2Y5YA

Crystal structure of lacy in complex with an affinity inactivator
Total Genus 121
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
400
structure length
386
Chain Sequence
LKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFSFNAGCPAVEAFIEKVSRRSNFEFGRARMFGAVGWALVASIVGIMFTINNQFVFWLGSGMALILAVLLFFAKANHSAFSLKLALELFRQPKLWFLSLYVIGVSSTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGSFKYITSQFEVRFSATIYLVAFAFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Lactose Permease in Complex with an Affinity Inactivator Yields Unique Insight Into Sugar Recognition.
pubmed doi rcsb
molecule tags Transport protein
source organism Escherichia coli
molecule keywords LACTOSE PERMEASE
total genus 121
structure length 386
sequence length 400
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01306 LacY_symp LacY proton/sugar symporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2y5yA02
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 2y5yA01
2CFPA 2CFQA 3WDOA 4ZYRA 1PV7A 4JA3A 4ZWCA 2Y5YA 1PV6A 5A2OA 4IKYA 4GC0A 4OAAA 4QIQA 4IU9A 5D6KA 4W6VA 4LDSA 5EQHA 4D2DA 2V8NA 4GBZA 4U4WA 4TPHA 4APSA 4U4VA 4OH3A 4ZWBA 4XNJA 5GXBA 1PW4A 5EQIA 4JR9A 5C65A 2XUTA 4IKVA 4TPGA 4U4TA 3O7QA 4IKXA 4J05A 4IKWA 4Q65A 4PYPA 4ZW9A 4D2CA 4IU8A 3O7PA 4XNIA 4D2BA 5A2NA 4IKZA 4TPJA 5EQGA 5D58A 4YBQA 4LEPA 5D59A 4YB9D 4JREA 4GBYA 4UVMA
chains in the Genus database with same CATH superfamily
1ITMA 1M4AA 4A3LD 3DLQI 1PVHB 4RS1A 5C44D 3QAZA 2CYKA 3PO3D 2R93D 2LAGA 4Q65A 5A2NA 1M47A 3QB1A 3SE3B 2OQPA 4YUEC 1WCMD 3BPNA 3H3VE 5C4XD 1PW6A 4OAAA 1Y6ML 1EKUA 3UF5A 1CD9A 2INTA 1BGEA 4YQXA 5IYBD 2Q98A 2XUTA 1D9CA 1NBPA 2B8UA 1KF9A 3D48P 1M49A 1EERA 4EXNA 1F45B 1ITFA 3HOUD 3S9DA 3MZGA 4Z5RD 3BPOA 3HOYD 3DGCL 5C65A 1SCFA 4A3FD 1RFBA 4EXPA 2HYMB 4I77Z 1HIJA 2JA5D 1BP3A 3G9VB 2B90A 1Y6KL 1QVNA 2D48A 2C35A 4DKCA 2B63D 1VLKA 3AYHA 2Q14A 4U4VA 2Q7NB 3PIVA 1IARA 2R92D 3NCBA 4XNJA 3UX9A 4CNIC 4DKEA 1N1FA 4NI9A 5D22A 1IL6A 4MHLA 5C3ED 1CN4C 1LKIA 3QB7A 1IK0A 3D85C 4DKDA 3FKID 1LQSL 2CFPA 3B5KA 4ZWCA 5IYDD 4U4WA 1PGRA 5IP7D 3QWRB 3LB6A 2O26A 2B8ZA 1GNCA 4U4TA 3D87A 1LK3A 3N06A 1HZIA 3BESL 