2C35A

Subunits rpb4 and rpb7 of human rna polymerase ii
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
128
structure length
128
Chain Sequence
EEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSFQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure and RNA Binding of the Rpb4/Rpb7 Subunits of Human RNA Polymerase II.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords DNA-DIRECTED RNA POLYMERASE II 16 KDA POLYPEPTIDE
total genus 45
structure length 128
sequence length 128
chains with identical sequence C, E, G
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2005-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03874 RNA_pol_Rpb4 RNA polymerase Rpb4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.40 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 2c35A00
3I4MD 3H0GD 3HOUD 5IP9D 3H3VE 4A3MD 4BY7D 3HOWD 4A3KD 5C44D 4A3ED 2R92D 4BXXD 4BBSD 3PO2D 3FKID 3HOXD 4A93D 1Y14A 2C35A 2JA6D 4A3BD 4A3FD 3I4ND 5IP7D 5IYBD 5C4XD 3HOYD 3AYHA 5IYDD 4BY1D 2JA8D 3HOVD 3HOZD 2B63D 4A3DD 4A3GD 2VUMD 4A3LD 5FLMD 5C3ED 2R7ZD 4A3CD 2JA5D 4BBRD 2R93D 4A3ID 2JA7D 1Y1VD 1WCMD 1Y1WD 3PO3D 4A3JD 5IYCD
chains in the Genus database with same CATH superfamily
3MZGA 3I4MD 1M4BA 4W6VA 1D9GA 4OAAA 1F6FA 5D28B 2R92D 1BBNA 1PW4A 2CFPA 3UEZE 3QAZA 2O27A 1CYLA 3NCEA 5FLMD 4GBZA 4BBRD 2JA5D 4D2CA 3WDOA 1CSGA 1M48A 3WCYI 4DKDA 5L6YC 3N06A 1BGCA 1CD9A 2L3YA 3H0GD 2HYMB 4BY7D 5C44D 4LRLA 3PO2D 4APSA 3I4ND 1Y6ML 1EVSA 2R93D 1YKBA 3BPOA 5FUCA 5E4EA 1GNCA 1HIKA 2D48A 2Z3RA 4IU8A 2L3OA 3DI2A 2Q98A 5EQGA 4NEMA 2XUTA 1BCNA 1GA3A 4J05A 1Y1VD 3EJJA 5GXBA 4IKZA 2IL6A 4NI7A 5D6KA 4LDSA 1IJZA 1LKIA 5A2OA 1P9MB 4ZYRA 5C7XA 3G6DA 3FKID 3INKC 4I77Z 5D71A 1AU1A 1AXIA 5C3ED 2Q14A 1KF9A 5D72A 3D48P 1HIJA 1LK3A 4BBSD 2B8YA 4NN6A 5LQBA 5TS9A 5IP7D 4DKFA 4YDYI 3O7QA 2B91A 3AYHA 4ZS7A 4YBQA 4J4LC 2ILKA 4JA3A 1AX8A 3DI3A 1JLIA 4DOHA 4A3JD 2V8NA 4GS7A 4O6KA 1M4AA 3TGXB 3HOWD 1EERA 4NN5A 