2CFQA

Sugar free lactose permease at neutral ph
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
417
structure length
417
Chain Sequence
MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALGASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSLLRRQVNEVA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Evidence for Induced Fit and a Mechanism for Sugar/H(+) Symport in Lacy.
pubmed doi rcsb
molecule tags Transport
source organism Escherichia coli
molecule keywords LACTOSE PERMEASE
total genus 115
structure length 417
sequence length 417
ec nomenclature
pdb deposition date 2006-02-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01306 LacY_symp LacY proton/sugar symporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2cfqA02
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2cfqA01
1PV7A 5GXBA 4OH3A 3O7QA 5A2NA 4XNIA 4D2BA 4D2DA 4TPJA 1PW4A 5EQIA 4IKVA 5D6KA 4YBQA 5EQHA 3O7PA 4YB9D 1PV6A 2CFQA 2V8NA 4JREA 4LEPA 5A2OA 4ZWCA 4JR9A 4ZYRA 2Y5YA 4LDSA 4APSA 4OAAA 4D2CA 4IKYA 5C65A 4IKXA 3WDOA 2XUTA 4IU9A 5D59A 4ZW9A 4IU8A 4U4TA 5EQGA 4IKZA 4GC0A 4JA3A 4PYPA 4QIQA 4XNJA 4U4WA 4TPHA 4UVMA 4J05A 4TPGA 4GBZA 5D58A 4ZWBA 4IKWA 4Q65A 4W6VA 4GBYA 2CFPA 4U4VA
chains in the Genus database with same CATH superfamily
1I1RB 1PW6A 1Y6KL 2D9QA 2VUMD 1F45B 1PW4A 3DLQI 2CFQA 4ZWCA 3NCCA 4APSA 3N06A 3WDOA 3SE3B 1PY2A 4EXNA 3IRHA 1EMRA 4NEMA 5IP9D 2C35A 1AU1A 5EQIA 3G6DA 2CYKA 5EQHA 4YB9D 3HOYD 3QB1A 2HYMB 5FUCA 3HMXB 1RHGA 3NCFA 2XUTA 3EW3A 4I77Z 4IU8A 3BPNA 4NN5A 3S9DA 1ITIA 3L5WI 4MHLA 2R92D 4BBRD 4A93D 1HZIA 4IKVA 1BGCA 5D71A 3BESL 4LRLA 1N1FA 4ZYRA 2LMSA 2L3OA 1Y1VD 2GMFA 5D72A 3OG4A 2V8NA 1A22A 3HOVD 5GXBA 4TPJA 3B5KA 3Q1SI 3PIWA 1PV6A 3UF2A 3PO2D 4NKQC 3D85C 1D9GA 3OG6A 4CNIC 2O26A 1HIKA 4UVMA 5D28B 1FYHA 3SE4B 4BXXD 3LB6B 5A2NA 4D2DA 1SCFA 2XQBA 1V7MV 5D6KA 3UEZE 5IYDD 3QAZA 5C65A 1F6FA 4U4WA 2ILKA 2INTA 4O9HA 1J7VL 4A3LD 1GNCA 4BY1D 4A3MD 1Z92A 1EKUA 4JREA 4GRWA 2B8XA 5IYCD 4OAAA 4NN6A 4YDYI 4IU9A 3I4ND 5EQGA 2Z3RA 2B90A 3MZGA 2IL6A 1PV7A 4BY7D 5C44D 1AXIA 4A3ED 1PGRA 2JA6D 4J4LC 5D70A 5LQBA 4A3ID 4RS1A 