3HHCA

Interferon-lambda is functionally an interferon but structurally related to the il-10 family
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
163
structure length
153
Chain Sequence
ARGCHIAQFKSLSPQELQAFKRAKDALEESLLLKDCKCRSRLFPRTWDLRQLQVRERPVALEAELALTLKVLEATADTDPALGDVLDQPLHTLHHILSQLRACIQGRLHHWLHRLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cytokine
source organism Homo sapiens
publication title Interferon-{lambda} Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family
pubmed doi rcsb
molecule keywords Interleukin-28B
total genus 57
structure length 153
sequence length 163
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2009-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15177 IL28A Interleukin-28A
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.60 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 3hhcA00
3OG4A 3OG6A 3HHCA
chains in the Genus database with same CATH superfamily
1JLIA 3DLQI 1Z7CA 3D87A 3PO2D 4U4WA 2XUTA 1EVSA 3D48P 4BY1D 5C44D 1ITFA 1PV7A 4EXPA 3BESL 3HOZD 2B8ZA 1HULA 1PGRA 4NN7A 2ILKA 3O7PA 3EJJA 3L5XA 4A3MD 2ERJD 3DI3A 3HMXB 4J4LC 4GBYA 4LRLA 5D28B 1AX8A 5LQBA 2B63D 4JA3A 1RFBA 2LMSA 2D48A 1AXIA 2B91A 1YKBA 4XNJA 3SE4B 4PS4A 1D9GA 3PO3D 3DUHC 2B90A 2R93D 5D70A 5IP9D 4ZW9A 4ZS7A 3NPZA 4Q65A 5D22A 5FLMD 4A3ID 2L3OA 1PVHB 3BPLA 3NCEA 4DOHA 4JR9A 2R7ZD 3IRHA 4YB9D 2VUMD 1IJZA 2V8NA 4A3ED 5C7XA 3LB6A 1ALUA 2HYMB 4A3GD 3NCCA 2O27A 1IL6A 1ITIA 1M47A 1GA3A 2GMFA 1F45B 3UX9A 4ZF7A 1M48A 5IYCD 2OQPA 1RHGA 3N06A 4NKQC 1BP3A 3S9DA 1M4BA 1Y6KL 3D85C 3TGXB 1CSGA 3QB1A 4GBZA 4DKEA 4ZWCA 4YBQA 4IKZA 4GS7A 4TPGA 4UVMA 5EQGA 1M4AA 4GRWA 5GXBA 4IKYA 2L3YA 1BBNA 3QT2C 3NCBA 5D6KA 2PSMA 3G9VB 4IU8A 5EQIA 1WU3I 1BGCA 2Q14A 1KF9A 4YQXA 3Q1SI 2KZ1A 1HWHA 4Z5RD 5IYDD 1M4RA 1PW4A 1EERA 2JA8D 5FUCA 1VLKA 1LQSL 1HWGA 4GC0A 3G6DA 2D9QA 5IYBD 4OAAA 4YPGC 1HIKA 5E4EA 4APSA 4D2CA 1PV6A 4IU9A 1ITLA 1WCMD 4XNIA 4LDSA 1FYHA 4NEMA 2CYKA 1FG9A 2JA5D 3I4ND 4OH3A 1Z92A 3DGCL 4DKFA 1D9CA 4BBRD 3QWRB 1F6FA 1LKIA 3DI2A 1V7NV 4EXNA 3SE3B 4DKCA 1ILKA 4LEPA 1IARA 4A3CD 1EMRA 4IKWA 1V7MV 4QIQA 4JREA 3HOUD 2CFQA 1GNCA 3I4MD 2Y5YA 4NEJA 3PIVA 3BPOA 1LK3A 5A2NA 3HOYD 4A3FD 4A3DD 