The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
52
|
sequence length |
190
|
structure length |
160
|
Chain Sequence |
FPTIPLSRLADNAWLRADRLNQLAFDTYQEFEEAYIPKEQIHSFWWNPQTSLCPSESIPTPSNKEETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLLLKNYGLLYCFNKDMSKVSTYLRTVQCRSSCG
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
pubmed doi rcsb |
| molecule keywords |
PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE
|
| molecule tags |
Hormone/growth factor
|
| source organism |
Homo sapiens
|
| total genus |
52
|
| structure length |
160
|
| sequence length |
190
|
| chains with identical sequence |
D
|
| ec nomenclature | |
| pdb deposition date | 2001-11-19 |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Up-down Bundle | Growth Hormone; Chain: A; | Growth Hormone; Chain: A; |
#chains in the Genus database with same CATH superfamily 1CN4 C; 1IAR A; 1EKU A; 1M47 A; 4X51 A; 1ITF A; 1CYL A; 1JLI A; 4O6K A; 4NEJ A; 1Y6N L; 2D9Q A; 3QT2 C; 1IJZ A; 5L6Y C; 3PIV A; 4NI7 A; 1ITL A; 2D48 A; 5E4E A; 1M4A A; 1N1F A; 1Z7C A; 1F45 B; 1QVN A; 3D48 P; 1BBN A; 3BPO A; 3UF5 A; 4ZS7 A; 2KZ1 A; 3D87 A; 3BES L; 3S9D A; 2L3O A; 2O26 A; 5D70 A; 1GA3 A; 3NCE A; 3QB1 A; 4MHL A; 4NKQ C; 3DLQ I; 2Q98 A; 1M49 A; 5D71 A; 4Z5R D; 1J7V L; 3HHR A; 4FA8 E; 2B8U A; 1SCF A; 1BUY A; 1AXI A; 1HIJ A; 4O9H A; 3G9V B; 1M4B A; 1RFB A; 1YKB A; 5D28 B; 1BGE A; 3NCF A; 1EER A; 2LMS A; 1PVH B; 3BPN A; 4PS4 A; 1GNC A; 2B91 A; 3MZG A; 4GRW A; 3N0P A; 1ILK A; 1HUL A; 1BGD A; 1CSG A; 2O27 A; 3G6D A; 1LQS L; 1ALU A; 1LKI A; 1PY2 A; 1WU3 I; 3B5K A; 1INR A; 3HMX B; 1PW6 A; 1HZI A; 1M48 A; 1P9M B; 3VA2 A; 2B5I A; 3SE4 B; 1HGU A; 1HWG A; 2IL6 A; 1D9C A; 3L5W I; 3NCC A; 3EJJ A; 3EW3 A; 3D85 C; 3PIW A; 3QB7 A; 1RHG A; 1KF9 A; 5FHX A; 3QWR B; 4YQX A; 1IRL A; 1Y6K L; 1AU1 A; 4NEM A; 3SE3 B; 1HIK A; 1I1R B; 1RCB A; 1BP3 A; 1FG9 A; 2B8Z A; 1ITI A; 3N06 A; 5C7X A; 3NPZ A; 2L3Y A; 1HUW A; 3UX9 A; 1CD9 A; 3DGC L; 