3DI2A

Crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain
Total Genus 35
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
145
structure length
115
Chain Sequence
DGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural and Biophysical Studies of the Human IL-7/IL-7Ralpha Complex.
pubmed doi rcsb
molecule tags Cytokine/cytokine receptor
source organism Homo sapiens
molecule keywords Interleukin-7
total genus 35
structure length 115
sequence length 145
chains with identical sequence C
ec nomenclature
pdb deposition date 2008-06-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01415 IL7 Interleukin 7/9 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.50 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 3di2A00
3DI3A 3DI2A
chains in the Genus database with same CATH superfamily
4FA8E 4TPGA 1HGUA 1F6FA 4DKCA 1ITMA 5D58A 4BBRD 3EW3A 4YUEC 5IP9D 4JREA 1M4CA 4X51A 4APSA 4NKQC 4BY1D 4BY7D 1A22A 1Y1WD 4NN6A 3Q1SI 1RW5A 4PYPA 3UF5A 4A3DD 2V8NA 3HOZD 4BXXD 1KF9A 2LMSA 1WCMD 5D71A 5FLMD 3WCYI 5C65A 3IRHA 1M49A 4JA3A 1AX8A 3OG4A 3HOUD 1AU1A 4GRWA 1HWGA 3OG6A 1LKIA 4A3FD 2LAGA 5IYCD 2R92D 3PIVA 5C4XD 5C7XA 5FHXA 4PS4A 2ILKA 5C44D 3INKC 1FG9A 2B8UA 3PO3D 1PGRA 1NBPA 1F45B 2B8YA 4GS7A 4LEPA 1RHGA 4RS1A 4D2BA 2O6IA 1IJZA 2Z3QA 1CN4C 3SE4B 4A93D 4A3CD 1BP3A 3DGCL 3BESL 3NCFA 2B8ZA 1HIJA 1Y14A 1GNCA 5E4EA 2XQBA 4NI7A 3HMXB 5EQHA 2VUMD 2INTA 2B8XA 4YPGC 4DKDA 3G9VB 5EQGA 4GC0A 2Z3RA 1INRA 2ERJD 1ITIA 1VLKA 4NN5A 4U4VA 3HOYD 3DI3A 4LDSA 4A3MD 4ZF7A 2O26A 1M48A 2B63D 1WU3I 4IKWA 4QIQA 1IRLA 4D2CA 2L3YA 3QAZA 3BPOA 4GBYA 3L5XA 4WRLB 4DKEA 3TGXB 4ZW9A 2XUTA 1Y6KL 1I1RB 4NEJA 1SCFA 4GBZA 4YQXA 3MZGA 5L6YC 3NPZA 4A3LD 1M4AA 3BPLA 5D6KA 1RCBA 1HZIA 4UVMA 4U4WA 1IL6A 2R93D 1HUWA 3D85C 2Q98A 2D48A 2Q14A 4O6KA 2R7ZD 2CYKA 1JLIA 1EERA 2CFQA 4YB9D 5KNHI 3HHCA 4YDYI 5EQIA 4A3ED 3OQ3A 1D9GA 1BGEA 4ZS7A 2B5IA 4J05A 1PW6A 4IU9A 3AYHA 4Z5RD 1HIKA 4NN7A 3UF2A 2OQPA 1V7NV 1BGDA 5C3ED 1Z92A 3EJJA 4NEMA 2PSMA 3D48P 1Y6NL 3L5WI 4IKYA 5IP7D 4A3GD 3DLQI 1EXZA 3BPNA 4NI9A 1LK3A 1V7MV 4TPHA 1EMRA 2IL6A 2CFPA 1IARA 1CSGA 3H0GD 3N06A 4DKFA 5A2OA 2JA8D 5D22A 4Q65A 4EXPA 3G6DA 