3HOWD

Complete rna polymerase ii elongation complex iii with a t-u mismatch and a frayed rna 3'-uridine
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
219
structure length
178
Chain Sequence
VSTSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIKEALVERRRAFKRSQKKTREKELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQLGSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA.
pubmed doi rcsb
molecule tags Transcription,transferase/dna/rna hybrid
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 42
structure length 178
sequence length 219
ec nomenclature
pdb deposition date 2009-06-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF03874 RNA_pol_Rpb4 RNA polymerase Rpb4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.40 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 3howD02
3H3VE 3HOYD 4A3LD 4A3ED 5C44D 2VUMD 2R7ZD 3PO3D 1Y1WD 3HOXD 5FLMD 1Y1VD 2JA8D 4A3CD 4A3DD 1Y14A 3PO2D 5C4XD 1WCMD 4BY1D 4A3MD 2C35A 4A3KD 4A3FD 2JA5D 3FKID 4A3GD 2R93D 5IYBD 3I4ND 4BBRD 2B63D 5IYDD 2JA6D 5IP7D 4A3ID 3I4MD 4BXXD 4A3JD 3HOZD 4BY7D 5IP9D 4A93D 2R92D 2JA7D 4BBSD 3HOWD 5C3ED 3H0GD 3AYHA 3HOUD 5IYCD 4A3BD 3HOVD
chains in the Genus database with same CATH superfamily
5KNHI 4ZYRA 2L3YA 3DI2A 2VUMD 2B8ZA 3HOXD 3QB7A 3DI3A 1RW5A 1N1FA 5L6YC 3BPOA 2JA6D 1BP3A 4ZWCA 4OH3A 3PIVA 4BBSD 4TPHA 2B63D 3PIWA 4TPJA 1F6FA 1EXZA 2R7ZD 4NEMA 1HIJA 1BGDA 4A3MD 2R93D 1QVNA 1CD9A 4O9HA 4D2DA 4LEPA 1PY2A 3HMXB 4A93D 1PV6A 3NCEA 4PYPA 3HOUD 4JREA 4TPGA 1HUWA 1D9GA 2B5IA 5GXBA 4D2CA 3PO3D 4NI9A 3DUHC 4A3DD 5C4XD 1WCMD 1Y6NL 2D9QA 4D2BA 4YPGC 3HOZD 4BY7D 2B8XA 1Y6ML 2PSMA 3UF2A 3LB6A 4IU8A 1HWHA 5D58A 2O27A 3Q1SI 3PO2D 2INTA 4NEJA 1ITFA 4IU9A 4LRLA 4NKQC 3G6DA 5D22A 4GRWA 5D59A 3NCBA 1WU3I 1HULA 3SE4B 4DKDA 3L5WI 4BY1D 4NN7A 4A3KD 2XQBA 1M4RA 4Q65A 3MZGA 5EQHA 1M49A 1V7NV 5IP9D 2ERJD 3HOYD 2OQPA 4A3CD 1Z7CA 2CYKA 1PVHB 3B5KA 4JR9A 2KZ1A 3WCYI 4A3ID 2ILKA 2Q98A 4A3JD 3BPLA 