3HHCA

Interferon-lambda is functionally an interferon but structurally related to the il-10 family
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
163
structure length
153
Chain Sequence
ARGCHIAQFKSLSPQELQAFKRAKDALEESLLLKDCKCRSRLFPRTWDLRQLQVRERPVALEAELALTLKVLEATADTDPALGDVLDQPLHTLHHILSQLRACIQGRLHHWLHRLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Interferon-{lambda} Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family
pubmed doi rcsb
molecule tags Cytokine
source organism Homo sapiens
molecule keywords Interleukin-28B
total genus 57
structure length 153
sequence length 163
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2009-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15177 IL28A Interleukin-28A
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.60 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 3hhcA00
3OG6A 3HHCA 3OG4A
chains in the Genus database with same CATH superfamily
5D70A 4BBSD 1LKIA 1I1RB 4Q65A 1Z92A 3O7QA 3UF5A 4GC0A 5A2OA 1Y1VD 4NKQC 1CYLA 5D72A 1Y14A 4D2CA 5C7XA 1M4CA 1BBNA 4CNIC 1KF9A 2KZ1A 4A3DD 1V7MV 4IKZA 2R93D 1RCBA 4GRWA 3DGCL 1ILKA 3HOZD 4IU9A 4X51A 4DKEA 1BP3A 4IKXA 1AU1A 1IARA 5C44D 4WRLB 4DKCA 3DI3A 2D48A 3HHRA 4PS4A 4U4TA 2C35A 4UVMA 1A7MA 3DI2A 4GS7A 2XQBA 1F45B 1PY2A 4BBRD 3G9VB 2OQPA 5EQGA 4A3CD 2ILKA 1GNCA 3Q1SI 1BUYA 4ZYRA 4A3JD 5C3ED 4DKDA 5IYDD 4W6VA 1EMRA 1HGUA 4GBYA 1ITFA 1BGDA 4IU8A 4A3BD 1BGCA 3EJJA 3NCEA 2R92D 2B8YA 1M48A 1WU3I 5FUCA 4YUEC 4ZWBA 2IL6A 2INTA 2E9WC 2JA8D 4EXPA 5L6YC 4NI9A 1IK0A 3VA2A 3TGXB 4LEPA 1HULA 2D9QA 5EQHA 4NEJA 1BCNA 4A93D 4J4LC 4YB9D 3QT2C 1AX8A 5IYBD 4FA8E 4A3ED 3QAZA 1D9GA 3D48P 3UX9A 4ZWCA 3HOUD 1EXZA 3PIVA 1RFBA 1LQSL 4QIQA 2Z3RA 4MHLA 2LMSA 3I4ND 3BPOA 4ZS7A 1HIJA 4IKVA 4A3FD 1CN4C 5D22A 3SE4B 2VUMD 3HMXB 1ETEA 1Y6ML 3FKID 3IRHA 3WCYI 4U4VA 1YKBA 4EXNA 4YBQA 1AXIA 3NCCA 2JA5D 5TS9A 1D9CA 1LK3A 1N1FA 2Q14A 1VLKA 1IL6A 3O7PA 3OG4A 3HOVD 4YDYI 3S9DA 