2R7ZD

Cisplatin lesion containing rna polymerase ii elongation complex
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
218
structure length
177
Chain Sequence
STSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIKEALVERRRAFKRSQKKTREKELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQLGSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of transcriptional stalling at cisplatin-damaged DNA.
pubmed doi rcsb
molecule tags Transcription/dna-rna hybrid
molecule keywords 5'-D(*TP*AP*CP*TP*TP*GUP*CP*CP*CP*TP*CP*CP*TP*CP*AP*T)-3'
total genus 43
structure length 177
sequence length 218
ec nomenclature
pdb deposition date 2007-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF03874 RNA_pol_Rpb4 RNA polymerase Rpb4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.40 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 2r7zD02
4BY7D 1Y14A 3HOVD 1Y1VD 5IP9D 2VUMD 3AYHA 2JA7D 3H0GD 3I4MD 5IYCD 2JA8D 2JA5D 5C4XD 1Y1WD 4A3DD 5IP7D 4A3MD 4A3ED 2JA6D 5IYDD 4A3ID 2B63D 4A3KD 4A3BD 3HOUD 3PO2D 4BBSD 5FLMD 2C35A 4A3CD 4BXXD 3HOYD 4A93D 4A3FD 5C3ED 3FKID 4BY1D 3HOWD 4A3JD 5C44D 2R7ZD 3PO3D 3HOXD 1WCMD 4BBRD 2R92D 2R93D 3HOZD 3I4ND 3H3VE 4A3LD 5IYBD 4A3GD
chains in the Genus database with same CATH superfamily
3HOVD 1YKBA 4DKEA 1HULA 1B5LA 1Z7CA 1IARA 1RFBA 3OG4A 1M49A 4DKDA 1BGCA 4A3ID 2E9WC 2LAGA 4D2DA 3LB6A 4ZS7A 1PW4A 2IL6A 4YDYI 1M4AA 1BUYA 4OAAA 5LQBA 2VUMD 3UF2A 4WRLB 1N1FA 2Z3QA 1M4CA 1IK0A 1Y6NL 5D71A 1FG9A 4J05A 5C3ED 4Q65A 1PVHB 3HOXD 3HHRA 1M4RA 4GRWA 4BY7D 1BP3A 3NPZA 3NCFA 4I77Z 4NN7A 1CD9A 1A22A 4YQXA 2B63D 5FHXA 3PO2D 2GMFA 3VA2A 1HZIA 3HMXB 4YUEC 4GBZA 3QWRB 2CYKA 3NCEA 5FUCA 2R92D 4EXPA 5IYBD 2JA8D 2JA5D 5C4XD 1HWGA 4NI9A 1ILKA 1BGEA 5IYDD 1AU1A 4A3FD 2XQBA 2Q14A 5A2NA 4ZW9A 4A3GD 4U4TA 3I4MD 4DOHA 2INTA 1ITFA 4TPHA 4A3KD 1ITMA 1ITLA 1KF9A 2L3YA 1LQSL 2L3OA 3HOYD 3FKID 4BY1D 4UVMA 4YPGC 3INKC 3UEZE 3QB7A 4QIQA 4A93D 1Y1VD 5GXBA 5IYCD 1VLKA 2B8XA 