2CFPA

Sugar free lactose permease at acidic ph
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
417
structure length
417
Chain Sequence
MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALGASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSLLRRQVNEVA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Evidence for Induced Fit and a Mechanism for Sugar/H(+) Symport in Lacy.
pubmed doi rcsb
molecule tags Transport
source organism Escherichia coli
molecule keywords LACTOSE PERMEASE
total genus 119
structure length 417
sequence length 417
ec nomenclature
pdb deposition date 2006-02-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01306 LacY_symp LacY proton/sugar symporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2cfpA02
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2cfpA01
4JREA 5D6KA 4IKYA 4LDSA 4JR9A 4W6VA 4OAAA 5C65A 5A2OA 4IU8A 5D58A 4ZWBA 4PYPA 4QIQA 4YB9D 4ZYRA 4APSA 1PW4A 4OH3A 3O7PA 4ZW9A 4TPJA 2CFPA 4UVMA 1PV7A 4IKVA 2Y5YA 3O7QA 4IKXA 5EQGA 5D59A 4YBQA 5EQHA 4D2DA 2XUTA 4U4VA 4LEPA 5EQIA 4IKWA 4XNJA 4JA3A 4GBZA 4U4TA 4TPHA 4IU9A 4J05A 4Q65A 4D2CA 4GBYA 5A2NA 3WDOA 2CFQA 4U4WA 5GXBA 4IKZA 4D2BA 4GC0A 1PV6A 4TPGA 2V8NA 4XNIA 4ZWCA
chains in the Genus database with same CATH superfamily
3MZGA 3I4MD 1M4BA 4W6VA 1D9GA 4OAAA 1F6FA 5D28B 2R92D 1BBNA 1PW4A 2CFPA 3UEZE 3QAZA 2O27A 1CYLA 3NCEA 5FLMD 4GBZA 4BBRD 2JA5D 4D2CA 3WDOA 1CSGA 1M48A 3WCYI 4DKDA 5L6YC 3N06A 1BGCA 1CD9A 2L3YA 3H0GD 2HYMB 4BY7D 5C44D 4LRLA 3PO2D 4APSA 3I4ND 1Y6ML 1EVSA 2R93D 1YKBA 3BPOA 5FUCA 5E4EA 1GNCA 1HIKA 2D48A 2Z3RA 4IU8A 2L3OA 3DI2A 2Q98A 5EQGA 4NEMA 2XUTA 1BCNA 1GA3A 4J05A 1Y1VD 3EJJA 5GXBA 4IKZA 2IL6A 4NI7A 5D6KA 4LDSA 1IJZA 1LKIA 5A2OA 1P9MB 4ZYRA 5C7XA 3G6DA 3FKID 3INKC 4I77Z 5D71A 1AU1A 1AXIA 5C3ED 2Q14A 1KF9A 5D72A 3D48P 1HIJA 1LK3A 4BBSD 2B8YA 4NN6A 5LQBA 5TS9A 5IP7D 4DKFA 4YDYI 3O7QA 2B91A 3AYHA 4ZS7A 4YBQA 4J4LC 2ILKA 4JA3A 1AX8A 3DI3A 1JLIA 4DOHA 4A3JD 2V8NA 4GS7A 4O6KA 1M4AA 3TGXB 3HOWD 1EERA 4NN5A 4EXPA 4ZW9A 2OQPA 1HUWA 1HWHA 4XNJA 1M4RA 5D22A 2GMFA 4Z5RD 4D2BA 1PV6A 4ZWCA 1IRLA 4XNIA 3D85C 