5DMVC

Polo-box domain of mouse polo-like kinase 1 complexed with emi2 (146-177)
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
230
structure length
230
Chain Sequence
CHLSDLLQQLTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLNYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGTVQINFFQDHTKLILCPLMAAVTYINEKRDFQTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization.
pubmed doi rcsb
molecule tags Transferase/metal binding protein
source organism Mus musculus
molecule keywords Serine/threonine-protein kinase PLK1
total genus 72
structure length 230
sequence length 230
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2015-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 5dmvC02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 5dmvC01
4O9WA 4LKLA 1Q4KA 4HCOA 4O6WA 4XB0A 4WHLA 4H71A 3P36A 4YYPA 3C5LA 5DMVC 5J19A 3HIKA 4HY2A 3Q1IA 4E9CA 5DNJA 2N19A 3P35A 4X9RA 5DMSA 3P34A 3RQ7A 4E9DA 4HABA 3BZIA 1Q4OA 4X9VA 1UMWA 3FVHA 4RCPA 4RS6A 4WHHA 3P37A 3P2WA 4WHKA 5LHZA 4E67A 4J7BB 4DFWA 4O56A 4LKMA 2OGQA 3HIHA 3P2ZA 4X9WA 2OJXA 4H5XA
chains in the Genus database with same CATH superfamily
4CYSA 1AUKA 4O9WA 4CXUA 4HCOA 4O6WA 3P36A 1HDHA 4YYPA 3GYWA 3Q1IA 3KDRA 4X9RA 2QZUA 3P34A 3RQ7A 4E9DA 3BZIA 4G7NA 4N7VA 4NK7A 1E2TA 3FVHA 5AJ9A 1N2LA 1E3CP 4J7BB 4DFWA 2OGQA 5DAYA 2N19A 4CXSA 4N7ZA 1Q4KA 4H71A 4E9CA 1Q4OA 1UMWA 4RS6A 4WHHA 3P2WA 4WHKA 4E67A 1E2SP 1FSUA 4LKMA 1E33P 3HIHA 3P2ZA 2OJXA 3LM3A 2UV8G 3ED4A 4FDIA 2VKZG 3C5LA 4CXKA 3P35A 5DMSA 4N9JA 1A87A 4HABA 1N2KA 3HFDA 2I9ZA 2E50A 4NKBA 4H5XA 2IA9A 4LKLA 4XB0A 4WHLA 4FDJA 5DMVC 5J19A 3HIKA 4HY2A 1F32A 5DNJA 1F34B 1E1ZP 2I9XA 4X9VA 4RCPA 3P37A 1P49A 3HMJG 5LHZA 4CYRA 4O56A 3LXQA 4X9WA 3GYVA 3FS3A
chains in the Genus database with same CATH topology
4O9WA 4LKLA 1Q4KA 4HCOA 4O6WA 4XB0A 4WHLA 4H71A 3P36A 4YYPA 3C5LA 5DMVC 5J19A 3HIKA 4HY2A 3Q1IA 4E9CA 5DNJA 2N19A 3P35A 4X9RA 5DMSA 3P34A 3RQ7A 4E9DA 4HABA 3BZIA 1Q4OA 4X9VA 1UMWA 3FVHA 4RCPA 4RS6A 4WHHA 3P37A 3P2WA 4WHKA 5LHZA 4E67A 4J7BB 4DFWA 4O56A 4LKMA 2OGQA 3HIHA 3P2ZA 4X9WA 2OJXA 4H5XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4O9W A;  4LKL A;  1Q4K A;  4HCO A;  4O6W A;  4XB0 A;  4WHL A;  4H71 A;  3P36 A;  4YYP A;  3C5L A;  5DMV C;  5J19 A;  3HIK A;  4HY2 A;  3Q1I A;  4E9C A;  5DNJ A;  2N19 A;  3P35 A;  4X9R A;  5DMS A;  3P34 A;  3RQ7 A;  4E9D A;  4HAB A;  3BZI A;  1Q4O A;  4X9V A;  1UMW A;  3FVH A;  4RCP A;  4RS6 A;  4WHH A;  3P37 A;  3P2W A;  4WHK A;  5LHZ A;  4E67 A;  4J7B B;  4DFW A;  4O56 A;  4LKM A;  2OGQ A;  3HIH A;  3P2Z A;  4X9W A;  2OJX A;  4H5X A; 
#chains in the Genus database with same CATH topology
 4CYS A;  1AUK A;  4O9W A;  4CXU A;  4HCO A;  4O6W A;  3P36 A;  1HDH A;  4YYP A;  3GYW A;  3Q1I A;  3KDR A;  4X9R A;  2QZU A;  3P34 A;  3RQ7 A;  4E9D A;  3BZI A;  4G7N A;  4N7V A;  4NK7 A;  1E2T A;  3FVH A;  5AJ9 A;  1N2L A;  1E3C P;  4J7B B;  4DFW A;  2OGQ A;  5DAY A;  2N19 A;  4CXS A;  4N7Z A;  1Q4K A;  4H71 A;  4E9C A;  1Q4O A;  1UMW A;  4RS6 A;  4WHH A;  3P2W A;  4WHK A;  4E67 A;  1E2S P;  1FSU A;  4LKM A;  1E33 P;  3HIH A;  3P2Z A;  2OJX A;  3LM3 A;  2UV8 G;  3ED4 A;  4FDI A;  2VKZ G;  3C5L A;  4CXK A;  3P35 A;  5DMS A;  4N9J A;  1A87 A;  4HAB A;  1N2K A;  3HFD A;  2I9Z A;  2E50 A;  4NKB A;  4H5X A;  2IA9 A;  4LKL A;  4XB0 A;  4WHL A;  4FDJ A;  5DMV C;  5J19 A;  3HIK A;  4HY2 A;  1F32 A;  5DNJ A;  1F34 B;  1E1Z P;  2I9X A;  4X9V A;  4RCP A;  3P37 A;  1P49 A;  3HMJ G;  5LHZ A;  4CYR A;  4O56 A;  3LXQ A;  4X9W A;  3GYV A;  3FS3 A; 
#chains in the Genus database with same CATH homology
 4O9W A;  4LKL A;  1Q4K A;  4HCO A;  4O6W A;  4XB0 A;  4WHL A;  4H71 A;  3P36 A;  4YYP A;  3C5L A;  5DMV C;  5J19 A;  3HIK A;  4HY2 A;  3Q1I A;  4E9C A;  5DNJ A;  2N19 A;  3P35 A;  4X9R A;  5DMS A;  3P34 A;  3RQ7 A;  4E9D A;  4HAB A;  3BZI A;  1Q4O A;  4X9V A;  1UMW A;  3FVH A;  4RCP A;  4RS6 A;  4WHH A;  3P37 A;  3P2W A;  4WHK A;  5LHZ A;  4E67 A;  4J7B B;  4DFW A;  4O56 A;  4LKM A;  2OGQ A;  3HIH A;  3P2Z A;  4X9W A;  2OJX A;  4H5X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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