2Y5YA

Crystal structure of lacy in complex with an affinity inactivator
Total Genus 121
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
400
structure length
386
Chain Sequence
LKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFSFNAGCPAVEAFIEKVSRRSNFEFGRARMFGAVGWALVASIVGIMFTINNQFVFWLGSGMALILAVLLFFAKANHSAFSLKLALELFRQPKLWFLSLYVIGVSSTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGSFKYITSQFEVRFSATIYLVAFAFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Lactose Permease in Complex with an Affinity Inactivator Yields Unique Insight Into Sugar Recognition.
pubmed doi rcsb
molecule tags Transport protein
source organism Escherichia coli
molecule keywords LACTOSE PERMEASE
total genus 121
structure length 386
sequence length 400
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01306 LacY_symp LacY proton/sugar symporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2y5yA02
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2y5yA01
5D58A 4J05A 2V8NA 4LDSA 4PYPA 2CFPA 4IKXA 5GXBA 5A2OA 3O7PA 4JA3A 4TPHA 4U4WA 4JREA 4ZWCA 4IU9A 4QIQA 4U4VA 4XNIA 4ZWBA 4JR9A 4OH3A 5EQIA 4IKYA 4APSA 5D59A 2CFQA 4IKZA 4IKWA 5A2NA 4ZW9A 4D2CA 2XUTA 4GBZA 4TPJA 3WDOA 4W6VA 4YBQA 4D2BA 4YB9D 4TPGA 3O7QA 4ZYRA 4Q65A 1PV7A 4GBYA 4GC0A 4U4TA 5D6KA 4IU8A 4D2DA 5EQGA 1PV6A 5C65A 1PW4A 4OAAA 4IKVA 4XNJA 4UVMA 4LEPA 5EQHA 2Y5YA
chains in the Genus database with same CATH superfamily
5D58A 1IL6A 1EERA 3EW3A 4JA3A 1FYHA 1V7MV 4ZWBA 3N06A 4IKZA 2O6IA 4GBZA 4I77Z 4DKCA 3NCBA 2C35A 1BGEA 1PY2A 3Q1SI 3UX9A 1CN4C 4XNJA 4UVMA 3D87A 4IKXA 3UEZE 4NN7A 5TS9A 1YKBA 5KNHI 1HWGA 4TPGA 5L6YC 5IYBD 4Q65A 2JA6D 3INKC 2JA5D 3HOZD 3AYHA 1F6FA 1EKUA 1BP3A 4YUEC 4WRLB 4ZS7A 3PO2D 1BBNA 5LQBA 1WU3I 5D59A 3QAZA 1P9MB 3WDOA 3HOUD 4FA8E 2Q7NB 5EQGA 3L5XA 5FUCA 1LK3A 5EQHA 4NI7A 1D9CA 4YPGC 4GRWA 2OQPA 4JR9A 4APSA 2B8XA 3QT2C 4BY7D 4U4TA 1Y14A 3TGXB 4A3ED 4CNIC 2HYMB 4A3MD 4A3LD 3B5KA 2LAGA 5A2OA 4IU9A 2B8UA 1HWHA 1KF9A 4YBQA 5IP9D 2H24A 3VA2A 1IK0A 4YDYI 3LB6A 4YQXA 1GA3A 5D71A 5D28B 3O7PA 3BPOA 3DI3A 1M48A 4O9HA 3SE3B 3HOWD 4BY1D 5IYDD 2Q14A 2B8YA 5D22A 3HHCA 1Y1VD 4ZF7A 4D2DA 1PV6A 