2R7ZD

Cisplatin lesion containing rna polymerase ii elongation complex
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
218
structure length
177
Chain Sequence
b'STSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIKEALVERRRAFKRSQKKTREKELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQLGSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords 5'-D(*TP*AP*CP*TP*TP*GUP*CP*CP*CP*TP*CP*CP*TP*CP*AP*T)-3'
publication title Mechanism of transcriptional stalling at cisplatin-damaged DNA.
pubmed doi rcsb
molecule tags Transcription/dna-rna hybrid
total genus 43
structure length 177
sequence length 218
ec nomenclature
pdb deposition date 2007-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF03874 RNA_pol_Rpb4 RNA polymerase Rpb4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.40 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 2r7zD02
2JA7D 3HOWD 2R92D 4A3BD 4A3GD 5IP7D 2VUMD 3PO2D 4A3ED 4A3FD 1Y1VD 3I4MD 5FLMD 5C4XD 2R7ZD 5IYCD 5C44D 4A3LD 3FKID 3HOYD 1Y14A 5C3ED 3HOVD 3HOZD 4BY7D 3H0GD 2JA8D 4A3JD 1WCMD 3I4ND 3AYHA 4A3DD 4BXXD 4BBSD 5IYBD 4A3MD 3PO3D 2C35A 3HOUD 2B63D 4BBRD 4A3KD 5IYDD 4A3ID 3H3VE 3HOXD 4A3CD 1Y1WD 4BY1D 2JA6D 2R93D 4A93D 5IP9D 2JA5D
chains in the Genus database with same CATH superfamily
5KNHI 3OG4A 5IP7D 2XUTA 1Z92A 2H24A 4TPGA 4LEPA 1Y14A 4A3JD 4NI7A 1EKUA 5EQGA 4DKEA 3AYHA 4A3DD 1VLKA 2B8XA 2LMSA 1AX8A 3DGCL 3PIWA 3BESL 4BBRD 5FHXA 2Y5YA 1AU1A 2B8ZA 2XQBA 1LKIA 3LB6A 5C3ED 1LK3A 1NBPA 1RW5A 1PW6A 4W6VA 4A3MD 4ZF7A 5EQHA 5TS9A 2C35A 1ITMA 1ETEA 3VA2A 1A7MA 2B63D 5GXBA 3UF2A 5IP9D 3G6DA 1N1FA 2JA7D 4YB9D 3G9VB 4A3FD 3L5XA 1HUWA 3HOYD 4IU8A 1J7VL 3SE4B 1M4AA 3PO3D 3HMXB 4GBZA 2B8UA 4J4LC 1KF9A 1ITFA 4GRWA 4NN7A 1BBNA 3O7QA 4A3ED 1M48A 1RHGA 2CYKA 3HOVD 1HZIA 1RFBA 3OG6A 5C65A 2V8NA 1HWHA 2O6IA 1EERA 1LQSL 1V7NV 4A3ID 4YPGC 4DKDA 5C7XA 1IL6A 4D2CA 3DUHC 4ZWCA 1Y1VD 1CSGA 5FLMD 4IU9A 1HIJA 1Z7CA 1IK0A 1JLIA 2L3OA 1BCNA 1F45B 3NCCA 