4EXPA 4ZW9A 2OQPA 1HUWA 1HWHA 4XNJA 1M4RA 5D22A 2GMFA 4Z5RD 4D2BA 1PV6A 4ZWCA 1IRLA 4XNIA 3D85C 5IP9D 4MHLA 3UF2A 1B5LA 1FYHA 1LQSL 2D9QA 2B8ZA 4D2DA 1V7NV 4A3LD 3OG4A 2R7ZD 3UF5A 1RW5A 4TPHA 4IU9A 1M4CA 3Q1SI 1HZIA 4NEJA 2B90A 5C65A 1M47A 3PIVA 1N1FA 4QIQA 1CN4C 5FHXA 2Z3QA 2LAGA 4IKXA 1NBPA 1BP3A 4BY1D 4LEPA 4CNIC 1HGUA 4NI9A 2CFQA 4U4WA 2O26A 1ETEA 3IRHA 5EQHA 4JREA 3VA2A 4A3KD 3DGCL 3NCBA 4YB9D 1BGEA 4ZF7A 4TPJA 3D87A 5IYBD 1BGDA 3HOZD 3BPLA 4U4VA 5EQIA 2VUMD 4Q65A 4GBYA 4TPGA 3HOUD 4PS4A 5D58A 3QWRB 4YQXA 3NCFA 2B8UA 4GRWA 3HOXD 4DKCA 1INRA 5IYDD 1Z7CA 4A3CD 3BPNA 3DLQI 1RHGA 4FA8E 4GC0A 1IARA 4NKQC 5IYCD 5D70A 1M49A 4X51A 4OH3A 3O7PA 2CYKA 3HOYD 5KNHI 2B8XA 1EKUA 1IK0A 1Y1WD 3BESL 3G9VB 3PO3D 1A22A 1ALUA 1WU3I 1HWGA 1IL6A 4EXNA 4A3MD 1Y6KL 4A3BD 1BUYA 2JA8D 4A3GD 2H24A 2Q7NB 4RS1A 1D9CA 1Y6NL 1WCMD 1A7MA 1CNT1 4IKYA 3UX9A 1ITFA 3QB7A 1Y14A 1F45B 3QB1A 4A3FD 2PSMA 1SCFA 3SE3B 4YPGC 4U4TA 1RCBA 4YUEC 3QT2C 2E9WC 3SE4B 1ITIA 1VLKA 3HMXB 1ILKA 1EMRA 4BXXD 2O6IA 3NPZA 2ERJD 1PGRA 1PW6A 5C4XD 3OQ3A 1FG9A 2B63D 3HOVD 2XQBA 1HULA 2B5IA 3EW3A 3L5WI 3B5KA 3DUHC 1ITMA 4WRLB 4DKEA 4NN7A 1EXZA 4ZWBA 4A3ED 1PVHB 1PY2A 4UVMA 4IKVA 3HHRA 3PIWA 4A3DD 5A2NA 3S9DA 4A3ID 2JA7D 2INTA 1I1RB 3OG6A 4JR9A 3H3VE 3N0PA 2LMSA 1RFBA 1Z92A 4PYPA 4O9HA 4A93D 2C35A 1ITLA 1QVNA 2JA6D 1PV7A 2Y5YA 5D59A 3L5XA 4IKWA 3LB6B 1V7MV 1J7VL 3HHCA 3LB6A 2KZ1A 3NCCA
chains in the Genus database with same CATH topology
3MZGA 5D72A 1M4BA 3I4MD 3D48P 3UX9A 1D9GA 1ITFA 3VA2A 1F6FA 4A3KD 1HIJA 5D28B 1LK3A 2R92D 3DGCL 1BBNA 4BBSD 2B8YA 3NCBA 3QB7A 1BGEA 4NN6A 4ZF7A 5LQBA 1Y14A 1F45B 3QB1A 3D87A 3UEZE 2PSMA 3QAZA 5IP7D 1SCFA 5TS9A 4DKFA 5IYBD 4YDYI 4ZS7A 2B91A 3AYHA 3SE3B 2O27A 1BGDA 4J4LC 1CYLA 3HOZD 3BPLA 2VUMD 3NCEA 5FLMD 4YPGC 2ILKA 2JA5D 4BBRD 1AX8A 3DI3A 1CSGA 1JLIA 1RCBA 1M48A 4YUEC 3QT2C 3WCYI 4DKDA 4DOHA 3N06A 2E9WC 3SE4B 5L6YC 4A3JD 1ITIA 1VLKA 1BGCA 1CD9A 2L3YA 3H0GD 4A3FD 2HYMB 3HMXB 4GS7A 