5C3ED 2ERJD 3HHRA 1NBPA 2O6IA 3FKID 4XNJA 4A3BD 3DI3A 1HWHA 1M49A 1INRA 1M47A 4A3GD 2CFPA 1CYLA 4A3KD 1FG9A 3TGXB 5KNHI 4A3FD 4EXPA 3PIVA 3HHCA 1ITMA 4LEPA 4LDSA 3LB6A 2PSMA 4IKYA 2Q7NB 1EXZA 4U4TA 4PYPA 5IYBD 1QVNA 2L3YA 1GA3A 1IJZA 2B5IA 1BGDA 3G9VB 4YPGC 1ILKA 4OH3A 3D48P 1D9CA 4DKCA 4XNIA 4ZF7A 1VLKA 2B8UA 3O7PA 4GS7A 5FHXA 4FA8E 3DUHC 1WU3I 4Z5RD 1LKIA 5FLMD 2Y5YA 1HULA 2E9WC 5D59A 4QIQA 1M4RA 1BGEA 4IKWA 1IL6A 3H3VE 4DKFA 2O27A 2Z3QA 5E4EA 2LAGA 4ZS7A 1P9MB 4JR9A 2H24A 3DI2A 2R7ZD 3INKC 4TPGA 1BCNA 1RCBA 4NI7A 1CNT1 4O6KA 2OQPA 1YKBA 1AX8A 4BBSD 5C7XA 3NCBA 1Z7CA 3HOZD 3EJJA 3NCEA 4DKEA 1ITLA 4GC0A 4YQXA 4J05A 4Q65A 4NN7A 4GBYA 4U4VA 3DGCL 4X51A 1A7MA 3BPOA 2B91A 3HOWD 3VA2A 4A3DD 3QB7A 3D87A 5C4XD 1CN4C 1Y1WD 5D58A 2D48A 1JLIA 1Y6ML 5D22A 1IARA 3I4MD 1LK3A 1IK0A 3QWRB 2JA5D 2Q14A 2R93D 3BPLA 4A3JD 1IRLA 4DKDA 1HWGA 5A2OA 1BUYA 1CD9A 4NI9A 4JA3A 2B63D 1V7NV 4GBZA 1RFBA 2JA7D 1M48A 1RW5A 3HOUD 1ETEA 4D2BA 1M4AA 1HUWA 4ZW9A 1M4CA 3AYHA 4DOHA 5L6YC 5IP7D 3H0GD 1WCMD 1B5LA 3HOXD 3WCYI 1EVSA 3O7QA 3UX9A 3QT2C 4YUEC 4NEJA 1PVHB 2B8YA 1EERA 1ALUA 4PS4A 2JA8D 3PO3D 1M4BA 5TS9A 1ITFA 4ZWBA 4W6VA 3OQ3A 1BP3A 3L5XA 2Q98A 4YBQA 1HIJA 3NPZA 1Y14A 2B8ZA 1CSGA 4A3CD 3UF5A 1KF9A 4D2CA 1HGUA 3N0PA 1LQSL 4IKXA 1BBNA 1Y6NL 2KZ1A 4IKZA 4TPHA 4WRLB
chains in the Genus database with same CATH topology
1PV7A 5GXBA 4OH3A 3O7QA 5A2NA 4XNIA 4D2BA 4D2DA 4TPJA 1PW4A 5EQIA 4IKVA 5D6KA 4YBQA 5EQHA 3O7PA 4YB9D 1PV6A 2CFQA 2V8NA 4JREA 4LEPA 5A2OA 4ZWCA 4JR9A 4ZYRA 2Y5YA 4LDSA 4APSA 4OAAA 4D2CA 4IKYA 5C65A 4IKXA 3WDOA 2XUTA 4IU9A 5D59A 4ZW9A 4IU8A 4U4TA 5EQGA 4IKZA 4GC0A 4JA3A 4PYPA 4QIQA 4XNJA 4U4WA 4TPHA 4UVMA 4J05A 4TPGA 4GBZA 5D58A 4ZWBA 4IKWA 4Q65A 4W6VA 4GBYA 2CFPA 4U4VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PV7 A;  5GXB A;  4OH3 A;  3O7Q A;  5A2N A;  4XNI A;  4D2B A;  4D2D A;  4TPJ A;  1PW4 A;  5EQI A;  4IKV A;  5D6K A;  4YBQ A;  5EQH A;  3O7P A;  4YB9 D;  1PV6 A;  2CFQ A;  2V8N A;  4JRE A;  4LEP A;  5A2O A;  4ZWC A;  4JR9 A;  4ZYR A;  2Y5Y A;  4LDS A;  4APS A;  4OAA A;  4D2C A;  4IKY A;  5C65 A;  4IKX A;  3WDO A;  2XUT A;  4IU9 A;  5D59 A;  4ZW9 A;  4IU8 A;  4U4T A;  5EQG A;  4IKZ A;  4GC0 A;  4JA3 A;  4PYP A;  4QIQ A;  4XNJ A;  4U4W A;  4TPH A;  4UVM A;  4J05 A;  4TPG A;  4GBZ A;  5D58 A;  4ZWB A;  4IKW A;  4Q65 A;  4W6V A;  4GBY A;  2CFP A;  4U4V A; 
