2Y5YA

Crystal structure of lacy in complex with an affinity inactivator
Total Genus 121
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
400
structure length
386
Chain Sequence
LKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFSFNAGCPAVEAFIEKVSRRSNFEFGRARMFGAVGWALVASIVGIMFTINNQFVFWLGSGMALILAVLLFFAKANHSAFSLKLALELFRQPKLWFLSLYVIGVSSTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGSFKYITSQFEVRFSATIYLVAFAFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Lactose Permease in Complex with an Affinity Inactivator Yields Unique Insight Into Sugar Recognition.
pubmed doi rcsb
molecule tags Transport protein
source organism Escherichia coli
molecule keywords LACTOSE PERMEASE
total genus 121
structure length 386
sequence length 400
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01306 LacY_symp LacY proton/sugar symporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2y5yA02
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2y5yA01
4UVMA 2Y5YA 4TPHA 4IKYA 4Q65A 4TPGA 4ZW9A 4U4WA 1PV6A 4ZYRA 4IU9A 2CFPA 4QIQA 5EQIA 4IKXA 4GC0A 4D2DA 2V8NA 4U4TA 3O7PA 4XNIA 5EQGA 4ZWCA 5A2NA 5D58A 1PV7A 5D59A 4ZWBA 4U4VA 4APSA 4IKVA 5EQHA 4D2CA 4TPJA 5GXBA 4GBZA 4OH3A 1PW4A 4IU8A 4JA3A 4D2BA 4IKZA 4PYPA 4LDSA 4YB9D 5D6KA 3O7QA 4JREA 2XUTA 3WDOA 4LEPA 4GBYA 4JR9A 4OAAA 4YBQA 4IKWA 4J05A 5C65A 5A2OA 2CFQA 4XNJA 4W6VA
chains in the Genus database with same CATH superfamily
2Y5YA 4ZF7A 1HUWA 2INTA 1M48A 4IU9A 5IYCD 3PO2D 1M47A 1Z7CA 1QVNA 3HHRA 3QAZA 4U4VA 4D2CA 1ALUA 3QB1A 3N0PA 4A3FD 3DI3A 3BPNA 4NEMA 2R93D 3H0GD 4ZS7A 4TPHA 2B5IA 1RFBA 4YUEC 1M4AA 4APSA 5D70A 2LAGA 2B63D 1EVSA 4LDSA 1PVHB 3FKID 5D22A 5FHXA 4YPGC 3VA2A 4BBRD 1EXZA 1CN4C 1PV6A 4WRLB 4A3KD 4GC0A 3BPOA 3SE4B 4TPJA 1RW5A 4DKEA 4YB9D 1BGDA 4JR9A 5A2OA 4XNJA 2GMFA 4TPGA 2L3OA 5C4XD 3PO3D 1YKBA 4A93D 4U4TA 4A3CD 5C44D 4DKFA 1FG9A 4IU8A 3HOZD 3QWRB 2L3YA 1CD9A 3EJJA 3QB7A 2E9WC 4LEPA 5FUCA 1ITMA 3S9DA 4UVMA 1HIJA 2O26A 2JA6D 3NPZA 3UF5A 1BUYA 2B90A 5D59A 4BXXD 4IKVA 1F6FA 1PW4A 3EW3A 4A3BD 4D2BA 1M4RA 2R92D 1N1FA 4NI9A 2O27A 3G6DA 3HOVD 1EMRA 1D9GA 4W6VA 2R7ZD 4A3ED 4NI7A 3HOXD 1A7MA 3OG6A 