3MZGA 2ILKA 3QT2C 5D71A 2L3YA 3NCEA 1QVNA 4TPJA 1EVSA 4ZWBA 4CNIC 4UVMA 5IYCD 4X51A 4OAAA 1PGRA 4D2DA 3QAZA 2B91A 1CYLA 5D70A 4O9HA 1Y6ML 4DOHA 1PY2A 4NN5A 1PV6A 5A2NA 4IKYA 4JR9A 4J05A 4QIQA 2JA8D 1P9MB 2D48A 2CFPA 4BBSD 4WRLB 4XNJA 4EXNA 4TPHA 5D72A 3UX9A 4LDSA 5EQIA 1M4RA 4A3GD 3Q1SI 3IRHA 1WCMD 3BPNA 4U4TA 4I77Z 3HOUD 1D9GA 1PV7A 4EXPA 5L6YC 4PS4A 1FYHA 3HOXD 1ITLA 1GNCA 2HYMB 1CD9A 2VUMD 1I1RB 1PVHB 3N0PA 5E4EA 3D87A 1B5LA 3HOZD 2LAGA 2INTA 3BPOA 5D6KA 3UF5A 4BXXD 5D58A 1ITIA 1GA3A 4A93D 1M4CA 3O7PA 1IARA 2O26A 3EW3A 3HOWD 3NCFA 1BGEA 4ZW9A 1M49A 4U4VA 1INRA 1D9CA 1M47A 1F6FA 3TGXB 3DI2A 4JREA 3N06A 4YUEC 4Q65A 1Y1WD 3I4ND 2Z3QA 1BP3A 4NKQC 1ALUA 1BGDA 2Q98A 2OQPA 2R7ZD 1FG9A 2D9QA 4O6KA 2Z3RA 4NEMA 2Q7NB 3QWRB 3SE3B 3HHCA 5D28B 4A3KD 1Y6NL 1ILKA 1EXZA 3INKC 2KZ1A 4RS1A 3B5KA 3DI3A 4LRLA 1M4BA 4IKXA 5FUCA 1HGUA 2O27A 4JA3A 4GC0A 2B8YA 1IJZA 2CFQA 2B5IA 4YDYI 1BGCA 5D22A 2ERJD 3LB6B 1Y6KL 1HWGA 2JA5D 3NPZA 3WDOA 4Z5RD 3I4MD 3BPLA 1A22A 4ZYRA 4MHLA 3UEZE 1AXIA 3D85C 1YKBA 4XNIA 3L5WI 4ZS7A 2IL6A 3QB7A 4U4WA 4BY1D 2E9WC 2PSMA 5D59A 4NI9A 4A3BD 4PYPA 4GBYA 1WU3I 3H0GD 1CN4C 3OQ3A 4NN6A 5LQBA 3PIVA 5IYBD 4D2BA 4A3CD 3DLQI 3HHRA 4YBQA 3S9DA 1RCBA 2B90A 4APSA 1PW4A 3WCYI 4DKFA 3PO2D 1SCFA 4GS7A 5C4XD 5C44D 3FKID 1CNT1 4BY7D 2Q14A 1EMRA 1IRLA 4DKCA 4IKZA 5IYDD 1HULA 2R93D 4IKVA 3QB1A 3D48P 3NCBA 2R92D 1V7MV 4OH3A 4A3LD 1BUYA 2GMFA 4FA8E 4IKWA 5A2OA 4NEJA 3H3VE 4YQXA 2JA6D 3EJJA 1HIKA
chains in the Genus database with same CATH topology
5KNHI 1GNCA 2HYMB 3DUHC 1CD9A 3OG4A 4A3ID 4Z5RD 5IP7D 2VUMD 1I1RB 1Z92A 1Y1VD 2H24A 3I4MD 1CSGA 1PVHB 3N0PA 3BPLA 5FLMD 5E4EA 1ITIA 1A22A 3D87A 4MHLA 1HIJA 1B5LA 1Y14A 1Z7CA 3HOZD 3UEZE 2LAGA 4A3JD 1AXIA 2INTA 4NI7A 3BPOA 1EKUA 4DKEA 3D85C 1IK0A 3AYHA 3UF5A 1VLKA 2B8XA 4A3DD 1JLIA 1YKBA 2L3OA 2LMSA 1AX8A 3DGCL 3PIWA 3BESL 1BCNA 1F45B 3L5WI 3NCCA 4BBRD 1GA3A 4ZS7A 3MZGA 2ILKA 3QT2C 2IL6A 3QB7A 5D71A 4BY1D 4A93D 1M4CA 2E9WC 2L3YA 1QVNA 3NCEA 