2O26A 4ZYRA 1BUYA 1IK0A 2JA7D 1RW5A 3HOXD 3OQ3A 4YDYI 5L6YC 4I77Z 4MHLA 1NBPA 4BBSD 3QAZA 5KNHI 3UF2A 1M49A 4D2DA 2E9WC 1SCFA 3INKC 5C3ED 3HHRA 4ZWBA 3QB7A 5IP7D 2C35A 3UEZE 4A3BD 3L5WI 1M4CA 4CNIC 1CN4C 1BCNA 1HUWA 3H0GD 4TPHA 3H3VE 5C65A 3WDOA 1PW6A 2CFPA 1RCBA 3HOWD 1J7VL 4X51A 4NI7A 1PY2A 2Q98A 1ITMA 1CNT1 4A3KD 1A7MA 4O6KA 1BGEA 5D71A 5EQHA 4U4VA 4TPJA 1P9MB 4BY7D 1CD9A 4WRLB 1BGDA 3MZGA 4RS1A 5D58A 1IRLA 4D2BA 1Y1VD 2IL6A 1QVNA 1Y6ML 3PIWA 4J05A 3HOVD 2B8YA 4IKXA 5TS9A 5D72A 2XQBA 1EXZA 4A3JD 5C4XD 4A3LD 1AU1A 4BXXD 1HIJA 3NCFA 1B5LA 1HZIA 2B8XA 3BPNA 1Y1WD 4NN5A 1Y6NL 4IKVA 2B8UA 3OG6A 4A93D 2R92D 4FA8E 4NN6A 1HGUA 4DKDA 3OG4A 1ETEA 4U4TA 2JA6D 1INRA 4PYPA 3AYHA 2INTA 1A22A 2Z3RA 3LB6B 3WCYI 3B5KA 3N0PA 4O9HA 1EKUA 1N1FA 3VA2A 1CYLA 3O7QA 4W6VA 4NI9A 2H24A 2LAGA 5FHXA 2B5IA 3HHCA 1Y14A 3EW3A 3FKID 3UF5A 2O6IA 2Q7NB 2Z3QA 5A2OA 5D59A 1I1RB 4YUEC
chains in the Genus database with same CATH topology
1JLIA 4RS1A 1IRLA 3D85C 3DLQI 1Z7CA 3D87A 3TGXB 4DKCA 1Y1VD 2IL6A 1QVNA 1CSGA 3QB1A 1Y6ML 3PO2D 4DKEA 3PIWA 1EVSA 3D48P 4BY1D 3HOVD 2B8YA 5TS9A 5D72A 5C44D 3HOUD 1ITFA 2XQBA 1EXZA 4GS7A 1GNCA 4A3JD 4EXPA 3BESL 3I4MD 4NEJA 3HOZD 5C4XD 2B8ZA 1HULA 1M4AA 1PGRA 3PIVA 4NN7A 4GRWA 3BPOA 1LK3A 2ILKA 3HOYD 4A3FD 2JA7D 4A3DD 2O26A 3EJJA 1AU1A 3L5XA 4A3LD 4BXXD 1HIJA 3NCFA 4A3MD 2ERJD 2L3YA 1BBNA 3DI3A 1BUYA 3HMXB 4J4LC 3QT2C 1IK0A 4LRLA 3NCBA 5D28B 1AX8A 5LQBA 2B63D 1B5LA 2PSMA 1HZIA 1RFBA 2B8XA 1RW5A 2LMSA 3BPNA 3G9VB 3OQ3A 3HOXD 4NN5A 1Y6NL 1Y1WD 4YDYI 2D48A 4I77Z 5L6YC 1AXIA 1WU3I 2B8UA 2B91A 3OG6A 4MHLA 1NBPA 4BBSD 1YKBA 4A93D 3SE4B 4PS4A 2R92D 4FA8E 1D9GA 3PO3D 3QAZA 4NN6A 3DUHC 2B90A 5KNHI 1BGCA 1HGUA 3UF2A 4DKDA 2R93D 1M49A 5D70A 2Q14A 1KF9A 3OG4A 4YQXA 2E9WC 3Q1SI 5IP9D 2KZ1A 1SCFA 1HWHA 3INKC 1ETEA 4ZS7A 5C3ED 4Z5RD 3NPZA 5D22A 5IYDD 2JA6D 3HHRA 1M4RA 3QB7A 5IP7D 5FLMD 4A3ID 2C35A 1EERA 1INRA 2L3OA 1PVHB 1VLKA 5FUCA 1LQSL 1HWGA 3BPLA 2JA8D 3AYHA 2INTA 3UEZE 4A3BD 3G6DA 3NCEA 3L5WI 1A22A 1M4CA 4CNIC 4DOHA 1CN4C 2R7ZD 2Z3RA 1BCNA 2D9QA 1HUWA 3IRHA 3H0GD 5IYBD 4YPGC 3HOWD 1HIKA 5E4EA 3H3VE 2VUMD 1ITLA 1PW6A 3LB6B 1WCMD 1FYHA 1RCBA 4NEMA 1IJZA 1J7VL 2CYKA 1FG9A 4X51A 4NI7A 3WCYI 2JA5D 1PY2A 2Q98A 