2GKJA

Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor dl-azidap
Total Genus 82
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
82
sequence length
274
structure length
274
Chain Sequence
MQFSKMHGLGNDFVVVDGVTQNVFFTPETIRRLANRHCGIGFDQLLIVEAPYDPELDFHYRIFNADGSEVSQCGNGARCFARFVTLKGLTNKKDISVSTQKGNMVLTVKDDNQIRVNMGEPIWEPAKIPFTANKFEKNYILRTDIQTVLCGAVSMGNPHCVVQVDDIQTANVEQLGPLLESHERFPERVNAGFMQIINKEHIKLRVYERGAGETQACGSGACAAVAVGIMQGLLNNNVQVDLPGGSLMIEWNGVGHPLYMTGEATHIYDGFITL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target.
pubmed doi rcsb
molecule tags Isomerase
source organism Haemophilus influenzae
molecule keywords Diaminopimelate epimerase
total genus 82
structure length 274
sequence length 274
ec nomenclature ec 5.1.1.7: Diaminopimelate epimerase.
pdb deposition date 2006-04-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01678 DAP_epimerase Diaminopimelate epimerase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.310.10 Alpha Beta Roll Diaminopimelate Epimerase; Chain A, domain 1 Diaminopimelate Epimerase; Chain A, domain 1 2gkjA02
3.10.310.10 Alpha Beta Roll Diaminopimelate Epimerase; Chain A, domain 1 Diaminopimelate Epimerase; Chain A, domain 1 2gkjA01
2H9FA 5H2GA 4K8LA 4J9WA 1W62A 3EDNA 1S7JA 2PW0A 4JD7A 1QYAA 4Q2HA 1XUBA 1T6KA 3FVEA 2Q9HA 4IK0A 4J9XA 4Q60A 4IJZA 3EJXA 4K7GB 1QY9A 1BWZA 1U1XA 2GKEA 2GKJA 5H2YA 1GQZA 5HA4A 2PVZA 4LB0A 4JUUA 3G7KA 1U0KA 5IWEA 2Q9JA 4K7XA 4JCIA 5M47A 2AZPA 4DUNA 4JBDA 1W61A 1SDJA 1YM5A 3EKMA 2OTNA 1TM0A 1U1VA 1XUAA 1U1WA
chains in the Genus database with same CATH superfamily
2H9FA 5H2GA 2IW4A 3W5WA 4J9WA 2ZXRA 2ZXOA 1QYAA 1XUBA 1T6KA 4IK0A 3PTJA 1IR6A 2QB8A 2YMAA 2MPBA 1QY9A 2KPTA 2GKEA 2PVZA 3DEVA 2QB6A 4JBDA 1W61A 2KW7A 1TM0A 2ZVFA 5H2YA 4LS9A 2HAWA 3G98A 4K8LA 1W62A 1S7JA 2PW0A 4JD7A 3ICJA 4Q2HA 3FVEA 4Q60A 4K7GB 1BWZA 2GKJA 4OA3A 3G7KA 2ZXPA 4K7XA 4JCIA 3WQZA 2AZPA 1YM5A 3EKMA 2OTNA 2QB7A 1XUAA 1U1WA 3EDNA 3PW9A 4RPAA 1K20A 4IJZA 3IGHX 5HA4A 1WPMA 2LT2A 5ANPA 1U0KA 5IWEA 2Q9JA 5M47A 3PVHA 4LG3A 1U1VA 4GL6A 4PY9A 4J9XA 2Q9HA 2ENXA 3EJXA 1U1XA 1GQZA 4LB0A 4JUUA 2EB0A 4DUNA 1SDJA 1WPPA 1K23A 1I74A
chains in the Genus database with same CATH topology
