1MYLA

Substituting hydrophobic residues for a buried salt bridge enhances protein stability but does not reduce conformational specificity
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
45
structure length
45
Chain Sequence
KMPQFNLRWPREVLDLVRKVAEENGMSVNSYIYQLVMESFKKEGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Are buried salt bridges important for protein stability and conformational specificity?
pubmed doi rcsb
molecule tags Transcription regulation
source organism Enterobacteria phage p22
molecule keywords ARC REPRESSOR
total genus 15
structure length 45
sequence length 45
chains with identical sequence B, C, D, E, F
ec nomenclature
pdb deposition date 1994-10-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03869 Arc Arc-like DNA binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1220.10 Mainly Alpha Orthogonal Bundle Arc Repressor Mutant Met repressor-like 1mylA00
1B01A 2BJ9A 2KELA 2WVFA 2HZAA 2K5JA 2JXIA 2BA3A 1ARRA 1MNTA 1EA4A 1BDVA 1U9PA 3GXQA 4D8JA 1P94A 4ME7E 1NLAA 3FMTA 1B28A 3VEBA 2JXHA 1Q5VA 2CAJA 1QTGA 2K1OA 1PARA 1ARQA 2JXGA 3VEAA 2BJ3A 2BNZA 1MYKA 2GPEA 2AY0A 2BJ8A 1BDTA 3VW4A 1BAZA 2H1OE 2BNWA 1X93A 2BSQE 3H87C 1MYLA 2WVEA 4HV0A 2RBFA 2CPGA 2BJ1A 2K9IA 2WVDA 3QOQA 3LGHA 2K6LA 2BJ7A 2WVBA 1IRQA 4FXEA 2CA9A 3OD2A 2CAXA 2K29A 2WVCA 3FT7A 2CADA 2HZVA
chains in the Genus database with same CATH superfamily
1SH3A 2KELA 2JBVA 1ARRA 1U9PA 3LJPA 3NAIA 4LQ9A 2H3AA 2UUWA 3VEBA 4MJWA 1Q5VA 3IR7A 1BDTA 1BAZA 3H87C 2RBFA 4HV0A 2K9IA 4LRVA 3UR0A 2K6LA 2WVBA 1IRQA 2ADLA 2HZVA 2HZAA 2K5JA 1BDVA 3QIDA 1OG7A 3H5YA 2Q2KA 1OHNA 3NAHA 2A2BA 2KOEA 2K1OA 1ARQA 2JXGA 3G5OA 1MYKA 2GPEA 2CKWA 3SFUA 4NRTA 3QOQA 2CPGA 2BJ1A 4O4RA 3LGHA 2WK4A 3NNEA 2CA9A 3OD2A 2CAXA 2K29A 2WVCA 3NO7A 2CADA 2KKEA 2JXIA 2BA3A 2B43A 1EA4A 1B28A 1NLAA 3VEAA 4NRUA 2UUTA 4QPXA 3H5XA 2AN7A 2BJ8A 3VW4A 3UQSA 2H1OE 2BNWA 1X93A 2BSQE 2WVEA 4FXEA 3SFGA 1B01A 4AAIA 2BJ9A 2WVFA 1MNTA 1SH0A 3GXQA 4D8JA 1P94A 4ME7E 3FMTA 3BSOA 2JXHA 1Q16A 2CAJA 1SIWA 1QTGA 1PARA 3UPFA 1SH2A 2BJ3A 2BNZA 2AY0A 4LQ3A 3BSNA 1MYLA 2WVDA 2BJ7A 3FT7A
chains in the Genus database with same CATH topology
1B01A 2BJ9A 2KELA 2WVFA 2HZAA 2K5JA 2JXIA 2BA3A 1ARRA 1MNTA 1EA4A 1BDVA 1U9PA 3GXQA 4D8JA 1P94A 4ME7E 1NLAA 3FMTA 1B28A 3VEBA 2JXHA 1Q5VA 2CAJA 1QTGA 2K1OA 1PARA 1ARQA 2JXGA 3VEAA 2BJ3A 2BNZA 1MYKA 2GPEA 2AY0A 2BJ8A 1BDTA 3VW4A 1BAZA 2H1OE 2BNWA 1X93A 2BSQE 3H87C 1MYLA 2WVEA 4HV0A 2RBFA 2CPGA 2BJ1A 2K9IA 2WVDA 3QOQA 3LGHA 2K6LA 2BJ7A 2WVBA 1IRQA 4FXEA 2CA9A 3OD2A 2CAXA 