1ITMA 3B5KA 3N0PA 4A3ED 3I4ND 1CNT1 1Z92A 4O9HA 4A3KD 1EKUA 5C7XA 3DGCL 1A7MA 1N1FA 3VA2A 1CYLA 4DKFA 3LB6A 4O6KA 1ALUA 2HYMB 1D9CA 4A3GD 1BGEA 3NCCA 4BBRD 2O27A 5D71A 1IL6A 4NI9A 2H24A 1ITIA 1M47A 2LAGA 5FHXA 1GA3A 3QWRB 1F6FA 1LKIA 2B5IA 2GMFA 3HHCA 1F45B 3UX9A 4ZF7A 1M48A 5IYCD 1Y14A 3DI2A 1V7NV 2OQPA 3EW3A 3SE3B 4EXNA 1P9MB 1RHGA 4BY7D 3N06A 3FKID 1CD9A 4NKQC 2O6IA 1ILKA 1BP3A 4WRLB 2Q7NB 1IARA 3UF5A 1BGDA 2Z3QA 3MZGA 3S9DA 1I1RB 4YUEC 1EMRA 4A3CD 1M4BA 1Y6KL 1V7MV
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OG4 A;  3OG6 A;  3HHC A; 
#chains in the Genus database with same CATH topology
 1JLI A;  3DLQ I;  1Z7C A;  3D87 A;  3PO2 D;  4U4W A;  2XUT A;  1EVS A;  3D48 P;  4BY1 D;  5C44 D;  1ITF A;  1PV7 A;  4EXP A;  3BES L;  3HOZ D;  2B8Z A;  1HUL A;  1PGR A;  4NN7 A;  2ILK A;  3O7P A;  3EJJ A;  3L5X A;  4A3M D;  2ERJ D;  3DI3 A;  3HMX B;  4J4L C;  4GBY A;  4LRL A;  5D28 B;  1AX8 A;  5LQB A;  2B63 D;  4JA3 A;  1RFB A;  2LMS A;  2D48 A;  1AXI A;  2B91 A;  1YKB A;  4XNJ A;  3SE4 B;  4PS4 A;  1D9G A;  3PO3 D;  3DUH C;  2B90 A;  2R93 D;  5D70 A;  5IP9 D;  4ZW9 A;  4ZS7 A;  3NPZ A;  4Q65 A;  5D22 A;  5FLM D;  4A3I D;  2L3O A;  1PVH B;  3BPL A;  3NCE A;  4DOH A;  4JR9 A;  2R7Z D;  3IRH A;  4YB9 D;  2VUM D;  1IJZ A;  2V8N A;  4A3E D;  5C7X A;  3LB6 A;  1ALU A;  2HYM B;  4A3G D;  3NCC A;  2O27 A;  1IL6 A;  1ITI A;  1M47 A;  1GA3 A;  2GMF A;  1F45 B;  3UX9 A;  4ZF7 A;  1M48 A;  5IYC D;  2OQP A;  1RHG A;  3N06 A;  4NKQ C;  1BP3 A;  3S9D A;  1M4B A;  1Y6K L;  3D85 C;  3TGX B;  1CSG A;  3QB1 A;  4GBZ A;  4DKE A;  4ZWC A;  4YBQ A;  4IKZ A;  4GS7 A;  4TPG A;  4UVM A;  5EQG A;  1M4A A;  4GRW A;  5GXB A;  4IKY A;  2L3Y A;  1BBN A;  3QT2 C;  3NCB A;  5D6K A;  2PSM A;  3G9V B;  4IU8 A;  5EQI A;  1WU3 I;  1BGC A;  2Q14 A;  1KF9 A;  4YQX A;  3Q1S I;  2KZ1 A;  1HWH A;  4Z5R D;  5IYD D;  1M4R A;  1PW4 A;  1EER A;  2JA8 D;  5FUC A;  1VLK A;  1LQS L;  1HWG A;  4GC0 A;  3G6D A;  2D9Q A;  5IYB D;  4OAA A;  4YPG C;  1HIK A;  5E4E A;  4APS A;  4D2C A;  1PV6 A;  4IU9 A;  1ITL A;  1WCM D;  4XNI A;  4LDS A;  1FYH A;  4NEM A;  2CYK A;  1FG9 A;  2JA5 D;  3I4N D;  4OH3 A;  1Z92 A;  3DGC L;  4DKF A;  1D9C A;  4BBR