3MZGA 4A3ED 2O6IA 3DI3A 3HOUD 2Z3RA 2LMSA 4U4VA 5E4EA 4IKWA 4GBYA 4LEPA 4OH3A 5C65A 1CN4C 4JR9A 4YBQA 4PS4A 1M48A 2KZ1A 4NN6A 4TPGA 4BBSD 1V7NV 2C35A 4APSA 5C44D 4J4LC 4PYPA 3DUHC 2R7ZD 4Z5RD 1IL6A 3O7QA 3QB1A 3I4ND 2O27A 3BESL 1NBPA 5A2OA 2O26A 3WCYI 3EW3A 3UF5A 4D2BA 1J7VL 1Y6ML 1EXZA 2ERJD 3IRHA 3N06A 4X51A 3OG6A 3HOWD 4W6VA 1WU3I 1HGUA 4ZYRA 3PIWA 1JLIA 1PW6A 2D9QA 3H0GD 4XNJA 1Y1WD 2JA6D 4EXNA 4A3BD 1QVNA 5FLMD 3D87A 4A3CD 3N0PA 3D48P 4IKYA 3PO3D 3Q1SI 3S9DA 1AX8A 3H3VE 3DLQI 1D9GA 3EJJA 3L5WI 1A7MA 5IP9D 2PSMA 2JA7D 4IKZA 1IJZA 2H24A 3QT2C 1RCBA 1Y6KL 4IU8A 3L5XA 1Y14A 2HYMB 1CNT1 5D58A 1M4BA 2CFQA 1CYLA 1HWHA 4ZWCA 4D2CA 2XUTA 1HIKA 1SCFA 3BPOA 4BBRD 4FA8E 5D59A 2Q7NB 1BBNA 4NEJA 4NN5A 1PV7A 3AYHA 1IRLA 4ZWBA 1LKIA 5D72A 3DGCL 4MHLA 4DKFA 1D9CA 3WDOA 4A3LD 4RS1A 1INRA 2Q98A 5EQIA 1EKUA 5TS9A 2ILKA 4NEMA 1F6FA 5D6KA 5EQGA 4LDSA 3D85C 3HHCA 5D28B 4CNIC 4NKQC 3UX9A 5C7XA 1FYHA 1WCMD 2R93D 1EMRA 3PIVA 4GS7A 1ETEA 1PGRA 1GNCA 1AXIA 3B5KA 4IKXA 1EERA 1V7MV 3QAZA 4GC0A 1BCNA 4A3MD 4NI7A 5D70A 1ALUA 2OQPA 1F45B 4TPJA 1HIJA 1LK3A 5L6YC 1CSGA 4JA3A 5EQHA 4DKCA 4O9HA 1M47A 3BPLA 1ITIA 4JREA 4A3DD 3SE3B 2B91A 3OQ3A 1GA3A 2B90A 1P9MB 1I1RB 4BXXD 1PY2A 4U4WA 4YB9D 4IU9A 1Z92A 2B8UA 1PV6A 3NCBA 5KNHI 1EVSA 4O6KA 2B8ZA 2D48A 4ZF7A 3DI2A 1BGDA 3SE4B 3NCCA 3G6DA 3G9VB 5IP7D 3TGXB 4IKVA 4XNIA 5D22A 2CFPA 3BPNA 1RHGA 1RW5A 2Y5YA 3O7PA 4A3JD 4LRLA 2B8YA 2V8NA 1HUWA 2B5IA 3LB6B 3HOZD
chains in the Genus database with same CATH topology
3HOVD 2Q98A 1YKBA 1PW6A 1EKUA 5TS9A 4DKEA 2D9QA 1HULA 2ILKA 3H0GD 3I4MD 1B5LA 4NEMA 1F6FA 4DOHA 1Z7CA 1Y1WD 1IARA 2INTA 1ITFA 1RFBA 3OG4A 1M49A 4DKDA 2JA6D 1BGCA 4A3ID 4EXNA 1ITMA 1QVNA 3D85C 3HHCA 2E9WC 4A3KD 4A3BD 1ITLA 1KF9A 3D87A 2L3YA 5FLMD 4A3CD 3N0PA 5D28B 4CNIC 1LQSL 2L3OA 3HOYD 4NKQC 3D48P 3FKID 3UX9A 5C7XA 4BY1D 1FYHA 4YPGC 2LAGA 3PO3D 3INKC 1WCMD 3Q1SI 3S9DA 2R93D 1AX8A 3LB6A 4ZS7A 2IL6A 3UEZE 4YDYI 1M4AA 3H3VE 3DLQI 1BUYA 3QB7A 4A93D 1D9GA 