4O6KA 4PS4A 3HOUD 4BY7D 1ILKA 1M4AA 3TGXB 3HOWD 1EERA 1EMRA 5C44D 4NN5A 4LRLA 3QWRB 4EXPA 4BXXD 4YQXA 3NCFA 2O6IA 2B8UA 3PO2D 4GRWA 3HOXD 4DKCA 1INRA 3NPZA 2ERJD 1PGRA 1PW6A 3I4ND 1Y6ML 2OQPA 1EVSA 5C4XD 3OQ3A 5IYDD 1FG9A 1HUWA 1HWHA 3HOVD 1Z7CA 1HULA 2B5IA 2XQBA 2B63D 1M4RA 4A3CD 5D22A 2R93D 3BPNA 1YKBA 3BPOA 3DLQI 5FUCA 1RHGA 2GMFA 3EW3A 4Z5RD 4FA8E 1IARA 4NKQC 1IRLA 3L5WI 5E4EA 5IYCD 5D70A 3B5KA 1GNCA 3D85C 1ITMA 1M49A 3DUHC 4WRLB 4DKEA 4MHLA 5IP9D 4NN7A 1HIKA 3UF2A 2D48A 1EXZA 1B5LA 1FYHA 2Z3RA 4A3ED 4X51A 1PVHB 2L3OA 3DI2A 1LQSL 2Q98A 1PY2A 2CYKA 2D9QA 2B8ZA 3HOYD 3HHRA 5KNHI 4NEMA 3PIWA 4A3DD 1BCNA 1V7NV 2B8XA 1GA3A 4A3LD 3OG4A 2R7ZD 1EKUA 3UF5A 1IK0A 1RW5A 3S9DA 4A3ID 1M4CA 3Q1SI 2JA7D 1Y1VD 3EJJA 1Y1WD 3BESL 2INTA 1HZIA 2IL6A 3G9VB 4NEJA 1I1RB 4NI7A 3PO3D 2B90A 1A22A 1ALUA 1WU3I 3OG6A 1HWGA 1IL6A 4EXNA 3H3VE 4A3MD 1IJZA 1LKIA 1M47A 2LMSA 3N0PA 1RFBA 3PIVA 1Z92A 1N1FA 1P9MB 1Y6KL 4O9HA 5C7XA 3G6DA 3FKID 4A93D 3INKC 4I77Z 1CN4C 5FHXA 2C35A 5D71A 1ITLA 2Z3QA 1QVNA 2JA6D 4A3BD 1AU1A 2LAGA 1NBPA 1BUYA 1BP3A 4BY1D 2JA8D 3L5XA 4A3GD 1AXIA 2H24A 3LB6B 2Q7NB 4RS1A 4CNIC 1HGUA 5C3ED 1V7MV 4NI9A 1J7VL 3HHCA 2Q14A 1D9CA 3LB6A 1KF9A 1Y6NL 1WCMD 2KZ1A 2O26A 3NCCA 1A7MA 1ETEA 3IRHA 1CNT1
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3I4M D;  3H0G D;  3HOU D;  5IP9 D;  3H3V E;  4A3M D;  4BY7 D;  3HOW D;  4A3K D;  5C44 D;  4A3E D;  2R92 D;  4BXX D;  4BBS D;  3PO2 D;  3FKI D;  3HOX D;  4A93 D;  1Y14 A;  2C35 A;  2JA6 D;  4A3B D;  4A3F D;  3I4N D;  5IP7 D;  5IYB D;  5C4X D;  3HOY D;  3AYH A;  5IYD D;  4BY1 D;  2JA8 D;  3HOV D;  3HOZ D;  2B63 D;  4A3D D;  4A3G D;  2VUM D;  4A3L D;  5FLM D;  5C3E D;  2R7Z D;  4A3C D;  2JA5 D;  4BBR D;  2R93 D;  4A3I D;  2JA7 D;  1Y1V D;  1WCM D;  1Y1W D;  3PO3 D;  4A3J D;  5IYC D; 
#chains in the Genus database with same CATH topology