D;  3QWR B;  1F6F A;  1LKI A;  3DI2 A;  1V7N V;  4EXN A;  3SE3 B;  4DKC A;  1ILK A;  4LEP A;  1IAR A;  4A3C D;  1EMR A;  4IKW A;  1V7M V;  4QIQ A;  4JRE A;  3HOU D;  2CFQ A;  1GNC A;  3I4M D;  2Y5Y A;  4NEJ A;  3PIV A;  3BPO A;  1LK3 A;  5A2N A;  3HOY D;  4A3F D;  4A3D D;  2O26 A;  4ZYR A;  1BUY A;  1IK0 A;  2JA7 D;  1RW5 A;  3HOX D;  3OQ3 A;  4YDY I;  5L6Y C;  4I77 Z;  4MHL A;  1NBP A;  4BBS D;  3QAZ A;  5KNH I;  3UF2 A;  1M49 A;  4D2D A;  2E9W C;  1SCF A;  3INK C;  5C3E D;  3HHR A;  4ZWB A;  3QB7 A;  5IP7 D;  2C35 A;  3UEZ E;  4A3B D;  3L5W I;  1M4C A;  4CNI C;  1CN4 C;  1BCN A;  1HUW A;  3H0G D;  4TPH A;  3H3V E;  5C65 A;  3WDO A;  1PW6 A;  2CFP A;  1RCB A;  3HOW D;  1J7V L;  4X51 A;  4NI7 A;  1PY2 A;  2Q98 A;  1ITM A;  1CNT 1;  4A3K D;  1A7M A;  4O6K A;  1BGE A;  5D71 A;  5EQH A;  4U4V A;  4TPJ A;  1P9M B;  4BY7 D;  1CD9 A;  4WRL B;  1BGD A;  3MZG A;  4RS1 A;  5D58 A;  1IRL A;  4D2B A;  1Y1V D;  2IL6 A;  1QVN A;  1Y6M L;  3PIW A;  4J05 A;  3HOV D;  2B8Y A;  4IKX A;  5TS9 A;  5D72 A;  2XQB A;  1EXZ A;  4A3J D;  5C4X D;  4A3L D;  1AU1 A;  4BXX D;  1HIJ A;  3NCF A;  1B5L A;  1HZI A;  2B8X A;  3BPN A;  1Y1W D;  4NN5 A;  1Y6N L;  4IKV A;  2B8U A;  3OG6 A;  4A93 D;  2R92 D;  4FA8 E;  4NN6 A;  1HGU A;  4DKD A;  3OG4 A;  1ETE A;  4U4T A;  2JA6 D;  1INR A;  4PYP A;  3AYH A;  2INT A;  1A22 A;  2Z3R A;  3LB6 B;  3WCY I;  3B5K A;  3N0P A;  4O9H A;  1EKU A;  1N1F A;  3VA2 A;  1CYL A;  3O7Q A;  4W6V A;  4NI9 A;  2H24 A;  2LAG A;  5FHX A;  2B5I A;  3HHC A;  1Y14 A;  3EW3 A;  3FKI D;  3UF5 A;  2O6I A;  2Q7N B;  2Z3Q A;  5A2O A;  5D59 A;  1I1R B;  4YUE C; 
#chains in the Genus database with same CATH homology
 1JLI A;  4RS1 A;  1IRL A;  3D85 C;  3DLQ I;  1Z7C A;  3D87 A;  3TGX B;  4DKC A;  1Y1V D;  2IL6 A;  1QVN A;  1CSG A;  3QB1 A;  1Y6M L;  3PO2 D;  4DKE A;  3PIW A;  1EVS A;  3D48 P;  4BY1 D;  3HOV D;  2B8Y A;  5TS9 A;  5D72 A;  5C44 D;  3HOU D;  1ITF A;  2XQB A;  1EXZ A;  4GS7 A;  1GNC A;  4A3J D;  4EXP A;  3BES L;  3I4M D;  4NEJ A;  3HOZ D;  5C4X D;  2B8Z A;  1HUL A;  1M4A A;  1PGR A;  3PIV A;  4NN7 A;  4GRW A;  3BPO A;  1LK3 A;  2ILK A;  3HOY D;  4A3F D;  2JA7 D;  4A3D D;  2O26 A;  3EJJ A;  1AU1 A;  