5IP9D 4MHLA 3UF2A 1B5LA 1FYHA 1LQSL 2D9QA 2B8ZA 4D2DA 1V7NV 4A3LD 3OG4A 2R7ZD 3UF5A 1RW5A 4TPHA 4IU9A 1M4CA 3Q1SI 1HZIA 4NEJA 2B90A 5C65A 1M47A 3PIVA 1N1FA 4QIQA 1CN4C 5FHXA 2Z3QA 2LAGA 4IKXA 1NBPA 1BP3A 4BY1D 4LEPA 4CNIC 1HGUA 4NI9A 2CFQA 4U4WA 2O26A 1ETEA 3IRHA 5EQHA 4JREA 3VA2A 4A3KD 3DGCL 3NCBA 4YB9D 1BGEA 4ZF7A 4TPJA 3D87A 5IYBD 1BGDA 3HOZD 3BPLA 4U4VA 5EQIA 2VUMD 4Q65A 4GBYA 4TPGA 3HOUD 4PS4A 5D58A 3QWRB 4YQXA 3NCFA 2B8UA 4GRWA 3HOXD 4DKCA 1INRA 5IYDD 1Z7CA 4A3CD 3BPNA 3DLQI 1RHGA 4FA8E 4GC0A 1IARA 4NKQC 5IYCD 5D70A 1M49A 4X51A 4OH3A 3O7PA 2CYKA 3HOYD 5KNHI 2B8XA 1EKUA 1IK0A 1Y1WD 3BESL 3G9VB 3PO3D 1A22A 1ALUA 1WU3I 1HWGA 1IL6A 4EXNA 4A3MD 1Y6KL 4A3BD 1BUYA 2JA8D 4A3GD 2H24A 2Q7NB 4RS1A 1D9CA 1Y6NL 1WCMD 1A7MA 1CNT1 4IKYA 3UX9A 1ITFA 3QB7A 1Y14A 1F45B 3QB1A 4A3FD 2PSMA 1SCFA 3SE3B 4YPGC 4U4TA 1RCBA 4YUEC 3QT2C 2E9WC 3SE4B 1ITIA 1VLKA 3HMXB 1ILKA 1EMRA 4BXXD 2O6IA 3NPZA 2ERJD 1PGRA 1PW6A 5C4XD 3OQ3A 1FG9A 2B63D 3HOVD 2XQBA 1HULA 2B5IA 3EW3A 3L5WI 3B5KA 3DUHC 1ITMA 4WRLB 4DKEA 4NN7A 1EXZA 4ZWBA 4A3ED 1PVHB 1PY2A 4UVMA 4IKVA 3HHRA 3PIWA 4A3DD 5A2NA 3S9DA 4A3ID 2JA7D 2INTA 1I1RB 3OG6A 4JR9A 3H3VE 3N0PA 2LMSA 1RFBA 1Z92A 4PYPA 4O9HA 4A93D 2C35A 1ITLA 1QVNA 2JA6D 1PV7A 2Y5YA 5D59A 3L5XA 4IKWA 3LB6B 1V7MV 1J7VL 3HHCA 3LB6A 2KZ1A 3NCCA
chains in the Genus database with same CATH topology
4JREA 5D6KA 4IKYA 4LDSA 4JR9A 4W6VA 4OAAA 5C65A 5A2OA 4IU8A 5D58A 4ZWBA 4PYPA 4QIQA 4YB9D 4ZYRA 4APSA 1PW4A 4OH3A 3O7PA 4ZW9A 4TPJA 2CFPA 4UVMA 1PV7A 4IKVA 2Y5YA 3O7QA 4IKXA 5EQGA 5D59A 4YBQA 5EQHA 4D2DA 2XUTA 4U4VA 4LEPA 5EQIA 4IKWA 4XNJA 4JA3A 4GBZA 4U4TA 4TPHA 4IU9A 4J05A 4Q65A 4D2CA 4GBYA 5A2NA 3WDOA 2CFQA 4U4WA 5GXBA 4IKZA 4D2BA 4GC0A 1PV6A 4TPGA 2V8NA 4XNIA 4ZWCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JRE A;  5D6K A;  4IKY A;  4LDS A;  4JR9 A;  4W6V A;  4OAA A;  5C65 A;  5A2O A;  4IU8 A;  5D58 A;  4ZWB A;  4PYP A;  4QIQ A;  4YB9 D;  4ZYR A;  4APS A;  1PW4 A;  4OH3 A;  3O7P A;  4ZW9 A;  4TPJ A;  2CFP A;  4UVM A;  1PV7 A;  4IKV A;  2Y5Y A;  3O7Q A;  4IKX A;  5EQG A;  5D59 A;  4YBQ A;  5EQH A;  4D2D A;  2XUT A;  4U4V A;  4LEP A;  5EQI A;  4IKW A;  4XNJ A;  4JA3 A;  4GBZ A;  4U4T A;  4TPH A;  4IU9 A;  4J05 A;  4Q65 A;  4D2C A;  4GBY A;  5A2N A;  3WDO A;  2CFQ A;  4U4W A;  5GXB A;  4IKZ A;  4D2B A;  4GC0 A;  1PV6 A;  4TPG A;  2V8N A;  4XNI A;  4ZWC A; 
