3DI3A

Crystal structure of the complex of human interleukin-7 with glycosylated human interleukin-7 receptor alpha ectodomain
Total Genus 33
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
33
sequence length
141
structure length
118
Chain Sequence
KDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQVKGQKKLNDLCFLKRLLQEIKTCWNKILM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Biophysical Studies of the Human IL-7/IL-7Ralpha Complex.
pubmed doi rcsb
molecule tags Cytokine/cytokine receptor
source organism Homo sapiens
molecule keywords Interleukin-7
total genus 33
structure length 118
sequence length 141
ec nomenclature
pdb deposition date 2008-06-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01415 IL7 Interleukin 7/9 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.50 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 3di3A00
3DI2A 3DI3A
chains in the Genus database with same CATH superfamily
4JA3A 4NEJA 4NKQC 4DOHA 5IYDD 3QT2C 1NBPA 3WCYI 1HIJA 3UX9A 4JR9A 4XNIA 4YB9D 1HWGA 1HWHA 4GBYA 5D72A 1M4BA 1ITIA 4J05A 2O27A 1M4RA 1AU1A 1PVHB 5D71A 3S9DA 3D48P 5D59A 1HUWA 2B8XA 4IKWA 1JLIA 1Y14A 4IU8A 3OG6A 1PV7A 3L5XA 1ILKA 4DKDA 5C4XD 4GS7A 3D87A 4UVMA 4A3JD 1A22A 2CFPA 4LEPA 3HMXB 3PO3D 4D2BA 4D2DA 1LQSL 3NCEA 3NCCA 1N1FA 2CYKA 3BPOA 1A7MA 1J7VL 4IKZA 3UF2A 4LDSA 2LAGA 2R93D 4PS4A 1FG9A 1ITMA 3HOUD 1SCFA 3HOVD 2OQPA 1EKUA 1CD9A 1V7MV 4DKCA 3N0PA 3WDOA 3G6DA 2L3OA 1F45B 1CN4C 3O7PA 2VUMD 4IU9A 1M4AA 2CFQA 3I4ND 3QWRB 2Y5YA 1Y6ML 1RW5A 3BPLA 4NN5A 1FYHA 2B90A 5D6KA 4NEMA 3UF5A 4J4LC 5EQIA 3PO2D 4YDYI 2HYMB 3OQ3A 2LMSA 3EW3A 4TPGA 5C7XA 1BGCA 1EVSA 4MHLA 5IYCD 3UEZE 4Q65A 3BESL 2B63D 5D70A 2INTA 4WRLB 1AX8A 4A3MD 4A3FD 2GMFA 1HZIA 2B5IA 1BBNA 2Z3QA 5IP9D 3DI2A 4GBZA 2Q7NB 1PY2A 2XUTA 1AXIA 3SE3B 4IKYA 4NI9A 1EXZA 4DKFA 4BY7D 2PSMA 3OG4A 1YKBA 1RFBA 3N06A 4BXXD 4EXNA 3B5KA 4X51A 1IJZA 4ZYRA 3INKC 4YPGC 3PIVA 4GC0A 3DLQI 5KNHI 4BBRD 2IL6A 3VA2A 3QB1A 1ITFA 3DGCL 5C44D 1HULA 3TGXB 4CNIC 3HOWD 1BGEA 1Y1WD 2B8YA 1KF9A 2O6IA 1CNT1 1IARA 1QVNA 4NN6A 4EXPA 5EQHA 1B5LA 1P9MB 3HHCA 1Y6KL 1RCBA 5C3ED 5L6YC 5A2OA 2Q14A 1BCNA 3DI3A 2L3YA 2C35A 4U4VA 1IL6A 5D28B 5FHXA 3NCFA 3D85C 