 3MZG A;  3I4M D;  1M4B A;  4W6V A;  1D9G A;  4OAA A;  1F6F A;  5D28 B;  2R92 D;  1BBN A;  1PW4 A;  2CFP A;  3UEZ E;  3QAZ A;  2O27 A;  1CYL A;  3NCE A;  5FLM D;  4GBZ A;  4BBR D;  2JA5 D;  4D2C A;  3WDO A;  1CSG A;  1M48 A;  3WCY I;  4DKD A;  5L6Y C;  3N06 A;  1BGC A;  1CD9 A;  2L3Y A;  3H0G D;  2HYM B;  4BY7 D;  5C44 D;  4LRL A;  3PO2 D;  4APS A;  3I4N D;  1Y6M L;  1EVS A;  2R93 D;  1YKB A;  3BPO A;  5FUC A;  5E4E A;  1GNC A;  1HIK A;  2D48 A;  2Z3R A;  4IU8 A;  2L3O A;  3DI2 A;  2Q98 A;  5EQG A;  4NEM A;  2XUT A;  1BCN A;  1GA3 A;  4J05 A;  1Y1V D;  3EJJ A;  5GXB A;  4IKZ A;  2IL6 A;  4NI7 A;  5D6K A;  4LDS A;  1IJZ A;  1LKI A;  5A2O A;  1P9M B;  4ZYR A;  5C7X A;  3G6D A;  3FKI D;  3INK C;  4I77 Z;  5D71 A;  1AU1 A;  1AXI A;  5C3E D;  2Q14 A;  1KF9 A;  5D72 A;  3D48 P;  1HIJ A;  1LK3 A;  4BBS D;  2B8Y A;  4NN6 A;  5LQB A;  5TS9 A;  5IP7 D;  4DKF A;  4YDY I;  3O7Q A;  2B91 A;  3AYH A;  4ZS7 A;  4YBQ A;  4J4L C;  2ILK A;  4JA3 A;  1AX8 A;  3DI3 A;  1JLI A;  4DOH A;  4A3J D;  2V8N A;  4GS7 A;  4O6K A;  1M4A A;  3TGX B;  3HOW D;  1EER A;  4NN5 A;  4EXP A;  4ZW9 A;  2OQP A;  1HUW A;  1HWH A;  4XNJ A;  1M4R A;  5D22 A;  2GMF A;  4Z5R D;  4D2B A;  1PV6 A;  4ZWC A;  1IRL A;  4XNI A;  3D85 C;  5IP9 D;  4MHL A;  3UF2 A;  1B5L A;  1FYH A;  1LQS L;  2D9Q A;  2B8Z A;  4D2D A;  1V7N V;  4A3L D;  3OG4 A;  2R7Z D;  3UF5 A;  1RW5 A;  4TPH A;  4IU9 A;  1M4C A;  3Q1S I;  1HZI A;  4NEJ A;  2B90 A;  5C65 A;  1M47 A;  3PIV A;  1N1F A;  4QIQ A;  1CN4 C;  5FHX A;  2Z3Q A;  2LAG A;  4IKX A;  1NBP A;  1BP3 A;  4BY1 D;  4LEP A;  4CNI C;  1HGU A;  4NI9 A;  2CFQ A;  4U4W A;  2O26 A;  1ETE A;  3IRH A;  5EQH A;  4JRE A;  3VA2 A;  4A3K D;  3DGC L;  3NCB A;  4YB9 D;  1BGE A;  4ZF7 A;  4TPJ A;  3D87 A;  5IYB D;  1BGD A;  3HOZ D;  3BPL A;  4U4V A;  5EQI A;  2VUM D;  4Q65 A;  4GBY A;  4TPG A;  3HOU D;  4PS4 A;  5D58 A;  3QWR B;  4YQX A;  3NCF A;  2B8U A;  4GRW A;  3HOX D;  4DKC A;  1INR A;  5IYD D;  1Z7C A;  4A3C D;  3BPN A;  3DLQ I;  1RHG A;  4FA8 E;  4GC0 A;  1IAR A;  4NKQ C;  5IYC D;  