1MYLA

Substituting hydrophobic residues for a buried salt bridge enhances protein stability but does not reduce conformational specificity
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
45
structure length
45
Chain Sequence
KMPQFNLRWPREVLDLVRKVAEENGMSVNSYIYQLVMESFKKEGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Are buried salt bridges important for protein stability and conformational specificity?
pubmed doi rcsb
molecule tags Transcription regulation
source organism Enterobacteria phage p22
molecule keywords ARC REPRESSOR
total genus 15
structure length 45
sequence length 45
chains with identical sequence B, C, D, E, F
ec nomenclature
pdb deposition date 1994-10-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03869 Arc Arc-like DNA binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1220.10 Mainly Alpha Orthogonal Bundle Arc Repressor Mutant Met repressor-like 1mylA00
2HZVA 2K1OA 2JXHA 3FT7A 3VW4A 3VEBA 4ME7E 2CA9A 1MNTA 3GXQA 1NLAA 2WVCA 1PARA 2JXIA 1QTGA 1BDTA 2WVBA 1B28A 4FXEA 1MYLA 2BJ8A 2JXGA 2CAXA 3H87C 1IRQA 2BJ3A 1P94A 1U9PA 1Q5VA 2BNZA 2K5JA 2WVFA 1X93A 3LGHA 3VEAA 1BDVA 2BJ7A 2RBFA 3QOQA 2BJ1A 2BSQE 3FMTA 1ARQA 2K9IA 2CADA 2AY0A 4D8JA 1B01A 2CAJA 4HV0A 2K29A 1BAZA 2WVEA 1EA4A 2CPGA 2WVDA 2H1OE 1ARRA 2BA3A 2GPEA 3OD2A 1MYKA 2HZAA 2KELA 2BJ9A 2BNWA 2K6LA
chains in the Genus database with same CATH superfamily
2HZVA 2CA9A 1MNTA 3GXQA 3IR7A 3NO7A 4O4RA 2Q2KA 4LQ9A 3NAHA 2BJ3A 1P94A 1U9PA 4QPXA 3BSOA 4NRUA 2RBFA 1ARQA 2H3AA 3SFUA 2JBVA 3UPFA 1SH3A 3NAIA 2KOEA 2WVEA 2H1OE 2WVDA 4LRVA 3UR0A 3NNEA 2K6LA 3VEBA 4ME7E 1PARA 2JXIA 3H87C 1IRQA 1Q16A 2WK4A 3LGHA 2BJ7A 2BJ1A 2BSQE 3FMTA 3H5XA 1OHNA 1B01A 3LJPA 1BAZA 1EA4A 3OD2A 4AAIA 1MYKA 2B43A 3VW4A 2ADLA 1NLAA 2WVCA 3QIDA 1B28A 2WVBA 1MYLA 2BJ8A 2JXGA 2A2BA 2CAXA 2CKWA 3BSNA 4LQ3A 1Q5VA 3VEAA 1BDVA 2CADA 3SFGA 4MJWA 3G5OA 2CAJA 2KKEA 4HV0A 2CPGA 1ARRA 1SH2A 2GPEA 4NRTA 3UQSA 2BJ9A 2KELA 1OG7A 2K1OA 2JXHA 3FT7A 3H5YA 1QTGA 1BDTA 4FXEA 2BNZA 2K5JA 2WVFA 1X93A 1SH0A 3QOQA 1SIWA 2K9IA 2AY0A 4D8JA 2K29A 2BA3A 2UUWA 2HZAA 2UUTA 2BNWA 2AN7A
chains in the Genus database with same CATH topology
2HZVA 2K1OA 2JXHA 3FT7A 3VW4A 3VEBA 4ME7E 2CA9A 1MNTA 3GXQA 1NLAA 2WVCA 1PARA 2JXIA 1QTGA 1BDTA 2WVBA 1B28A 4FXEA 1MYLA 2BJ8A 2JXGA 2CAXA 3H87C 1IRQA 2BJ3A 1P94A 1U9PA 1Q5VA 2BNZA 2K5JA 2WVFA 1X93A 3LGHA 3VEAA 1BDVA 2BJ7A 2RBFA 3QOQA 2BJ1A 2BSQE 3FMTA 1ARQA 2K9IA 2CADA 2AY0A 4D8JA 1B01A 2CAJA 4HV0A 2K29A 1BAZA 2WVEA 1EA4A 2CPGA 2WVDA 2H1OE 1ARRA 2BA3A 2GPEA 3OD2A 1MYKA 