1IARA 3D85C 3OQ3A 3NCCA 4PYPA 2CYKA 2CFPA 4U4VA 1A22A 1HIKA 3HOXD 2B5IA 1I1RB 3L5WI 2XUTA 4W6VA 1FG9A 3WCYI 1HIJA 3LB6B 4IU8A 3N0PA 4PS4A 1JLIA 4A3ID 1D9GA 1PW4A 2Z3QA 1WCMD 1ALUA 2E9WC 4DOHA 3I4ND 1HGUA 3H3VE 4LRLA 4LDSA 1IRLA 5FHXA 4MHLA 3EJJA 2ERJD 2VUMD 5D72A 1RW5A 2XQBA 4ZW9A 2B63D 2PSMA 3UF5A 1PGRA 3NCFA 4A3CD 5D6KA 1F45B 4NN6A 4LEPA 4A93D 1BCNA 4GS7A 1AX8A 1J7VL 5GXBA 2D9QA 2Q98A 3BPNA 1V7NV 4IKWA 5A2NA 1LKIA 3PIWA 1NBPA 2INTA 1HZIA 3G6DA 4OAAA 1ITMA 5C4XD 4EXNA 1SCFA 1M49A 2V8NA 2JA8D 4JREA 2IL6A 3QWRB 4TPJA 4D2BA 4YB9D 1BGDA 1INRA 4GBYA 1EMRA 3D48P 3H0GD 1PW6A 1M4BA 3BESL 3QB1A 3UF2A 4J05A 4EXPA 1CSGA 2R7ZD 4BBRD 1CYLA 3MZGA 4OH3A 3NCEA 4A3BD 3O7QA 1IJZA 4GC0A 1M4CA 1RFBA 3HOYD 2B8ZA 1PVHB 1ITLA 2LMSA 4NEMA 4TPHA 1ETEA 1N1FA 2KZ1A 2Z3RA 3DGCL 3G9VB 4D2CA 2O27A 4BBSD 3PIVA 1Y1WD 3I4MD 1PV7A 1Y6ML 2JA7D 1ILKA 2R93D 5C65A 4NI9A 1AU1A 3HHRA 4J4LC 4IKVA 3OG6A 4A3JD 2Y5YA 4A3DD 1M4AA 1A7MA 3PO3D 1EVSA 4NEJA 3BPLA 4ZWCA 4XNIA 4DKFA 1BUYA 1GNCA 1ITFA 4ZYRA 4A3GD 4X51A 3HOVD 1VLKA 2R92D 1HUWA 3QB7A 1RHGA 1Z92A 1RCBA 1QVNA 4BXXD 5IYCD 2CFQA 1EXZA 2L3OA 1Z7CA 4O6KA 5E4EA 2D48A 3S9DA 4A3KD 3IRHA 1CNT1 1Y6KL 5C44D 2B91A 1CD9A 4DKDA 4RS1A 5EQIA 4IKYA 3SE4B 5D70A 4DKEA 4A3FD 3DLQI 2ILKA 5IP7D 3DI2A 5C7XA 1AXIA 1Y6NL 3DUHC 1M47A 1ITIA 5C3ED 1HULA 4U4WA 4NKQC 4QIQA 2GMFA 2B90A 3NPZA 4Z5RD 5FLMD 1BGCA 3OG4A 1LQSL 2L3YA 2O26A 1M4RA 4NN5A 1B5LA 3HMXB 3FKID
chains in the Genus database with same CATH topology
5D58A 4J05A 2V8NA 4LDSA 4PYPA 2CFPA 4IKXA 5GXBA 5A2OA 3O7PA 4JA3A 4TPHA 4U4WA 4JREA 4ZWCA 4IU9A 4QIQA 4U4VA 4XNIA 4ZWBA 4JR9A 4OH3A 5EQIA 4IKYA 4APSA 5D59A 2CFQA 4IKZA 4IKWA 5A2NA 4ZW9A 4D2CA 2XUTA 4GBZA 4TPJA 3WDOA 4W6VA 4YBQA 4D2BA 4YB9D 4TPGA 3O7QA 4ZYRA 4Q65A 1PV7A 4GBYA 4GC0A 4U4TA 5D6KA 4IU8A 4D2DA 5EQGA 1PV6A 5C65A 1PW4A 4OAAA 4IKVA 4XNJA 4UVMA 4LEPA 5EQHA 2Y5YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5D58 A;  4J05 A;  2V8N A;  4LDS A;  4PYP A;  2CFP A;  4IKX A;  5GXB A;  5A2O A;  3O7P A;  4JA3 A;  4TPH A;  4U4W A;  4JRE A;  4ZWC A;  4IU9 A;  4QIQ A;  4U4V A;  4XNI A;  4ZWB A;  4JR9 A;  4OH3 A;  5EQI A;  4IKY A;  4APS A;  5D59 A;  2CFQ A;  