1M47A 3O7PA 4GS7A 3D87A 4PS4A 3QB1A 4I77Z 3HOWD 3H0GD 1CN4C 1Y6KL 1A22A 3EJJA 3H3VE 1I1RB 1NBPA 5FUCA 1Y1VD 4IKXA 4J4LC 3FKID 4W6VA 3D48P 1PW6A 1YKBA 5EQIA 1AXIA 3BESL 1EERA 3L5XA 3UX9A 2V8NA 1SCFA 2CFPA 5D71A 4X51A 1BBNA 4EXNA 4CNIC 2IL6A 4DKFA 1EKUA 1D9CA 4NI7A 4OAAA 5E4EA 4NN6A 1HIKA 5IYCD 4ZF7A 1GNCA 2B8UA 2B90A 4ZW9A 4GBYA 4ZWBA 3NPZA 4DOHA 3UF5A 2LMSA 2B91A 3INKC 1ITLA 1GA3A 1HWGA 4YB9D 3O7QA 5D6KA 1ITMA 1JLIA 2XUTA 1J7VL 1PV7A 5C7XA 4QIQA 4LDSA 4JA3A 4A3LD 3EW3A 3QAZA 5C65A 2Z3QA 4U4WA 3UEZE 4DKEA 2C35A 4YDYI 3DLQI 4WRLB 1IARA 4A3FD 4FA8E 1AX8A 4BBRD 3N0PA 1IJZA 3OQ3A 5LQBA 3QWRB 1HGUA 4U4VA 4YBQA 1BGCA 2R92D 4ZS7A 5C3ED 2CFQA 2O6IA 3TGXB 2LAGA 5TS9A 5A2NA 1CSGA 1FG9A 4NN5A 1FYHA 3I4ND 1CYLA 3N06A 4Z5RD 4BXXD 3G9VB 2Y5YA 3BPNA 1RHGA 1INRA 3HOVD 1IL6A 2D48A 2JA8D 4RS1A 4J05A 5FHXA 2JA5D 1ALUA 3SE3B 1EMRA 5IYDD 2L3OA 5IP7D 3VA2A 1PGRA 2Q14A 4IKZA 1ETEA 1LKIA 1IK0A 4A3ED 2Q7NB 1RCBA 1Z92A 1V7MV 3OG4A 4YQXA 1HZIA 4A3GD 1M4AA 3HHCA 4EXPA 1M4CA 3S9DA 3NCCA 5D70A 3I4MD 2E9WC 2Z3RA 3WDOA 2JA7D 1BGEA 1VLKA 1A7MA 4A3BD 1M48A 3QT2C 1ITIA 3NCFA 4YUEC 2HYMB 5IYBD 1KF9A 2O26A 3DGCL 4XNJA 2GMFA 4APSA 1PW4A 1M4BA 1BCNA 1RFBA 4MHLA 1ILKA 1IRLA 3LB6B 4U4TA 1P9MB 1AU1A 1F45B 4GC0A 4GBZA 4DKCA 5D28B 1LK3A 5C44D 5EQGA 4O6KA 1Y1WD 5FLMD 2H24A 1Y14A 5D72A 3HHRA 4UVMA 5A2OA 1B5LA 3OG6A 4IKVA 1CNT1 1BUYA 4XNIA 4IKWA 1LQSL 4IKYA 3IRHA 2B8YA 1EVSA 3AYHA 3D85C
chains in the Genus database with same CATH topology
1LKIA 5KNHI 3NCBA 1IK0A 1WU3I 1HULA 2L3YA 3DI2A 4A3ED 2Q7NB 2VUMD 2B8ZA 2B8UA 2B90A 1GNCA 3SE4B 4DKDA 3HOXD 1RCBA 3L5WI 1Z92A 1V7MV 4A3MD 3QB7A 4BY1D 3OG4A 3NPZA 3DI3A 1RW5A 1HZIA 1N1FA 2XQBA 1M4AA 4NN7A 4YQXA 5D22A 4DOHA 4A3KD 4A3GD 2R93D 3UF5A 1M4RA 2B91A 2LMSA 3HHCA 3INKC 4EXPA 1M4CA 3S9DA 5L6YC 1ITLA 3BPOA 2JA6D 1BP3A 1GA3A 1HWGA 3NCCA 5D70A 3I4MD 3MZGA 2E9WC 1M49A 2Z3RA 1V7NV 1ITMA 5IP9D 3PIVA 1JLIA 1J7VL 2JA7D 5C7XA 4BBSD 1BGEA 1VLKA 1A7MA 4A3BD 2ERJD 2B63D 1M48A 3HOYD 