3NCEA 5TS9A 3PO2D 2B91A 2JA7D 5D59A 3D87A 4XNIA 1BBNA 4ZYRA 1ILKA 4IKVA 3PIWA 5IYBD 4A3BD 2Q7NB 4MHLA 5GXBA 1FYHA 1PV6A 1J7VL 4LRLA 1CNT1 5D70A 4BBSD 3DI2A 3LB6B 2L3OA 1B5LA 1EVSA 3QB1A 1ITLA 1N1FA 3O7PA 3O7QA 5LQBA 1PW4A 4DOHA 3UX9A 1A7MA 1CD9A 2E9WC 3HOWD 4IKZA 3SE3B 4JR9A 2GMFA 4U4TA 1GA3A 5D72A 3DUHC 3I4ND 3S9DA 4OH3A 1D9CA 5IYDD 4D2DA 2H24A 3LB6A 4ZWCA 4EXNA 4A3JD 2KZ1A 1M4BA 3NCBA 4I77Z 4A3ID 1ITFA 2D9QA 1ALUA 2O27A 1BCNA 1QVNA 1AXIA 1Z7CA 4W6VA 3QB7A 3QT2C 3HOVD 3N0PA 3HOXD 3I4MD 1ETEA 1HULA 3UEZE 5D28B 2Y5YA 4IU8A 4O9HA 1LQSL 1PV7A 1BGCA 4A3KD 3NCCA 1PVHB 1Y6ML 1YKBA 2HYMB 1M47A 1IK0A 1HWHA 3H3VE 4OAAA 4XNJA 1BUYA 3VA2A 5FUCA 2JA5D 1CYLA 5A2NA 2JA6D 4YBQA 3QWRB 1PY2A 4ZWBA 2B90A 1RFBA 4IKXA 4J4LC 1P9MB 4CNIC 3WDOA 1Y1VD 2C35A 3FKID 1M4RA 3HHRA 4TPJA 1EKUA 3B5KA
chains in the Genus database with same CATH topology
4FA8E 1HGUA 1F6FA 4DKCA 3AYHA 3HMXB 5D72A 1ITMA 4BBRD 2VUMD 2INTA 4Z5RD 3DUHC 3EW3A 3I4ND 1HIKA 2B8XA 4NN7A 4YUEC 3UF2A 5IP9D 4YPGC 2OQPA 3S9DA 4NI7A 1V7NV 1BGDA 1M4CA 1D9CA 5C3ED 4X51A 1Z92A 3EJJA 4DKDA 5IYDD 4NEMA 2PSMA 2H24A 4NKQC 3LB6A 3D48P 3G9VB 4EXNA 4BY1D 4A3JD 2KZ1A 4BY7D 1Y6NL 2Z3RA 1A22A 1INRA 3L5WI 5IP7D 4A3GD 1M4BA 3DLQI 3NCBA 1EXZA 2ERJD 3BPNA 4I77Z 4A3ID 4NI9A 1ITIA 1LK3A 1V7MV 1ITFA 2D9QA 1EMRA 1ALUA 2O27A 1VLKA 4NN5A 1BCNA 1Y1WD 1QVNA 2IL6A 4NN6A 1AXIA 1Z7CA 3QB7A 3QT2C 3Q1SI 1RW5A 3UF5A 3HOVD 3HOYD 4A3DD 3DI3A 3HOZD 4BXXD 1IARA 1KF9A 2LMSA 1CSGA 1WCMD 3N0PA 5D71A 4ZF7A 3WCYI 3H0GD 5FLMD 2O26A 1M48A 4A3MD 2B63D 1WU3I 3IRHA 3N06A 4DKFA 3HOXD 3I4MD 1ETEA 1M49A 2JA8D 5D22A 1HULA 1IRLA 4EXPA 1AX8A 3G6DA 2L3YA 3NCEA 3QAZA 5TS9A 3UEZE 3PO2D 2B91A 5D28B 3BPOA 2JA7D 3L5XA 3OG4A 3HOUD 4O9HA 1AU1A 4GRWA 1LQSL 3D87A 1HWGA 4WRLB 4DKEA 3TGXB 3OG6A 1LKIA 4A3FD 2LAGA 1BGCA 1Y6KL 5IYCD 1I1RB 3PIVA 1BBNA 4NEJA 4A3KD 2R92D 3NCCA 1SCFA 5C4XD 5C7XA 1PVHB 1Y6ML 4YQXA 5FHXA 3MZGA 5L6YC 4PS4A 2ILKA 3NPZA 4A3LD 1YKBA 2HYMB 1M47A 1ILKA 1M4AA 3BPLA 3PIWA 5IYBD 4A3BD 1IK0A 2Q7NB 4MHLA 1RCBA 1HWHA 3INKC 1HZIA 5C44D 3H3VE 1FG9A 1FYHA 2B8UA 3PO3D 1J7VL 1IL6A 1PGRA 4LRLA 1NBPA 2R93D 1HUWA 1CNT1 3D85C 1BUYA 5D70A 5FUCA 3VA2A 2Q98A 3DI2A 3LB6B 2JA5D 4BBSD 