#chains in the Genus database with same CATH topology
 3MZG A;  3I4M D;  1M4B A;  4W6V A;  1D9G A;  4OAA A;  1F6F A;  5D28 B;  2R92 D;  1BBN A;  1PW4 A;  2CFP A;  3UEZ E;  3QAZ A;  2O27 A;  1CYL A;  3NCE A;  5FLM D;  4GBZ A;  4BBR D;  2JA5 D;  4D2C A;  3WDO A;  1CSG A;  1M48 A;  3WCY I;  4DKD A;  5L6Y C;  3N06 A;  1BGC A;  1CD9 A;  2L3Y A;  3H0G D;  2HYM B;  4BY7 D;  5C44 D;  4LRL A;  3PO2 D;  4APS A;  3I4N D;  1Y6M L;  1EVS A;  2R93 D;  1YKB A;  3BPO A;  5FUC A;  5E4E A;  1GNC A;  1HIK A;  2D48 A;  2Z3R A;  4IU8 A;  2L3O A;  3DI2 A;  2Q98 A;  5EQG A;  4NEM A;  2XUT A;  1BCN A;  1GA3 A;  4J05 A;  1Y1V D;  3EJJ A;  5GXB A;  4IKZ A;  2IL6 A;  4NI7 A;  5D6K A;  4LDS A;  1IJZ A;  1LKI A;  5A2O A;  1P9M B;  4ZYR A;  5C7X A;  3G6D A;  3FKI D;  3INK C;  4I77 Z;  5D71 A;  1AU1 A;  1AXI A;  5C3E D;  2Q14 A;  1KF9 A;  5D72 A;  3D48 P;  1HIJ A;  1LK3 A;  4BBS D;  2B8Y A;  4NN6 A;  5LQB A;  5TS9 A;  5IP7 D;  4DKF A;  4YDY I;  3O7Q A;  2B91 A;  3AYH A;  4ZS7 A;  4YBQ A;  4J4L C;  2ILK A;  4JA3 A;  1AX8 A;  3DI3 A;  1JLI A;  4DOH A;  4A3J D;  2V8N A;  4GS7 A;  4O6K A;  1M4A A;  3TGX B;  3HOW D;  1EER A;  4NN5 A;  4EXP A;  4ZW9 A;  2OQP A;  1HUW A;  1HWH A;  4XNJ A;  1M4R A;  5D22 A;  2GMF A;  4Z5R D;  4D2B A;  1PV6 A;  4ZWC A;  1IRL A;  4XNI A;  3D85 C;  5IP9 D;  4MHL A;  3UF2 A;  1B5L A;  1FYH A;  1LQS L;  2D9Q A;  2B8Z A;  4D2D A;  1V7N V;  4A3L D;  3OG4 A;  2R7Z D;  3UF5 A;  1RW5 A;  4TPH A;  4IU9 A;  1M4C A;  3Q1S I;  1HZI A;  4NEJ A;  2B90 A;  5C65 A;  1M47 A;  3PIV A;  1N1F A;  4QIQ A;  1CN4 C;  5FHX A;  2Z3Q A;  2LAG A;  4IKX A;  1NBP A;  1BP3 A;  4BY1 D;  4LEP A;  4CNI C;  1HGU A;  4NI9 A;  2CFQ A;  4U4W A;  2O26 A;  1ETE A;  3IRH A;  5EQH A;  4JRE A;  3VA2 A;  4A3K D;  3DGC L;  3NCB A;  4YB9 D;  1BGE A;  4ZF7 A;  4TPJ A;  3D87 A;  5IYB D;  1BGD A;  3HOZ D;  3BPL A;  4U4V A;  5EQI A;  