4NK7A

Crystal structure of the d. melanogaster plk4 cryptic polo box (cpb)
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
216
structure length
212
Chain Sequence
HMRISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKFRPTYNEDRINDICRISDDGQRIIIYQPDPGRGLPVREQPPDLQIPSGDCVYNYDNLPSKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKCQLMETMTDFEIRFYSGAKLLKTPSEGLKVYDRNGMLLCSESRSLIEHGNECFTHCVNISNALEVAQTKDNSCFPVTIGRRP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of the C. elegans ZYG-1 Cryptic Polo Box Suggests a Conserved Mechanism for Centriolar Docking of Plk4 Kinases.
pubmed doi rcsb
molecule tags Transferase
source organism Drosophila melanogaster
molecule keywords Serine/threonine-protein kinase PLK4
total genus 47
structure length 212
sequence length 216
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF18190 Plk4_PB1 Polo-like Kinase 4 Polo Box 1
A PF18409 Plk4_PB2 Polo-like Kinase 4 Polo Box 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.120 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4nk7A01
3.30.1120.130 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4nk7A02
4N7ZA 4N7VA 4NK7A 4N9JA 4NKBA 4G7NA
chains in the Genus database with same CATH superfamily
1Q4OA 4WHHA 5DMSA 4FDIA 3P2WA 1N2LA 4NK7A 5J19A 1E33P 4O56A 3ED4A 2I9XA 4HY2A 1E1ZP 4G7NA 4RCPA 3BZIA 4LKMA 1F34B 1F32A 4CYRA 3C5LA 3LM3A 4X9RA 3FVHA 3P35A 1UMWA 1FSUA 3HFDA 1E2SP 3KDRA 4N7VA 3HMJG 4HABA 1Q4KA 4J7BB 4WHLA 4O6WA 1A87A 5DNJA 5AJ9A 3GYVA 4NKBA 4FDJA 4LKLA 4E67A 4CXSA 1E2TA 4E9CA 3FS3A 1P49A 4H71A 4CXUA 3LXQA 2OJXA 2UV8G 5DAYA 4DFWA 4N7ZA 1E3CP 5DMVC 2QZUA 2N19A 3HIKA 1AUKA 4E9DA 4CXKA 3Q1IA 2IA9A 3HIHA 1N2KA 2OGQA 4X9VA 4RS6A 3P37A 4X9WA 4CYSA 2VKZG 3P34A 3P36A 4XB0A 3P2ZA 4HCOA 4H5XA 2E50A 4O9WA 3RQ7A 4YYPA 4N9JA 2I9ZA 5LHZA 4WHKA 3GYWA 1HDHA
chains in the Genus database with same CATH topology
4CXSA 1E2TA 4N7VA 3HMJG 4CYSA 2VKZG 3FS3A 1P49A 4FDIA 4CXUA 3LXQA 1N2LA 4NK7A 1E33P 3ED4A 2UV8G 1E1ZP 5DAYA 4G7NA 4N7ZA 2E50A 1E3CP 5AJ9A 2QZUA 3GYVA 4N9JA 1AUKA 4NKBA 4CYRA 3LM3A 4CXKA 1N2KA 1FSUA 3HFDA 4FDJA 3GYWA 1HDHA 1E2SP 3KDRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4N7Z A;  4N7V A;  4NK7 A;  4N9J A;  4NKB A;  4G7N A; 
#chains in the Genus database with same CATH topology
 1Q4O A;  4WHH A;  5DMS A;  4FDI A;  3P2W A;  1N2L A;  4NK7 A;  5J19 A;  1E33 P;  4O56 A;  3ED4 A;  2I9X A;  4HY2 A;  1E1Z P;  4G7N A;  4RCP A;  3BZI A;  4LKM A;  1F34 B;  1F32 A;  4CYR A;  3C5L A;  3LM3 A;  4X9R A;  3FVH A;  3P35 A;  1UMW A;  1FSU A;  3HFD A;  1E2S P;  3KDR A;  4N7V A;  3HMJ G;  4HAB A;  1Q4K A;  4J7B B;  4WHL A;  4O6W A;  1A87 A;  5DNJ A;  5AJ9 A;  3GYV A;  4NKB A;  4FDJ A;  4LKL A;  4E67 A;  4CXS A;  1E2T A;  4E9C A;  3FS3 A;  1P49 A;  4H71 A;  4CXU A;  3LXQ A;  2OJX A;  2UV8 G;  5DAY A;  4DFW A;  4N7Z A;  1E3C P;  5DMV C;  2QZU A;  2N19 A;  3HIK A;  1AUK A;  4E9D A;  4CXK A;  3Q1I A;  2IA9 A;  3HIH A;  1N2K A;  2OGQ A;  4X9V A;  4RS6 A;  3P37 A;  4X9W A;  4CYS A;  2VKZ G;  3P34 A;  3P36 A;  4XB0 A;  3P2Z A;  4HCO A;  4H5X A;  2E50 A;  4O9W A;  3RQ7 A;  4YYP A;  4N9J A;  2I9Z A;  5LHZ A;  4WHK A;  3GYW A;  1HDH A; 
#chains in the Genus database with same CATH homology
 4CXS A;  1E2T A;  4N7V A;  3HMJ G;  4CYS A;  2VKZ G;  3FS3 A;  1P49 A;  4FDI A;  4CXU A;  3LXQ A;  1N2L A;  4NK7 A;  1E33 P;  3ED4 A;  2UV8 G;  1E1Z P;  5DAY A;  4G7N A;  4N7Z A;  2E50 A;  1E3C P;  5AJ9 A;  2QZU A;  3GYV A;  4N9J A;  1AUK A;  4NKB A;  4CYR A;  3LM3 A;  4CXK A;  1N2K A;  1FSU A;  3HFD A;  4FDJ A;  3GYW A;  1HDH A;  1E2S P;  3KDR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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