4IKZ A;  4IKW A;  5A2N A;  4ZW9 A;  4D2C A;  2XUT A;  4GBZ A;  4TPJ A;  3WDO A;  4W6V A;  4YBQ A;  4D2B A;  4YB9 D;  4TPG A;  3O7Q A;  4ZYR A;  4Q65 A;  1PV7 A;  4GBY A;  4GC0 A;  4U4T A;  5D6K A;  4IU8 A;  4D2D A;  5EQG A;  1PV6 A;  5C65 A;  1PW4 A;  4OAA A;  4IKV A;  4XNJ A;  4UVM A;  4LEP A;  5EQH A;  2Y5Y A; 
#chains in the Genus database with same CATH topology
 5D58 A;  1IL6 A;  1EER A;  3EW3 A;  4JA3 A;  1FYH A;  1V7M V;  4ZWB A;  3N06 A;  4IKZ A;  2O6I A;  4GBZ A;  4I77 Z;  4DKC A;  3NCB A;  2C35 A;  1BGE A;  1PY2 A;  3Q1S I;  3UX9 A;  1CN4 C;  4XNJ A;  4UVM A;  3D87 A;  4IKX A;  3UEZ E;  4NN7 A;  5TS9 A;  1YKB A;  5KNH I;  1HWG A;  4TPG A;  5L6Y C;  5IYB D;  4Q65 A;  2JA6 D;  3INK C;  2JA5 D;  3HOZ D;  3AYH A;  1F6F A;  1EKU A;  1BP3 A;  4YUE C;  4WRL B;  4ZS7 A;  3PO2 D;  1BBN A;  5LQB A;  1WU3 I;  5D59 A;  3QAZ A;  1P9M B;  3WDO A;  3HOU D;  4FA8 E;  2Q7N B;  5EQG A;  3L5X A;  5FUC A;  1LK3 A;  5EQH A;  4NI7 A;  1D9C A;  4YPG C;  4GRW A;  2OQP A;  4JR9 A;  4APS A;  2B8X A;  3QT2 C;  4BY7 D;  4U4T A;  1Y14 A;  3TGX B;  4A3E D;  4CNI C;  2HYM B;  4A3M D;  4A3L D;  3B5K A;  2LAG A;  5A2O A;  4IU9 A;  2B8U A;  1HWH A;  1KF9 A;  4YBQ A;  5IP9 D;  2H24 A;  3VA2 A;  1IK0 A;  4YDY I;  3LB6 A;  4YQX A;  1GA3 A;  5D71 A;  5D28 B;  3O7P A;  3BPO A;  3DI3 A;  1M48 A;  4O9H A;  3SE3 B;  3HOW D;  4BY1 D;  5IYD D;  2Q14 A;  2B8Y A;  5D22 A;  3HHC A;  1Y1V D;  4ZF7 A;  4D2D A;  1PV6 A;  1IAR A;  3D85 C;  3OQ3 A;  3NCC A;  4PYP A;  2CYK A;  2CFP A;  4U4V A;  1A22 A;  1HIK A;  3HOX D;  2B5I A;  1I1R B;  3L5W I;  2XUT A;  4W6V A;  1FG9 A;  3WCY I;  1HIJ A;  3LB6 B;  4IU8 A;  3N0P A;  4PS4 A;  1JLI A;  4A3I D;  1D9G A;  1PW4 A;  2Z3Q A;  1WCM D;  1ALU A;  2E9W C;  4DOH A;  3I4N D;  1HGU A;  3H3V E;  4LRL A;  4LDS A;  1IRL A;  5FHX A;  4MHL A;  3EJJ A;  2ERJ D;  2VUM D;  5D72 A;  1RW5 A;  2XQB A;  4ZW9 A;  2B63 D;  2PSM A;  3UF5 A;  1PGR A;  3NCF A;  4A3C D;  5D6K A;  1F45 B;  4NN6 A;  4LEP A;  4A93 D;  1BCN A;  4GS7 A;  1AX8 A;  1J7V L;  5GXB A;  2D9Q A;  2Q98 A;  3BPN A;  1V7N V;  4IKW A;  5A2N A;  1LKI A;  3PIW A;  1NBP A;  2INT A;  1HZI A;  3G6D A;  4OAA