4QIQA 4GS7A 4IKXA 1BGEA 1J7VL 4DKDA 4A3JD 4JA3A 1V7MV 1IARA 1WCMD 4PYPA 2B8UA 2XQBA 5E4EA 1RCBA 1GNCA 1RHGA 4YBQA 4IKWA 2OQPA 1WU3I 3H3VE 1A22A 2V8NA 3DUHC 3B5KA 2Q98A 5A2NA 2B8XA 5D58A 1PV7A 5C7XA 5GXBA 2Q7NB 3SE3B 5EQHA 2IL6A 3LB6B 5D6KA 3NCEA 1GA3A 1LQSL 1I1RB 4O6KA 1ITLA 2CYKA 1NBPA 5IYDD 1IK0A 1HWGA 3HOWD 3DGCL 4A3GD 1AX8A 2LMSA 1D9CA 4U4WA 2B91A 1Y6KL 1IJZA 5IP7D 4A3DD 4IKZA 1Y1WD 1KF9A 3WDOA 4Z5RD 3UX9A 3I4MD 1LK3A 1JLIA 4A3ID 2H24A 5KNHI 3INKC 4ZYRA 1CSGA 2O6IA 1ITFA 1SCFA 4ZWBA 2Z3RA 1BP3A 1LKIA 4J4LC 4OH3A 1M4BA 4O9HA 4BY1D 4EXNA 1B5LA 4NEJA 4EXPA 3PIVA 1IRLA 1BBNA 4GBYA 2D48A 5D72A 3NCFA 1FYHA 1IL6A 1CNT1 5L6YC 3LB6A 3O7PA 1Y6NL 2ERJD 4RS1A 4CNIC 1P9MB 4A3LD 3L5WI 3Q1SI 1BCNA 1HGUA 2PSMA 5C65A 2CFQA 4GRWA 2HYMB 2B8ZA 2JA7D 3UEZE 3BPLA 4Q65A 2Z3QA 4ZW9A 5IP9D 1PY2A 2CFPA 4LRLA 3QT2C 1EKUA 5EQIA 3N06A 3D85C 4NKQC 3PIWA 3L5XA 1BGCA 2JA8D 5FLMD 3DLQI 1HULA 4BY7D 1VLKA 4JREA 1CYLA 4X51A 1Y14A 1V7NV 3NCBA 3OG4A 1INRA 2KZ1A 1ITIA 4ZWCA 3HHCA 2C35A 4YQXA 3HOYD 4FA8E 1HWHA 4NN6A 4DOHA 4NN7A 1Y6ML 4BBSD 4IKYA 3MZGA 5C3ED 5EQGA 5D71A 3G9VB 3TGXB 1Y1VD 1PGRA 4YDYI 2ILKA 3BESL 1Z92A 1AXIA 4A3MD 3I4ND 5IYBD 3NCCA 1AU1A 1HZIA 4XNIA 3HOUD 1M4CA 1M49A 4NN5A 2JA5D 2Q14A 3O7QA 2B8YA 3D87A 4J05A 1HIKA 5LQBA 1PW6A 4MHLA 2VUMD 4D2DA 4DKCA 2D9QA 3AYHA 4I77Z 1ETEA 1F45B 4PS4A 4GBZA 1EERA 3DI2A 3WCYI 1ILKA 5TS9A 2XUTA 4OAAA 3HMXB 3UF2A 3D48P 3OQ3A 5D28B 3IRHA
chains in the Genus database with same CATH topology
4UVMA 2Y5YA 4TPHA 4IKYA 4Q65A 4TPGA 4ZW9A 4U4WA 1PV6A 4ZYRA 4IU9A 2CFPA 4QIQA 5EQIA 4IKXA 4GC0A 4D2DA 2V8NA 4U4TA 3O7PA 4XNIA 5EQGA 4ZWCA 5A2NA 5D58A 1PV7A 5D59A 4ZWBA 4U4VA 4APSA 4IKVA 5EQHA 4D2CA 4TPJA 5GXBA 4GBZA 4OH3A 1PW4A 4IU8A 4JA3A 4D2BA 4IKZA 4PYPA 4LDSA 4YB9D 5D6KA 3O7QA 4JREA 2XUTA 3WDOA 4LEPA 4GBYA 4JR9A 4OAAA 4YBQA 4IKWA 4J05A 5C65A 5A2OA 2CFQA 4XNJA 4W6VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UVM A;  2Y5Y A;  4TPH A;  4IKY A;  4Q65 A;  4TPG A;  4ZW9 A;  4U4W A;  1PV6 A;  4ZYR A;  4IU9 A;  2CFP A;  4QIQ A;  5EQI A;  4IKX A;  4GC0 A;  4D2D A;  2V8N A;  4U4T A;  3O7P A;  4XNI A;  5EQG A;  4ZWC A;  5A2N A;  5D58 A;  1PV7 A;  5D59 A;  