2K29A 2WVCA 3FT7A 2CADA 2HZVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1B01 A;  2BJ9 A;  2KEL A;  2WVF A;  2HZA A;  2K5J A;  2JXI A;  2BA3 A;  1ARR A;  1MNT A;  1EA4 A;  1BDV A;  1U9P A;  3GXQ A;  4D8J A;  1P94 A;  4ME7 E;  1NLA A;  3FMT A;  1B28 A;  3VEB A;  2JXH A;  1Q5V A;  2CAJ A;  1QTG A;  2K1O A;  1PAR A;  1ARQ A;  2JXG A;  3VEA A;  2BJ3 A;  2BNZ A;  1MYK A;  2GPE A;  2AY0 A;  2BJ8 A;  1BDT A;  3VW4 A;  1BAZ A;  2H1O E;  2BNW A;  1X93 A;  2BSQ E;  3H87 C;  1MYL A;  2WVE A;  4HV0 A;  2RBF A;  2CPG A;  2BJ1 A;  2K9I A;  2WVD A;  3QOQ A;  3LGH A;  2K6L A;  2BJ7 A;  2WVB A;  1IRQ A;  4FXE A;  2CA9 A;  3OD2 A;  2CAX A;  2K29 A;  2WVC A;  3FT7 A;  2CAD A;  2HZV A; 
#chains in the Genus database with same CATH topology
 1SH3 A;  2KEL A;  2JBV A;  1ARR A;  1U9P A;  3LJP A;  3NAI A;  4LQ9 A;  2H3A A;  2UUW A;  3VEB A;  4MJW A;  1Q5V A;  3IR7 A;  1BDT A;  1BAZ A;  3H87 C;  2RBF A;  4HV0 A;  2K9I A;  4LRV A;  3UR0 A;  2K6L A;  2WVB A;  1IRQ A;  2ADL A;  2HZV A;  2HZA A;  2K5J A;  1BDV A;  3QID A;  1OG7 A;  3H5Y A;  2Q2K A;  1OHN A;  3NAH A;  2A2B A;  2KOE A;  2K1O A;  1ARQ A;  2JXG A;  3G5O A;  1MYK A;  2GPE A;  2CKW A;  3SFU A;  4NRT A;  3QOQ A;  2CPG A;  2BJ1 A;  4O4R A;  3LGH A;  2WK4 A;  3NNE A;  2CA9 A;  3OD2 A;  2CAX A;  2K29 A;  2WVC A;  3NO7 A;  2CAD A;  2KKE A;  2JXI A;  2BA3 A;  2B43 A;  1EA4 A;  1B28 A;  1NLA A;  3VEA A;  4NRU A;  2UUT A;  4QPX A;  3H5X A;  2AN7 A;  2BJ8 A;  3VW4 A;  3UQS A;  2H1O E;  2BNW A;  1X93 A;  2BSQ E;  2WVE A;  4FXE A;  3SFG A;  1B01 A;  4AAI A;  2BJ9 A;  2WVF A;  1MNT A;  1SH0 A;  3GXQ A;  4D8J A;  1P94 A;  4ME7 E;  3FMT A;  3BSO A;  2JXH A;  1Q16 A;  2CAJ A;  1SIW A;  1QTG A;  1PAR A;  3UPF A;  1SH2 A;  2BJ3 A;  2BNZ A;  2AY0 A;  4LQ3 A;  3BSN A;  1MYL A;  2WVD A;  2BJ7 A;  3FT7 A; 
#chains in the Genus database with same CATH homology
 1B01 A;  2BJ9 A;  2KEL A;  2WVF A;  2HZA A;  2K5J A;  2JXI A;  2BA3 A;  1ARR A;  1MNT A;  1EA4 A;  1BDV A;  1U9P A;  3GXQ A;  4D8J A;  1P94 A;  4ME7 E;  1NLA A;  3FMT A;  1B28 A;  3VEB A;  2JXH A;  1Q5V A;  2CAJ A;  1QTG A;  2K1O A;  1PAR A;  1ARQ A;  2JXG A;  3VEA A;  2BJ3 A;  2BNZ A;  1MYK A;  2GPE A;  2AY0 A;  2BJ8 A;  1BDT A;  3VW4 A;  1BAZ A;  2H1O E;  2BNW A;  1X93 A;  2BSQ E;  3H87 C;  1MYL A;  2WVE A;  4HV0 A;  2RBF A;  2CPG A;  2BJ1 A;  2K9I A;  2WVD A;  3QOQ A;  3LGH A;  2K6L A;  2BJ7 A;  2WVB A;  1IRQ A;  4FXE A;  2CA9 A;  3OD2 A;  2CAX A;  2K29 A;  2WVC A;  3FT7 A;  2CAD A;  2HZV A; 
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