4ZYRA

Crystal structure of e. coli lactose permease g46w/g262w bound to p-nitrophenyl alpha-d-galactopyranoside (alpha-npg)
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
403
structure length
387
Chain Sequence
NTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTWIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFWYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of LacY with an alpha-substituted galactoside: Connecting the binding site to the protonation site.
pubmed doi rcsb
molecule keywords Lactose permease
molecule tags Transport protein
source organism Escherichia coli (strain k12)
total genus 136
structure length 387
sequence length 403
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01306 LacY_symp LacY proton/sugar symporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 4zyrA02
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 4zyrA01
4OAAA 5D6KA 4ZW9A 4UVMA 5GXBA 2XUTA 5A2OA 4JR9A 4D2DA 2CFQA 4XNJA 4W6VA 4GBYA 4IU8A 4IKVA 5D58A 3WDOA 5C65A 5D59A 4QIQA 4YBQA 1PV6A 4ZWCA 4LEPA 4YB9D 4TPHA 4J05A 1PW4A 4GC0A 4TPJA 4D2CA 4XNIA 4IU9A 4IKXA 4ZWBA 4IKZA 4OH3A 4D2BA 4LDSA 2V8NA 4U4WA 5A2NA 2CFPA 3O7QA 4Q65A 4GBZA 4U4TA 4PYPA 2Y5YA 3O7PA 5EQIA 5EQGA 5EQHA 4JREA 1PV7A 4IKYA 4APSA 4ZYRA 4TPGA 4JA3A 4IKWA 4U4VA
chains in the Genus database with same CATH superfamily
1V7NV 1AXIA 4OAAA 2VUMD 4DOHA 4NEJA 4YDYI 4QIQA 5FUCA 1NBPA 3UF2A 5TS9A 5L6YC 3HHRA 1AU1A 3IRHA 3O7QA 4BXXD 4ZF7A 1Z92A 4JA3A 5C7XA 3BPOA 3MZGA 1CD9A 3HOUD 2JA5D 1F45B 1ILKA 3NPZA 1Y14A 2E9WC 3NCBA 4NN6A 4A3LD 3PIVA 3B5KA 3N06A 1M4CA 1PW6A 4ZYRA 1VLKA 1GNCA 2ILKA 1HWGA 3WCYI 3QWRB 2JA6D 2R92D 1Y1WD 2B90A 1RCBA 1BGCA 4GBZA 1HUWA 3HMXB 1IRLA 4IKWA 5EQIA 4GS7A 4UVMA 3I4ND 3UF5A 3QB7A 3OQ3A 1D9CA 4YPGC 2D48A 4TPJA 3AYHA 4FA8E 1CNT1 4LDSA 2OQPA 4Z5RD 2B63D 3UEZE 3OG6A 4A3MD 5FLMD 4BY7D 4A3FD 2XQBA 5A2OA 4D2DA 1Y6ML 4IU8A 5C65A 5D59A 4NKQC 2LMSA 2O26A 4DKDA 5IYCD 4IKXA 4PS4A 5FHXA 4IKZA 3I4MD 4Q65A 4I77Z 3VA2A 1J7VL 3HHCA 3D48P 1Y6KL 3Q1SI 4XNJA 3S9DA 3D85C 4A3GD 4XNIA 3HOZD 4IU9A 1HIKA 4PYPA 3DLQI 1Y1VD 2CYKA 5A2NA 4A3DD 3UX9A 2ERJD 2CFQA 4GBYA 