3L5X A;  4A3L D;  4BXX D;  1HIJ A;  3NCF A;  4A3M D;  2ERJ D;  2L3Y A;  1BBN A;  3DI3 A;  1BUY A;  3HMX B;  4J4L C;  3QT2 C;  1IK0 A;  4LRL A;  3NCB A;  5D28 B;  1AX8 A;  5LQB A;  2B63 D;  1B5L A;  2PSM A;  1HZI A;  1RFB A;  2B8X A;  1RW5 A;  2LMS A;  3BPN A;  3G9V B;  3OQ3 A;  3HOX D;  4NN5 A;  1Y6N L;  1Y1W D;  4YDY I;  2D48 A;  4I77 Z;  5L6Y C;  1AXI A;  1WU3 I;  2B8U A;  2B91 A;  3OG6 A;  4MHL A;  1NBP A;  4BBS D;  1YKB A;  4A93 D;  3SE4 B;  4PS4 A;  2R92 D;  4FA8 E;  1D9G A;  3PO3 D;  3QAZ A;  4NN6 A;  3DUH C;  2B90 A;  5KNH I;  1BGC A;  1HGU A;  3UF2 A;  4DKD A;  2R93 D;  1M49 A;  5D70 A;  2Q14 A;  1KF9 A;  3OG4 A;  4YQX A;  2E9W C;  3Q1S I;  5IP9 D;  2KZ1 A;  1SCF A;  1HWH A;  3INK C;  1ETE A;  4ZS7 A;  5C3E D;  4Z5R D;  3NPZ A;  5D22 A;  5IYD D;  2JA6 D;  3HHR A;  1M4R A;  3QB7 A;  5IP7 D;  5FLM D;  4A3I D;  2C35 A;  1EER A;  1INR A;  2L3O A;  1PVH B;  1VLK A;  5FUC A;  1LQS L;  1HWG A;  3BPL A;  2JA8 D;  3AYH A;  2INT A;  3UEZ E;  4A3B D;  3G6D A;  3NCE A;  3L5W I;  1A22 A;  1M4C A;  4CNI C;  4DOH A;  1CN4 C;  2R7Z D;  2Z3R A;  1BCN A;  2D9Q A;  1HUW A;  3IRH A;  3H0G D;  5IYB D;  4YPG C;  3HOW D;  1HIK A;  5E4E A;  3H3V E;  2VUM D;  1ITL A;  1PW6 A;  3LB6 B;  1WCM D;  1FYH A;  1RCB A;  4NEM A;  1IJZ A;  1J7V L;  2CYK A;  1FG9 A;  4X51 A;  4NI7 A;  3WCY I;  2JA5 D;  1PY2 A;  2Q98 A;  1ITM A;  3B5K A;  3N0P A;  4A3E D;  3I4N D;  1CNT 1;  1Z92 A;  4O9H A;  4A3K D;  1EKU A;  5C7X A;  3DGC L;  1A7M A;  1N1F A;  3VA2 A;  1CYL A;  4DKF A;  3LB6 A;  4O6K A;  1ALU A;  2HYM B;  1D9C A;  4A3G D;  1BGE A;  3NCC A;  4BBR D;  2O27 A;  5D71 A;  1IL6 A;  4NI9 A;  2H24 A;  1ITI A;  1M47 A;  2LAG A;  5FHX A;  1GA3 A;  3QWR B;  1F6F A;  1LKI A;  2B5I A;  2GMF A;  3HHC A;  1F45 B;  3UX9 A;  4ZF7 A;  1M48 A;  5IYC D;  1Y14 A;  3DI2 A;  1V7N V;  2OQP A;  3EW3 A;  3SE3 B;  4EXN A;  1P9M B;  1RHG A;  4BY7 D;  3N06 A;  3FKI D;  1CD9 A;  4NKQ C;  2O6I A;  1ILK A;  1BP3 A;  4WRL B;  2Q7N B;  1IAR A;  3UF5 A;  1BGD A;  2Z3Q A;  3MZG A;  3S9D A;  1I1R B;  4YUE C;  1EMR A;  4A3C D;  1M4B A;  1Y6K L;  1V7M V; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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