2V8NA

Wild-type structure of lactose permease
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
417
structure length
417
Chain Sequence
MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSLLRRQVNEVA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Determination of Wild-Type Lactose Permease.
pubmed doi rcsb
molecule keywords LACTOSE PERMEASE
molecule tags Transport protein
source organism Escherichia coli
total genus 115
structure length 417
sequence length 417
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-08-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01306 LacY_symp LacY proton/sugar symporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2v8nA02
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2v8nA01
4ZWCA 2CFPA 5D6KA 4TPHA 4OAAA 4GBYA 4XNIA 4TPGA 5EQIA 4GC0A 4APSA 4JA3A 4IKXA 4J05A 5GXBA 4IU9A 4ZW9A 5D58A 3O7QA 4GBZA 4IKYA 5D59A 4W6VA 4LEPA 4UVMA 1PV6A 4JR9A 4JREA 2CFQA 4LDSA 4OH3A 5A2NA 5C65A 2V8NA 4IU8A 1PW4A 3O7PA 4Q65A 2Y5YA 4IKVA 4ZYRA 4PYPA 4YBQA 3WDOA 1PV7A 2XUTA 5A2OA 4IKWA 4QIQA 4XNJA 4D2CA 5EQHA 4U4WA 4TPJA 4U4TA 5EQGA 4YB9D 4IKZA 4D2DA 4ZWBA 4D2BA 4U4VA
chains in the Genus database with same CATH superfamily
1BGCA 3HOVD 5D6KA 5C3ED 4XNIA 1HIKA 3OG4A 4JA3A 3PIVA 3WCYI 3O7QA 4BBSD 2B91A 1I1RB 4JREA 1HUWA 2INTA 4NN5A 1PV7A 3D85C 2XQBA 3PIWA 5EQHA 1BUYA 5IP7D 1BCNA 4LRLA 4W6VA 5IYCD 1FYHA 1HULA 5D72A 1ITFA 2Q14A 4D2DA 3HOYD 3DUHC 5EQIA 2LMSA 5C4XD 3BPNA 1EMRA 1ITLA 1HWHA 4FA8E 5KNHI 3QB1A 4IKVA 3LB6A 2JA5D 3UEZE 3G6DA 1GA3A 2B8XA 5IYDD 3OG6A 2Z3QA 4ZW9A 5D58A 4YPGC 1Y6ML 1BP3A 3MZGA 4A3BD 4LEPA 3D48P 4OH3A 3HHRA 3HOZD 1CYLA 1D9GA 4ZYRA 4YBQA 2Q7NB 4XNJA 4A3ID 1EERA 3NCEA 4NEMA 2D9QA 1LK3A 1GNCA 4IKXA 2R92D 1V7MV 1Z7CA 4DKFA 2IL6A 2L3OA 4CNIC 4J4LC 4PS4A 3HMXB 1JLIA 3BESL 2B8ZA 2B8YA 4A3KD 3DLQI 2O26A 5TS9A 4Z5RD 4BBRD 5A2NA 4A3DD 2OQPA 1BGEA 5IP9D 2GMFA 2KZ1A 5FUCA 3L5XA 1F45B 1PY2A 2L3YA 1ALUA 4OAAA 5FHXA 1LQSL 1CD9A 4IKYA 1ETEA 4UVMA 1Y14A 1IJZA 1M47A 3O7PA 2VUMD 4A3JD 1PVHB 1Z92A 4D2BA 4U4VA 4O6KA 2CFPA 3Q1SI 5LQBA 5GXBA 3NCFA 4A3ED 1ILKA 4JR9A 