1CYLA 2L3OA 2JA6D 1F45B 2D48A 2B8YA 4GS7A 3QWRB 1B5LA 1EVSA 2Q14A 1PY2A 1RHGA 3QB1A 4RS1A 4O6KA 2R7ZD 1ITLA 2CYKA 1JLIA 2B90A 2O6IA 1RFBA 1IJZA 1N1FA 2Z3QA 4J4LC 1CN4C 1EERA 3SE4B 1P9MB 4DOHA 5LQBA 4CNIC 4A3CD 5KNHI 4A93D 1BP3A 3HHCA 3DGCL 3UX9A 4YDYI 4A3ED 1A7MA 3OQ3A 1Y1VD 3BESL 1CD9A 3NCFA 2C35A 2E9WC 3HOWD 2B8ZA 3FKID 1HIJA 1Y14A 1D9GA 1M4RA 3HHRA 1BGEA 5E4EA 3SE3B 4ZS7A 1GNCA 2XQBA 2GMFA 2B5IA 1PW6A 1EKUA 3B5KA 1GA3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DI3 A;  3DI2 A; 
#chains in the Genus database with same CATH topology
 4FA8 E;  4TPG A;  1HGU A;  1F6F A;  4DKC A;  1ITM A;  5D58 A;  4BBR D;  3EW3 A;  4YUE C;  5IP9 D;  4JRE A;  1M4C A;  4X51 A;  4APS A;  4NKQ C;  4BY1 D;  4BY7 D;  1A22 A;  1Y1W D;  4NN6 A;  3Q1S I;  1RW5 A;  4PYP A;  3UF5 A;  4A3D D;  2V8N A;  3HOZ D;  4BXX D;  1KF9 A;  2LMS A;  1WCM D;  5D71 A;  5FLM D;  3WCY I;  5C65 A;  3IRH A;  1M49 A;  4JA3 A;  1AX8 A;  3OG4 A;  3HOU D;  1AU1 A;  4GRW A;  1HWG A;  3OG6 A;  1LKI A;  4A3F D;  2LAG A;  5IYC D;  2R92 D;  3PIV A;  5C4X D;  5C7X A;  5FHX A;  4PS4 A;  2ILK A;  5C44 D;  3INK C;  1FG9 A;  2B8U A;  3PO3 D;  1PGR A;  1NBP A;  1F45 B;  2B8Y A;  4GS7 A;  4LEP A;  1RHG A;  4RS1 A;  4D2B A;  2O6I A;  1IJZ A;  2Z3Q A;  1CN4 C;  3SE4 B;  4A93 D;  4A3C D;  1BP3 A;  3DGC L;  3BES L;  3NCF A;  2B8Z A;  1HIJ A;  1Y14 A;  1GNC A;  5E4E A;  2XQB A;  4NI7 A;  3HMX B;  5EQH A;  2VUM D;  2INT A;  2B8X A;  4YPG C;  4DKD A;  3G9V B;  5EQG A;  4GC0 A;  2Z3R A;  1INR A;  2ERJ D;  1ITI A;  1VLK A;  4NN5 A;  4U4V A;  3HOY D;  3DI3 A;  4LDS A;  4A3M D;  4ZF7 A;  2O26 A;  1M48 A;  2B63 D;  1WU3 I;  4IKW A;  4QIQ A;  1IRL A;  4D2C A;  2L3Y A;  3QAZ A;  3BPO A;  4GBY A;  3L5X A;  4WRL B;  4DKE A;  3TGX B;  4ZW9 A;  2XUT A;  1Y6K L;  1I1R B;  4NEJ A;  1SCF A;  4GBZ A;  4YQX A;  3MZG A;  5L6Y C;  3NPZ A;  4A3L D;  1M4A A;  3BPL A;  5D6K A;  1RCB A;  1HZI A;  4UVM A;  4U4W A;  1IL6 A;  2R93 D;  1HUW A;  3D85 C;  2Q98 A;  2D48 A;  2Q14 A;  4O6K A;  2R7Z D;  2CYK A;  1JLI A;  1EER A;  2CFQ A;  4YB9 D;  5KNH I;  3HHC A;  4YDY I;  5EQI A;  4A3E D;  3OQ3 A;  1D9G A;  1BGE A;  4ZS7 A;  2B5I A;  4J05 A;  