#chains in the Genus database with same CATH topology
 1I1R B;  1PW6 A;  1Y6K L;  2D9Q A;  2VUM D;  1F45 B;  1PW4 A;  3DLQ I;  2CFQ A;  4ZWC A;  3NCC A;  4APS A;  3N06 A;  3WDO A;  3SE3 B;  1PY2 A;  4EXN A;  3IRH A;  1EMR A;  4NEM A;  5IP9 D;  2C35 A;  1AU1 A;  5EQI A;  3G6D A;  2CYK A;  5EQH A;  4YB9 D;  3HOY D;  3QB1 A;  2HYM B;  5FUC A;  3HMX B;  1RHG A;  3NCF A;  2XUT A;  3EW3 A;  4I77 Z;  4IU8 A;  3BPN A;  4NN5 A;  3S9D A;  1ITI A;  3L5W I;  4MHL A;  2R92 D;  4BBR D;  4A93 D;  1HZI A;  4IKV A;  1BGC A;  5D71 A;  3BES L;  4LRL A;  1N1F A;  4ZYR A;  2LMS A;  2L3O A;  1Y1V D;  2GMF A;  5D72 A;  3OG4 A;  2V8N A;  1A22 A;  3HOV D;  5GXB A;  4TPJ A;  3B5K A;  3Q1S I;  3PIW A;  1PV6 A;  3UF2 A;  3PO2 D;  4NKQ C;  3D85 C;  1D9G A;  3OG6 A;  4CNI C;  2O26 A;  1HIK A;  4UVM A;  5D28 B;  1FYH A;  3SE4 B;  4BXX D;  3LB6 B;  5A2N A;  4D2D A;  1SCF A;  2XQB A;  1V7M V;  5D6K A;  3UEZ E;  5IYD D;  3QAZ A;  5C65 A;  1F6F A;  4U4W A;  2ILK A;  2INT A;  4O9H A;  1J7V L;  4A3L D;  1GNC A;  4BY1 D;  4A3M D;  1Z92 A;  1EKU A;  4JRE A;  4GRW A;  2B8X A;  5IYC D;  4OAA A;  4NN6 A;  4YDY I;  4IU9 A;  3I4N D;  5EQG A;  2Z3R A;  2B90 A;  3MZG A;  2IL6 A;  1PV7 A;  4BY7 D;  5C44 D;  1AXI A;  4A3E D;  1PGR A;  2JA6 D;  4J4L C;  5D70 A;  5LQB A;  4A3I D;  4RS1 A;  5C3E D;  2ERJ D;  3HHR A;  1NBP A;  2O6I A;  3FKI D;  4XNJ A;  4A3B D;  3DI3 A;  1HWH A;  1M49 A;  1INR A;  1M47 A;  4A3G D;  2CFP A;  1CYL A;  4A3K D;  1FG9 A;  3TGX B;  5KNH I;  4A3F D;  4EXP A;  3PIV A;  3HHC A;  1ITM A;  4LEP A;  4LDS A;  3LB6 A;  2PSM A;  4IKY A;  2Q7N B;  1EXZ A;  4U4T A;  4PYP A;  5IYB D;  1QVN A;  2L3Y A;  1GA3 A;  1IJZ A;  2B5I A;  1BGD A;  3G9V B;  4YPG C;  1ILK A;  4OH3 A;  3D48 P;  1D9C A;  4DKC A;  4XNI A;  4ZF7 A;  1VLK A;  2B8U A;  3O7P A;  4GS7 A;  5FHX A;  4FA8 E;  3DUH C;  1WU3 I;  4Z5R D;  1LKI A;  5FLM D;  