2VUM D;  4Q65 A;  4GBY A;  4TPG A;  3HOU D;  4PS4 A;  5D58 A;  3QWR B;  4YQX A;  3NCF A;  2B8U A;  4GRW A;  3HOX D;  4DKC A;  1INR A;  5IYD D;  1Z7C A;  4A3C D;  3BPN A;  3DLQ I;  1RHG A;  4FA8 E;  4GC0 A;  1IAR A;  4NKQ C;  5IYC D;  5D70 A;  1M49 A;  4X51 A;  4OH3 A;  3O7P A;  2CYK A;  3HOY D;  5KNH I;  2B8X A;  1EKU A;  1IK0 A;  1Y1W D;  3BES L;  3G9V B;  3PO3 D;  1A22 A;  1ALU A;  1WU3 I;  1HWG A;  1IL6 A;  4EXN A;  4A3M D;  1Y6K L;  4A3B D;  1BUY A;  2JA8 D;  4A3G D;  2H24 A;  2Q7N B;  4RS1 A;  1D9C A;  1Y6N L;  1WCM D;  1A7M A;  1CNT 1;  4IKY A;  3UX9 A;  1ITF A;  3QB7 A;  1Y14 A;  1F45 B;  3QB1 A;  4A3F D;  2PSM A;  1SCF A;  3SE3 B;  4YPG C;  4U4T A;  1RCB A;  4YUE C;  3QT2 C;  2E9W C;  3SE4 B;  1ITI A;  1VLK A;  3HMX B;  1ILK A;  1EMR A;  4BXX D;  2O6I A;  3NPZ A;  2ERJ D;  1PGR A;  1PW6 A;  5C4X D;  3OQ3 A;  1FG9 A;  2B63 D;  3HOV D;  2XQB A;  1HUL A;  2B5I A;  3EW3 A;  3L5W I;  3B5K A;  3DUH C;  1ITM A;  4WRL B;  4DKE A;  4NN7 A;  1EXZ A;  4ZWB A;  4A3E D;  1PVH B;  1PY2 A;  4UVM A;  4IKV A;  3HHR A;  3PIW A;  4A3D D;  5A2N A;  3S9D A;  4A3I D;  2JA7 D;  2INT A;  1I1R B;  3OG6 A;  4JR9 A;  3H3V E;  3N0P A;  2LMS A;  1RFB A;  1Z92 A;  4PYP A;  4O9H A;  4A93 D;  2C35 A;  1ITL A;  1QVN A;  2JA6 D;  1PV7 A;  2Y5Y A;  5D59 A;  3L5X A;  4IKW A;  3LB6 B;  1V7M V;  1J7V L;  3HHC A;  3LB6 A;  2KZ1 A;  3NCC A; 
#chains in the Genus database with same CATH homology
 4JRE A;  5D6K A;  4IKY A;  4LDS A;  4JR9 A;  4W6V A;  4OAA A;  5C65 A;  5A2O A;  4IU8 A;  5D58 A;  4ZWB A;  4PYP A;  4QIQ A;  4YB9 D;  4ZYR A;  4APS A;  1PW4 A;  4OH3 A;  3O7P A;  4ZW9 A;  4TPJ A;  2CFP A;  4UVM A;  1PV7 A;  4IKV A;  2Y5Y A;  3O7Q A;  4IKX A;  5EQG A;  5D59 A;  4YBQ A;  5EQH A;  4D2D A;  2XUT A;  4U4V A;  4LEP A;  5EQI A;  4IKW A;  4XNJ A;  4JA3 A;  4GBZ A;  4U4T A;  4TPH A;  4IU9 A;  4J05 A;  4Q65 A;  4D2C A;  4GBY A;  5A2N A;  3WDO A;  2CFQ A;  4U4W A;  5GXB A;  4IKZ A;  4D2B A;  4GC0 A;  1PV6 A;  4TPG A;  2V8N A;  4XNI A;  4ZWC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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