3QB7A 1RHGA 4A3LD 1I1RB 2B8UA 5GXBA 1F6FA 2D9QA 3I4MD 1Y6NL 4NI7A 3IRHA 2R7ZD 3G9VB 4ZF7A 1VLKA 2JA7D 1LKIA 3NCBA 5IYBD 3BPNA 4TPJA 2R92D 4OH3A 4A3KD 2JA8D 4A3CD 2B8ZA 4IKVA 5A2NA 3LB6A 5TS9A 3NPZA 4I77Z 2B91A 3AYHA 3HOXD 3SE4B 4A3BD 2KZ1A 3O7QA 5FUCA 3HOYD 2JA5D 1V7NV 2ERJD 4APSA 1WCMD 4OAAA 4ZS7A 1LK3A 1D9GA 1PW4A 4O9HA 1IRLA 1WU3I 4TPHA 3DUHC 5C65A 1EMRA 1M4CA 2E9WC 3H0GD 2O26A 4A3DD 1BUYA 1CSGA 1EERA 1M49A 4Z5RD 5EQGA 1Y1VD 1M47A 5D58A 4A3ID 4YBQA 5D22A 5IP7D 4ZWCA 4FA8E 4ZW9A 1ETEA 1IK0A 1BP3A 4O6KA 1Z7CA 1D9CA 4U4WA 1CYLA 2ILKA 4XNJA 2Z3RA 5FLMD 4A3GD 3Q1SI 1PW6A 1PGRA 4IKXA 1Z92A 2V8NA 3QAZA 1PV6A 3HOZD 4GRWA 2XQBA 4YUEC 4NN7A 3FKID 4DKEA 4JREA 4YQXA 4A3ED 4LRLA 1HGUA 3PIWA 3L5WI 1GNCA 1M48A 5E4EA 1ALUA 4U4TA 1GA3A 3EJJA 4BY1D 2H24A 4D2CA 3MZGA 2JA6D 4RS1A 4QIQA 5LQBA 4PYPA 3HHRA 3H3VE 2Q98A 1HIKA 1ITLA 1BGDA 4BBSD 2D48A 4W6VA 4ZWBA 1INRA 4A93D 3LB6B
chains in the Genus database with same CATH topology
1M4AA 4NEJA 4NKQC 4A3DD 4NN6A 1BUYA 4EXPA 1CSGA 4DOHA 1EERA 1M49A 3QWRB 4Z5RD 5IYDD 1B5LA 3QT2C 3I4ND 1NBPA 1P9MB 3HHCA 1Y6ML 3WCYI 1HIJA 1Y1VD 1RW5A 3UX9A 1M47A 3BPLA 4A3ID 1HWGA 1Y6KL 4NN5A 1FYHA 1HWHA 1RCBA 2B90A 1M4BA 5D72A 1ITIA 5D22A 2O27A 1M4RA 4NEMA 5C3ED 3UF5A 5IP7D 4J4LC 1AU1A 1PVHB 5D71A 3S9DA 3PO2D 4YDYI 4FA8E 3D48P 5L6YC 2HYMB 1HUWA 1ETEA 2Q14A 1IK0A 1BP3A 2B8XA 3OQ3A 2LMSA 1BCNA 1JLIA 1Y14A 3DI3A 1Z7CA 2L3YA 3EW3A 3OG6A 1D9CA 4O6KA 1CYLA 5C7XA 2ILKA 1BGCA 1EVSA 2Z3RA 2C35A 4MHLA 5IYCD 3UEZE 5FLMD 3BESL 4A3GD 3Q1SI 2B63D 1IL6A 1PW6A 1PGRA 5D28B 1Z92A 3L5XA 3QAZA 5D70A 3NCFA 2INTA 3D85C 4WRLB 5FHXA 1ILKA 1AX8A 4DKDA 4A3FD 4GS7A 4A3MD 3D87A 5C4XD 2GMFA 3HOZD 3QB7A 1HZIA 1RHGA 1BBNA 2B5IA 4GRWA 4A3JD 1A22A 2Z3QA 5IP9D 4A3LD 2XQBA 4YUEC 1I1RB 4NN7A 3DI2A 2B8UA 3FKID 3HMXB 4DKEA 1F6FA 2D9QA 3I4MD 3PO3D 4YQXA 4A3ED 1Y6NL 2Q7NB 4LRLA 1LQSL 1PY2A 4NI7A 1HGUA 3IRHA 3PIWA 2R7ZD 1AXIA 3SE3B 3L5WI 3G9VB 3NCEA 4ZF7A 1GNCA 1M48A 1VLKA 2JA7D 1LKIA 5E4EA 3NCCA 1N1FA 2CYKA 3NCBA 4NI9A 5IYBD 1EXZA 3BPOA 1ALUA 4DKFA 3BPNA 1GA3A 3EJJA 2R92D 4BY7D 1A7MA 1J7VL 4A3KD 2PSMA 4BY1D 3OG4A 2JA8D 3UF2A 1YKBA 4A3CD 1RFBA 2B8ZA 3N06A 2LAGA 4BXXD 4EXNA 2R93D 3LB6A 5TS9A 4PS4A 3B5KA 2H24A 3NPZA 1FG9A 4X51A 