1VLKA 1RCBA 4IU8A 1YKBA 3UF5A 3QT2C 3N0PA 2XUTA 1B5LA 1M48A 1IRLA 3TGXB 1BBNA 3PO3D 4DKEA 4GBYA 4A3GD 1Y1WD 1AX8A 4DOHA 1M4AA 2Q98A 3H3VE 1KF9A 2JA8D 4NEJA 2PSMA 3NCCA 1F6FA 1BGDA 1QVNA 1PW6A 1CSGA 3DI2A 4MHLA 1IARA 2JA7D 5EQGA 4IKZA 5FLMD 1RW5A 1M4RA 3G9VB 3HOXD 4TPGA 3QWRB 3UF2A 4IU9A 3INKC 3BPOA 4BXXD 1P9MB 3DI3A 1SCFA 4BY7D 5C44D 4WRLB 5A2OA 1N1FA 4QIQA 4D2CA 1HGUA 5D71A 4ZWCA 1EVSA 1HIJA 1J7VL 1Y6KL 4YQXA 4A3FD 4GBZA 1HZIA 5D59A 1M4CA 3QB7A 1LKIA 4LDSA 5E4EA 4ZS7A 4NI7A 1EXZA 5C7XA 3HOWD 3B5KA 1RFBA 1Y1VD 2LAGA 3EJJA 4GRWA 2O27A 5D70A 1Y6NL 2CFQA 5C65A 4YDYI 1PW4A 3EW3A 1D9CA 4Q65A 1EKUA 1WCMD 1V7NV 4A3MD 4EXNA 4TPJA 4U4WA 4U4TA 2B63D 1M49A 5IYBD 1ITIA 1ITMA 2ERJD 1FG9A 4GC0A 3I4ND 2Z3RA 1IK0A 4NN6A 3SE3B 2R93D 2R7ZD 1PGRA 3DGCL 1CNT1 3S9DA 1AXIA 4O9HA 4A93D 3IRHA 4YB9D 1IL6A 2C35A 2HYMB 4DKDA 4ZWBA 1RHGA 2B5IA 3PO2D 2H24A 3HOUD 4APSA 4J05A 1A7MA 2O6IA 4ZF7A 4A3CD 2B8UA 1A22A 5D28B 3N06A 2V8NA 5D22A 2D48A 3FKID 1INRA 4IKWA 1NBPA 4YUEC 1HWGA 4TPHA 4NKQC 2ILKA 4NN7A 1CN4C 1AU1A 5L6YC 1PV6A 3QAZA 3NCBA 3AYHA 2Y5YA 3H0GD 2B90A 4PYPA 3WDOA 3OQ3A 4I77Z 3NPZA 2CYKA 3UX9A 3I4MD 4A3LD 1WU3I 3HHCA 3VA2A 2JA6D 3L5WI 4EXPA 2E9WC 3SE4B 3D87A 4DKCA 1M4BA 3BPLA 4GS7A 4X51A 4RS1A 4NI9A 4BY1D 3LB6B
chains in the Genus database with same CATH topology
4ZWCA 2CFPA 5D6KA 4TPHA 4OAAA 4GBYA 4XNIA 4TPGA 5EQIA 4GC0A 4APSA 4JA3A 4IKXA 4J05A 5GXBA 4IU9A 4ZW9A 5D58A 3O7QA 4GBZA 4IKYA 5D59A 4W6VA 4LEPA 4UVMA 1PV6A 4JR9A 4JREA 2CFQA 4LDSA 4OH3A 5A2NA 5C65A 2V8NA 4IU8A 1PW4A 3O7PA 4Q65A 2Y5YA 4IKVA 4ZYRA 4PYPA 4YBQA 3WDOA 1PV7A 2XUTA 5A2OA 4IKWA 4QIQA 4XNJA 4D2CA 5EQHA 4U4WA 4TPJA 4U4TA 5EQGA 4YB9D 4IKZA 4D2DA 4ZWBA 4D2BA 4U4VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZWC A;  2CFP A;  5D6K A;  4TPH A;  4OAA A;  4GBY A;  4XNI A;  4TPG A;  5EQI A;  4GC0 A;  4APS A;  4JA3 A;  4IKX A;  4J05 A;  5GXB A;  4IU9 A;  4ZW9 A;  5D58 A;  3O7Q A;  4GBZ A;  4IKY A;  5D59 A;  4W6V A;  4LEP A;  4UVM A;  1PV6 A;  4JR9 A;  4JRE A;  2CFQ A;  4LDS A;  4OH3 A;  5A2N A;  5C65 A;  2V8N A;  4IU8 A;  1PW4 A;  3O7P A;  4Q65 A;  2Y5Y A;  4IKV A;  4ZYR A;  4PYP A;  4YBQ A;  3WDO A;  1PV7 A;  2XUT A;  5A2O A;  4IKW A;  4QIQ A;  4XNJ A;  4D2C A;  5EQH A;  4U4W A;  4TPJ A;  4U4T A;  5EQG A;  4YB9 D;  4IKZ A;  4D2D A;  4ZWB A;  4D2B A;  4U4V A; 