1EMRA 3EJJA 3PIVA 4GS7A 3L5WI 1ETEA 1Y1VD 5LQBA 1A7MA 1PGRA 5IP9D 2VUMD 1GNCA 1AXIA 2PSMA 3B5KA 3UF2A 2JA7D 4WRLB 1N1FA 1EERA 1V7MV 1M4CA 2Z3QA 1Y6NL 5IYCD 1IK0A 1VLKA 3QAZA 2B8XA 5D71A 1FG9A 3MZGA 4A3ED 4A3MD 1BCNA 2O6IA 3DI3A 4NI7A 5D70A 3HOUD 2Z3RA 1ALUA 5C3ED 2LMSA 2OQPA 1F45B 5E4EA 1IJZA 1PVHB 2H24A 3QT2C 3HOXD 1RCBA 3HHRA 1Y6KL 1HIJA 1LK3A 5L6YC 1CSGA 1M4RA 1CN4C 3L5XA 4GRWA 4BY7D 1BP3A 1Y14A 3NPZA 2HYMB 1CNT1 4DKCA 4PS4A 3NCFA 4O9HA 1M47A 1M48A 4I77Z 2KZ1A 1M4BA 3BPLA 4NN7A 1CD9A 1A22A 1ITIA 4YQXA 4NN6A 4A3DD 1CYLA 3SE3B 2B91A 3OQ3A 1GA3A 1HWHA 2B90A 2B63D 5FHXA 1P9MB 3PO2D 4BBSD 1V7NV 2C35A 1I1RB 4BXXD 1PY2A 2GMFA 3VA2A 1HIKA 1HZIA 3HMXB 4J4LC 5C44D 4YUEC 3DUHC 1SCFA 2R7ZD 3BPOA 3QWRB 2CYKA 3NCEA 5FUCA 4BBRD 1Z92A 4Z5RD 1IL6A 4FA8E 2R92D 2B8UA 4EXPA 3QB1A 3I4ND 3NCBA 2Q7NB 5KNHI 5IYBD 1EVSA 1BBNA 4NEJA 4NN5A 2O27A 3BESL 4O6KA 1NBPA 2B8ZA 2D48A 3AYHA 4ZF7A 2O26A 3DI2A 3WCYI 1IRLA 3EW3A 1BGDA 3SE4B 1J7VL 3NCCA 3UF5A 3G6DA 2JA5D 2JA8D 1Y6ML 3G9VB 5C4XD 1HWGA 5IP7D 3TGXB 4NI9A 1ILKA 1BGEA 1EXZA 2ERJD 5IYDD 1AU1A 3IRHA 5D22A 1LKIA 5D72A 4A3FD 3BPNA 3N06A 3OG6A 4X51A 3HOWD 1RHGA 1RW5A 3DGCL 4A3JD 4MHLA 2XQBA 4LRLA 4DKFA 2B8YA 1D9CA 1HUWA 2Q14A 1WU3I 2B5IA 3LB6B 1HGUA 3HOZD 4A3LD 4RS1A 1INRA 3PIWA 1JLIA 4A3GD
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BY7 D;  1Y14 A;  3HOV D;  1Y1V D;  5IP9 D;  2VUM D;  3AYH A;  2JA7 D;  3H0G D;  3I4M D;  5IYC D;  2JA8 D;  2JA5 D;  5C4X D;  1Y1W D;  4A3D D;  5IP7 D;  4A3M D;  4A3E D;  2JA6 D;  5IYD D;  4A3I D;  2B63 D;  4A3K D;  4A3B D;  3HOU D;  3PO2 D;  4BBS D;  5FLM D;  2C35 A;  4A3C D;  4BXX D;  3HOY D;  4A93 D;  4A3F D;  5C3E D;  3FKI D;  4BY1 D;  3HOW D;  4A3J D;  5C44 D;  2R7Z D;  3PO3 D;  3HOX D;  1WCM D;  4BBR D;  2R92 D;  2R93 D;  3HOZ D;  3I4N D;  3H3V E;  4A3L D;  5IYB D;  4A3G D; 
#chains in the Genus database with same CATH topology