4IKVA 1LQSL 5E4EA 3PO3D 1ITFA 1CYLA 2IL6A 1AX8A 1EVSA 4ZWBA 1BP3A 4A3ED 5EQGA 4A93D 4BBSD 3LB6B 4TPGA 4U4VA 3QAZA 4EXNA 4ZW9A 2Z3RA 3PO2D 4LRLA 4GRWA 3NCEA 4RS1A 1BUYA 5D58A 4MHLA 2JA8D 3FKID 2O27A 2KZ1A 4U4WA 1BCNA 1YKBA 1V7MV 2JA7D 1GA3A 1LKIA 1EERA 3DUHC 1WU3I 5D6KA 2B8ZA 4YUEC 1IK0A 3D87A 2XUTA 1QVNA 4CNIC 5IYBD 1HGUA 1BGDA 2R7ZD 5C4XD 3HOXD 4WRLB 3H3VE 1PV6A 1M4BA 3BESL 1A22A 1EMRA 3G6DA 4NI9A 3DI2A 3O7PA 1D9GA 1ITLA 4IKYA 4APSA 2Z3QA 1PY2A 3L5WI 3LB6A 4A3ID 3DI3A 3WDOA 5D71A 2L3OA 3H0GD 1IARA 4LEPA 2B8XA 2B5IA 4NN5A 4D2CA 1SCFA 4YQXA 3INKC 5IYDD 2CFPA 4EXPA 1PV7A 1EXZA 1ITMA 4DKCA 2Q98A 4JR9A 1FG9A 3OG4A 4A3BD 4J05A 1CSGA 5KNHI 4GC0A 1JLIA 3HOYD 1CN4C 4OH3A 2V8NA 1PVHB 1RFBA 1M49A 5D28B 1ITIA 3SE3B 1IJZA 1EKUA 4NEMA 1PW4A 3HOWD 1Z7CA 4O6KA 5D72A 1A7MA 2C35A 4DKEA 5GXBA 3QT2C 3N0PA 4BBRD 5C44D 3NCCA 4W6VA 2R93D 2L3YA 2B91A 3PIWA 3BPLA 4TPHA 5IP9D 1F6FA 2HYMB 1LK3A 2PSMA 3SE4B 4BY1D 1RHGA 2B8UA 1HZIA 1HIJA 4YBQA 4ZWCA 4X51A 2LAGA 1I1RB 3HOVD 4NN7A 3TGXB 4D2BA 1BBNA 5IP7D 1ALUA 1M47A 2Y5YA 5D70A 5EQHA 4J4LC 4A3KD 1BGEA 1N1FA 1ETEA 1INRA 4A3CD 1P9MB 3BPNA 2D9QA 1FYHA 2H24A 1IL6A 2Q14A 3EJJA 5LQBA 4JREA 1RW5A 2O6IA 3NCFA 5D22A 2B8YA 1HWHA 1M48A 1PGRA 1B5LA 3DGCL 2GMFA 2INTA 5C3ED 2Q7NB 4YB9D 1M4RA 4O9HA 3EW3A 4DKFA 3L5XA 1KF9A 1HULA 1M4AA 3G9VB 3QB1A 4U4TA 1Y6NL 4A3JD 1WCMD 4ZS7A 4NI7A
chains in the Genus database with same CATH topology
4OAAA 5D6KA 4ZW9A 4UVMA 5GXBA 2XUTA 5A2OA 4JR9A 4D2DA 2CFQA 4XNJA 4W6VA 4GBYA 4IU8A 4IKVA 5D58A 3WDOA 5C65A 5D59A 4QIQA 4YBQA 1PV6A 4ZWCA 4LEPA 4YB9D 4TPHA 4J05A 1PW4A 4GC0A 4TPJA 4D2CA 4XNIA 4IU9A 4IKXA 4ZWBA 4IKZA 4OH3A 4D2BA 4LDSA 2V8NA 4U4WA 5A2NA 2CFPA 3O7QA 4Q65A 4GBZA 4U4TA 4PYPA 2Y5YA 3O7PA 5EQIA 5EQGA 5EQHA 4JREA 1PV7A 4IKYA 4APSA 4ZYRA 4TPGA 4JA3A 4IKWA 4U4VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OAA A;  5D6K A;  4ZW9 A;  4UVM A;  5GXB A;  2XUT A;  5A2O A;  4JR9 A;  4D2D A;  2CFQ A;  4XNJ A;  4W6V A;  4GBY A;  4IU8 A;  4IKV A;  5D58 A;  3WDO A;  5C65 A;  5D59 A;  4QIQ A;  4YBQ A;  1PV6 A;  4ZWC A;  4LEP A;  4YB9 D;  4TPH A;  4J05 A;  1PW4 A;  4GC0 A;  4TPJ A;  4D2C A;  4XNI A;  4IU9 A;  4IKX A;  4ZWB A;  4IKZ A;  4OH3 A;  4D2B A;  4LDS A;  2V8N A;  4U4W A;  5A2N A;  2CFP A;  3O7Q A;  4Q65 A;  4GBZ A;  4U4T A;  4PYP A;  2Y5Y A;  3O7P A;  5EQI A;  5EQG A;  5EQH A;  4JRE A;  1PV7 A;  4IKY A;  4APS A;  4ZYR A;  4TPG A;  4JA3 A;  4IKW A;  4U4V A; 