3EW3A 3PIWA 3QAZA 4A3LD 1F6FA 1EXZA 2OQPA 2Z3QA 3QT2C 4NEMA 1HIJA 2R7ZD 1ITIA 3NCFA 4A3CD 3UEZE 1BGDA 1Z7CA 2CYKA 4YUEC 1PVHB 4DKEA 2C35A 4YDYI 3DLQI 4WRLB 1IARA 2HYMB 4GRWA 4FA8E 4A3FD 1AX8A 1QVNA 3B5KA 1KF9A 5IYBD 2O26A 3N0PA 4BBRD 3DGCL 1IJZA 3OQ3A 2KZ1A 3WCYI 5LQBA 2GMFA 3QWRB 1CD9A 1HGUA 4A3ID 4O9HA 1BCNA 2ILKA 2Q98A 4A3JD 3BPLA 1M47A 1M4BA 1PY2A 3HMXB 4GS7A 3D87A 1BGCA 4PS4A 2R92D 1RFBA 3QB1A 4I77Z 4MHLA 4A93D 3HOWD 3NCEA 1ILKA 3H0GD 4ZS7A 1CN4C 1Y6KL 5C3ED 3HOUD 1HUWA 1A22A 2O6IA 1IRLA 3TGXB 3EJJA 2LAGA 1D9GA 3H3VE 1I1RB 1NBPA 3LB6B 2B5IA 1P9MB 5FUCA 3PO3D 4NI9A 1Y1VD 3DUHC 4A3DD 5TS9A 4J4LC 1AU1A 1CSGA 1F45B 1FG9A 1WCMD 5C4XD 4NN5A 3FKID 1FYHA 1Y6NL 3I4ND 1CYLA 2D9QA 3D48P 1PW6A 3N06A 4Z5RD 4BXXD 3G9VB 4YPGC 1YKBA 4DKCA 5D28B 3HOZD 1AXIA 3BESL 4BY7D 3BPNA 1LK3A 1EERA 3L5XA 3UX9A 1RHGA 1INRA 2B8XA 1Y6ML 3HOVD 1SCFA 1IL6A 2PSMA 5D71A 3UF2A 5C44D 2D48A 4O6KA 1Y1WD 3LB6A 4X51A 1BBNA 5FLMD 1HWHA 2JA8D 2H24A 4RS1A 1Y14A 2O27A 3Q1SI 4EXNA 3PO2D 2INTA 5D72A 5FHXA 2JA5D 1ALUA 4NEJA 3SE3B 4CNIC 3HHRA 1EMRA 1ITFA 5IYDD 2L3OA 2IL6A 5IP7D 1B5LA 3OG6A 4DKFA 1EKUA 1D9CA 3VA2A 1CNT1 4NI7A 1BUYA 1PGRA 4LRLA 2Q14A 5E4EA 4NKQC 1LQSL 3G6DA 4NN6A 1HIKA 3IRHA 2B8YA 1EVSA 1ETEA 3AYHA 3D85C 5IYCD 4ZF7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3H3V E;  3HOY D;  4A3L D;  4A3E D;  5C44 D;  2VUM D;  2R7Z D;  3PO3 D;  1Y1W D;  3HOX D;  5FLM D;  1Y1V D;  2JA8 D;  4A3C D;  4A3D D;  1Y14 A;  3PO2 D;  5C4X D;  1WCM D;  4BY1 D;  4A3M D;  2C35 A;  4A3K D;  4A3F D;  2JA5 D;  3FKI D;  4A3G D;  2R93 D;  5IYB D;  3I4N D;  4BBR D;  2B63 D;  5IYD D;  2JA6 D;  5IP7 D;  4A3I D;  3I4M D;  4BXX D;  4A3J D;  3HOZ D;  4BY7 D;  5IP9 D;  4A93 D;  2R92 D;  2JA7 D;  4BBS D;  3HOW D;  5C3E D;  3H0G D;  3AYH A;  3HOU D;  5IYC D;  4A3B D;  3HOV D; 
#chains in the Genus database with same CATH topology