1IARA 1EVSA 2O26A 3EW3A 2PSMA 5FHXA 3HOWD 4NI9A 4A3BD 3NCFA 1BGEA 4CNIC 1ITLA 1AU1A 2B8ZA 2XQBA 1M49A 4BXXD 1LKIA 3LB6A 5IYCD 1WU3I 5C3ED 1INRA 1LK3A 1NBPA 3H0GD 4X51A 1RW5A 1CN4C 1D9CA 1M47A 3OQ3A 3PIVA 1F6FA 4NN6A 5LQBA 1PW6A 3TGXB 3DI2A 5IYBD 4A3MD 1PGRA 4ZF7A 5TS9A 3VA2A 2C35A 1ITMA 1ETEA 3N06A 4YUEC 2B63D 3H3VE 1A7MA 3QAZA 4A3CD 1Y1WD 2B91A 3UF2A 3DLQI 5IP9D 3G6DA 2Z3QA 1BP3A 3HHRA 4NKQC 3I4ND 1CYLA 5D70A 1N1FA 2JA7D 3S9DA 1RCBA 2B90A 3G9VB 4O9HA 3WCYI 4DKFA 1Y6ML 3PO2D 4DOHA 1PY2A 4NN5A 1ALUA 1SCFA 3L5XA 1BGDA 4A3FD 2Q98A 4GS7A 5C4XD 1HUWA 2OQPA 5C44D 1FG9A 2R7ZD 3FKID 3HOYD 1CNT1 4BY7D 2JA8D 1P9MB 2D48A 2D9QA 2Q14A 4O6KA 2Z3RA 1EMRA 1IRLA 1J7VL 4NEMA 3SE4B 2Q7NB 4BBSD 4WRLB 1M4AA 3QWRB 3SE3B 4DKCA 3PO3D 4EXNA 3HHCA 5D28B 4A3KD 5IYDD 3HMXB 1HULA 5D72A 1Y6NL 1ILKA 1EXZA 3INKC 2R93D 2KZ1A 3QB1A 4RS1A 2B8UA 4J4LC 1KF9A 3B5KA 3UX9A 1ITFA 4GRWA 4NN7A 3D48P 3NCBA 1BBNA 1M4RA 2R92D 4A3GD 1V7MV 3DI3A 4LRLA 3Q1SI 4A3ED 1M4BA 1M48A 1RHGA 5FUCA 1HGUA 2O27A 3IRHA 2CYKA 4A3LD 3HOVD 1HZIA 2B8YA 1BUYA 1RFBA 3OG6A 1WCMD 2GMFA 1IJZA 3BPNA 1HWHA 4FA8E 2B5IA 4YDYI 2O6IA 1BGCA 1EERA 1LQSL 4I77Z 3HOUD 5D22A 1D9GA 1V7NV 3NPZA 4YPGC 4DKDA 4NEJA 4EXPA 2ERJD 4PS4A 5C7XA 1FYHA 5L6YC 3LB6B 3HOXD 1Y6KL 4YQXA 1IL6A 1HWGA 2JA6D 3EJJA 2JA5D 1HIKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JA7 D;  3HOW D;  2R92 D;  4A3B D;  4A3G D;  5IP7 D;  2VUM D;  3PO2 D;  4A3E D;  4A3F D;  1Y1V D;  3I4M D;  5FLM D;  5C4X D;  2R7Z D;  5IYC D;  5C44 D;  4A3L D;  3FKI D;  3HOY D;  1Y14 A;  5C3E D;  3HOV D;  3HOZ D;  4BY7 D;  3H0G D;  2JA8 D;  4A3J D;  1WCM D;  3I4N D;  3AYH A;  4A3D D;  4BXX D;  4BBS D;  5IYB D;  4A3M D;  3PO3 D;  2C35 A;  3HOU D;  2B63 D;  4BBR D;  4A3K D;  5IYD D;  4A3I D;  3H3V E;  3HOX D;  4A3C D;  1Y1W D;  4BY1 D;  2JA6 D;  2R93 D;  4A93 D;  5IP9 D;  2JA5 D; 
#chains in the Genus database with same CATH topology