4ZWB A;  4U4V A;  4APS A;  4IKV A;  5EQH A;  4D2C A;  4TPJ A;  5GXB A;  4GBZ A;  4OH3 A;  1PW4 A;  4IU8 A;  4JA3 A;  4D2B A;  4IKZ A;  4PYP A;  4LDS A;  4YB9 D;  5D6K A;  3O7Q A;  4JRE A;  2XUT A;  3WDO A;  4LEP A;  4GBY A;  4JR9 A;  4OAA A;  4YBQ A;  4IKW A;  4J05 A;  5C65 A;  5A2O A;  2CFQ A;  4XNJ A;  4W6V A; 
#chains in the Genus database with same CATH topology
 2Y5Y A;  4ZF7 A;  1HUW A;  2INT A;  1M48 A;  4IU9 A;  5IYC D;  3PO2 D;  1M47 A;  1Z7C A;  1QVN A;  3HHR A;  3QAZ A;  4U4V A;  4D2C A;  1ALU A;  3QB1 A;  3N0P A;  4A3F D;  3DI3 A;  3BPN A;  4NEM A;  2R93 D;  3H0G D;  4ZS7 A;  4TPH A;  2B5I A;  1RFB A;  4YUE C;  1M4A A;  4APS A;  5D70 A;  2LAG A;  2B63 D;  1EVS A;  4LDS A;  1PVH B;  3FKI D;  5D22 A;  5FHX A;  4YPG C;  3VA2 A;  4BBR D;  1EXZ A;  1CN4 C;  1PV6 A;  4WRL B;  4A3K D;  4GC0 A;  3BPO A;  3SE4 B;  4TPJ A;  1RW5 A;  4DKE A;  4YB9 D;  1BGD A;  4JR9 A;  5A2O A;  4XNJ A;  2GMF A;  4TPG A;  2L3O A;  5C4X D;  3PO3 D;  1YKB A;  4A93 D;  4U4T A;  4A3C D;  5C44 D;  4DKF A;  1FG9 A;  4IU8 A;  3HOZ D;  3QWR B;  2L3Y A;  1CD9 A;  3EJJ A;  3QB7 A;  2E9W C;  4LEP A;  5FUC A;  1ITM A;  3S9D A;  4UVM A;  1HIJ A;  2O26 A;  2JA6 D;  3NPZ A;  3UF5 A;  1BUY A;  2B90 A;  5D59 A;  4BXX D;  4IKV A;  1F6F A;  1PW4 A;  3EW3 A;  4A3B D;  4D2B A;  1M4R A;  2R92 D;  1N1F A;  4NI9 A;  2O27 A;  3G6D A;  3HOV D;  1EMR A;  1D9G A;  4W6V A;  2R7Z D;  4A3E D;  4NI7 A;  3HOX D;  1A7M A;  3OG6 A;  4QIQ A;  4GS7 A;  4IKX A;  1BGE A;  1J7V L;  4DKD A;  4A3J D;  4JA3 A;  1V7M V;  1IAR A;  1WCM D;  4PYP A;  2B8U A;  2XQB A;  5E4E A;  1RCB A;  1GNC A;  1RHG A;  4YBQ A;  4IKW A;  2OQP A;  1WU3 I;  3H3V E;  1A22 A;  2V8N A;  3DUH C;  3B5K A;  2Q98 A;  5A2N A;  2B8X A;  5D58 A;  1PV7 A;  5C7X A;  5GXB A;  2Q7N B;  3SE3 B;  5EQH A;  2IL6 A;  3LB6 B;  5D6K A;  3NCE A;  1GA3 A;  1LQS L;  1I1R B;  4O6K A;  1ITL A;  2CYK A;  1NBP A;  5IYD D;  1IK0 A;  1HWG A;  3HOW D;  3DGC L;  4A3G D;  1AX8 A;  2LMS A;  1D9C A;  4U4W A;  2B91 A;  1Y6K L;  1IJZ A;  5IP7 D;  4A3D D;  4IKZ A;  1Y1W D;  1KF9 A;  3WDO A;  4Z5R D;  3UX9 A;  3I4M D;  1LK3 A;  1JLI A;  4A3I D;  2H24 A;  5KNH I;  3INK