4NK7A

Crystal structure of the d. melanogaster plk4 cryptic polo box (cpb)
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
216
structure length
212
Chain Sequence
HMRISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKFRPTYNEDRINDICRISDDGQRIIIYQPDPGRGLPVREQPPDLQIPSGDCVYNYDNLPSKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKCQLMETMTDFEIRFYSGAKLLKTPSEGLKVYDRNGMLLCSESRSLIEHGNECFTHCVNISNALEVAQTKDNSCFPVTIGRRP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of the C. elegans ZYG-1 Cryptic Polo Box Suggests a Conserved Mechanism for Centriolar Docking of Plk4 Kinases.
pubmed doi rcsb
molecule tags Transferase
source organism Drosophila melanogaster
molecule keywords Serine/threonine-protein kinase PLK4
total genus 47
structure length 212
sequence length 216
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2013-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF18190 Plk4_PB1 Polo-like Kinase 4 Polo Box 1
A PF18409 Plk4_PB2 Polo-like Kinase 4 Polo Box 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.120 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4nk7A01
3.30.1120.130 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4nk7A02
4NKBA 4NK7A 4N7VA 4G7NA 4N9JA 4N7ZA
chains in the Genus database with same CATH superfamily
2VKZG 1E2SP 3HMJG 4WHHA 4E9CA 1UMWA 1Q4OA 4FDIA 5DMVC 3GYWA 1E1ZP 1E33P 2E50A 4CXKA 1F32A 3FS3A 3Q1IA 1Q4KA 3P34A 3P35A 4YYPA 1E2TA 4N7ZA 4XB0A 4N7VA 3LM3A 1P49A 2I9ZA 4LKLA 3HFDA 4E67A 1HDHA 2OGQA 2OJXA 4O6WA 5DAYA 4H5XA 4FDJA 5DMSA 3BZIA 1F34B 4HABA 4HCOA 3RQ7A 2N19A 5LHZA 1FSUA 3HIHA 3P2WA 1E3CP 3FVHA 1A87A 3LXQA 4CXSA 4O9WA 4G7NA 3ED4A 3KDRA 5DNJA 4X9VA 4NK7A 4CXUA 3C5LA 3GYVA 4H71A 4CYSA 1AUKA 4LKMA 4N9JA 2UV8G 4J7BB 4DFWA 2QZUA 2IA9A 2I9XA 4WHKA 3HIKA 5AJ9A 5J19A 3P2ZA 4CYRA 4RCPA 1N2LA 4WHLA 4E9DA 4HY2A 4X9RA 4RS6A 3P37A 3P36A 4NKBA 1N2KA 4X9WA 4O56A
chains in the Genus database with same CATH topology
1P49A 2VKZG 1E2SP 2QZUA 3LXQA 4CXSA 4G7NA 3HMJG 3HFDA 3ED4A 1HDHA 5AJ9A 4FDIA 3GYWA 5DAYA 1E1ZP 1E33P 1N2LA 2E50A 3KDRA 4FDJA 4CYRA 4CXKA 4NK7A 3FS3A 1E2TA 4N7ZA 4CXUA 4NKBA 3GYVA 1N2KA 4CYSA 1AUKA 4N7VA 1FSUA 2UV8G 4N9JA 3LM3A 1E3CP
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NKB A;  4NK7 A;  4N7V A;  4G7N A;  4N9J A;  4N7Z A; 
#chains in the Genus database with same CATH topology
 2VKZ G;  1E2S P;  3HMJ G;  4WHH A;  4E9C A;  1UMW A;  1Q4O A;  4FDI A;  5DMV C;  3GYW A;  1E1Z P;  1E33 P;  2E50 A;  4CXK A;  1F32 A;  3FS3 A;  3Q1I A;  1Q4K A;  3P34 A;  3P35 A;  4YYP A;  1E2T A;  4N7Z A;  4XB0 A;  4N7V A;  3LM3 A;  1P49 A;  2I9Z A;  4LKL A;  3HFD A;  4E67 A;  1HDH A;  2OGQ A;  2OJX A;  4O6W A;  5DAY A;  4H5X A;  4FDJ A;  5DMS A;  3BZI A;  1F34 B;  4HAB A;  4HCO A;  3RQ7 A;  2N19 A;  5LHZ A;  1FSU A;  3HIH A;  3P2W A;  1E3C P;  3FVH A;  1A87 A;  3LXQ A;  4CXS A;  4O9W A;  4G7N A;  3ED4 A;  3KDR A;  5DNJ A;  4X9V A;  4NK7 A;  4CXU A;  3C5L A;  3GYV A;  4H71 A;  4CYS A;  1AUK A;  4LKM A;  4N9J A;  2UV8 G;  4J7B B;  4DFW A;  2QZU A;  2IA9 A;  2I9X A;  4WHK A;  3HIK A;  5AJ9 A;  5J19 A;  3P2Z A;  4CYR A;  4RCP A;  1N2L A;  4WHL A;  4E9D A;  4HY2 A;  4X9R A;  4RS6 A;  3P37 A;  3P36 A;  4NKB A;  1N2K A;  4X9W A;  4O56 A; 
#chains in the Genus database with same CATH homology
 1P49 A;  2VKZ G;  1E2S P;  2QZU A;  3LXQ A;  4CXS A;  4G7N A;  3HMJ G;  3HFD A;  3ED4 A;  1HDH A;  5AJ9 A;  4FDI A;  3GYW A;  5DAY A;  1E1Z P;  1E33 P;  1N2L A;  2E50 A;  3KDR A;  4FDJ A;  4CYR A;  4CXK A;  4NK7 A;  3FS3 A;  1E2T A;  4N7Z A;  4CXU A;  4NKB A;  3GYV A;  1N2K A;  4CYS A;  1AUK A;  4N7V A;  1FSU A;  2UV8 G;  4N9J A;  3LM3 A;  1E3C P; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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