2Y5Y A;  1HUL A;  2E9W C;  5D59 A;  4QIQ A;  1M4R A;  1BGE A;  4IKW A;  1IL6 A;  3H3V E;  4DKF A;  2O27 A;  2Z3Q A;  5E4E A;  2LAG A;  4ZS7 A;  1P9M B;  4JR9 A;  2H24 A;  3DI2 A;  2R7Z D;  3INK C;  4TPG A;  1BCN A;  1RCB A;  4NI7 A;  1CNT 1;  4O6K A;  2OQP A;  1YKB A;  1AX8 A;  4BBS D;  5C7X A;  3NCB A;  1Z7C A;  3HOZ D;  3EJJ A;  3NCE A;  4DKE A;  1ITL A;  4GC0 A;  4YQX A;  4J05 A;  4Q65 A;  4NN7 A;  4GBY A;  4U4V A;  3DGC L;  4X51 A;  1A7M A;  3BPO A;  2B91 A;  3HOW D;  3VA2 A;  4A3D D;  3QB7 A;  3D87 A;  5C4X D;  1CN4 C;  1Y1W D;  5D58 A;  2D48 A;  1JLI A;  1Y6M L;  5D22 A;  1IAR A;  3I4M D;  1LK3 A;  1IK0 A;  3QWR B;  2JA5 D;  2Q14 A;  2R93 D;  3BPL A;  4A3J D;  1IRL A;  4DKD A;  1HWG A;  5A2O A;  1BUY A;  1CD9 A;  4NI9 A;  4JA3 A;  2B63 D;  1V7N V;  4GBZ A;  1RFB A;  2JA7 D;  1M48 A;  1RW5 A;  3HOU D;  1ETE A;  4D2B A;  1M4A A;  1HUW A;  4ZW9 A;  1M4C A;  3AYH A;  4DOH A;  5L6Y C;  5IP7 D;  3H0G D;  1WCM D;  1B5L A;  3HOX D;  3WCY I;  1EVS A;  3O7Q A;  3UX9 A;  3QT2 C;  4YUE C;  4NEJ A;  1PVH B;  2B8Y A;  1EER A;  1ALU A;  4PS4 A;  2JA8 D;  3PO3 D;  1M4B A;  5TS9 A;  1ITF A;  4ZWB A;  4W6V A;  3OQ3 A;  1BP3 A;  3L5X A;  2Q98 A;  4YBQ A;  1HIJ A;  3NPZ A;  1Y14 A;  2B8Z A;  1CSG A;  4A3C D;  3UF5 A;  1KF9 A;  4D2C A;  1HGU A;  3N0P A;  1LQS L;  4IKX A;  1BBN A;  1Y6N L;  2KZ1 A;  4IKZ A;  4TPH A;  4WRL B; 
#chains in the Genus database with same CATH homology
 1PV7 A;  5GXB A;  4OH3 A;  3O7Q A;  5A2N A;  4XNI A;  4D2B A;  4D2D A;  4TPJ A;  1PW4 A;  5EQI A;  4IKV A;  5D6K A;  4YBQ A;  5EQH A;  3O7P A;  4YB9 D;  1PV6 A;  2CFQ A;  2V8N A;  4JRE A;  4LEP A;  5A2O A;  4ZWC A;  4JR9 A;  4ZYR A;  2Y5Y A;  4LDS A;  4APS A;  4OAA A;  4D2C A;  4IKY A;  5C65 A;  4IKX A;  3WDO A;  2XUT A;  4IU9 A;  5D59 A;  4ZW9 A;  4IU8 A;  4U4T A;  5EQG A;  4IKZ A;  4GC0 A;  4JA3 A;  4PYP A;  4QIQ A;  4XNJ A;  4U4W A;  4TPH A;  4UVM A;  4J05 A;  4TPG A;  4GBZ A;  5D58 A;  4ZWB A;  4IKW A;  4Q65 A;  4W6V A;  4GBY A;  2CFP A;  4U4V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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