1PW6 A;  4IU9 A;  3AYH A;  4Z5R D;  1HIK A;  4NN7 A;  3UF2 A;  2OQP A;  1V7N V;  1BGD A;  5C3E D;  1Z92 A;  3EJJ A;  4NEM A;  2PSM A;  3D48 P;  1Y6N L;  3L5W I;  4IKY A;  5IP7 D;  4A3G D;  3DLQ I;  1EXZ A;  3BPN A;  4NI9 A;  1LK3 A;  1V7M V;  4TPH A;  1EMR A;  2IL6 A;  2CFP A;  1IAR A;  1CSG A;  3H0G D;  3N06 A;  4DKF A;  5A2O A;  2JA8 D;  5D22 A;  4Q65 A;  4EXP A;  3G6D A;  3NCE A;  5TS9 A;  3PO2 D;  2B91 A;  2JA7 D;  5D59 A;  3D87 A;  4XNI A;  1BBN A;  4ZYR A;  1ILK A;  4IKV A;  3PIW A;  5IYB D;  4A3B D;  2Q7N B;  4MHL A;  5GXB A;  1FYH A;  1PV6 A;  1J7V L;  4LRL A;  1CNT 1;  5D70 A;  4BBS D;  3DI2 A;  3LB6 B;  2L3O A;  1B5L A;  1EVS A;  3QB1 A;  1ITL A;  1N1F A;  3O7P A;  3O7Q A;  5LQB A;  1PW4 A;  4DOH A;  3UX9 A;  1A7M A;  1CD9 A;  2E9W C;  3HOW D;  4IKZ A;  3SE3 B;  4JR9 A;  2GMF A;  4U4T A;  1GA3 A;  5D72 A;  3DUH C;  3I4N D;  3S9D A;  4OH3 A;  1D9C A;  5IYD D;  4D2D A;  2H24 A;  3LB6 A;  4ZWC A;  4EXN A;  4A3J D;  2KZ1 A;  1M4B A;  3NCB A;  4I77 Z;  4A3I D;  1ITF A;  2D9Q A;  1ALU A;  2O27 A;  1BCN A;  1QVN A;  1AXI A;  1Z7C A;  4W6V A;  3QB7 A;  3QT2 C;  3HOV D;  3N0P A;  3HOX D;  3I4M D;  1ETE A;  1HUL A;  3UEZ E;  5D28 B;  2Y5Y A;  4IU8 A;  4O9H A;  1LQS L;  1PV7 A;  1BGC A;  4A3K D;  3NCC A;  1PVH B;  1Y6M L;  1YKB A;  2HYM B;  1M47 A;  1IK0 A;  1HWH A;  3H3V E;  4OAA A;  4XNJ A;  1BUY A;  3VA2 A;  5FUC A;  2JA5 D;  1CYL A;  5A2N A;  2JA6 D;  4YBQ A;  3QWR B;  1PY2 A;  4ZWB A;  2B90 A;  1RFB A;  4IKX A;  4J4L C;  1P9M B;  4CNI C;  3WDO A;  1Y1V D;  2C35 A;  3FKI D;  1M4R A;  3HHR A;  4TPJ A;  1EKU A;  3B5K A; 
#chains in the Genus database with same CATH homology
 4FA8 E;  1HGU A;  1F6F A;  4DKC A;  3AYH A;  3HMX B;  5D72 A;  1ITM A;  4BBR D;  2VUM D;  2INT A;  4Z5R D;  3DUH C;  3EW3 A;  3I4N D;  1HIK A;  2B8X A;  4NN7 A;  4YUE C;  3UF2 A;  5IP9 D;  4YPG C;  2OQP A;  3S9D A;  4NI7 A;  1V7N V;  1BGD A;  1M4C A;  1D9C A;  5C3E D;  4X51 A;  1Z92 A;  3EJJ A;  4DKD A;  5IYD D;  4NEM A;  2PSM A;  2H24 A;  4NKQ C;  3LB6 A;  3D48 P;  3G9V B;  4EXN A;  4BY1 D;  4A3J D;  2KZ1 A;  4BY7 D;  1Y6N L;  2Z3R A;  1A22 A;  1INR A;  3L5W I;  5IP7 D;  4A3G D;  1M4B