5D70 A;  1M49 A;  4X51 A;  4OH3 A;  3O7P A;  2CYK A;  3HOY D;  5KNH I;  2B8X A;  1EKU A;  1IK0 A;  1Y1W D;  3BES L;  3G9V B;  3PO3 D;  1A22 A;  1ALU A;  1WU3 I;  1HWG A;  1IL6 A;  4EXN A;  4A3M D;  1Y6K L;  4A3B D;  1BUY A;  2JA8 D;  4A3G D;  2H24 A;  2Q7N B;  4RS1 A;  1D9C A;  1Y6N L;  1WCM D;  1A7M A;  1CNT 1;  4IKY A;  3UX9 A;  1ITF A;  3QB7 A;  1Y14 A;  1F45 B;  3QB1 A;  4A3F D;  2PSM A;  1SCF A;  3SE3 B;  4YPG C;  4U4T A;  1RCB A;  4YUE C;  3QT2 C;  2E9W C;  3SE4 B;  1ITI A;  1VLK A;  3HMX B;  1ILK A;  1EMR A;  4BXX D;  2O6I A;  3NPZ A;  2ERJ D;  1PGR A;  1PW6 A;  5C4X D;  3OQ3 A;  1FG9 A;  2B63 D;  3HOV D;  2XQB A;  1HUL A;  2B5I A;  3EW3 A;  3L5W I;  3B5K A;  3DUH C;  1ITM A;  4WRL B;  4DKE A;  4NN7 A;  1EXZ A;  4ZWB A;  4A3E D;  1PVH B;  1PY2 A;  4UVM A;  4IKV A;  3HHR A;  3PIW A;  4A3D D;  5A2N A;  3S9D A;  4A3I D;  2JA7 D;  2INT A;  1I1R B;  3OG6 A;  4JR9 A;  3H3V E;  3N0P A;  2LMS A;  1RFB A;  1Z92 A;  4PYP A;  4O9H A;  4A93 D;  2C35 A;  1ITL A;  1QVN A;  2JA6 D;  1PV7 A;  2Y5Y A;  5D59 A;  3L5X A;  4IKW A;  3LB6 B;  1V7M V;  1J7V L;  3HHC A;  3LB6 A;  2KZ1 A;  3NCC A; 
#chains in the Genus database with same CATH homology
 3MZG A;  5D72 A;  1M4B A;  3I4M D;  3D48 P;  3UX9 A;  1D9G A;  1ITF A;  3VA2 A;  1F6F A;  4A3K D;  1HIJ A;  5D28 B;  1LK3 A;  2R92 D;  3DGC L;  1BBN A;  4BBS D;  2B8Y A;  3NCB A;  3QB7 A;  1BGE A;  4NN6 A;  4ZF7 A;  5LQB A;  1Y14 A;  1F45 B;  3QB1 A;  3D87 A;  3UEZ E;  2PSM A;  3QAZ A;  5IP7 D;  1SCF A;  5TS9 A;  4DKF A;  5IYB D;  4YDY I;  4ZS7 A;  2B91 A;  3AYH A;  3SE3 B;  2O27 A;  1BGD A;  4J4L C;  1CYL A;  3HOZ D;  3BPL A;  2VUM D;  3NCE A;  5FLM D;  4YPG C;  2ILK A;  2JA5 D;  4BBR D;  1AX8 A;  3DI3 A;  1CSG A;  1JLI A;  1RCB A;  1M48 A;  4YUE C;  3QT2 C;  3WCY I;  4DKD A;  4DOH A;  3N06 A;  2E9W C;  3SE4 B;  5L6Y C;  4A3J D;  1ITI A;  1VLK A;  1BGC A;  1CD9 A;  2L3Y A;  3H0G D;  4A3F D;  2HYM B;  3HMX B;  4GS7 A;  4O6K A;  4PS4 