 5KNH I;  4ZYR A;  2L3Y A;  3DI2 A;  2VUM D;  2B8Z A;  3HOX D;  3QB7 A;  3DI3 A;  1RW5 A;  1N1F A;  5L6Y C;  3BPO A;  2JA6 D;  1BP3 A;  4ZWC A;  4OH3 A;  3PIV A;  4BBS D;  4TPH A;  2B63 D;  3PIW A;  4TPJ A;  1F6F A;  1EXZ A;  2R7Z D;  4NEM A;  1HIJ A;  1BGD A;  4A3M D;  2R93 D;  1QVN A;  1CD9 A;  4O9H A;  4D2D A;  4LEP A;  1PY2 A;  3HMX B;  4A93 D;  1PV6 A;  3NCE A;  4PYP A;  3HOU D;  4JRE A;  4TPG A;  1HUW A;  1D9G A;  2B5I A;  5GXB A;  4D2C A;  3PO3 D;  4NI9 A;  3DUH C;  4A3D D;  5C4X D;  1WCM D;  1Y6N L;  2D9Q A;  4D2B A;  4YPG C;  3HOZ D;  4BY7 D;  2B8X A;  1Y6M L;  2PSM A;  3UF2 A;  3LB6 A;  4IU8 A;  1HWH A;  5D58 A;  2O27 A;  3Q1S I;  3PO2 D;  2INT A;  4NEJ A;  1ITF A;  4IU9 A;  4LRL A;  4NKQ C;  3G6D A;  5D22 A;  4GRW A;  5D59 A;  3NCB A;  1WU3 I;  1HUL A;  3SE4 B;  4DKD A;  3L5W I;  4BY1 D;  4NN7 A;  4A3K D;  2XQB A;  1M4R A;  4Q65 A;  3MZG A;  5EQH A;  1M49 A;  1V7N V;  5IP9 D;  2ERJ D;  3HOY D;  2OQP A;  4A3C D;  1Z7C A;  2CYK A;  1PVH B;  3B5K A;  4JR9 A;  2KZ1 A;  3WCY I;  4A3I D;  2ILK A;  2Q98 A;  4A3J D;  3BPL A;  1M47 A;  3O7P A;  4GS7 A;  3D87 A;  4PS4 A;  3QB1 A;  4I77 Z;  3HOW D;  3H0G D;  1CN4 C;  1Y6K L;  1A22 A;  3EJJ A;  3H3V E;  1I1R B;  1NBP A;  5FUC A;  1Y1V D;  4IKX A;  4J4L C;  3FKI D;  4W6V A;  3D48 P;  1PW6 A;  1YKB A;  5EQI A;  1AXI A;  3BES L;  1EER A;  3L5X A;  3UX9 A;  2V8N A;  1SCF A;  2CFP A;  5D71 A;  4X51 A;  1BBN A;  4EXN A;  4CNI C;  2IL6 A;  4DKF A;  1EKU A;  1D9C A;  4NI7 A;  4OAA A;  5E4E A;  4NN6 A;  1HIK A;  5IYC D;  4ZF7 A;  1GNC A;  2B8U A;  2B90 A;  4ZW9 A;  4GBY A;  4ZWB A;  3NPZ A;  4DOH A;  3UF5 A;  2LMS A;  2B91 A;  3INK C;  1ITL A;  1GA3 A;  1HWG A;  4YB9 D;  3O7Q A;  5D6K A;  1ITM A;  1JLI A;  2XUT A;  1J7V L;  1PV7 A;  5C7X A;  4QIQ A;  4LDS A;  4JA3 A;  4A3L D;  3EW3 A;  3QAZ A;  5C65 A;  2Z3Q A;  4U4W A;  3UEZ E;  4DKE A;  2C35 A;  4YDY I;  3DLQ I;  4WRL B;  1IAR A;  4A3F D;  4FA8 E;  1AX8 A;  4BBR D;  3N0P A;  1IJZ A;  3OQ3 A;  5LQB A;  3QWR B;  1HGU A;  4U4V A;  4YBQ A;  1BGC A;  2R92 D;  4ZS7 