4J4L C; 4YDY I; 2Q7N B; 3BPL A; 1BCN A; 5KNH I; 1EVS A; 1NBP A; 5D72 A; 2B8Y A; 2INT A; 1A7M A; 1F6F A; 3OQ3 A; 1VLK A; 2GMF A; 1ITM A; 4RS1 A; 4WRL B; 4I77 Z; 3DUH C; 4CNI C; 3UEZ E; 1RW5 A; 3Q1S I; 3NCB A; 1IK0 A; 1B5L A; 3LB6 B; 2LAG A; 1M4C A; 1Z92 A; 4YPG C; 1BGC A; 3LB6 A; 2ILK A; 1V7M V; 5LQB A; 3UF2 A; 2B8X A; 1V7N V; 2H24 A; 1Y6M L; 1HWH A; 1IL6 A; 2CYK A; 1ETE A; 3WCY I; 4ZF7 A; 4DOH A; 3L5X A; 1EMR A; 3INK C; 1CNT 1; 1D9G A; 2E9W C; 4YUE C; 4NI9 A; 1M4R A; 2HYM B; 5FUC A; 1FYH A; 5D22 A; 2B90 A; 1PGR A; 1EXZ A; 1LK3 A; 3QAZ A; 1AX8 A; 1A22 A; 2ERJ D; #chains in the Genus database with same CATH topology 1CN4 C; 1IAR A; 4X51 A; 2JA5 D; 4LDS A; 1IJZ A; 1M4A A; 3D48 P; 1PV7 A; 2KZ1 A; 3QB1 A; 3O7Q A; 2Q98 A; 1WCM D; 3HHC A; 4FA8 E; 3HHR A; 3DI3 A; 2B8U A; 4IKW A; 1BUY A; 1PV6 A; 3I4M D; 1Y14 A; 4D2B A; 5C44 D; 3BPN A; 1GNC A; 2O27 A; 1LQS L; 1PY2 A; 4UVM A; 3HMX B; 1P9M B; 1HWG A; 3L5W I; 3D85 C; 1RHG A; 2Z3Q A; 1Y6K L; 3HOZ D; 3AYH A; 4DKF A; 2PSM A; 5TS9 A; 3UX9 A; 1CD9 A; 4J4L C; 4A3F D; 5GXB A; 4U4T A; 1BCN A; 4OH3 A; 2B8Y A; 3H0G D; 1F6F A; 1VLK A; 4A3J D; 2GMF A; 4NN7 A; 3WDO A; 4A3L D; 4TPH A; 4CNI C; 5FLM D; 3PO2 D; 3NCB A; 1B5L A; 4IKV A; 1M4C A; 1V7M V; 5IYD D; 4U4V A; 5A2O A; 1HWH A; 4IU9 A; 4DOH A; 3INK C; 3H3V E; 4YUE C; 2V8N A; 5D22 A; 2B90 A; 1EXZ A; 2B63 D; 4BY7 D; 2D9Q A; 2D48 A; 5E4E A; 3TGX B; 1N1F A; 1F45 B; 4ZS7 A; 3BES L; 2O26 A; 4TPG A; 3FKI D; 3NCE A; 2CFP A; 4BY1 D; 4A3K D; 1J7V L; 4ZWC A; 3HOV D; 4O9H A; 3G9V B; 2XUT A; 1RFB A; 4D2D A; 4A3I D; 5D28 B; 1EER A; 4PS4 A; 2B91 A; 3MZG A; 4JA3 A; 5EQG A; 1ILK A; 1PW4 A; 1HZI A; 1M48 A; 4Q65 A; 1HGU A; 2IL6 A; 3OG4 A; 3NCC A; 3EJJ A; 3EW3 A; 3QB7 A; 3QWR B; 1AU1 A; 1I1R B; 5EQH A; 2JA7 D; 3N06 A; 5C7X A; 4APS A; 1HUW A; 3DGC L; 4YDY I; 5D59 A; 2Q7N B; 4JR9 A; 5KNH I; 1EVS A; 4IKX A; 3OQ3 A; 4RS1 A; 4XNJ A; 2R92 D; 3UEZ E; 1IK0 A; 5IP7 D; 3LB6 A; 2ILK A; 5LQB A; 1V7N V; 2CYK A; 3WCY I; 3L5X A; 2E9W