2CFPA

Sugar free lactose permease at acidic ph
Total Genus 119
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
417
structure length
417
Chain Sequence
MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALGASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSLLRRQVNEVA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Transport
source organism Escherichia coli
publication title Structural Evidence for Induced Fit and a Mechanism for Sugar/H(+) Symport in Lacy.
pubmed doi rcsb
molecule keywords LACTOSE PERMEASE
total genus 119
structure length 417
sequence length 417
ec nomenclature
pdb deposition date 2006-02-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01306 LacY_symp LacY proton/sugar symporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2cfpA02
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2cfpA01
4XNJA 5EQHA 4ZWBA 5EQGA 4IKZA 4APSA 1PV7A 4LEPA 4TPGA 4ZWCA 2Y5YA 4Q65A 5D58A 5GXBA 4ZYRA 4JREA 5A2NA 2V8NA 4OAAA 3O7PA 4JR9A 3O7QA 4IKYA 4XNIA 4ZW9A 4QIQA 4IKWA 4PYPA 2CFPA 5D6KA 4D2DA 4TPHA 4J05A 4YB9D 4IKVA 2CFQA 4GC0A 4GBYA 1PV6A 4JA3A 4IKXA 4D2BA 2XUTA 1PW4A 4W6VA 3WDOA 4IU9A 4UVMA 5A2OA 4U4TA 4GBZA 5EQIA 4LDSA 5D59A 4U4WA 5C65A 4TPJA 4U4VA 4D2CA 4IU8A 4YBQA 4OH3A
chains in the Genus database with same CATH superfamily
2LAGA 3AYHA 5C44D 1EMRA 4IKZA 1KF9A 5D58A 3G6DA 3DGCL 1RCBA 1AX8A 5IYCD 4NI7A 5D6KA 2JA5D 4NN6A 4JA3A 3HHCA 4A3BD 1WCMD 1A7MA 3UX9A 4D2CA 3O7PA 1HIKA 2O6IA 4MHLA 2CYKA 4GRWA 1ETEA 1HGUA 2D48A 1B5LA 3HOVD 1HWGA 1ILKA 1LK3A 4Z5RD 2B5IA 1A22A 4I77Z 1WU3I 1HIJA 3HMXB 4NN7A 4Q65A 1BP3A 5IYDD 1P9MB 3BESL 2LMSA 3MZGA 1M4BA 1RFBA 2HYMB 1NBPA 2B8ZA 4GBYA 1Y6KL 4CNIC 2Q98A 3QAZA 5L6YC 3WCYI 1F45B 1GA3A 5FHXA 3Q1SI 3OG6A 4OH3A 4ZWCA 3L5XA 4A3JD 1VLKA 3NCFA 1I1RB 2O27A 3EJJA 4O6KA 3HOXD 4QIQA 2ERJD 4ZS7A 3I4ND 2B90A 1GNCA 1Y6NL 4DKFA 1ITIA 4YUEC 2KZ1A 1M4CA 3SE3B 4A3GD 1ITLA 4NKQC 1D9CA 1FG9A 4BY7D 4U4VA 4A3KD 3TGXB 5EQHA 3D85C 5FUCA 2CFPA 3BPLA 5E4EA 4NEMA 2VUMD 4D2BA 2R93D 1PW4A 2JA8D 3BPOA 3LB6B 4PS4A 3I4MD 2B63D 5TS9A 4TPJA 5C65A 4IU8A 4ZWBA 4LEPA 3G9VB 5C4XD 4LRLA 