3N0PA 4NKQC 5D6KA 1A22A 4IU9A 1BBNA 1Y1VD 4OH3A 5D70A 5GXBA 3TGXB 4BXXD 1ETEA 3SE4B 1BCNA 1M4BA 1HIKA 2B5IA 3VA2A 5D58A 4A3ID 1FYHA 1A7MA 4UVMA 3OG4A 3HOXD 3DI2A 5IP9D 2GMFA 4ZWBA 1WU3I 1V7NV 2LMSA 3LB6B 1B5LA 3Q1SI 3HHRA 4BY1D 1ITIA 4YPGC 2V8NA 2Z3RA 1JLIA 5D28B 3O7QA 4PYPA 3I4ND 4IKZA 4BY7D 4GRWA 1D9GA 5C7XA 4A3MD 4NN6A 5L6YC 1Y1WD 2XQBA 3QT2C 5FUCA 3L5WI 4LRLA 5EQIA 4PS4A 3IRHA 3EW3A 4TPGA 1IRLA 5D72A 2JA7D 4IKXA 1M4CA 4NN7A 4A3GD 1HGUA 4NI7A 1M4RA 1I1RB 2KZ1A 4ZYRA 1AX8A 4JA3A 4DOHA 4IKYA 3H0GD 4LDSA 5EQHA 3NCFA 4X51A 3NCEA 2Z3QA 3UEZE 5FHXA 1HWHA 3OQ3A 1BGDA 4BBSD 3O7PA 4GS7A 1AU1A 3HHCA 4A3ED 2B8XA 3BPLA 3EJJA 4YDYI 3I4MD 4FA8E 1RHGA 1PV7A 4BBRD 4GC0A 1Y6NL 2VUMD 1RCBA 1CNT1 2D9QA 4A3DD 1HUWA 2PSMA 4A93D 4IKWA 1PY2A 1M48A 3HOVD 4XNIA 1BUYA 1V7MV 2L3OA 1BGCA 2JA6D 4LEPA 1Y14A 1PV6A 1CYLA 1HWGA 3WCYI 2O27A 5FLMD 3HMXB 4WRLB 4DKFA 4YB9D 2L3YA 4JREA 5KNHI 3UF2A 4A3KD 2Y5YA 4QIQA 1J7VL 4TPHA 1ALUA 2R7ZD 2B8YA 5LQBA 4J05A 4D2BA 3DUHC 4TPJA 2E9WC 5EQGA 4YBQA 5IYCD 3WDOA 2CFQA 5A2OA 4D2DA 2O6IA 1CSGA 3PO2D 4NEMA 4ZS7A 5E4EA 1P9MB 1AXIA 1IJZA 3DI3A 1Z92A 1EVSA 2ILKA 2B91A 1Z7CA 3HOWD 5D59A 4D2CA 1RW5A 4GBYA 3NCCA 4W6VA 4GBZA 2H24A 1ITLA 3OG6A 5D71A 3INKC 3HOZD 1FG9A 4IKVA 1ILKA 4ZW9A 4J4LC 2ERJD 1GA3A 3PIWA 4A3CD 4A3JD 2JA8D 2IL6A 4O9HA 1EXZA 4APSA 4NN5A 1F6FA 5TS9A 1HULA 3G6DA 1PW4A 4A3BD 4JR9A 3NPZA 1YKBA 4O6KA 4ZF7A 3L5XA 4IU8A 1EMRA 1INRA 4NEJA
chains in the Genus database with same CATH topology
2CFPA 2CFQA 3WDOA 4ZYRA 1PV7A 4JA3A 4ZWCA 2Y5YA 1PV6A 5A2OA 4IKYA 4GC0A 4OAAA 4QIQA 4IU9A 5D6KA 4W6VA 4LDSA 5EQHA 4D2DA 2V8NA 4GBZA 4U4WA 4TPHA 4APSA 4U4VA 4OH3A 4ZWBA 4XNJA 5GXBA 1PW4A 5EQIA 4JR9A 5C65A 2XUTA 4IKVA 4TPGA 4U4TA 3O7QA 4IKXA 4J05A 4IKWA 4Q65A 4PYPA 4ZW9A 4D2CA 4IU8A 3O7PA 4XNIA 4D2BA 5A2NA 4IKZA 4TPJA 5EQGA 5D58A 4YBQA 4LEPA 5D59A 4YB9D 4JREA 4GBYA 4UVMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2CFP A;  2CFQ A;  3WDO A;  4ZYR A;  1PV7 A;  4JA3 A;  4ZWC A;  2Y5Y A;  1PV6 A;  5A2O A;  4IKY A;  4GC0 A;  4OAA A;  4QIQ A;  4IU9 A;  5D6K A;  4W6V A;  4LDS A;  5EQH A;  4D2D A;  2V8N A;  4GBZ A;  4U4W A;  4TPH A;  4APS A;  4U4V A;  4OH3 A;  