2HYMB 1CD9A 5D58A 3HHCA 4TPJA 1ALUA 3EW3A 2JA7D 1P9MB 1PW4A 1B5LA 4JREA 3DLQI 4A3KD 1Y1WD 4NN7A 1RHGA 5C65A 3MZGA 4NI7A 4J05A 2Y5YA 3UEZE 5GXBA 5KNHI 2XUTA 4O6KA 3PIWA 4PYPA 5EQIA 1Y6KL 3BPNA 3OG6A 4OH3A 1A22A 2L3YA 3D87A 1EVSA 4BY1D 4GBZA 3NCFA 4ZW9A 1M4BA 1PV6A 4IKYA 2B91A 5LQBA 3OQ3A 2B8ZA 2CYKA 1M47A 4OAAA 3QWRB 1IJZA 2V8NA 3LB6B 1PV7A 4XNIA 5E4EA 2B5IA 5A2NA 4BY7D 4BXXD 3AYHA 1WCMD 1SCFA 3N0PA 4XNJA 3N06A 1IRLA 3LB6A 1HWGA 1ITIA 5C4XD 1EERA 4Z5RD 5FHXA 4LRLA 4A3GD 4LDSA 2B63D 1HZIA 2R7ZD 2ERJD 2O6IA 5D71A 2CFQA 3B5KA 1CNT1 2B8UA 2Q7NB 4NEMA 1JLIA 1QVNA 4TPHA 3QB1A 3QB7A 4A3MD 1HWHA 4U4WA 3BPLA 1HIKA 4A3ID 4ZF7A 4JR9A 4O9HA 1INRA 1RW5A 3NCBA 1GA3A 5FLMD 3HOXD 3WDOA 5IP9D 1CSGA 1ITMA 1HUWA 2H24A 1FG9A 3INKC 4D2DA 3PO2D 3UF2A 3L5XA 5IP7D 1BGEA 4YQXA 3HOWD 1FYHA 1NBPA 4A3LD 4DKFA 1Z7CA 5D28B 1M4RA 3NPZA 2GMFA 3PO3D 1Y6NL 3H0GD 1PGRA 2L3OA 3D85C 4NN6A 4DOHA 2CFPA 3SE3B 4D2BA 2B90A 2JA6D 1ITLA 1PW6A 2LAGA 1J7VL 1M4AA 3L5WI 5D6KA 1M49A 3I4MD 1PVHB 4YPGC 4TPGA 3BESL 2B8XA 2Z3QA 4JA3A 3DUHC 2O26A 4NN5A 1F6FA 3G6DA 3H3VE 2O27A 2PSMA 5IYCD 5D59A 4RS1A 1EKUA 1V7NV 4IKWA 4I77Z 3HOYD 4APSA 2Q98A
chains in the Genus database with same CATH topology
1WU3I 5FUCA 4YUEC 3B5KA 1CNT1 2B8UA 5D70A 2IL6A 2INTA 4NEMA 2Q7NB 1JLIA 1QVNA 4BBSD 1LKIA 2E9WC 1I1RB 2JA8D 3UEZE 4EXPA 3QB1A 1Z92A 5L6YC 3UF5A 4NI9A 3QB7A 4A3MD 1HWHA 1IK0A 3VA2A 3TGXB 1Y1VD 3BPLA 1HIKA 4A3ID 4NKQC 4ZF7A 1CYLA 5D72A 1Y14A 1HULA 5KNHI 2D9QA 4O6KA 3PIWA 5C7XA 1M4CA 1BBNA 4O9HA 4NEJA 1BCNA 4CNIC 4A93D 1KF9A 4J4LC 2KZ1A 3QT2C 1Y6KL 1AX8A 5IYBD 1INRA 4FA8E 3BPNA 1RW5A 3OG6A 4A3ED 3QAZA 3NCBA 4A3DD 1GA3A 1D9GA 1V7MV 5FLMD 3HOXD 2R93D 1RCBA 1A22A 3D48P 3UX9A 5IP9D 3HOUD 1EXZA 1CSGA 2L3YA 1ITMA 3D87A 1RFBA 3PIVA 4GRWA 1EVSA 3DGCL 1LQSL 1HUWA 2Z3RA 4BY1D 1ILKA 4MHLA 3HOZD 2LMSA 4X51A 3I4ND 2H24A 4DKEA 1BP3A 1FG9A 3INKC 3NCFA 3BPOA 1AU1A 3PO2D 1IARA 3UF2A 4ZS7A 3L5XA 5IP7D 5C44D 1BGEA 1HIJA 1M4BA 4YQXA 4A3FD 