#chains in the Genus database with same CATH topology
 1BGC A;  3HOV D;  5D6K A;  5C3E D;  4XNI A;  1HIK A;  3OG4 A;  4JA3 A;  3PIV A;  3WCY I;  3O7Q A;  4BBS D;  2B91 A;  1I1R B;  4JRE A;  1HUW A;  2INT A;  4NN5 A;  1PV7 A;  3D85 C;  2XQB A;  3PIW A;  5EQH A;  1BUY A;  5IP7 D;  1BCN A;  4LRL A;  4W6V A;  5IYC D;  1FYH A;  1HUL A;  5D72 A;  1ITF A;  2Q14 A;  4D2D A;  3HOY D;  3DUH C;  5EQI A;  2LMS A;  5C4X D;  3BPN A;  1EMR A;  1ITL A;  1HWH A;  4FA8 E;  5KNH I;  3QB1 A;  4IKV A;  3LB6 A;  2JA5 D;  3UEZ E;  3G6D A;  1GA3 A;  2B8X A;  5IYD D;  3OG6 A;  2Z3Q A;  4ZW9 A;  5D58 A;  4YPG C;  1Y6M L;  1BP3 A;  3MZG A;  4A3B D;  4LEP A;  3D48 P;  4OH3 A;  3HHR A;  3HOZ D;  1CYL A;  1D9G A;  4ZYR A;  4YBQ A;  2Q7N B;  4XNJ A;  4A3I D;  1EER A;  3NCE A;  4NEM A;  2D9Q A;  1LK3 A;  1GNC A;  4IKX A;  2R92 D;  1V7M V;  1Z7C A;  4DKF A;  2IL6 A;  2L3O A;  4CNI C;  4J4L C;  4PS4 A;  3HMX B;  1JLI A;  3BES L;  2B8Z A;  2B8Y A;  4A3K D;  3DLQ I;  2O26 A;  5TS9 A;  4Z5R D;  4BBR D;  5A2N A;  4A3D D;  2OQP A;  1BGE A;  5IP9 D;  2GMF A;  2KZ1 A;  5FUC A;  3L5X A;  1F45 B;  1PY2 A;  2L3Y A;  1ALU A;  4OAA A;  5FHX A;  1LQS L;  1CD9 A;  4IKY A;  1ETE A;  4UVM A;  1Y14 A;  1IJZ A;  1M47 A;  3O7P A;  2VUM D;  4A3J D;  1PVH B;  1Z92 A;  4D2B A;  4U4V A;  4O6K A;  2CFP A;  3Q1S I;  5LQB A;  5GXB A;  3NCF A;  4A3E D;  1ILK A;  4JR9 A;  1VLK A;  1RCB A;  4IU8 A;  1YKB A;  3UF5 A;  3QT2 C;  3N0P A;  2XUT A;  1B5L A;  1M48 A;  1IRL A;  3TGX B;  1BBN A;  3PO3 D;  4DKE A;  4GBY A;  4A3G D;  1Y1W D;  1AX8 A;  4DOH A;  1M4A A;  2Q98 A;  3H3V E;  1KF9 A;  2JA8 D;  4NEJ A;  2PSM A;  3NCC A;  1F6F A;  1BGD A;  1QVN A;  1PW6 A;  1CSG A;  3DI2 A;  4MHL A;  1IAR A;  2JA7 D;  5EQG A;  4IKZ A;  5FLM D;  1RW5 A;  1M4R A;  3G9V B;  3HOX D;  4TPG A;  3QWR B;  3UF2 A;  4IU9 A;  3INK C;  3BPO A;  4BXX D;  1P9M B;  3DI3 A;  1SCF A;  4BY7 