4NI9A 3DI3A 4IKVA 1ITFA 4GC0A 1JLIA 4W6VA 4BY1D 4UVMA 5IP7D 2B8UA 1BGCA 4ZF7A 4U4WA 4D2DA 4BBSD 1CN4C 3UF2A 5D72A 4XNIA 1IARA 1ALUA 3NCEA 5FLMD 4FA8E 3N0PA 5C3ED 1BBNA 3H3VE 2L3YA 4U4TA 2B91A 3S9DA 3L5WI 4A3MD 2O26A 4DOHA 3HOWD 5EQGA 3D87A 2B8XA 4TPGA 4GS7A 3O7QA 1HWHA 5D22A 1AXIA 3NCCA 2OQPA 2JA6D 1PV6A 4IKXA 1CYLA 3BPNA 4EXNA 4NEJA 4X51A 5D59A 3DI2A 3EW3A 3PO2D 4A3LD 3QB1A 4OAAA 3DLQI 1IK0A 3B5KA 1J7VL 2D9QA 3SE4B 4DKCA 4A3ID 1IRLA 3IRHA 1QVNA 3H0GD 4A3DD 3HOZD 1M49A 1D9GA 1F6FA 4XNJA 5D28B 5D71A 1CD9A 1AU1A 1Z7CA 1N1FA 4YDYI 2Z3RA 1EERA 1RW5A 4J05A 1IJZA 3WDOA 1PGRA 3HOUD 4O9HA 4A3FD 4BXXD 2ILKA 3PIVA 3INKC 4APSA 2Y5YA 4J4LC 3UF5A 4ZYRA 2V8NA 4JR9A 4IKYA 1BGEA 3QT2C 3D48P 1EXZA 5LQBA 4IU9A 3PO3D 5A2OA 4NN5A 1YKBA 4LDSA 4DKEA 4YPGC 4ZW9A 2Q7NB 5A2NA 4A3ED 4PYPA 2B8YA 4YB9D 4EXPA 1CSGA 2GMFA 1HULA 3OQ3A 3HHRA 1M48A 1PW6A 4GBZA 4DKDA 1ITMA 3QWRB 1V7NV 4BBRD 2Q14A 1LQSL 3NCBA 2R7ZD 2C35A 5C7XA 5IP9D 4A3CD 1Y1WD 2H24A 1M4RA 2E9WC 3UEZE 1RHGA 1M47A 1V7MV 1PV7A 1Y14A 2XQBA 5D70A 2R92D 4IKWA 1Z92A 1CNT1 2L3OA 4WRLB 1EKUA 1LKIA 2PSMA 4YQXA 1Y6ML 3VA2A 1HZIA 5EQIA 4RS1A 3PIWA 3LB6A 4YBQA 2INTA 1BUYA 4JREA 1BCNA 1PY2A 2IL6A 2JA7D 1PVHB 3QB7A 4A93D 3OG4A 1BGDA 1INRA 5KNHI 1IL6A 1FYHA 5IYBD 5GXBA 3N06A 3NPZA 3FKID 2Z3QA 1SCFA 1EVSA 4TPHA 2CFQA 2XUTA 1Y1VD 1HUWA 3HOYD 1M4AA 3DUHC
chains in the Genus database with same CATH topology
4XNJA 5EQHA 4ZWBA 5EQGA 4IKZA 4APSA 1PV7A 4LEPA 4TPGA 4ZWCA 2Y5YA 4Q65A 5D58A 5GXBA 4ZYRA 4JREA 5A2NA 2V8NA 4OAAA 3O7PA 4JR9A 3O7QA 4IKYA 4XNIA 4ZW9A 4QIQA 4IKWA 4PYPA 2CFPA 5D6KA 4D2DA 4TPHA 4J05A 4YB9D 4IKVA 2CFQA 4GC0A 4GBYA 1PV6A 4JA3A 4IKXA 4D2BA 2XUTA 1PW4A 4W6VA 3WDOA 4IU9A 4UVMA 5A2OA 4U4TA 4GBZA 5EQIA 4LDSA 5D59A 4U4WA 5C65A 4TPJA 4U4VA 4D2CA 4IU8A 4YBQA 4OH3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4XNJ A;  5EQH A;  4ZWB A;  5EQG A;  4IKZ A;  4APS A;  1PV7 A;  4LEP A;  4TPG A;  4ZWC A;  2Y5Y A;  4Q65 A;  5D58 A;  5GXB A;  4ZYR A;  4JRE A;  5A2N A;  2V8N A;  4OAA A;  3O7P A;  4JR9 A;  3O7Q A;  4IKY A;  4XNI A;  4ZW9 A;  4QIQ A;  4IKW A;  4PYP A;  2CFP A;  5D6K A;  4D2D A;  4TPH A;  4J05 A;  4YB9 D;  4IKV A;  2CFQ A;  4GC0 A;  4GBY A;  1PV6 A;  4JA3 A;  4IKX A;  4D2B A;  2XUT A;  1PW4 A;  4W6V A;  3WDO A;  4IU9 A;  4UVM A;  5A2O A;  4U4T A;  4GBZ A;  5EQI A;  4LDS A;  5D59 A;  4U4W A;  5C65 A;  4TPJ A;  4U4V A;  4D2C A;  4IU8 A;  4YBQ A;  4OH3 A; 