4ZWB A;  4XNJ A;  5GXB A;  1PW4 A;  5EQI A;  4JR9 A;  5C65 A;  2XUT A;  4IKV A;  4TPG A;  4U4T A;  3O7Q A;  4IKX A;  4J05 A;  4IKW A;  4Q65 A;  4PYP A;  4ZW9 A;  4D2C A;  4IU8 A;  3O7P A;  4XNI A;  4D2B A;  5A2N A;  4IKZ A;  4TPJ A;  5EQG A;  5D58 A;  4YBQ A;  4LEP A;  5D59 A;  4YB9 D;  4JRE A;  4GBY A;  4UVM A; 
#chains in the Genus database with same CATH topology
 1ITM A;  1M4A A;  4A3L D;  3DLQ I;  1PVH B;  4RS1 A;  5C44 D;  3QAZ A;  2CYK A;  3PO3 D;  2R93 D;  2LAG A;  4Q65 A;  5A2N A;  1M47 A;  3QB1 A;  3SE3 B;  2OQP A;  4YUE C;  1WCM D;  3BPN A;  3H3V E;  5C4X D;  1PW6 A;  4OAA A;  1Y6M L;  1EKU A;  3UF5 A;  1CD9 A;  2INT A;  1BGE A;  4YQX A;  5IYB D;  2Q98 A;  2XUT A;  1D9C A;  1NBP A;  2B8U A;  1KF9 A;  3D48 P;  1M49 A;  1EER A;  4EXN A;  1F45 B;  1ITF A;  3HOU D;  3S9D A;  3MZG A;  4Z5R D;  3BPO A;  3HOY D;  3DGC L;  5C65 A;  1SCF A;  4A3F D;  1RFB A;  4EXP A;  2HYM B;  4I77 Z;  1HIJ A;  2JA5 D;  1BP3 A;  3G9V B;  2B90 A;  1Y6K L;  1QVN A;  2D48 A;  2C35 A;  4DKC A;  2B63 D;  1VLK A;  3AYH A;  2Q14 A;  4U4V A;  2Q7N B;  3PIV A;  1IAR A;  2R92 D;  3NCB A;  4XNJ A;  3UX9 A;  4CNI C;  4DKE A;  1N1F A;  4NI9 A;  5D22 A;  1IL6 A;  4MHL A;  5C3E D;  1CN4 C;  1LKI A;  3QB7 A;  1IK0 A;  3D85 C;  4DKD A;  3FKI D;  1LQS L;  2CFP A;  3B5K A;  4ZWC A;  5IYD D;  4U4W A;  1PGR A;  5IP7 D;  3QWR B;  3LB6 A;  2O26 A;  2B8Z A;  1GNC A;  4U4T A;  3D87 A;  1LK3 A;  3N06 A;  1HZI A;  3BES L;  3N0P A;  4NKQ C;  5D6K A;  1A22 A;  4IU9 A;  1BBN A;  1Y1V D;  4OH3 A;  5D70 A;  5GXB A;  3TGX B;  4BXX D;  1ETE A;  3SE4 B;  1BCN A;  1M4B A;  1HIK A;  2B5I A;  3VA2 A;  5D58 A;  4A3I D;  1FYH A;  1A7M A;  4UVM A;  3OG4 A;  3HOX D;  3DI2 A;  5IP9 D;  2GMF A;  4ZWB A;  1WU3 I;  1V7N V;  2LMS A;  3LB6 B;  1B5L A;  3Q1S I;  3HHR A;  4BY1 D;  1ITI A;  4YPG C;  2V8N A;  2Z3R A;  1JLI A;  5D28 B;  3O7Q A;  4PYP A;  3I4N D;  4IKZ A;  4BY7 D;  4GRW A;  1D9G A;  5C7X A;  4A3M D;  4NN6 A;  5L6Y C;  1Y1W D;  2XQB A;  3QT2 C;  5FUC A;  3L5W I;  4LRL A;  5EQI A;  4PS4 A;  3IRH A;  3EW3 A;  4TPG A;  1IRL A;  5D72 A;  2JA7 D;  4IKX A;  1M4C A;  4NN7 A;  4A3G D;  1HGU A;  4NI7 A;  1M4R