A;  3DLQ I;  3NCB A;  1EXZ A;  2ERJ D;  3BPN A;  4I77 Z;  4A3I D;  4NI9 A;  1ITI A;  1LK3 A;  1V7M V;  1ITF A;  2D9Q A;  1EMR A;  1ALU A;  2O27 A;  1VLK A;  4NN5 A;  1BCN A;  1Y1W D;  1QVN A;  2IL6 A;  4NN6 A;  1AXI A;  1Z7C A;  3QB7 A;  3QT2 C;  3Q1S I;  1RW5 A;  3UF5 A;  3HOV D;  3HOY D;  4A3D D;  3DI3 A;  3HOZ D;  4BXX D;  1IAR A;  1KF9 A;  2LMS A;  1CSG A;  1WCM D;  3N0P A;  5D71 A;  4ZF7 A;  3WCY I;  3H0G D;  5FLM D;  2O26 A;  1M48 A;  4A3M D;  2B63 D;  1WU3 I;  3IRH A;  3N06 A;  4DKF A;  3HOX D;  3I4M D;  1ETE A;  1M49 A;  2JA8 D;  5D22 A;  1HUL A;  1IRL A;  4EXP A;  1AX8 A;  3G6D A;  2L3Y A;  3NCE A;  3QAZ A;  5TS9 A;  3UEZ E;  3PO2 D;  2B91 A;  5D28 B;  3BPO A;  2JA7 D;  3L5X A;  3OG4 A;  3HOU D;  4O9H A;  1AU1 A;  4GRW A;  1LQS L;  3D87 A;  1HWG A;  4WRL B;  4DKE A;  3TGX B;  3OG6 A;  1LKI A;  4A3F D;  2LAG A;  1BGC A;  1Y6K L;  5IYC D;  1I1R B;  3PIV A;  1BBN A;  4NEJ A;  4A3K D;  2R92 D;  3NCC A;  1SCF A;  5C4X D;  5C7X A;  1PVH B;  1Y6M L;  4YQX A;  5FHX A;  3MZG A;  5L6Y C;  4PS4 A;  2ILK A;  3NPZ A;  4A3L D;  1YKB A;  2HYM B;  1M47 A;  1ILK A;  1M4A A;  3BPL A;  3PIW A;  5IYB D;  4A3B D;  1IK0 A;  2Q7N B;  4MHL A;  1RCB A;  1HWH A;  3INK C;  1HZI A;  5C44 D;  3H3V E;  1FG9 A;  1FYH A;  2B8U A;  3PO3 D;  1J7V L;  1IL6 A;  1PGR A;  4LRL A;  1NBP A;  2R93 D;  1HUW A;  1CNT 1;  3D85 C;  1BUY A;  5D70 A;  5FUC A;  3VA2 A;  2Q98 A;  3DI2 A;  3LB6 B;  2JA5 D;  4BBS D;  1CYL A;  2L3O A;  2JA6 D;  1F45 B;  2D48 A;  2B8Y A;  4GS7 A;  3QWR B;  1B5L A;  1EVS A;  2Q14 A;  1PY2 A;  1RHG A;  3QB1 A;  4RS1 A;  4O6K A;  2R7Z D;  1ITL A;  2CYK A;  1JLI A;  2B90 A;  2O6I A;  1RFB A;  1IJZ A;  1N1F A;  2Z3Q A;  4J4L C;  1CN4 C;  1EER A;  3SE4 B;  1P9M B;  4DOH A;  5LQB A;  4CNI C;  4A3C D;  5KNH I;  4A93 D;  1BP3 A;  3HHC A;  3DGC L;  3UX9 A;  4YDY I;  4A3E D;  1A7M A;  3OQ3 A;  1Y1V D;  3BES L;  1CD9 A;  3NCF A;  2C35 A;  2E9W C;  3HOW D;  2B8Z A;  3FKI D;  1HIJ A;  1Y14 A;  1D9G A;  1M4R A;  3HHR A;  1BGE A;  5E4E A;  3SE3 B;  4ZS7 A;  1GNC A;  2XQB A;  2GMF A;  2B5I A;  1PW6 A;  1EKU A;  3B5K A;  1GA3 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...