1IJZA 4I77Z 1ITMA 2B91A 3INKC 4YPGC 3AYHA 3MZGA 3PIVA 3HOXD 2JA6D 3SE4B 4A3BD 3HOUD 1SCFA 3DLQI 2KZ1A 5FUCA 5KNHI 4RS1A 3HOYD 4BBRD 3HOVD 2IL6A 2JA5D 1V7NV 2OQPA 3VA2A 3QB1A 1EKUA 5LQBA 2ERJD 1ITFA 3DGCL 1WCMD 1CD9A 5C44D 3HHRA 4ZS7A 3H3VE 2Q98A 1HIKA 1ITLA 1D9GA 1HULA 1LK3A 1BGDA 1V7MV 3TGXB 2D48A 4DKCA 3N0PA 4CNIC 3HOWD 4BBSD 4O9HA 1BGEA 1Y1WD 2B8YA 1IRLA 1WU3I 1KF9A 3G6DA 2O6IA 3DUHC 1CNT1 2L3OA 1IARA 1EMRA 1F45B 1CN4C 1QVNA 1M4CA 1INRA 2E9WC 2VUMD 3H0GD 3LB6B 4A93D 2O26A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DI2 A;  3DI3 A; 
#chains in the Genus database with same CATH topology
 4JA3 A;  4NEJ A;  4NKQ C;  4DOH A;  5IYD D;  3QT2 C;  1NBP A;  3WCY I;  1HIJ A;  3UX9 A;  4JR9 A;  4XNI A;  4YB9 D;  1HWG A;  1HWH A;  4GBY A;  5D72 A;  1M4B A;  1ITI A;  4J05 A;  2O27 A;  1M4R A;  1AU1 A;  1PVH B;  5D71 A;  3S9D A;  3D48 P;  5D59 A;  1HUW A;  2B8X A;  4IKW A;  1JLI A;  1Y14 A;  4IU8 A;  3OG6 A;  1PV7 A;  3L5X A;  1ILK A;  4DKD A;  5C4X D;  4GS7 A;  3D87 A;  4UVM A;  4A3J D;  1A22 A;  2CFP A;  4LEP A;  3HMX B;  3PO3 D;  4D2B A;  4D2D A;  1LQS L;  3NCE A;  3NCC A;  1N1F A;  2CYK A;  3BPO A;  1A7M A;  1J7V L;  4IKZ A;  3UF2 A;  4LDS A;  2LAG A;  2R93 D;  4PS4 A;  1FG9 A;  1ITM A;  3HOU D;  1SCF A;  3HOV D;  2OQP A;  1EKU A;  1CD9 A;  1V7M V;  4DKC A;  3N0P A;  3WDO A;  3G6D A;  2L3O A;  1F45 B;  1CN4 C;  3O7P A;  2VUM D;  4IU9 A;  1M4A A;  2CFQ A;  3I4N D;  3QWR B;  2Y5Y A;  1Y6M L;  1RW5 A;  3BPL A;  4NN5 A;  1FYH A;  2B90 A;  5D6K A;  4NEM A;  3UF5 A;  4J4L C;  5EQI A;  3PO2 D;  4YDY I;  2HYM B;  3OQ3 A;  2LMS A;  3EW3 A;  4TPG A;  5C7X A;  1BGC A;  1EVS A;  4MHL A;  5IYC D;  3UEZ E;  4Q65 A;  3BES L;  2B63 D;  5D70 A;  2INT A;  4WRL B;  1AX8 A;  4A3M D;  4A3F D;  2GMF A;  1HZI A;  2B5I A;  1BBN A;  2Z3Q A;  5IP9 D;  3DI2 A;  4GBZ A;  2Q7N B;  1PY2 A;  2XUT A;  1AXI A;  3SE3 B;  4IKY A;  4NI9 A;  1EXZ A;  4DKF A;  4BY7 D;  2PSM A;  3OG4 A;  1YKB A;  1RFB A;  3N06 A;  4BXX D;  4EXN A;  3B5K A;  4X51 A;  1IJZ A;  4ZYR A;  3INK C;  4YPG C;  3PIV A;  4GC0 A;  3DLQ I;  5KNH I;  4BBR D;  2IL6 A;  3VA2 A;  3QB1 A;  1ITF A;  3DGC L;  5C44 D;  1HUL A;  3TGX B;  4CNI C;  3HOW D;  1BGE A;  