A;  3HOU D;  4BY7 D;  1ILK A;  1M4A A;  3TGX B;  3HOW D;  1EER A;  1EMR A;  5C44 D;  4NN5 A;  4LRL A;  3QWR B;  4EXP A;  4BXX D;  4YQX A;  3NCF A;  2O6I A;  2B8U A;  3PO2 D;  4GRW A;  3HOX D;  4DKC A;  1INR A;  3NPZ A;  2ERJ D;  1PGR A;  1PW6 A;  3I4N D;  1Y6M L;  2OQP A;  1EVS A;  5C4X D;  3OQ3 A;  5IYD D;  1FG9 A;  1HUW A;  1HWH A;  3HOV D;  1Z7C A;  1HUL A;  2B5I A;  2XQB A;  2B63 D;  1M4R A;  4A3C D;  5D22 A;  2R93 D;  3BPN A;  1YKB A;  3BPO A;  3DLQ I;  5FUC A;  1RHG A;  2GMF A;  3EW3 A;  4Z5R D;  4FA8 E;  1IAR A;  4NKQ C;  1IRL A;  3L5W I;  5E4E A;  5IYC D;  5D70 A;  3B5K A;  1GNC A;  3D85 C;  1ITM A;  1M49 A;  3DUH C;  4WRL B;  4DKE A;  4MHL A;  5IP9 D;  4NN7 A;  1HIK A;  3UF2 A;  2D48 A;  1EXZ A;  1B5L A;  1FYH A;  2Z3R A;  4A3E D;  4X51 A;  1PVH B;  2L3O A;  3DI2 A;  1LQS L;  2Q98 A;  1PY2 A;  2CYK A;  2D9Q A;  2B8Z A;  3HOY D;  3HHR A;  5KNH I;  4NEM A;  3PIW A;  4A3D D;  1BCN A;  1V7N V;  2B8X A;  1GA3 A;  4A3L D;  3OG4 A;  2R7Z D;  1EKU A;  3UF5 A;  1IK0 A;  1RW5 A;  3S9D A;  4A3I D;  1M4C A;  3Q1S I;  2JA7 D;  1Y1V D;  3EJJ A;  1Y1W D;  3BES L;  2INT A;  1HZI A;  2IL6 A;  3G9V B;  4NEJ A;  1I1R B;  4NI7 A;  3PO3 D;  2B90 A;  1A22 A;  1ALU A;  1WU3 I;  3OG6 A;  1HWG A;  1IL6 A;  4EXN A;  3H3V E;  4A3M D;  1IJZ A;  1LKI A;  1M47 A;  2LMS A;  3N0P A;  1RFB A;  3PIV A;  1Z92 A;  1N1F A;  1P9M B;  1Y6K L;  4O9H A;  5C7X A;  3G6D A;  3FKI D;  4A93 D;  3INK C;  4I77 Z;  1CN4 C;  5FHX A;  2C35 A;  5D71 A;  1ITL A;  2Z3Q A;  1QVN A;  2JA6 D;  4A3B D;  1AU1 A;  2LAG A;  1NBP A;  1BUY A;  1BP3 A;  4BY1 D;  2JA8 D;  3L5X A;  4A3G D;  1AXI A;  2H24 A;  3LB6 B;  2Q7N B;  4RS1 A;  4CNI C;  1HGU A;  5C3E D;  1V7M V;  4NI9 A;  1J7V L;  3HHC A;  2Q14 A;  1D9C A;  3LB6 A;  1KF9 A;  1Y6N L;  1WCM D;  2KZ1 A;  2O26 A;  3NCC A;  1A7M A;  1ETE A;  3IRH A;  1CNT 1; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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