 3HOV D;  1YKB A;  4DKE A;  1HUL A;  1B5L A;  1Z7C A;  1IAR A;  1RFB A;  3OG4 A;  1M49 A;  4DKD A;  1BGC A;  4A3I D;  2E9W C;  2LAG A;  4D2D A;  3LB6 A;  4ZS7 A;  1PW4 A;  2IL6 A;  4YDY I;  1M4A A;  1BUY A;  4OAA A;  5LQB A;  2VUM D;  3UF2 A;  4WRL B;  1N1F A;  2Z3Q A;  1M4C A;  1IK0 A;  1Y6N L;  5D71 A;  1FG9 A;  4J05 A;  5C3E D;  4Q65 A;  1PVH B;  3HOX D;  3HHR A;  1M4R A;  4GRW A;  4BY7 D;  1BP3 A;  3NPZ A;  3NCF A;  4I77 Z;  4NN7 A;  1CD9 A;  1A22 A;  4YQX A;  2B63 D;  5FHX A;  3PO2 D;  2GMF A;  3VA2 A;  1HZI A;  3HMX B;  4YUE C;  4GBZ A;  3QWR B;  2CYK A;  3NCE A;  5FUC A;  2R92 D;  4EXP A;  5IYB D;  2JA8 D;  2JA5 D;  5C4X D;  1HWG A;  4NI9 A;  1ILK A;  1BGE A;  5IYD D;  1AU1 A;  4A3F D;  2XQB A;  2Q14 A;  5A2N A;  4ZW9 A;  4A3G D;  4U4T A;  3I4M D;  4DOH A;  2INT A;  1ITF A;  4TPH A;  4A3K D;  1ITM A;  1ITL A;  1KF9 A;  2L3Y A;  1LQS L;  2L3O A;  3HOY D;  3FKI D;  4BY1 D;  4UVM A;  4YPG C;  3INK C;  3UEZ E;  3QB7 A;  4QIQ A;  4A93 D;  1Y1V D;  5GXB A;  5IYC D;  1VLK A;  2B8X A;  3MZG A;  4A3E D;  2O6I A;  3DI3 A;  3HOU D;  2Z3R A;  2LMS A;  4U4V A;  5E4E A;  4IKW A;  4GBY A;  4LEP A;  4OH3 A;  5C65 A;  1CN4 C;  4JR9 A;  4YBQ A;  4PS4 A;  1M48 A;  2KZ1 A;  4NN6 A;  4TPG A;  4BBS D;  1V7N V;  2C35 A;  4APS A;  5C44 D;  4J4L C;  4PYP A;  3DUH C;  2R7Z D;  4Z5R D;  1IL6 A;  3O7Q A;  3QB1 A;  3I4N D;  2O27 A;  3BES L;  1NBP A;  5A2O A;  2O26 A;  3WCY I;  3EW3 A;  3UF5 A;  4D2B A;  1J7V L;  1Y6M L;  1EXZ A;  2ERJ D;  3IRH A;  3N06 A;  4X51 A;  3OG6 A;  3HOW D;  4W6V A;  1WU3 I;  1HGU A;  4ZYR A;  3PIW A;  1JLI A;  1PW6 A;  2D9Q A;  3H0G D;  4XNJ A;  1Y1W D;  2JA6 D;  4EXN A;  4A3B D;  1QVN A;  5FLM D;  3D87 A;  4A3C D;  3N0P A;  3D48 P;  4IKY A;  3PO3 D;  3Q1S I;  3S9D A;  1AX8 A;  3H3V E;  3DLQ I;  1D9G A;  3EJJ A;  3L5W I;  1A7M A;  5IP9 D;  2PSM A;  2JA7 D;  4IKZ A;  1IJZ A;  2H24 A;  3QT2 C;  1RCB A;  1Y6K L;  4IU8 A;  3L5X A;  1Y14 A;  2HYM B;  1CNT 1;  5D58 A;  1M4B A;  2CFQ A;  1CYL A;  1HWH A;  4ZWC A;  4D2C A;  2XUT A;  1HIK A;  1SCF