C; 4DKC A; 4A3B D; 5FUC A; 4GC0 A; 4ZF7 A; 4QIQ A; 2CFQ A; 2ERJ D; 1EKU A; 1M47 A; 4O6K A; 1Y6N L; 5L6Y C; 3PIV A; 5D6K A; 4W6V A; 1Z7C A; 1QVN A; 4PYP A; 3UF5 A; 1GA3 A; 4MHL A; 4NKQ C; 3DLQ I; 1M49 A; 5D71 A; 4BXX D; 1AXI A; 1YKB A; 4A3C D; 1BGE A; 3NCF A; 5C4X D; 2LMS A; 3N0P A; 1CSG A; 5C65 A; 3G6D A; 1ALU A; 1LKI A; 4NN6 A; 1WU3 I; 3B5K A; 4OAA A; 2JA6 D; 2B5I A; 3SE4 B; 4IKY A; 1D9C A; 3PO3 D; 4GBZ A; 3PIW A; 1KF9 A; 5FHX A; 4YBQ A; 1IRL A; 5EQI A; 1RCB A; 1BP3 A; 3HOX D; 2B8Z A; 2O6I A; 3DI2 A; 3NPZ A; 2L3Y A; 3BPL A; 1NBP A; 2JA8 D; 1A7M A; 2R93 D; 1ITM A; 4WRL B; 4I77 Z; 3HOW D; 1RW5 A; 4TPJ A; 4A3E D; 3LB6 B; 2LAG A; 1Z92 A; 4YPG C; 1BGC A; 4BBS D; 4GBY A; 4LEP A; 3I4N D; 3UF2 A; 2B8X A; 2Q14 A; 1Y1V D; 1EMR A; 4JRE A; 4DKE A; 1D9G A; 4XNI A; 2HYM B; 4LRL A; 1FYH A; 5C3E D; 4IU8 A; 3QAZ A; 3HOU D; 1ITF A; 1CYL A; 1JLI A; 4NEJ A; 3QT2 C; 2R7Z D; 4NI7 A; 5IYB D; 4ZW9 A; 1ITL A; 1BBN A; 2Z3R A; 3BPO A; 1Y1W D; 3D87 A; 2OQP A; 4U4W A; 2L3O A; 3S9D A; 5D70 A; 4Z5R D; 4A3D D; 1SCF A; 1HIJ A; 4NN5 A; 2XQB A; 1M4B A; 2C35 A; 4A3G D; 1PVH B; 5A2N A; 4GRW A; 1HUL A; 1BGD A; 1INR A; 4J05 A; 4A93 D; 1PW6 A; 3VA2 A; 4IKZ A; 4YB9 D; 4YQX A; 4ZWB A; 4NEM A; 3SE3 B; 1HIK A; 1FG9 A; 1ITI A; 3OG6 A; 5IP9 D; 5D72 A; 4DKD A; 2INT A; 4EXP A; 4ZYR A; 3HOY D; 3DUH C; 3Q1S I; 3IRH A; 4A3M D; 4BBR D; 2VUM D; 2Y5Y A; 5D58 A; 3O7P A; 5IYC D; 2H24 A; 1Y6M L; 1IL6 A; 1ETE A; 4GS7 A; 4EXN A; 1CNT 1; 4D2C A; 4NI9 A; 1M4R A; 1PGR A; 1LK3 A; 1AX8 A; 1A22 A; #chains in the Genus database with same CATH homology 1CN4 C; 1IAR A; 1EKU A; 1M47 A; 4X51 A; 2JA5 D; 3HOU D; 1ITF A; 1JLI A; 4BY7 D; 1CYL A; 4O6K A; 4NEJ A; 1Y6N L; 2D9Q A; 3QT2 C; 1IJZ A; 5L6Y C; 2R7Z D; 3PIV A; 4NI7 A; 5IYB D; 1ITL A; 2D48 A; 5E4E A; 3TGX B; 1M4A A; 1N1F A; 1Z7C A; 1F45 B; 1QVN A; 3D48 P; 1BBN A; 2Z3R A; 3BPO A; 3UF5 A; 4ZS7 A; 1Y1W D; 2KZ1 A; 3D87 A; 2OQP A; 3BES L; 3S9D A; 2L3O A; 2O26 A; 5D70 A; 1GA3 A; 3FKI D; 3NCE A; 