#chains in the Genus database with same CATH topology
 2LAG A;  3AYH A;  5C44 D;  1EMR A;  4IKZ A;  1KF9 A;  5D58 A;  3G6D A;  3DGC L;  1RCB A;  1AX8 A;  5IYC D;  4NI7 A;  5D6K A;  2JA5 D;  4NN6 A;  4JA3 A;  3HHC A;  4A3B D;  1WCM D;  1A7M A;  3UX9 A;  4D2C A;  3O7P A;  1HIK A;  2O6I A;  4MHL A;  2CYK A;  4GRW A;  1ETE A;  1HGU A;  2D48 A;  1B5L A;  3HOV D;  1HWG A;  1ILK A;  1LK3 A;  4Z5R D;  2B5I A;  1A22 A;  4I77 Z;  1WU3 I;  1HIJ A;  3HMX B;  4NN7 A;  4Q65 A;  1BP3 A;  5IYD D;  1P9M B;  3BES L;  2LMS A;  3MZG A;  1M4B A;  1RFB A;  2HYM B;  1NBP A;  2B8Z A;  4GBY A;  1Y6K L;  4CNI C;  2Q98 A;  3QAZ A;  5L6Y C;  3WCY I;  1F45 B;  1GA3 A;  5FHX A;  3Q1S I;  3OG6 A;  4OH3 A;  4ZWC A;  3L5X A;  4A3J D;  1VLK A;  3NCF A;  1I1R B;  2O27 A;  3EJJ A;  4O6K A;  3HOX D;  4QIQ A;  2ERJ D;  4ZS7 A;  3I4N D;  2B90 A;  1GNC A;  1Y6N L;  4DKF A;  1ITI A;  4YUE C;  2KZ1 A;  1M4C A;  3SE3 B;  4A3G D;  1ITL A;  4NKQ C;  1D9C A;  1FG9 A;  4BY7 D;  4U4V A;  4A3K D;  3TGX B;  5EQH A;  3D85 C;  5FUC A;  2CFP A;  3BPL A;  5E4E A;  4NEM A;  2VUM D;  4D2B A;  2R93 D;  1PW4 A;  2JA8 D;  3BPO A;  3LB6 B;  4PS4 A;  3I4M D;  2B63 D;  5TS9 A;  4TPJ A;  5C65 A;  4IU8 A;  4ZWB A;  4LEP A;  3G9V B;  5C4X D;  4LRL A;  4NI9 A;  3DI3 A;  4IKV A;  1ITF A;  4GC0 A;  1JLI A;  4W6V A;  4BY1 D;  4UVM A;  5IP7 D;  2B8U A;  1BGC A;  4ZF7 A;  4U4W A;  4D2D A;  4BBS D;  1CN4 C;  3UF2 A;  5D72 A;  4XNI A;  1IAR A;  1ALU A;  3NCE A;  5FLM D;  4FA8 E;  3N0P A;  5C3E D;  1BBN A;  3H3V E;  2L3Y A;  4U4T A;  2B91 A;  3S9D A;  3L5W I;  4A3M D;  2O26 A;  4DOH A;  3HOW D;  5EQG A;  3D87 A;  2B8X A;  4TPG A;  4GS7 A;  3O7Q A;  1HWH A;  5D22 A;  1AXI A;  3NCC A;  2OQP A;  2JA6 D;  1PV6 A;  4IKX A;  1CYL A;  3BPN A;  4EXN A;  4NEJ A;  4X51 A;  5D59 A;  3DI2 A;  3EW3 A;  3PO2 D;  4A3L D;  