2HZAA 2KELA 2BJ9A 2BNWA 2K6LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HZV A;  2K1O A;  2JXH A;  3FT7 A;  3VW4 A;  3VEB A;  4ME7 E;  2CA9 A;  1MNT A;  3GXQ A;  1NLA A;  2WVC A;  1PAR A;  2JXI A;  1QTG A;  1BDT A;  2WVB A;  1B28 A;  4FXE A;  1MYL A;  2BJ8 A;  2JXG A;  2CAX A;  3H87 C;  1IRQ A;  2BJ3 A;  1P94 A;  1U9P A;  1Q5V A;  2BNZ A;  2K5J A;  2WVF A;  1X93 A;  3LGH A;  3VEA A;  1BDV A;  2BJ7 A;  2RBF A;  3QOQ A;  2BJ1 A;  2BSQ E;  3FMT A;  1ARQ A;  2K9I A;  2CAD A;  2AY0 A;  4D8J A;  1B01 A;  2CAJ A;  4HV0 A;  2K29 A;  1BAZ A;  2WVE A;  1EA4 A;  2CPG A;  2WVD A;  2H1O E;  1ARR A;  2BA3 A;  2GPE A;  3OD2 A;  1MYK A;  2HZA A;  2KEL A;  2BJ9 A;  2BNW A;  2K6L A; 
#chains in the Genus database with same CATH topology
 2HZV A;  2CA9 A;  1MNT A;  3GXQ A;  3IR7 A;  3NO7 A;  4O4R A;  2Q2K A;  4LQ9 A;  3NAH A;  2BJ3 A;  1P94 A;  1U9P A;  4QPX A;  3BSO A;  4NRU A;  2RBF A;  1ARQ A;  2H3A A;  3SFU A;  2JBV A;  3UPF A;  1SH3 A;  3NAI A;  2KOE A;  2WVE A;  2H1O E;  2WVD A;  4LRV A;  3UR0 A;  3NNE A;  2K6L A;  3VEB A;  4ME7 E;  1PAR A;  2JXI A;  3H87 C;  1IRQ A;  1Q16 A;  2WK4 A;  3LGH A;  2BJ7 A;  2BJ1 A;  2BSQ E;  3FMT A;  3H5X A;  1OHN A;  1B01 A;  3LJP A;  1BAZ A;  1EA4 A;  3OD2 A;  4AAI A;  1MYK A;  2B43 A;  3VW4 A;  2ADL A;  1NLA A;  2WVC A;  3QID A;  1B28 A;  2WVB A;  1MYL A;  2BJ8 A;  2JXG A;  2A2B A;  2CAX A;  2CKW A;  3BSN A;  4LQ3 A;  1Q5V A;  3VEA A;  1BDV A;  2CAD A;  3SFG A;  4MJW A;  3G5O A;  2CAJ A;  2KKE A;  4HV0 A;  2CPG A;  1ARR A;  1SH2 A;  2GPE A;  4NRT A;  3UQS A;  2BJ9 A;  2KEL A;  1OG7 A;  2K1O A;  2JXH A;  3FT7 A;  3H5Y A;  1QTG A;  1BDT A;  4FXE A;  2BNZ A;  2K5J A;  2WVF A;  1X93 A;  1SH0 A;  3QOQ A;  1SIW A;  2K9I A;  2AY0 A;  4D8J A;  2K29 A;  2BA3 A;  2UUW A;  2HZA A;  2UUT A;  2BNW A;  2AN7 A; 
#chains in the Genus database with same CATH homology
 2HZV A;  2K1O A;  2JXH A;  3FT7 A;  3VW4 A;  3VEB A;  4ME7 E;  2CA9 A;  1MNT A;  3GXQ A;  1NLA A;  2WVC A;  1PAR A;  2JXI A;  1QTG A;  1BDT A;  2WVB A;  1B28 A;  4FXE A;  1MYL A;  2BJ8 A;  2JXG A;  2CAX A;  3H87 C;  1IRQ A;  2BJ3 A;  1P94 A;  1U9P A;  1Q5V A;  2BNZ A;  2K5J A;  2WVF A;  1X93 A;  3LGH A;  3VEA A;  1BDV A;  2BJ7 A;  2RBF A;  3QOQ A;  2BJ1 A;  2BSQ E;  3FMT A;  1ARQ A;  2K9I A;  2CAD A;  2AY0 A;  4D8J A;  1B01 A;  2CAJ A;  4HV0 A;  2K29 A;  1BAZ A;  2WVE A;  1EA4 A;  2CPG A;  2WVD A;  2H1O E;  1ARR A;  2BA3 A;  2GPE A;  3OD2 A;  1MYK A;  2HZA A;  2KEL A;  2BJ9 A;  2BNW A;  2K6L A; 
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