1Y1W D;  2B8Y A;  1KF9 A;  2O6I A;  1CNT 1;  1IAR A;  1QVN A;  4NN6 A;  4EXP A;  5EQH A;  1B5L A;  1P9M B;  3HHC A;  1Y6K L;  1RCB A;  5C3E D;  5L6Y C;  5A2O A;  2Q14 A;  1BCN A;  3DI3 A;  2L3Y A;  2C35 A;  4U4V A;  1IL6 A;  5D28 B;  5FHX A;  3NCF A;  3D85 C;  3QB7 A;  1RHG A;  4A3L D;  1I1R B;  2B8U A;  5GXB A;  1F6F A;  2D9Q A;  3I4M D;  1Y6N L;  4NI7 A;  3IRH A;  2R7Z D;  3G9V B;  4ZF7 A;  1VLK A;  2JA7 D;  1LKI A;  3NCB A;  5IYB D;  3BPN A;  4TPJ A;  2R92 D;  4OH3 A;  4A3K D;  2JA8 D;  4A3C D;  2B8Z A;  4IKV A;  5A2N A;  3LB6 A;  5TS9 A;  3NPZ A;  4I77 Z;  2B91 A;  3AYH A;  3HOX D;  3SE4 B;  4A3B D;  2KZ1 A;  3O7Q A;  5FUC A;  3HOY D;  2JA5 D;  1V7N V;  2ERJ D;  4APS A;  1WCM D;  4OAA A;  4ZS7 A;  1LK3 A;  1D9G A;  1PW4 A;  4O9H A;  1IRL A;  1WU3 I;  4TPH A;  3DUH C;  5C65 A;  1EMR A;  1M4C A;  2E9W C;  3H0G D;  2O26 A;  4A3D D;  1BUY A;  1CSG A;  1EER A;  1M49 A;  4Z5R D;  5EQG A;  1Y1V D;  1M47 A;  5D58 A;  4A3I D;  4YBQ A;  5D22 A;  5IP7 D;  4ZWC A;  4FA8 E;  4ZW9 A;  1ETE A;  1IK0 A;  1BP3 A;  4O6K A;  1Z7C A;  1D9C A;  4U4W A;  1CYL A;  2ILK A;  4XNJ A;  2Z3R A;  5FLM D;  4A3G D;  3Q1S I;  1PW6 A;  1PGR A;  4IKX A;  1Z92 A;  2V8N A;  3QAZ A;  1PV6 A;  3HOZ D;  4GRW A;  2XQB A;  4YUE C;  4NN7 A;  3FKI D;  4DKE A;  4JRE A;  4YQX A;  4A3E D;  4LRL A;  1HGU A;  3PIW A;  3L5W I;  1GNC A;  1M48 A;  5E4E A;  1ALU A;  4U4T A;  1GA3 A;  3EJJ A;  4BY1 D;  2H24 A;  4D2C A;  3MZG A;  2JA6 D;  4RS1 A;  4QIQ A;  5LQB A;  4PYP A;  3HHR A;  3H3V E;  2Q98 A;  1HIK A;  1ITL A;  1BGD A;  4BBS D;  2D48 A;  4W6V A;  4ZWB A;  1INR A;  4A93 D;  3LB6 B; 
#chains in the Genus database with same CATH homology
 1M4A A;  4NEJ A;  4NKQ C;  4A3D D;  4NN6 A;  1BUY A;  4EXP A;  1CSG A;  4DOH A;  1EER A;  1M49 A;  3QWR B;  4Z5R D;  5IYD D;  1B5L A;  3QT2 C;  3I4N D;  1NBP A;  1P9M B;  3HHC A;  1Y6M L;  3WCY I;  1HIJ A;  1Y1V D;  1RW5 A;  3UX9 A;  1M47 A;  3BPL A;  4A3I D;  1HWG A;  1Y6K L;  4NN5 A;  1FYH A;  1HWH A;  1RCB A;  2B90 A;  1M4B A;  5D72 A;  1ITI A;  5D22 A;  2O27 A;  1M4R A;  4NEM A;  5C3E D;  3UF5 A;  5IP7 D;  4J4L C;  1AU1 A;  1PVH B;  5D71 A;  3S9D A;  3PO2 D;  4YDY I;  4FA8 E;  3D48 P;  5L6Y C;  