 5KNH I;  3OG4 A;  5IP7 D;  2XUT A;  1Z92 A;  2H24 A;  4TPG A;  4LEP A;  1Y14 A;  4A3J D;  4NI7 A;  1EKU A;  5EQG A;  4DKE A;  3AYH A;  4A3D D;  1VLK A;  2B8X A;  2LMS A;  1AX8 A;  3DGC L;  3PIW A;  3BES L;  4BBR D;  5FHX A;  2Y5Y A;  1AU1 A;  2B8Z A;  2XQB A;  1LKI A;  3LB6 A;  5C3E D;  1LK3 A;  1NBP A;  1RW5 A;  1PW6 A;  4W6V A;  4A3M D;  4ZF7 A;  5EQH A;  5TS9 A;  2C35 A;  1ITM A;  1ETE A;  3VA2 A;  1A7M A;  2B63 D;  5GXB A;  3UF2 A;  5IP9 D;  3G6D A;  1N1F A;  2JA7 D;  4YB9 D;  3G9V B;  4A3F D;  3L5X A;  1HUW A;  3HOY D;  4IU8 A;  1J7V L;  3SE4 B;  1M4A A;  3PO3 D;  3HMX B;  4GBZ A;  2B8U A;  4J4L C;  1KF9 A;  1ITF A;  4GRW A;  4NN7 A;  1BBN A;  3O7Q A;  4A3E D;  1M48 A;  1RHG A;  2CYK A;  3HOV D;  1HZI A;  1RFB A;  3OG6 A;  5C65 A;  2V8N A;  1HWH A;  2O6I A;  1EER A;  1LQS L;  1V7N V;  4A3I D;  4YPG C;  4DKD A;  5C7X A;  1IL6 A;  4D2C A;  3DUH C;  4ZWC A;  1Y1V D;  1CSG A;  5FLM D;  4IU9 A;  1HIJ A;  1Z7C A;  1IK0 A;  1JLI A;  2L3O A;  1BCN A;  1F45 B;  3NCC A;  3MZG A;  2ILK A;  3QT2 C;  5D71 A;  2L3Y A;  3NCE A;  1QVN A;  4TPJ A;  1EVS A;  4ZWB A;  4CNI C;  4UVM A;  5IYC D;  4X51 A;  4OAA A;  1PGR A;  4D2D A;  3QAZ A;  2B91 A;  1CYL A;  5D70 A;  4O9H A;  1Y6M L;  4DOH A;  1PY2 A;  4NN5 A;  1PV6 A;  5A2N A;  4IKY A;  4JR9 A;  4J05 A;  4QIQ A;  2JA8 D;  1P9M B;  2D48 A;  2CFP A;  4BBS D;  4WRL B;  4XNJ A;  4EXN A;  4TPH A;  5D72 A;  3UX9 A;  4LDS A;  5EQI A;  1M4R A;  4A3G D;  3Q1S I;  3IRH A;  1WCM D;  3BPN A;  4U4T A;  4I77 Z;  3HOU D;  1D9G A;  1PV7 A;  4EXP A;  5L6Y C;  4PS4 A;  1FYH A;  3HOX D;  1ITL A;  1GNC A;  2HYM B;  1CD9 A;  2VUM D;  1I1R B;  1PVH B;  3N0P A;  5E4E A;  3D87 A;  1B5L A;  3HOZ D;  2LAG A;  2INT A;  3BPO A;  5D6K A;  3UF5 A;  4BXX D;  5D58 A;  1ITI A;  1GA3 A;  4A93 D;  1M4C A;  3O7P A;  1IAR A;  2O26 A;  3EW3 A;  3HOW D;  3NCF A;  1BGE A;  4ZW9 A;  1M49 A;  4U4V A;  1INR A;  1D9C A;  1M47 A;  1F6F A;  3TGX B;  3DI2 A;  4JRE A;  3N06 A;  4YUE C;  4Q65 A;  1Y1W D;  3I4N D;  2Z3Q A;  1BP3 A;  4NKQ C;  1ALU