A;  1I1R B;  2KZ1 A;  4ZYR A;  1AX8 A;  4JA3 A;  4DOH A;  4IKY A;  3H0G D;  4LDS A;  5EQH A;  3NCF A;  4X51 A;  3NCE A;  2Z3Q A;  3UEZ E;  5FHX A;  1HWH A;  3OQ3 A;  1BGD A;  4BBS D;  3O7P A;  4GS7 A;  1AU1 A;  3HHC A;  4A3E D;  2B8X A;  3BPL A;  3EJJ A;  4YDY I;  3I4M D;  4FA8 E;  1RHG A;  1PV7 A;  4BBR D;  4GC0 A;  1Y6N L;  2VUM D;  1RCB A;  1CNT 1;  2D9Q A;  4A3D D;  1HUW A;  2PSM A;  4A93 D;  4IKW A;  1PY2 A;  1M48 A;  3HOV D;  4XNI A;  1BUY A;  1V7M V;  2L3O A;  1BGC A;  2JA6 D;  4LEP A;  1Y14 A;  1PV6 A;  1CYL A;  1HWG A;  3WCY I;  2O27 A;  5FLM D;  3HMX B;  4WRL B;  4DKF A;  4YB9 D;  2L3Y A;  4JRE A;  5KNH I;  3UF2 A;  4A3K D;  2Y5Y A;  4QIQ A;  1J7V L;  4TPH A;  1ALU A;  2R7Z D;  2B8Y A;  5LQB A;  4J05 A;  4D2B A;  3DUH C;  4TPJ A;  2E9W C;  5EQG A;  4YBQ A;  5IYC D;  3WDO A;  2CFQ A;  5A2O A;  4D2D A;  2O6I A;  1CSG A;  3PO2 D;  4NEM A;  4ZS7 A;  5E4E A;  1P9M B;  1AXI A;  1IJZ A;  3DI3 A;  1Z92 A;  1EVS A;  2ILK A;  2B91 A;  1Z7C A;  3HOW D;  5D59 A;  4D2C A;  1RW5 A;  4GBY A;  3NCC A;  4W6V A;  4GBZ A;  2H24 A;  1ITL A;  3OG6 A;  5D71 A;  3INK C;  3HOZ D;  1FG9 A;  4IKV A;  1ILK A;  4ZW9 A;  4J4L C;  2ERJ D;  1GA3 A;  3PIW A;  4A3C D;  4A3J D;  2JA8 D;  2IL6 A;  4O9H A;  1EXZ A;  4APS A;  4NN5 A;  1F6F A;  5TS9 A;  1HUL A;  3G6D A;  1PW4 A;  4A3B D;  4JR9 A;  3NPZ A;  1YKB A;  4O6K A;  4ZF7 A;  3L5X A;  4IU8 A;  1EMR A;  1INR A;  4NEJ A; 
#chains in the Genus database with same CATH homology
 2CFP A;  2CFQ A;  3WDO A;  4ZYR A;  1PV7 A;  4JA3 A;  4ZWC A;  2Y5Y A;  1PV6 A;  5A2O A;  4IKY A;  4GC0 A;  4OAA A;  4QIQ A;  4IU9 A;  5D6K A;  4W6V A;  4LDS A;  5EQH A;  4D2D A;  2V8N A;  4GBZ A;  4U4W A;  4TPH A;  4APS A;  4U4V A;  4OH3 A;  4ZWB A;  4XNJ A;  5GXB A;  1PW4 A;  5EQI A;  4JR9 A;  5C65 A;  2XUT A;  4IKV A;  4TPG A;  4U4T A;  3O7Q A;  4IKX A;  4J05 A;  4IKW A;  4Q65 A;  4PYP A;  4ZW9 A;  4D2C A;  4IU8 A;  3O7P A;  4XNI A;  4D2B A;  5A2N A;  4IKZ A;  4TPJ A;  5EQG A;  5D58 A;  4YBQ A;  4LEP A;  5D59 A;  4YB9 D;  4JRE A;  4GBY A;  4UVM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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