4ZYRA

Crystal structure of e. coli lactose permease g46w/g262w bound to p-nitrophenyl alpha-d-galactopyranoside (alpha-npg)
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
403
structure length
387
Chain Sequence
b'NTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTWIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFWYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Lactose permease
publication title Structure of LacY with an alpha-substituted galactoside: Connecting the binding site to the protonation site.
pubmed doi rcsb
source organism Escherichia coli (strain k12)
molecule tags Transport protein
total genus 136
structure length 387
sequence length 403
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01306 LacY_symp LacY proton/sugar symporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 4zyrA02
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 4zyrA01
2XUTA 4YB9D 5A2OA 4LDSA 4W6VA 3WDOA 3O7QA 4LEPA 4JREA 4XNJA 4GBZA 4IKXA 4J05A 4TPHA 4IKYA 4IKWA 4OH3A 4PYPA 2Y5YA 5EQIA 4APSA 5C65A 4U4WA 5EQHA 5A2NA 4TPJA 4IKVA 4GBYA 4OAAA 4D2DA 4TPGA 4U4TA 4U4VA 5D6KA 5GXBA 4ZW9A 4UVMA 4ZYRA 1PW4A 4IU8A 4QIQA 4GC0A 4D2BA 5EQGA 4JA3A 4Q65A 4IKZA 1PV7A 4YBQA 4D2CA 4IU9A 5D58A 4ZWCA 4ZWBA 4XNIA 2CFPA 3O7PA 2CFQA 5D59A 4JR9A 2V8NA 1PV6A
chains in the Genus database with same CATH superfamily
1M49A 1Y6KL 1CYLA 3O7QA 4DKEA 1RCBA 1EKUA 5IYCD 5IP7D 1M4BA 2R7ZD 1F45B 2O6IA 2Q14A 1BGDA 1PGRA 2B63D 3QWRB 4GRWA 5D59A 3S9DA 3OG6A 1VLKA 5A2OA 2B90A 4LEPA 2B5IA 3L5XA 3HOZD 4NN5A 3Q1SI 4CNIC 1BUYA 4GBZA 4J05A 4I77Z 3DLQI 2O26A 1KF9A 5A2NA 4IU8A 3DUHC 2HYMB 5EQGA 1B5LA 4BXXD 3NCFA 1HWGA 3NCEA 3NPZA 4A3MD 4BY1D 4YB9D 3WDOA 5D70A 2GMFA 3NCBA 1JLIA 5IP9D 4MHLA 3VA2A 2H24A 2CYKA 1HIJA 4D2CA 5KNHI 2E9WC 3WCYI 4ZF7A 2CFQA 3IRHA 4YUEC 3BESL 1EMRA 1AU1A 3MZGA 3PIVA 1HUWA 5C4XD 1D9CA 1GNCA 4A3GD 5FLMD 5IYBD 3DI2A 3UF2A 2D48A 3BPOA 1M48A 3H3VE 2B8ZA 2PSMA 2Z3RA 1HULA 1PY2A 4XNIA 4Z5RD 1HGUA 1Z92A 2R92D 3HOUD 4TPHA 4IKYA 5C65A 4GBYA 1V7MV 5E4EA 4A3BD 3G6DA 3OQ3A 3DGCL 4IKZA 1PV7A 4ZWBA 1ITMA 3UX9A 2CFPA 2L3OA 3I4MD 1P9MB 2B8XA 4XNJA 1YKBA 