A;  1BGD A;  2Q98 A;  2OQP A;  2R7Z D;  1FG9 A;  2D9Q A;  4O6K A;  2Z3R A;  4NEM A;  2Q7N B;  3QWR B;  3SE3 B;  3HHC A;  5D28 B;  4A3K D;  1Y6N L;  1ILK A;  1EXZ A;  3INK C;  2KZ1 A;  4RS1 A;  3B5K A;  3DI3 A;  4LRL A;  1M4B A;  4IKX A;  5FUC A;  1HGU A;  2O27 A;  4JA3 A;  4GC0 A;  2B8Y A;  1IJZ A;  2CFQ A;  2B5I A;  4YDY I;  1BGC A;  5D22 A;  2ERJ D;  3LB6 B;  1Y6K L;  1HWG A;  2JA5 D;  3NPZ A;  3WDO A;  4Z5R D;  3I4M D;  3BPL A;  1A22 A;  4ZYR A;  4MHL A;  3UEZ E;  1AXI A;  3D85 C;  1YKB A;  4XNI A;  3L5W I;  4ZS7 A;  2IL6 A;  3QB7 A;  4U4W A;  4BY1 D;  2E9W C;  2PSM A;  5D59 A;  4NI9 A;  4A3B D;  4PYP A;  4GBY A;  1WU3 I;  3H0G D;  1CN4 C;  3OQ3 A;  4NN6 A;  5LQB A;  3PIV A;  5IYB D;  4D2B A;  4A3C D;  3DLQ I;  3HHR A;  4YBQ A;  3S9D A;  1RCB A;  2B90 A;  4APS A;  1PW4 A;  3WCY I;  4DKF A;  3PO2 D;  1SCF A;  4GS7 A;  5C4X D;  5C44 D;  3FKI D;  1CNT 1;  4BY7 D;  2Q14 A;  1EMR A;  1IRL A;  4DKC A;  4IKZ A;  5IYD D;  1HUL A;  2R93 D;  4IKV A;  3QB1 A;  3D48 P;  3NCB A;  2R92 D;  1V7M V;  4OH3 A;  4A3L D;  1BUY A;  2GMF A;  4FA8 E;  4IKW A;  5A2O A;  4NEJ A;  3H3V E;  4YQX A;  2JA6 D;  3EJJ A;  1HIK A; 
#chains in the Genus database with same CATH homology
 5KNH I;  1GNC A;  2HYM B;  3DUH C;  1CD9 A;  3OG4 A;  4A3I D;  4Z5R D;  5IP7 D;  2VUM D;  1I1R B;  1Z92 A;  1Y1V D;  2H24 A;  3I4M D;  1CSG A;  1PVH B;  3N0P A;  3BPL A;  5FLM D;  5E4E A;  1ITI A;  1A22 A;  3D87 A;  4MHL A;  1HIJ A;  1B5L A;  1Y14 A;  1Z7C A;  3HOZ D;  3UEZ E;  2LAG A;  4A3J D;  1AXI A;  2INT A;  4NI7 A;  3BPO A;  1EKU A;  4DKE A;  3D85 C;  1IK0 A;  3AYH A;  3UF5 A;  1VLK A;  2B8X A;  4A3D D;  1JLI A;  1YKB A;  2L3O A;  2LMS A;  1AX8 A;  3DGC L;  3PIW A;  3BES L;  1BCN A;  1F45 B;  3L5W I;  3NCC A;  4BBR D;  1GA3 A;  4ZS7 A;  3MZG A;  2ILK A;  3QT2 C;  2IL6 A;  3QB7 A;  5D71 A;  4BY1 D;  4A93 D;  1M4C A;  2E9W C;  2L3Y A;  1QVN A;  3NCE A;  1IAR A;  1EVS A;  2O26 A;  3EW3 A;  2PSM A;  5FHX A;  3HOW D;  