3QB1 A;  4OAA A;  3DLQ I;  1IK0 A;  3B5K A;  1J7V L;  2D9Q A;  3SE4 B;  4DKC A;  4A3I D;  1IRL A;  3IRH A;  1QVN A;  3H0G D;  4A3D D;  3HOZ D;  1M49 A;  1D9G A;  1F6F A;  4XNJ A;  5D28 B;  5D71 A;  1CD9 A;  1AU1 A;  1Z7C A;  1N1F A;  4YDY I;  2Z3R A;  1EER A;  1RW5 A;  4J05 A;  1IJZ A;  3WDO A;  1PGR A;  3HOU D;  4O9H A;  4A3F D;  4BXX D;  2ILK A;  3PIV A;  3INK C;  4APS A;  2Y5Y A;  4J4L C;  3UF5 A;  4ZYR A;  2V8N A;  4JR9 A;  4IKY A;  1BGE A;  3QT2 C;  3D48 P;  1EXZ A;  5LQB A;  4IU9 A;  3PO3 D;  5A2O A;  4NN5 A;  1YKB A;  4LDS A;  4DKE A;  4YPG C;  4ZW9 A;  2Q7N B;  5A2N A;  4A3E D;  4PYP A;  2B8Y A;  4YB9 D;  4EXP A;  1CSG A;  2GMF A;  1HUL A;  3OQ3 A;  3HHR A;  1M48 A;  1PW6 A;  4GBZ A;  4DKD A;  1ITM A;  3QWR B;  1V7N V;  4BBR D;  2Q14 A;  1LQS L;  3NCB A;  2R7Z D;  2C35 A;  5C7X A;  5IP9 D;  4A3C D;  1Y1W D;  2H24 A;  1M4R A;  2E9W C;  3UEZ E;  1RHG A;  1M47 A;  1V7M V;  1PV7 A;  1Y14 A;  2XQB A;  5D70 A;  2R92 D;  4IKW A;  1Z92 A;  1CNT 1;  2L3O A;  4WRL B;  1EKU A;  1LKI A;  2PSM A;  4YQX A;  1Y6M L;  3VA2 A;  1HZI A;  5EQI A;  4RS1 A;  3PIW A;  3LB6 A;  4YBQ A;  2INT A;  1BUY A;  4JRE A;  1BCN A;  1PY2 A;  2IL6 A;  2JA7 D;  1PVH B;  3QB7 A;  4A93 D;  3OG4 A;  1BGD A;  1INR A;  5KNH I;  1IL6 A;  1FYH A;  5IYB D;  5GXB A;  3N06 A;  3NPZ A;  3FKI D;  2Z3Q A;  1SCF A;  1EVS A;  4TPH A;  2CFQ A;  2XUT A;  1Y1V D;  1HUW A;  3HOY D;  1M4A A;  3DUH C; 
#chains in the Genus database with same CATH homology
 4XNJ A;  5EQH A;  4ZWB A;  5EQG A;  4IKZ A;  4APS A;  1PV7 A;  4LEP A;  4TPG A;  4ZWC A;  2Y5Y A;  4Q65 A;  5D58 A;  5GXB A;  4ZYR A;  4JRE A;  5A2N A;  2V8N A;  4OAA A;  3O7P A;  4JR9 A;  3O7Q A;  4IKY A;  4XNI A;  4ZW9 A;  4QIQ A;  4IKW A;  4PYP A;  2CFP A;  5D6K A;  4D2D A;  4TPH A;  4J05 A;  4YB9 D;  4IKV A;  2CFQ A;  4GC0 A;  4GBY A;  1PV6 A;  4JA3 A;  4IKX A;  4D2B A;  2XUT A;  1PW4 A;  4W6V A;  3WDO A;  4IU9 A;  4UVM A;  5A2O A;  4U4T A;  4GBZ A;  5EQI A;  4LDS A;  5D59 A;  4U4W A;  5C65 A;  4TPJ A;  4U4V A;  4D2C A;  4IU8 A;  4YBQ A;  4OH3 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...