2JA5D 2L3YA 1LK3A 3HMXB 1IARA 4JA3A 4YBQA 5D28B 3EJJA 1CSGA 2D9QA 4FA8E 5C44D 3LB6A 1LQSL 3HHCA 1PVHB 1A7MA 3D48P 1Y1WD 4BBRD 5C7XA 4A3LD 3EW3A 4TPGA 4DKCA 3BPLA 4D2BA 3SE3B 1M4RA 1Z7CA 4IU9A 1FG9A 5D58A 1AX8A 4A3DD 2XQBA 3DI3A 3QAZA 2R93D 5FHXA 1M4CA 3SE4B 2LAGA 1HZIA 1FYHA 4TPJA 5C3ED 1I1RB 2ILKA 3G9VB 3HHRA 2OQPA 1RFBA 4NN6A 1BBNA 4NKQC 1LKIA 4W6VA 1A22A 3PO2D 1EVSA 3OG4A 4YQXA 4A3JD 4D2DA 1BCNA 1BP3A 4QIQA 1ITIA 2Q98A 4GS7A 3QB7A 4NN7A 3UF5A 1V7NV 1Y6ML 1RW5A 1ETEA 4NI7A 3PO3D 1BGCA 2Q7NB 4NEJA 4IKXA 4IKWA 1EXZA 2IL6A 5GXBA 1Y6NL 5D72A 1J7VL 3PIWA 1CNT1 1ITFA 1CN4C 1Y1VD 1AXIA 3NCCA 2JA7D 4ZS7A 1IRLA 3H0GD 1WCMD 4A3FD 2JA6D 5LQBA 1EERA 1PW6A 3HOYD 4BY7D 4EXNA 1HWHA 4JR9A 3FKID 4LDSA 3AYHA 5TS9A 1F6FA 4APSA 4LRLA 4ZW9A 4Q65A 4YDYI 4DKDA 1M4AA 4O9HA 1ALUA 2O27A 4NI9A 3HOWD 3N06A 3QT2C 1IK0A 1IL6A 2KZ1A 4NEMA 5EQIA 4IKVA 4EXPA 2INTA 4A3ED 4DOHA 1IJZA 1M47A 1CD9A 5FUCA 4ZYRA 1PW4A 4GC0A 4DKFA 4ZWCA 1NBPA 5D22A 3N0PA 2V8NA 2XUTA 2B8YA 1QVNA 2VUMD 2JA8D 4OH3A 1GA3A 5IYDD 4A3ID 1Y14A 4OAAA 4U4VA 4PS4A 5D6KA 3LB6B 4UVMA 1RHGA 3D85C 1SCFA 4A3CD 1D9GA 3O7PA 2Z3QA 1ITLA 2B8UA 4A3KD 3B5KA 2Y5YA 4U4WA 3I4ND 4U4TA 3D87A 1BGEA 1ILKA 1WU3I 2LMSA 3UEZE 3HOXD 4X51A 1HIKA 1PV6A 4WRLB 1N1FA 3TGXB 4BBSD 4JREA 1INRA 4J4LC 5D71A 3INKC 3QB1A 4PYPA 4O6KA 5EQHA 3BPNA 5L6YC 4YPGC 3L5WI 4A93D 2C35A 2B91A 4RS1A 3HOVD 2ERJD
chains in the Genus database with same CATH topology
2XUTA 4YB9D 5A2OA 4LDSA 4W6VA 3WDOA 3O7QA 4LEPA 4JREA 4XNJA 4GBZA 4IKXA 4J05A 4TPHA 4IKYA 4IKWA 4OH3A 4PYPA 2Y5YA 5EQIA 4APSA 5C65A 4U4WA 5EQHA 5A2NA 4TPJA 4IKVA 4GBYA 4OAAA 4D2DA 4TPGA 4U4TA 4U4VA 5D6KA 5GXBA 4ZW9A 4UVMA 4ZYRA 1PW4A 4IU8A 4QIQA 4GC0A 4D2BA 5EQGA 4JA3A 4Q65A 4IKZA 1PV7A 4YBQA 4D2CA 4IU9A 5D58A 4ZWCA 4ZWBA 4XNIA 2CFPA 3O7PA 2CFQA 5D59A 4JR9A 2V8NA 1PV6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XUT A;  4YB9 D;  5A2O A;  4LDS A;  4W6V A;  3WDO A;  3O7Q A;  4LEP A;  4JRE A;  4XNJ A;  4GBZ A;  4IKX A;  4J05 A;  4TPH A;  4IKY A;  4IKW A;  4OH3 A;  4PYP A;  2Y5Y A;  5EQI A;  4APS A;  5C65 A;  4U4W A;  5EQH A;  5A2N A;  4TPJ A;  4IKV A;  4GBY A;  4OAA A;  4D2D A;  4TPG A;  4U4T A;  4U4V A;  5D6K A;  5GXB A;  4ZW9 A;  4UVM A;  4ZYR A;  1PW4 A;  4IU8 A;  4QIQ A;  4GC0 A;  4D2B A;  5EQG A;  4JA3 A;  4Q65 A;  4IKZ A;  1PV7 A;  4YBQ A;  4D2C A;  4IU9 A;  5D58 A;  4ZWC A;  4ZWB A;  4XNI A;  2CFP A;  3O7P A;  2CFQ A;  5D59 A;  4JR9 A;  2V8N A;  1PV6 A; 