#chains in the Genus database with same CATH topology
 1V7N V;  1AXI A;  4OAA A;  2VUM D;  4DOH A;  4NEJ A;  4YDY I;  4QIQ A;  5FUC A;  1NBP A;  3UF2 A;  5TS9 A;  5L6Y C;  3HHR A;  1AU1 A;  3IRH A;  3O7Q A;  4BXX D;  4ZF7 A;  1Z92 A;  4JA3 A;  5C7X A;  3BPO A;  3MZG A;  1CD9 A;  3HOU D;  2JA5 D;  1F45 B;  1ILK A;  3NPZ A;  1Y14 A;  2E9W C;  3NCB A;  4NN6 A;  4A3L D;  3PIV A;  3B5K A;  3N06 A;  1M4C A;  1PW6 A;  4ZYR A;  1VLK A;  1GNC A;  2ILK A;  1HWG A;  3WCY I;  3QWR B;  2JA6 D;  2R92 D;  1Y1W D;  2B90 A;  1RCB A;  1BGC A;  4GBZ A;  1HUW A;  3HMX B;  1IRL A;  4IKW A;  5EQI A;  4GS7 A;  4UVM A;  3I4N D;  3UF5 A;  3QB7 A;  3OQ3 A;  1D9C A;  4YPG C;  2D48 A;  4TPJ A;  3AYH A;  4FA8 E;  1CNT 1;  4LDS A;  2OQP A;  4Z5R D;  2B63 D;  3UEZ E;  3OG6 A;  4A3M D;  5FLM D;  4BY7 D;  4A3F D;  2XQB A;  5A2O A;  4D2D A;  1Y6M L;  4IU8 A;  5C65 A;  5D59 A;  4NKQ C;  2LMS A;  2O26 A;  4DKD A;  5IYC D;  4IKX A;  4PS4 A;  5FHX A;  4IKZ A;  3I4M D;  4Q65 A;  4I77 Z;  3VA2 A;  1J7V L;  3HHC A;  3D48 P;  1Y6K L;  3Q1S I;  4XNJ A;  3S9D A;  3D85 C;  4A3G D;  4XNI A;  3HOZ D;  4IU9 A;  1HIK A;  4PYP A;  3DLQ I;  1Y1V D;  2CYK A;  5A2N A;  4A3D D;  3UX9 A;  2ERJ D;  2CFQ A;  4GBY A;  4IKV A;  1LQS L;  5E4E A;  3PO3 D;  1ITF A;  1CYL A;  2IL6 A;  1AX8 A;  1EVS A;  4ZWB A;  1BP3 A;  4A3E D;  5EQG A;  4A93 D;  4BBS D;  3LB6 B;  4TPG A;  4U4V A;  3QAZ A;  4EXN A;  4ZW9 A;  2Z3R A;  3PO2 D;  4LRL A;  4GRW A;  3NCE A;  4RS1 A;  1BUY A;  5D58 A;  4MHL A;  2JA8 D;  3FKI D;  2O27 A;  2KZ1 A;  4U4W A;  1BCN A;  1YKB A;  1V7M V;  2JA7 D;  1GA3 A;  1LKI A;  1EER A;  3DUH C;  1WU3 I;  5D6K A;  2B8Z A;  4YUE C;  1IK0 A;  3D87 A;  2XUT A;  1QVN A;  4CNI C;  5IYB D;  1HGU A;  1BGD A;  2R7Z D;  5C4X D;  3HOX D;  4WRL B;  3H3V E;  1PV6 A;  1M4B A;  3BES L;  1A22 A;  1EMR A;  3G6D A;  4NI9 A;  3DI2 