A;  3BPO A;  4BBR D;  4FA8 E;  5D59 A;  2Q7N B;  1BBN A;  4NEJ A;  4NN5 A;  1PV7 A;  3AYH A;  1IRL A;  4ZWB A;  1LKI A;  5D72 A;  3DGC L;  4MHL A;  4DKF A;  1D9C A;  3WDO A;  4A3L D;  4RS1 A;  1INR A;  2Q98 A;  5EQI A;  1EKU A;  5TS9 A;  2ILK A;  4NEM A;  1F6F A;  5D6K A;  5EQG A;  4LDS A;  3D85 C;  3HHC A;  5D28 B;  4CNI C;  4NKQ C;  3UX9 A;  5C7X A;  1FYH A;  1WCM D;  2R93 D;  1EMR A;  3PIV A;  4GS7 A;  1ETE A;  1PGR A;  1GNC A;  1AXI A;  3B5K A;  4IKX A;  1EER A;  1V7M V;  3QAZ A;  4GC0 A;  1BCN A;  4A3M D;  4NI7 A;  5D70 A;  1ALU A;  2OQP A;  1F45 B;  4TPJ A;  1HIJ A;  1LK3 A;  5L6Y C;  1CSG A;  4JA3 A;  5EQH A;  4DKC A;  4O9H A;  1M47 A;  3BPL A;  1ITI A;  4JRE A;  4A3D D;  3SE3 B;  2B91 A;  3OQ3 A;  1GA3 A;  2B90 A;  1P9M B;  1I1R B;  4BXX D;  1PY2 A;  4U4W A;  4YB9 D;  4IU9 A;  1Z92 A;  2B8U A;  1PV6 A;  3NCB A;  5KNH I;  1EVS A;  4O6K A;  2B8Z A;  2D48 A;  4ZF7 A;  3DI2 A;  1BGD A;  3SE4 B;  3NCC A;  3G6D A;  3G9V B;  5IP7 D;  3TGX B;  4IKV A;  4XNI A;  5D22 A;  2CFP A;  3BPN A;  1RHG A;  1RW5 A;  2Y5Y A;  3O7P A;  4A3J D;  4LRL A;  2B8Y A;  2V8N A;  1HUW A;  2B5I A;  3LB6 B;  3HOZ D; 
#chains in the Genus database with same CATH homology
 3HOV D;  2Q98 A;  1YKB A;  1PW6 A;  1EKU A;  5TS9 A;  4DKE A;  2D9Q A;  1HUL A;  2ILK A;  3H0G D;  3I4M D;  1B5L A;  4NEM A;  1F6F A;  4DOH A;  1Z7C A;  1Y1W D;  1IAR A;  2INT A;  1ITF A;  1RFB A;  3OG4 A;  1M49 A;  4DKD A;  2JA6 D;  1BGC A;  4A3I D;  4EXN A;  1ITM A;  1QVN A;  3D85 C;  3HHC A;  2E9W C;  4A3K D;  4A3B D;  1ITL A;  1KF9 A;  3D87 A;  2L3Y A;  5FLM D;  4A3C D;  3N0P A;  5D28 B;  4CNI C;  1LQS L;  2L3O A;  3HOY D;  4NKQ C;  3D48 P;  3FKI D;  3UX9 A;  5C7X A;  4BY1 D;  1FYH A;  4YPG C;  2LAG A;  3PO3 D;  3INK C;  1WCM D;  3Q1S I;  3S9D A;  2R93 D;  1AX8 A;  3LB6 A;  4ZS7 A;  2IL6 A;  3UEZ E;  4YDY I;  1M4A A;  3H3V E;  3DLQ I;  1BUY A;  3QB7 A;  4A93 D;  1D9G A;  1EMR A;  3EJJ A;  3PIV A;  4GS7 A;  3L5W I;  1ETE