#chains in the Genus database with same CATH topology
 1M49 A;  1Y6K L;  1CYL A;  3O7Q A;  4DKE A;  1RCB A;  1EKU A;  5IYC D;  5IP7 D;  1M4B A;  2R7Z D;  1F45 B;  2O6I A;  2Q14 A;  1BGD A;  1PGR A;  2B63 D;  3QWR B;  4GRW A;  5D59 A;  3S9D A;  3OG6 A;  1VLK A;  5A2O A;  2B90 A;  4LEP A;  2B5I A;  3L5X A;  3HOZ D;  4NN5 A;  3Q1S I;  4CNI C;  1BUY A;  4GBZ A;  4J05 A;  4I77 Z;  3DLQ I;  2O26 A;  1KF9 A;  5A2N A;  4IU8 A;  3DUH C;  2HYM B;  5EQG A;  1B5L A;  4BXX D;  3NCF A;  1HWG A;  3NCE A;  3NPZ A;  4A3M D;  4BY1 D;  4YB9 D;  3WDO A;  5D70 A;  2GMF A;  3NCB A;  1JLI A;  5IP9 D;  4MHL A;  3VA2 A;  2H24 A;  2CYK A;  1HIJ A;  4D2C A;  5KNH I;  2E9W C;  3WCY I;  4ZF7 A;  2CFQ A;  3IRH A;  4YUE C;  3BES L;  1EMR A;  1AU1 A;  3MZG A;  3PIV A;  1HUW A;  5C4X D;  1D9C A;  1GNC A;  4A3G D;  5FLM D;  5IYB D;  3DI2 A;  3UF2 A;  2D48 A;  3BPO A;  1M48 A;  3H3V E;  2B8Z A;  2PSM A;  2Z3R A;  1HUL A;  1PY2 A;  4XNI A;  4Z5R D;  1HGU A;  1Z92 A;  2R92 D;  3HOU D;  4TPH A;  4IKY A;  5C65 A;  4GBY A;  1V7M V;  5E4E A;  4A3B D;  3G6D A;  3OQ3 A;  3DGC L;  4IKZ A;  1PV7 A;  4ZWB A;  1ITM A;  3UX9 A;  2CFP A;  2L3O A;  3I4M D;  1P9M B;  2B8X A;  4XNJ A;  1YKB A;  2JA5 D;  2L3Y A;  1LK3 A;  3HMX B;  1IAR A;  4JA3 A;  4YBQ A;  5D28 B;  3EJJ A;  1CSG A;  2D9Q A;  4FA8 E;  5C44 D;  3LB6 A;  1LQS L;  3HHC A;  1PVH B;  1A7M A;  3D48 P;  1Y1W D;  4BBR D;  5C7X A;  4A3L D;  3EW3 A;  4TPG A;  4DKC A;  3BPL A;  4D2B A;  3SE3 B;  1M4R A;  1Z7C A;  4IU9 A;  1FG9 A;  5D58 A;  1AX8 A;  4A3D D;  2XQB A;  3DI3 A;  3QAZ A;  2R93 D;  5FHX A;  1M4C A;  3SE4 B;  2LAG A;  1HZI A;  1FYH A;  4TPJ A;  5C3E D;  1I1R B;  2ILK A;  3G9V B;  3HHR A;  2OQP A;  1RFB A;  4NN6 A;  1BBN A;  4NKQ C;  1LKI A;  4W6V A;  1A22 A;  3PO2 D;  1EVS A;  3OG4 A;  4YQX A;  4A3J D;  4D2D A;  1BCN A;  1BP3 A;  4QIQ A;  1ITI