C;  4ZYR A;  1CSG A;  2O6I A;  1ITF A;  1SCF A;  4ZWB A;  2Z3R A;  1BP3 A;  1LKI A;  4J4L C;  4OH3 A;  1M4B A;  4O9H A;  4BY1 D;  4EXN A;  1B5L A;  4NEJ A;  4EXP A;  3PIV A;  1IRL A;  1BBN A;  4GBY A;  2D48 A;  5D72 A;  3NCF A;  1FYH A;  1IL6 A;  1CNT 1;  5L6Y C;  3LB6 A;  3O7P A;  1Y6N L;  2ERJ D;  4RS1 A;  4CNI C;  1P9M B;  4A3L D;  3L5W I;  3Q1S I;  1BCN A;  1HGU A;  2PSM A;  5C65 A;  2CFQ A;  4GRW A;  2HYM B;  2B8Z A;  2JA7 D;  3UEZ E;  3BPL A;  4Q65 A;  2Z3Q A;  4ZW9 A;  5IP9 D;  1PY2 A;  2CFP A;  4LRL A;  3QT2 C;  1EKU A;  5EQI A;  3N06 A;  3D85 C;  4NKQ C;  3PIW A;  3L5X A;  1BGC A;  2JA8 D;  5FLM D;  3DLQ I;  1HUL A;  4BY7 D;  1VLK A;  4JRE A;  1CYL A;  4X51 A;  1Y14 A;  1V7N V;  3NCB A;  3OG4 A;  1INR A;  2KZ1 A;  1ITI A;  4ZWC A;  3HHC A;  2C35 A;  4YQX A;  3HOY D;  4FA8 E;  1HWH A;  4NN6 A;  4DOH A;  4NN7 A;  1Y6M L;  4BBS D;  4IKY A;  3MZG A;  5C3E D;  5EQG A;  5D71 A;  3G9V B;  3TGX B;  1Y1V D;  1PGR A;  4YDY I;  2ILK A;  3BES L;  1Z92 A;  1AXI A;  4A3M D;  3I4N D;  5IYB D;  3NCC A;  1AU1 A;  1HZI A;  4XNI A;  3HOU D;  1M4C A;  1M49 A;  4NN5 A;  2JA5 D;  2Q14 A;  3O7Q A;  2B8Y A;  3D87 A;  4J05 A;  1HIK A;  5LQB A;  1PW6 A;  4MHL A;  2VUM D;  4D2D A;  4DKC A;  2D9Q A;  3AYH A;  4I77 Z;  1ETE A;  1F45 B;  4PS4 A;  4GBZ A;  1EER A;  3DI2 A;  3WCY I;  1ILK A;  5TS9 A;  2XUT A;  4OAA A;  3HMX B;  3UF2 A;  3D48 P;  3OQ3 A;  5D28 B;  3IRH A; 
#chains in the Genus database with same CATH homology
 4UVM A;  2Y5Y A;  4TPH A;  4IKY A;  4Q65 A;  4TPG A;  4ZW9 A;  4U4W A;  1PV6 A;  4ZYR A;  4IU9 A;  2CFP A;  4QIQ A;  5EQI A;  4IKX A;  4GC0 A;  4D2D A;  2V8N A;  4U4T A;  3O7P A;  4XNI A;  5EQG A;  4ZWC A;  5A2N A;  5D58 A;  1PV7 A;  5D59 A;  4ZWB A;  4U4V A;  4APS A;  4IKV A;  5EQH A;  4D2C A;  4TPJ A;  5GXB A;  4GBZ A;  4OH3 A;  1PW4 A;  4IU8 A;  4JA3 A;  4D2B A;  4IKZ A;  4PYP A;  4LDS A;  4YB9 D;  5D6K A;  3O7Q A;  4JRE A;  2XUT A;  3WDO A;  4LEP A;  4GBY A;  4JR9 A;  4OAA A;  4YBQ A;  4IKW A;  4J05 A;  5C65 A;  5A2O A;  2CFQ A;  4XNJ A;  4W6V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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