A;  3O7P A;  1D9G A;  1ITL A;  4IKY A;  4APS A;  2Z3Q A;  1PY2 A;  3L5W I;  3LB6 A;  4A3I D;  3DI3 A;  3WDO A;  5D71 A;  2L3O A;  3H0G D;  1IAR A;  4LEP A;  2B8X A;  2B5I A;  4NN5 A;  4D2C A;  1SCF A;  4YQX A;  3INK C;  5IYD D;  2CFP A;  4EXP A;  1PV7 A;  1EXZ A;  1ITM A;  4DKC A;  2Q98 A;  4JR9 A;  1FG9 A;  3OG4 A;  4A3B D;  4J05 A;  1CSG A;  5KNH I;  4GC0 A;  1JLI A;  3HOY D;  1CN4 C;  4OH3 A;  2V8N A;  1PVH B;  1RFB A;  1M49 A;  5D28 B;  1ITI A;  3SE3 B;  1IJZ A;  1EKU A;  4NEM A;  1PW4 A;  3HOW D;  1Z7C A;  4O6K A;  5D72 A;  1A7M A;  2C35 A;  4DKE A;  5GXB A;  3QT2 C;  3N0P A;  4BBR D;  5C44 D;  3NCC A;  4W6V A;  2R93 D;  2L3Y A;  2B91 A;  3PIW A;  3BPL A;  4TPH A;  5IP9 D;  1F6F A;  2HYM B;  1LK3 A;  2PSM A;  3SE4 B;  4BY1 D;  1RHG A;  2B8U A;  1HZI A;  1HIJ A;  4YBQ A;  4ZWC A;  4X51 A;  2LAG A;  1I1R B;  3HOV D;  4NN7 A;  3TGX B;  4D2B A;  1BBN A;  5IP7 D;  1ALU A;  1M47 A;  2Y5Y A;  5D70 A;  5EQH A;  4J4L C;  4A3K D;  1BGE A;  1N1F A;  1ETE A;  1INR A;  4A3C D;  1P9M B;  3BPN A;  2D9Q A;  1FYH A;  2H24 A;  1IL6 A;  2Q14 A;  3EJJ A;  5LQB A;  4JRE A;  1RW5 A;  2O6I A;  3NCF A;  5D22 A;  2B8Y A;  1HWH A;  1M48 A;  1PGR A;  1B5L A;  3DGC L;  2GMF A;  2INT A;  5C3E D;  2Q7N B;  4YB9 D;  1M4R A;  4O9H A;  3EW3 A;  4DKF A;  3L5X A;  1KF9 A;  1HUL A;  1M4A A;  3G9V B;  3QB1 A;  4U4T A;  1Y6N L;  4A3J D;  1WCM D;  4ZS7 A;  4NI7 A; 
#chains in the Genus database with same CATH homology
 4OAA A;  5D6K A;  4ZW9 A;  4UVM A;  5GXB A;  2XUT A;  5A2O A;  4JR9 A;  4D2D A;  2CFQ A;  4XNJ A;  4W6V A;  4GBY A;  4IU8 A;  4IKV A;  5D58 A;  3WDO A;  5C65 A;  5D59 A;  4QIQ A;  4YBQ A;  1PV6 A;  4ZWC A;  4LEP A;  4YB9 D;  4TPH A;  4J05 A;  1PW4 A;  4GC0 A;  4TPJ A;  4D2C A;  4XNI A;  4IU9 A;  4IKX A;  4ZWB A;  4IKZ A;  4OH3 A;  4D2B A;  4LDS A;  2V8N A;  4U4W A;  5A2N A;  2CFP A;  3O7Q A;  4Q65 A;  4GBZ A;  4U4T A;  4PYP A;  2Y5Y A;  3O7P A;  5EQI A;  5EQG A;  5EQH A;  4JRE A;  1PV7 A;  4IKY A;  4APS A;  4ZYR A;  4TPG A;  4JA3 A;  4IKW A;  4U4V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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