4NI9 A;  4A3B D;  3NCF A;  1BGE A;  4CNI C;  1ITL A;  1AU1 A;  2B8Z A;  2XQB A;  1M49 A;  4BXX D;  1LKI A;  3LB6 A;  5IYC D;  1WU3 I;  5C3E D;  1INR A;  1LK3 A;  1NBP A;  3H0G D;  4X51 A;  1RW5 A;  1CN4 C;  1D9C A;  1M47 A;  3OQ3 A;  3PIV A;  1F6F A;  4NN6 A;  5LQB A;  1PW6 A;  3TGX B;  3DI2 A;  5IYB D;  4A3M D;  1PGR A;  4ZF7 A;  5TS9 A;  3VA2 A;  2C35 A;  1ITM A;  1ETE A;  3N06 A;  4YUE C;  2B63 D;  3H3V E;  1A7M A;  3QAZ A;  4A3C D;  1Y1W D;  2B91 A;  3UF2 A;  3DLQ I;  5IP9 D;  3G6D A;  2Z3Q A;  1BP3 A;  3HHR A;  4NKQ C;  3I4N D;  1CYL A;  5D70 A;  1N1F A;  2JA7 D;  3S9D A;  1RCB A;  2B90 A;  3G9V B;  4O9H A;  3WCY I;  4DKF A;  1Y6M L;  3PO2 D;  4DOH A;  1PY2 A;  4NN5 A;  1ALU A;  1SCF A;  3L5X A;  1BGD A;  4A3F D;  2Q98 A;  4GS7 A;  5C4X D;  1HUW A;  2OQP A;  5C44 D;  1FG9 A;  2R7Z D;  3FKI D;  3HOY D;  1CNT 1;  4BY7 D;  2JA8 D;  1P9M B;  2D48 A;  2D9Q A;  2Q14 A;  4O6K A;  2Z3R A;  1EMR A;  1IRL A;  1J7V L;  4NEM A;  3SE4 B;  2Q7N B;  4BBS D;  4WRL B;  1M4A A;  3QWR B;  3SE3 B;  4DKC A;  3PO3 D;  4EXN A;  3HHC A;  5D28 B;  4A3K D;  5IYD D;  3HMX B;  1HUL A;  5D72 A;  1Y6N L;  1ILK A;  1EXZ A;  3INK C;  2R93 D;  2KZ1 A;  3QB1 A;  4RS1 A;  2B8U A;  4J4L C;  1KF9 A;  3B5K A;  3UX9 A;  1ITF A;  4GRW A;  4NN7 A;  3D48 P;  3NCB A;  1BBN A;  1M4R A;  2R92 D;  4A3G D;  1V7M V;  3DI3 A;  4LRL A;  3Q1S I;  4A3E D;  1M4B A;  1M48 A;  1RHG A;  5FUC A;  1HGU A;  2O27 A;  3IRH A;  2CYK A;  4A3L D;  3HOV D;  1HZI A;  2B8Y A;  1BUY A;  1RFB A;  3OG6 A;  1WCM D;  2GMF A;  1IJZ A;  3BPN A;  1HWH A;  4FA8 E;  2B5I A;  4YDY I;  2O6I A;  1BGC A;  1EER A;  1LQS L;  4I77 Z;  3HOU D;  5D22 A;  1D9G A;  1V7N V;  3NPZ A;  4YPG C;  4DKD A;  4NEJ A;  4EXP A;  2ERJ D;  4PS4 A;  5C7X A;  1FYH A;  5L6Y C;  3LB6 B;  3HOX D;  1Y6K L;  4YQX A;  1IL6 A;  1HWG A;  2JA6 D;  3EJJ A;  2JA5 D;  1HIK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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