2HYM B;  1HUW A;  1ETE A;  2Q14 A;  1IK0 A;  1BP3 A;  2B8X A;  3OQ3 A;  2LMS A;  1BCN A;  1JLI A;  1Y14 A;  3DI3 A;  1Z7C A;  2L3Y A;  3EW3 A;  3OG6 A;  1D9C A;  4O6K A;  1CYL A;  5C7X A;  2ILK A;  1BGC A;  1EVS A;  2Z3R A;  2C35 A;  4MHL A;  5IYC D;  3UEZ E;  5FLM D;  3BES L;  4A3G D;  3Q1S I;  2B63 D;  1IL6 A;  1PW6 A;  1PGR A;  5D28 B;  1Z92 A;  3L5X A;  3QAZ A;  5D70 A;  3NCF A;  2INT A;  3D85 C;  4WRL B;  5FHX A;  1ILK A;  1AX8 A;  4DKD A;  4A3F D;  4GS7 A;  4A3M D;  3D87 A;  5C4X D;  2GMF A;  3HOZ D;  3QB7 A;  1HZI A;  1RHG A;  1BBN A;  2B5I A;  4GRW A;  4A3J D;  1A22 A;  2Z3Q A;  5IP9 D;  4A3L D;  2XQB A;  4YUE C;  1I1R B;  4NN7 A;  3DI2 A;  2B8U A;  3FKI D;  3HMX B;  4DKE A;  1F6F A;  2D9Q A;  3I4M D;  3PO3 D;  4YQX A;  4A3E D;  1Y6N L;  2Q7N B;  4LRL A;  1LQS L;  1PY2 A;  4NI7 A;  1HGU A;  3IRH A;  3PIW A;  2R7Z D;  1AXI A;  3SE3 B;  3L5W I;  3G9V B;  3NCE A;  4ZF7 A;  1GNC A;  1M48 A;  1VLK A;  2JA7 D;  1LKI A;  5E4E A;  3NCC A;  1N1F A;  2CYK A;  3NCB A;  4NI9 A;  5IYB D;  1EXZ A;  3BPO A;  1ALU A;  4DKF A;  3BPN A;  1GA3 A;  3EJJ A;  2R92 D;  4BY7 D;  1A7M A;  1J7V L;  4A3K D;  2PSM A;  4BY1 D;  3OG4 A;  2JA8 D;  3UF2 A;  1YKB A;  4A3C D;  1RFB A;  2B8Z A;  3N06 A;  2LAG A;  4BXX D;  4EXN A;  2R93 D;  3LB6 A;  5TS9 A;  4PS4 A;  3B5K A;  2H24 A;  3NPZ A;  1FG9 A;  4X51 A;  1IJZ A;  4I77 Z;  1ITM A;  2B91 A;  3INK C;  4YPG C;  3AYH A;  3MZG A;  3PIV A;  3HOX D;  2JA6 D;  3SE4 B;  4A3B D;  3HOU D;  1SCF A;  3DLQ I;  2KZ1 A;  5FUC A;  5KNH I;  4RS1 A;  3HOY D;  4BBR D;  3HOV D;  2IL6 A;  2JA5 D;  1V7N V;  2OQP A;  3VA2 A;  3QB1 A;  1EKU A;  5LQB A;  2ERJ D;  1ITF A;  3DGC L;  1WCM D;  1CD9 A;  5C44 D;  3HHR A;  4ZS7 A;  3H3V E;  2Q98 A;  1HIK A;  1ITL A;  1D9G A;  1HUL A;  1LK3 A;  1BGD A;  1V7M V;  3TGX B;  2D48 A;  4DKC A;  3N0P A;  4CNI C;  3HOW D;  4BBS D;  4O9H A;  1BGE A;  1Y1W D;  2B8Y A;  1IRL A;  1WU3 I;  1KF9 A;  3G6D A;  2O6I A;  3DUH C;  1CNT 1;  2L3O A;  1IAR A;  1EMR A;  1F45 B;  1CN4 C;  1QVN A;  1M4C A;  1INR A;  2E9W C;  2VUM D;  3H0G D;  3LB6 B;  4A93 D;  2O26 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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