A;  5C3E D;  2CFQ A;  2O6I A;  3TGX B;  2LAG A;  5TS9 A;  5A2N A;  1CSG A;  1FG9 A;  4NN5 A;  1FYH A;  3I4N D;  1CYL A;  3N06 A;  4Z5R D;  4BXX D;  3G9V B;  2Y5Y A;  3BPN A;  1RHG A;  1INR A;  3HOV D;  1IL6 A;  2D48 A;  2JA8 D;  4RS1 A;  4J05 A;  5FHX A;  2JA5 D;  1ALU A;  3SE3 B;  1EMR A;  5IYD D;  2L3O A;  5IP7 D;  3VA2 A;  1PGR A;  2Q14 A;  4IKZ A;  1ETE A;  1LKI A;  1IK0 A;  4A3E D;  2Q7N B;  1RCB A;  1Z92 A;  1V7M V;  3OG4 A;  4YQX A;  1HZI A;  4A3G D;  1M4A A;  3HHC A;  4EXP A;  1M4C A;  3S9D A;  3NCC A;  5D70 A;  3I4M D;  2E9W C;  2Z3R A;  3WDO A;  2JA7 D;  1BGE A;  1VLK A;  1A7M A;  4A3B D;  1M48 A;  3QT2 C;  1ITI A;  3NCF A;  4YUE C;  2HYM B;  5IYB D;  1KF9 A;  2O26 A;  3DGC L;  4XNJ A;  2GMF A;  4APS A;  1PW4 A;  1M4B A;  1BCN A;  1RFB A;  4MHL A;  1ILK A;  1IRL A;  3LB6 B;  4U4T A;  1P9M B;  1AU1 A;  1F45 B;  4GC0 A;  4GBZ A;  4DKC A;  5D28 B;  1LK3 A;  5C44 D;  5EQG A;  4O6K A;  1Y1W D;  5FLM D;  2H24 A;  1Y14 A;  5D72 A;  3HHR A;  4UVM A;  5A2O A;  1B5L A;  3OG6 A;  4IKV A;  1CNT 1;  1BUY A;  4XNI A;  4IKW A;  1LQS L;  4IKY A;  3IRH A;  2B8Y A;  1EVS A;  3AYH A;  3D85 C; 
#chains in the Genus database with same CATH homology
 1LKI A;  5KNH I;  3NCB A;  1IK0 A;  1WU3 I;  1HUL A;  2L3Y A;  3DI2 A;  4A3E D;  2Q7N B;  2VUM D;  2B8Z A;  2B8U A;  2B90 A;  1GNC A;  3SE4 B;  4DKD A;  3HOX D;  1RCB A;  3L5W I;  1Z92 A;  1V7M V;  4A3M D;  3QB7 A;  4BY1 D;  3OG4 A;  3NPZ A;  3DI3 A;  1RW5 A;  1HZI A;  1N1F A;  2XQB A;  1M4A A;  4NN7 A;  4YQX A;  5D22 A;  4DOH A;  4A3K D;  4A3G D;  2R93 D;  3UF5 A;  1M4R A;  2B91 A;  2LMS A;  3HHC A;  3INK C;  4EXP A;  1M4C A;  3S9D A;  5L6Y C;  1ITL A;  3BPO A;  2JA6 D;  1BP3 A;  1GA3 A;  1HWG A;  3NCC A;  5D70 A;  3I4M D;  3MZG A;  2E9W C;  1M49 A;  2Z3R A;  1V7N V;  1ITM A;  5IP9 D;  3PIV A;  1JLI A;  1J7V L;  2JA7 D;  5C7X A;  4BBS D;  1BGE A;  1VLK A;  1A7M A;  4A3B D;  2ERJ D;  2B63 D;  1M48 A;  3HOY D;  3EW3 A;  3PIW A;  