHKA 1P49A 4E9CA
chains in the Genus database with same CATH topology
3Q1IA 4O6WA 4RCPA 2OJXA 4E9DA 3P35A 4X9VA 4E9CA 4X9WA 4E67A 4WHLA 5DMVC 3P2ZA 1Q4KA 3HIHA 5DNJA 3BZIA 4WHHA 3P34A 4HABA 4X9RA 3FVHA 4H71A 4HY2A 1UMWA 3P36A 4DFWA 4XB0A 2N19A 5J19A 4O9WA 4HCOA 4YYPA 4O56A 5LHZA 1Q4OA 3RQ7A 4RS6A 5DMSA 4H5XA 4LKLA 3C5LA 3P2WA 3HIKA 4LKMA 4J7BB 4WHKA 2OGQA 3P37A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q1I A;  4O6W A;  4RCP A;  2OJX A;  4E9D A;  3P35 A;  4X9V A;  4E9C A;  4X9W A;  4E67 A;  4WHL A;  5DMV C;  3P2Z A;  1Q4K A;  3HIH A;  5DNJ A;  3BZI A;  4WHH A;  3P34 A;  4HAB A;  4X9R A;  3FVH A;  4H71 A;  4HY2 A;  1UMW A;  3P36 A;  4DFW A;  4XB0 A;  2N19 A;  5J19 A;  4O9W A;  4HCO A;  4YYP A;  4O56 A;  5LHZ A;  1Q4O A;  3RQ7 A;  4RS6 A;  5DMS A;  4H5X A;  4LKL A;  3C5L A;  3P2W A;  3HIK A;  4LKM A;  4J7B B;  4WHK A;  2OGQ A;  3P37 A; 
#chains in the Genus database with same CATH topology
 3Q1I A;  4O6W A;  5DAY A;  4CXK A;  3BZI A;  3P34 A;  3KDR A;  4H71 A;  3P36 A;  3GYW A;  5J19 A;  4FDJ A;  1F34 B;  2I9Z A;  2QZU A;  5LHZ A;  1E2S P;  5DMS A;  4N7Z A;  3ED4 A;  3P2W A;  4J7B B;  1HDH A;  2OGQ A;  4N7V A;  1N2L A;  4NKB A;  2OJX A;  4E9D A;  5DMV C;  1AUK A;  1A87 A;  3FS3 A;  4G7N A;  4CYR A;  3HIH A;  4CYS A;  4WHH A;  3LM3 A;  3FVH A;  3HMJ G;  1UMW A;  2N19 A;  5AJ9 A;  4RS6 A;  4CXS A;  4H5X A;  3HIK A;  2E50 A;  1N2K A;  3P37 A;  4RCP A;  4NK7 A;  1F32 A;  3P35 A;  4WHL A;  4HAB A;  2VKZ G;  4O9W A;  4HCO A;  4YYP A;  3LXQ A;  1E1Z P;  3HFD A;  4LKM A;  1FSU A;  2I9X A;  4X9V A;  4X9W A;  2IA9 A;  4E67 A;  2UV8 G;  3P2Z A;  1E33 P;  1Q4K A;  5DNJ A;  4X9R A;  4HY2 A;  4DFW A;  4XB0 A;  3GYV A;  4O56 A;  4N9J A;  1Q4O A;  4FDI A;  4CXU A;  3RQ7 A;  4LKL A;  1E2T A;  1E3C P;  3C5L A;  4WHK A;  1P49 A;  4E9C A; 
#chains in the Genus database with same CATH homology
 3Q1I A;  4O6W A;  4RCP A;  2OJX A;  4E9D A;  3P35 A;  4X9V A;  4E9C A;  4X9W A;  4E67 A;  4WHL A;  5DMV C;  3P2Z A;  1Q4K A;  3HIH A;  5DNJ A;  3BZI A;  4WHH A;  3P34 A;  4HAB A;  4X9R A;  3FVH A;  4H71 A;  4HY2 A;  1UMW A;  3P36 A;  4DFW A;  4XB0 A;  2N19 A;  5J19 A;  4O9W A;  4HCO A;  4YYP A;  4O56 A;  5LHZ A;  1Q4O A;  3RQ7 A;  4RS6 A;  5DMS A;  4H5X A;  4LKL A;  3C5L A;  3P2W A;  3HIK A;  4LKM A;  4J7B B;  4WHK A;  2OGQ A;  3P37 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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