A;  1ITM A;  5C4X D;  4EXN A;  1SCF A;  1M49 A;  2V8N A;  2JA8 D;  4JRE A;  2IL6 A;  3QWR B;  4TPJ A;  4D2B A;  4YB9 D;  1BGD A;  1INR A;  4GBY A;  1EMR A;  3D48 P;  3H0G D;  1PW6 A;  1M4B A;  3BES L;  3QB1 A;  3UF2 A;  4J05 A;  4EXP A;  1CSG A;  2R7Z D;  4BBR D;  1CYL A;  3MZG A;  4OH3 A;  3NCE A;  4A3B D;  3O7Q A;  1IJZ A;  4GC0 A;  1M4C A;  1RFB A;  3HOY D;  2B8Z A;  1PVH B;  1ITL A;  2LMS A;  4NEM A;  4TPH A;  1ETE A;  1N1F A;  2KZ1 A;  2Z3R A;  3DGC L;  3G9V B;  4D2C A;  2O27 A;  4BBS D;  3PIV A;  1Y1W D;  3I4M D;  1PV7 A;  1Y6M L;  2JA7 D;  1ILK A;  2R93 D;  5C65 A;  4NI9 A;  1AU1 A;  3HHR A;  4J4L C;  4IKV A;  3OG6 A;  4A3J D;  2Y5Y A;  4A3D D;  1M4A A;  1A7M A;  3PO3 D;  1EVS A;  4NEJ A;  3BPL A;  4ZWC A;  4XNI A;  4DKF A;  1BUY A;  1GNC A;  1ITF A;  4ZYR A;  4A3G D;  4X51 A;  3HOV D;  1VLK A;  2R92 D;  1HUW A;  3QB7 A;  1RHG A;  1Z92 A;  1RCB A;  1QVN A;  4BXX D;  5IYC D;  2CFQ A;  1EXZ A;  2L3O A;  1Z7C A;  4O6K A;  5E4E A;  2D48 A;  3S9D A;  4A3K D;  3IRH A;  1CNT 1;  1Y6K L;  5C44 D;  2B91 A;  1CD9 A;  4DKD A;  4RS1 A;  5EQI A;  4IKY A;  3SE4 B;  5D70 A;  4DKE A;  4A3F D;  3DLQ I;  2ILK A;  5IP7 D;  3DI2 A;  5C7X A;  1AXI A;  1Y6N L;  3DUH C;  1M47 A;  1ITI A;  5C3E D;  1HUL A;  4U4W A;  4NKQ C;  4QIQ A;  2GMF A;  2B90 A;  3NPZ A;  4Z5R D;  5FLM D;  1BGC A;  3OG4 A;  1LQS L;  2L3Y A;  2O26 A;  1M4R A;  4NN5 A;  1B5L A;  3HMX B;  3FKI D; 
#chains in the Genus database with same CATH homology
 5D58 A;  4J05 A;  2V8N A;  4LDS A;  4PYP A;  2CFP A;  4IKX A;  5GXB A;  5A2O A;  3O7P A;  4JA3 A;  4TPH A;  4U4W A;  4JRE A;  4ZWC A;  4IU9 A;  4QIQ A;  4U4V A;  4XNI A;  4ZWB A;  4JR9 A;  4OH3 A;  5EQI A;  4IKY A;  4APS A;  5D59 A;  2CFQ A;  4IKZ A;  4IKW A;  5A2N A;  4ZW9 A;  4D2C A;  2XUT A;  4GBZ A;  4TPJ A;  3WDO A;  4W6V A;  4YBQ A;  4D2B A;  4YB9 D;  4TPG A;  3O7Q A;  4ZYR A;  4Q65 A;  1PV7 A;  4GBY A;  4GC0 A;  4U4T A;  5D6K A;  4IU8 A;  4D2D A;  5EQG A;  1PV6 A;  5C65 A;  1PW4 A;  4OAA A;  4IKV A;  4XNJ A;  4UVM A;  4LEP A;  5EQH A;  2Y5Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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