A;  1Y1V D;  5LQB A;  1A7M A;  1PGR A;  5IP9 D;  2VUM D;  1GNC A;  1AXI A;  2PSM A;  3B5K A;  3UF2 A;  2JA7 D;  4WRL B;  1N1F A;  1EER A;  1V7M V;  1M4C A;  2Z3Q A;  1Y6N L;  5IYC D;  1IK0 A;  1VLK A;  3QAZ A;  2B8X A;  5D71 A;  1FG9 A;  3MZG A;  4A3E D;  4A3M D;  1BCN A;  2O6I A;  3DI3 A;  4NI7 A;  5D70 A;  3HOU D;  2Z3R A;  1ALU A;  5C3E D;  2LMS A;  2OQP A;  1F45 B;  5E4E A;  1IJZ A;  1PVH B;  2H24 A;  3QT2 C;  3HOX D;  1RCB A;  3HHR A;  1Y6K L;  1HIJ A;  1LK3 A;  5L6Y C;  1CSG A;  1M4R A;  1CN4 C;  3L5X A;  4GRW A;  4BY7 D;  1BP3 A;  1Y14 A;  3NPZ A;  2HYM B;  1CNT 1;  4DKC A;  4PS4 A;  3NCF A;  4O9H A;  1M47 A;  1M48 A;  4I77 Z;  2KZ1 A;  1M4B A;  3BPL A;  4NN7 A;  1CD9 A;  1A22 A;  1ITI A;  4YQX A;  4NN6 A;  4A3D D;  1CYL A;  3SE3 B;  2B91 A;  3OQ3 A;  1GA3 A;  1HWH A;  2B90 A;  2B63 D;  5FHX A;  1P9M B;  3PO2 D;  4BBS D;  1V7N V;  2C35 A;  1I1R B;  4BXX D;  1PY2 A;  2GMF A;  3VA2 A;  1HIK A;  1HZI A;  3HMX B;  4J4L C;  5C44 D;  4YUE C;  3DUH C;  1SCF A;  2R7Z D;  3BPO A;  3QWR B;  2CYK A;  3NCE A;  5FUC A;  4BBR D;  1Z92 A;  4Z5R D;  1IL6 A;  4FA8 E;  2R92 D;  2B8U A;  4EXP A;  3QB1 A;  3I4N D;  3NCB A;  2Q7N B;  5KNH I;  5IYB D;  1EVS A;  1BBN A;  4NEJ A;  4NN5 A;  2O27 A;  3BES L;  4O6K A;  1NBP A;  2B8Z A;  2D48 A;  3AYH A;  4ZF7 A;  2O26 A;  3DI2 A;  3WCY I;  1IRL A;  3EW3 A;  1BGD A;  3SE4 B;  1J7V L;  3NCC A;  3UF5 A;  3G6D A;  2JA5 D;  2JA8 D;  1Y6M L;  3G9V B;  5C4X D;  1HWG A;  5IP7 D;  3TGX B;  4NI9 A;  1ILK A;  1BGE A;  1EXZ A;  2ERJ D;  5IYD D;  1AU1 A;  3IRH A;  5D22 A;  1LKI A;  5D72 A;  4A3F D;  3BPN A;  3N06 A;  3OG6 A;  4X51 A;  3HOW D;  1RHG A;  1RW5 A;  3DGC L;  4A3J D;  4MHL A;  2XQB A;  4LRL A;  4DKF A;  2B8Y A;  1D9C A;  1HUW A;  2Q14 A;  1WU3 I;  2B5I A;  3LB6 B;  1HGU A;  3HOZ D;  4A3L D;  4RS1 A;  1INR A;  3PIW A;  1JLI A;  4A3G D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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