3QB1 A; 4MHL A; 4NKQ C; 3DLQ I; 4BY1 D; 2Q98 A; 1M49 A; 5D71 A; 1WCM D; 4A3K D; 3HHC A; 4Z5R D; 4BXX D; 1J7V L; 3HHR A; 3DI3 A; 2B8U A; 4FA8 E; 1SCF A; 1BUY A; 4A3D D; 1AXI A; 1HIJ A; 3HOV D; 4O9H A; 4NN5 A; 3G9V B; 2XQB A; 1M4B A; 1RFB A; 4A3I D; 1YKB A; 2C35 A; 1Y14 A; 5D28 B; 3I4M D; 4A3C D; 4A3G D; 1BGE A; 3NCF A; 5C4X D; 1EER A; 5C44 D; 2LMS A; 1PVH B; 3BPN A; 4PS4 A; 1GNC A; 2B91 A; 3MZG A; 4GRW A; 3N0P A; 1ILK A; 1HUL A; 1BGD A; 1CSG A; 2O27 A; 3G6D A; 1LQS L; 1ALU A; 1LKI A; 4NN6 A; 1PY2 A; 1WU3 I; 3B5K A; 1INR A; 4A93 D; 3HMX B; 1PW6 A; 1HZI A; 1M48 A; 1P9M B; 2JA6 D; 3VA2 A; 2B5I A; 3SE4 B; 1HGU A; 1HWG A; 2IL6 A; 3OG4 A; 1D9C A; 3PO3 D; 3L5W I; 3NCC A; 3EJJ A; 3EW3 A; 3D85 C; 3PIW A; 3QB7 A; 1RHG A; 1KF9 A; 5FHX A; 2Z3Q A; 3QWR B; 4YQX A; 1IRL A; 1Y6K L; 1AU1 A; 4NEM A; 3SE3 B; 1HIK A; 1I1R B; 1RCB A; 1BP3 A; 1FG9 A; 3HOX D; 2B8Z A; 3HOZ D; 1ITI A; 2JA7 D; 3AYH A; 3N06 A; 2O6I A; 3DI2 A; 3NPZ A; 4DKF A; 2L3Y A; 2PSM A; 5TS9 A; 5C7X A; 1HUW A; 3UX9 A; 3OG6 A; 1CD9 A; 3DGC L; 4J4L C; 4YDY I; 2Q7N B; 3BPL A; 4A3F D; 1BCN A; 5KNH I; 1EVS A; 1NBP A; 5IP9 D; 5D72 A; 2JA8 D; 4DKD A; 2B8Y A; 2INT A; 3H0G D; 1A7M A; 1F6F A; 3OQ3 A; 4EXP A; 1VLK A; 2R93 D; 4A3J D; 2GMF A; 4NN7 A; 3HOY D; 1ITM A; 4RS1 A; 4WRL B; 4A3L D; 4I77 Z; 3DUH C; 2R92 D; 3HOW D; 4CNI C; 3UEZ E; 1RW5 A; 3Q1S I; 5FLM D; 3PO2 D; 3NCB A; 1IK0 A; 3IRH A; 4A3M D; 4A3E D; 1B5L A; 3LB6 B; 2LAG A; 5IP7 D; 1M4C A; 1Z92 A; 4YPG C; 1BGC A; 4BBS D; 3LB6 A; 4BBR D; 2ILK A; 2VUM D; 1V7M V; 3I4N D; 5LQB A; 5IYD D; 3UF2 A; 2B8X A; 5IYC D; 1V7N V; 2H24 A; 1Y6M L; 1HWH A; 2Q14 A; 1IL6 A; 2CYK A; 1ETE A; 1Y1V D; 4GS7 A; 3WCY I; 4ZF7 A; 4DOH A; 4EXN A; 3L5X A; 1EMR A; 3INK C; 1CNT 1; 4DKE A; 1D9G A; 2E9W C; 3H3V E; 4DKC A; 4YUE C; 4NI9 A; 4A3B D; 1M4R A; 2HYM B; 4LRL A; 5FUC A; 1FYH A; 5D22 A; 5C3E D; 2B90 A; 1PGR A; 1EXZ A; 1LK3 A; 2B63 D; 3QAZ A; 1AX8 A; 1A22 A; 2ERJ D;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