2H9FA 5H2GA 2IW4A 3W5WA 4J9WA 2ZXRA 2ZXOA 1QYAA 1XUBA 1T6KA 4IK0A 3PTJA 1IR6A 2QB8A 2YMAA 2MPBA 1QY9A 2KPTA 2GKEA 2PVZA 3DEVA 2QB6A 4JBDA 1W61A 2KW7A 1TM0A 2ZVFA 5H2YA 4LS9A 2HAWA 3G98A 4K8LA 1W62A 1S7JA 2PW0A 4JD7A 3ICJA 4Q2HA 3FVEA 4Q60A 4K7GB 1BWZA 2GKJA 4OA3A 3G7KA 2ZXPA 4K7XA 4JCIA 3WQZA 2AZPA 1YM5A 3EKMA 2OTNA 2QB7A 1XUAA 1U1WA 3EDNA 3PW9A 4RPAA 1K20A 4IJZA 3IGHX 5HA4A 1WPMA 2LT2A 5ANPA 1U0KA 5IWEA 2Q9JA 5M47A 3PVHA 4LG3A 1U1VA 4GL6A 4PY9A 4J9XA 2Q9HA 2ENXA 3EJXA 1U1XA 1GQZA 4LB0A 4JUUA 2EB0A 4DUNA 1SDJA 1WPPA 1K23A 1I74A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2H9F A;  5H2G A;  4K8L A;  4J9W A;  1W62 A;  3EDN A;  1S7J A;  2PW0 A;  4JD7 A;  1QYA A;  4Q2H A;  1XUB A;  1T6K A;  3FVE A;  2Q9H A;  4IK0 A;  4J9X A;  4Q60 A;  4IJZ A;  3EJX A;  4K7G B;  1QY9 A;  1BWZ A;  1U1X A;  2GKE A;  2GKJ A;  5H2Y A;  1GQZ A;  5HA4 A;  2PVZ A;  4LB0 A;  4JUU A;  3G7K A;  1U0K A;  5IWE A;  2Q9J A;  4K7X A;  4JCI A;  5M47 A;  2AZP A;  4DUN A;  4JBD A;  1W61 A;  1SDJ A;  1YM5 A;  3EKM A;  2OTN A;  1TM0 A;  1U1V A;  1XUA A;  1U1W A; 
#chains in the Genus database with same CATH topology
 2H9F A;  5H2G A;  2IW4 A;  3W5W A;  4J9W A;  2ZXR A;  2ZXO A;  1QYA A;  1XUB A;  1T6K A;  4IK0 A;  3PTJ A;  1IR6 A;  2QB8 A;  2YMA A;  2MPB A;  1QY9 A;  2KPT A;  2GKE A;  2PVZ A;  3DEV A;  2QB6 A;  4JBD A;  1W61 A;  2KW7 A;  1TM0 A;  2ZVF A;  5H2Y A;  4LS9 A;  2HAW A;  3G98 A;  4K8L A;  1W62 A;  1S7J A;  2PW0 A;  4JD7 A;  3ICJ A;  4Q2H A;  3FVE A;  4Q60 A;  4K7G B;  1BWZ A;  2GKJ A;  4OA3 A;  3G7K A;  2ZXP A;  4K7X A;  4JCI A;  3WQZ A;  2AZP A;  1YM5 A;  3EKM A;  2OTN A;  2QB7 A;  1XUA A;  1U1W A;  3EDN A;  3PW9 A;  4RPA A;  1K20 A;  4IJZ A;  3IGH X;  5HA4 A;  1WPM A;  2LT2 A;  5ANP A;  1U0K A;  5IWE A;  2Q9J A;  5M47 A;  3PVH A;  4LG3 A;  1U1V A;  4GL6 A;  4PY9 A;  4J9X A;  2Q9H A;  2ENX A;  3EJX A;  1U1X A;  1GQZ A;  4LB0 A;  4JUU A;  2EB0 A;  4DUN A;  1SDJ A;  1WPP A;  1K23 A;  1I74 A; 
#chains in the Genus database with same CATH homology
 2H9F A;  5H2G A;  2IW4 A;  3W5W A;  4J9W A;  2ZXR A;  2ZXO A;  1QYA A;  1XUB A;  1T6K A;  4IK0 A;  3PTJ A;  1IR6 A;  2QB8 A;  2YMA A;  2MPB A;  1QY9 A;  2KPT A;  2GKE A;  2PVZ A;  3DEV A;  2QB6 A;  4JBD A;  1W61 A;  2KW7 A;  1TM0 A;  2ZVF A;  5H2Y A;  4LS9 A;  2HAW A;  3G98 A;  4K8L A;  1W62 A;  1S7J A;  2PW0 A;  4JD7 A;  3ICJ A;  4Q2H A;  3FVE A;  4Q60 A;  4K7G B;  1BWZ A;  2GKJ A;  4OA3 A;  3G7K A;  2ZXP A;  4K7X A;  4JCI A;  3WQZ A;  2AZP A;  1YM5 A;  3EKM A;  2OTN A;  2QB7 A;  1XUA A;  1U1W A;  3EDN A;  3PW9 A;  4RPA A;  1K20 A;  4IJZ A;  3IGH X;  5HA4 A;  1WPM A;  2LT2 A;  5ANP A;  1U0K A;  5IWE A;  2Q9J A;  5M47 A;  3PVH A;  4LG3 A;  1U1V A;  4GL6 A;  4PY9 A;  4J9X A;  2Q9H A;  2ENX A;  3EJX A;  1U1X A;  1GQZ A;  4LB0 A;  4JUU A;  2EB0 A;  4DUN A;  1SDJ A;  1WPP A;  1K23 A;  1I74 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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