A;  2Q98 A;  4GS7 A;  3QB7 A;  4NN7 A;  3UF5 A;  1V7N V;  1Y6M L;  1RW5 A;  1ETE A;  4NI7 A;  3PO3 D;  1BGC A;  2Q7N B;  4NEJ A;  4IKX A;  4IKW A;  1EXZ A;  2IL6 A;  5GXB A;  1Y6N L;  5D72 A;  1J7V L;  3PIW A;  1CNT 1;  1ITF A;  1CN4 C;  1Y1V D;  1AXI A;  3NCC A;  2JA7 D;  4ZS7 A;  1IRL A;  3H0G D;  1WCM D;  4A3F D;  2JA6 D;  5LQB A;  1EER A;  1PW6 A;  3HOY D;  4BY7 D;  4EXN A;  1HWH A;  4JR9 A;  3FKI D;  4LDS A;  3AYH A;  5TS9 A;  1F6F A;  4APS A;  4LRL A;  4ZW9 A;  4Q65 A;  4YDY I;  4DKD A;  1M4A A;  4O9H A;  1ALU A;  2O27 A;  4NI9 A;  3HOW D;  3N06 A;  3QT2 C;  1IK0 A;  1IL6 A;  2KZ1 A;  4NEM A;  5EQI A;  4IKV A;  4EXP A;  2INT A;  4A3E D;  4DOH A;  1IJZ A;  1M47 A;  1CD9 A;  5FUC A;  4ZYR A;  1PW4 A;  4GC0 A;  4DKF A;  4ZWC A;  1NBP A;  5D22 A;  3N0P A;  2V8N A;  2XUT A;  2B8Y A;  1QVN A;  2VUM D;  2JA8 D;  4OH3 A;  1GA3 A;  5IYD D;  4A3I D;  1Y14 A;  4OAA A;  4U4V A;  4PS4 A;  5D6K A;  3LB6 B;  4UVM A;  1RHG A;  3D85 C;  1SCF A;  4A3C D;  1D9G A;  3O7P A;  2Z3Q A;  1ITL A;  2B8U A;  4A3K D;  3B5K A;  2Y5Y A;  4U4W A;  3I4N D;  4U4T A;  3D87 A;  1BGE A;  1ILK A;  1WU3 I;  2LMS A;  3UEZ E;  3HOX D;  4X51 A;  1HIK A;  1PV6 A;  4WRL B;  1N1F A;  3TGX B;  4BBS D;  4JRE A;  1INR A;  4J4L C;  5D71 A;  3INK C;  3QB1 A;  4PYP A;  4O6K A;  5EQH A;  3BPN A;  5L6Y C;  4YPG C;  3L5W I;  4A93 D;  2C35 A;  2B91 A;  4RS1 A;  3HOV D;  2ERJ D; 
#chains in the Genus database with same CATH homology
 2XUT A;  4YB9 D;  5A2O A;  4LDS A;  4W6V A;  3WDO A;  3O7Q A;  4LEP A;  4JRE A;  4XNJ A;  4GBZ A;  4IKX A;  4J05 A;  4TPH A;  4IKY A;  4IKW A;  4OH3 A;  4PYP A;  2Y5Y A;  5EQI A;  4APS A;  5C65 A;  4U4W A;  5EQH A;  5A2N A;  4TPJ A;  4IKV A;  4GBY A;  4OAA A;  4D2D A;  4TPG A;  4U4T A;  4U4V A;  5D6K A;  5GXB A;  4ZW9 A;  4UVM A;  4ZYR A;  1PW4 A;  4IU8 A;  4QIQ A;  4GC0 A;  4D2B A;  5EQG A;  4JA3 A;  4Q65 A;  4IKZ A;  1PV7 A;  4YBQ A;  4D2C A;  4IU9 A;  5D58 A;  4ZWC A;  4ZWB A;  4XNI A;  2CFP A;  3O7P A;  2CFQ A;  5D59 A;  4JR9 A;  2V8N A;  1PV6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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