3QAZ A;  4A3L D;  1F6F A;  1EXZ A;  2OQP A;  2Z3Q A;  3QT2 C;  4NEM A;  1HIJ A;  2R7Z D;  1ITI A;  3NCF A;  4A3C D;  3UEZ E;  1BGD A;  1Z7C A;  2CYK A;  4YUE C;  1PVH B;  4DKE A;  2C35 A;  4YDY I;  3DLQ I;  4WRL B;  1IAR A;  2HYM B;  4GRW A;  4FA8 E;  4A3F D;  1AX8 A;  1QVN A;  3B5K A;  1KF9 A;  5IYB D;  2O26 A;  3N0P A;  4BBR D;  3DGC L;  1IJZ A;  3OQ3 A;  2KZ1 A;  3WCY I;  5LQB A;  2GMF A;  3QWR B;  1CD9 A;  1HGU A;  4A3I D;  4O9H A;  1BCN A;  2ILK A;  2Q98 A;  4A3J D;  3BPL A;  1M47 A;  1M4B A;  1PY2 A;  3HMX B;  4GS7 A;  3D87 A;  1BGC A;  4PS4 A;  2R92 D;  1RFB A;  3QB1 A;  4I77 Z;  4MHL A;  4A93 D;  3HOW D;  3NCE A;  1ILK A;  3H0G D;  4ZS7 A;  1CN4 C;  1Y6K L;  5C3E D;  3HOU D;  1HUW A;  1A22 A;  2O6I A;  1IRL A;  3TGX B;  3EJJ A;  2LAG A;  1D9G A;  3H3V E;  1I1R B;  1NBP A;  3LB6 B;  2B5I A;  1P9M B;  5FUC A;  3PO3 D;  4NI9 A;  1Y1V D;  3DUH C;  4A3D D;  5TS9 A;  4J4L C;  1AU1 A;  1CSG A;  1F45 B;  1FG9 A;  1WCM D;  5C4X D;  4NN5 A;  3FKI D;  1FYH A;  1Y6N L;  3I4N D;  1CYL A;  2D9Q A;  3D48 P;  1PW6 A;  3N06 A;  4Z5R D;  4BXX D;  3G9V B;  4YPG C;  1YKB A;  4DKC A;  5D28 B;  3HOZ D;  1AXI A;  3BES L;  4BY7 D;  3BPN A;  1LK3 A;  1EER A;  3L5X A;  3UX9 A;  1RHG A;  1INR A;  2B8X A;  1Y6M L;  3HOV D;  1SCF A;  1IL6 A;  2PSM A;  5D71 A;  3UF2 A;  5C44 D;  2D48 A;  4O6K A;  1Y1W D;  3LB6 A;  4X51 A;  1BBN A;  5FLM D;  1HWH A;  2JA8 D;  2H24 A;  4RS1 A;  1Y14 A;  2O27 A;  3Q1S I;  4EXN A;  3PO2 D;  2INT A;  5D72 A;  5FHX A;  2JA5 D;  1ALU A;  4NEJ A;  3SE3 B;  4CNI C;  3HHR A;  1EMR A;  1ITF A;  5IYD D;  2L3O A;  2IL6 A;  5IP7 D;  1B5L A;  3OG6 A;  4DKF A;  1EKU A;  1D9C A;  3VA2 A;  1CNT 1;  4NI7 A;  1BUY A;  1PGR A;  4LRL A;  2Q14 A;  5E4E A;  4NKQ C;  1LQS L;  3G6D A;  4NN6 A;  1HIK A;  3IRH A;  2B8Y A;  1EVS A;  1ETE A;  3AYH A;  3D85 C;  5IYC D;  4ZF7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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