D;  5C44 D;  4WRL B;  5A2O A;  1N1F A;  4QIQ A;  4D2C A;  1HGU A;  5D71 A;  4ZWC A;  1EVS A;  1HIJ A;  1J7V L;  1Y6K L;  4YQX A;  4A3F D;  4GBZ A;  1HZI A;  5D59 A;  1M4C A;  3QB7 A;  1LKI A;  4LDS A;  5E4E A;  4ZS7 A;  4NI7 A;  1EXZ A;  5C7X A;  3HOW D;  3B5K A;  1RFB A;  1Y1V D;  2LAG A;  3EJJ A;  4GRW A;  2O27 A;  5D70 A;  1Y6N L;  2CFQ A;  5C65 A;  4YDY I;  1PW4 A;  3EW3 A;  1D9C A;  4Q65 A;  1EKU A;  1WCM D;  1V7N V;  4A3M D;  4EXN A;  4TPJ A;  4U4W A;  4U4T A;  2B63 D;  1M49 A;  5IYB D;  1ITI A;  1ITM A;  2ERJ D;  1FG9 A;  4GC0 A;  3I4N D;  2Z3R A;  1IK0 A;  4NN6 A;  3SE3 B;  2R93 D;  2R7Z D;  1PGR A;  3DGC L;  1CNT 1;  3S9D A;  1AXI A;  4O9H A;  4A93 D;  3IRH A;  4YB9 D;  1IL6 A;  2C35 A;  2HYM B;  4DKD A;  4ZWB A;  1RHG A;  2B5I A;  3PO2 D;  2H24 A;  3HOU D;  4APS A;  4J05 A;  1A7M A;  2O6I A;  4ZF7 A;  4A3C D;  2B8U A;  1A22 A;  5D28 B;  3N06 A;  2V8N A;  5D22 A;  2D48 A;  3FKI D;  1INR A;  4IKW A;  1NBP A;  4YUE C;  1HWG A;  4TPH A;  4NKQ C;  2ILK A;  4NN7 A;  1CN4 C;  1AU1 A;  5L6Y C;  1PV6 A;  3QAZ A;  3NCB A;  3AYH A;  2Y5Y A;  3H0G D;  2B90 A;  4PYP A;  3WDO A;  3OQ3 A;  4I77 Z;  3NPZ A;  2CYK A;  3UX9 A;  3I4M D;  4A3L D;  1WU3 I;  3HHC A;  3VA2 A;  2JA6 D;  3L5W I;  4EXP A;  2E9W C;  3SE4 B;  3D87 A;  4DKC A;  1M4B A;  3BPL A;  4GS7 A;  4X51 A;  4RS1 A;  4NI9 A;  4BY1 D;  3LB6 B; 
#chains in the Genus database with same CATH homology
 4ZWC A;  2CFP A;  5D6K A;  4TPH A;  4OAA A;  4GBY A;  4XNI A;  4TPG A;  5EQI A;  4GC0 A;  4APS A;  4JA3 A;  4IKX A;  4J05 A;  5GXB A;  4IU9 A;  4ZW9 A;  5D58 A;  3O7Q A;  4GBZ A;  4IKY A;  5D59 A;  4W6V A;  4LEP A;  4UVM A;  1PV6 A;  4JR9 A;  4JRE A;  2CFQ A;  4LDS A;  4OH3 A;  5A2N A;  5C65 A;  2V8N A;  4IU8 A;  1PW4 A;  3O7P A;  4Q65 A;  2Y5Y A;  4IKV A;  4ZYR A;  4PYP A;  4YBQ A;  3WDO A;  1PV7 A;  2XUT A;  5A2O A;  4IKW A;  4QIQ A;  4XNJ A;  4D2C A;  5EQH A;  4U4W A;  4TPJ A;  4U4T A;  5EQG A;  4YB9 D;  4IKZ A;  4D2D A;  4ZWB A;  4D2B A;  4U4V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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