3HOWD 1FYHA 1CN4C 1NBPA 5D22A 3SE4B 2VUMD 3HMXB 4WRLB 4A3LD 1ETEA 1Y6ML 2B91A 4DKCA 5LQBA 3DI3A 3OQ3A 4DKFA 1Z7CA 2B8ZA 2D48A 3FKID 3HHRA 2CYKA 3IRHA 4PS4A 5D28B 1M4RA 1M47A 3NPZA 2GMFA 3WCYI 2C35A 3PO3D 3QWRB 1A7MA 1IJZA 1YKBA 4EXNA 1Y6NL 3DI2A 3H0GD 3LB6B 4GS7A 1PGRA 2XQBA 1F45B 1PY2A 1AXIA 2L3OA 3D85C 3NCCA 4NN6A 3G9VB 2OQPA 5E4EA 5TS9A 4BBRD 4DOHA 2JA5D 1D9CA 3SE3B 4A3CD 1LK3A 1N1FA 2B5IA 2ILKA 2B90A 2Q14A 2JA6D 1GNCA 4BY7D 1ITLA 3Q1SI 1BUYA 1PW6A 1VLKA 2LAGA 4BXXD 1J7VL 1M4AA 3AYHA 3L5WI 1IL6A 1WCMD 1M49A 3I4MD 1SCFA 1PVHB 3N0PA 4YPGC 3N06A 1IRLA 3OG4A 3BESL 4A3JD 5C3ED 2B8XA 4DKDA 3LB6A 3HOVD 4YDYI 1HWGA 1ITIA 2Z3QA 3DUHC 2O26A 5C4XD 3S9DA 5IYDD 2HYMB 1EERA 4NN5A 1CD9A 1F6FA 4Z5RD 3HHCA 3G6DA 5FHXA 1ALUA 3EW3A 1EMRA 4LRLA 4A3GD 2JA7D 3H3VE 1HGUA 1P9MB 2B63D 1HZIA 2R7ZD 2ERJD 1B5LA 2O27A 2O6IA 2PSMA 1ITFA 3DLQI 5IYCD 1BGDA 4A3BD 1BGCA 4A3KD 3EJJA 3NCEA 2R92D 4RS1A 1EKUA 1V7NV 5D71A 4I77Z 1Y1WD 2B8YA 1M48A 1RHGA 4NN7A 3HOYD 3MZGA 4NI7A 2Q98A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OG6 A;  3HHC A;  3OG4 A; 
#chains in the Genus database with same CATH topology
 5D70 A;  4BBS D;  1LKI A;  1I1R B;  4Q65 A;  1Z92 A;  3O7Q A;  3UF5 A;  4GC0 A;  5A2O A;  1Y1V D;  4NKQ C;  1CYL A;  5D72 A;  1Y14 A;  4D2C A;  5C7X A;  1M4C A;  1BBN A;  4CNI C;  1KF9 A;  2KZ1 A;  4A3D D;  1V7M V;  4IKZ A;  2R93 D;  1RCB A;  4GRW A;  3DGC L;  1ILK A;  3HOZ D;  4IU9 A;  4X51 A;  4DKE A;  1BP3 A;  4IKX A;  1AU1 A;  1IAR A;  5C44 D;  4WRL B;  4DKC A;  3DI3 A;  2D48 A;  3HHR A;  4PS4 A;  4U4T A;  2C35 A;  4UVM A;  1A7M A;  3DI2 A;  4GS7 A;  2XQB A;  1F45 B;  1PY2 A;  4BBR D;  3G9V B;  2OQP A;  5EQG A;  4A3C D;  2ILK A;  1GNC A;  3Q1S I;  1BUY A;  4ZYR A;  4A3J D;  5C3E D;  4DKD A;  5IYD D;  4W6V A;  1EMR A;  1HGU A;  4GBY A;  1ITF A;  1BGD A;  4IU8 A;  4A3B D;  1BGC A;  3EJJ A;  3NCE A;  2R92 D;  2B8Y A;  1M48 A;  1WU3 I;  5FUC A;  4YUE C;  4ZWB A;  2IL6 A;  2INT A;  2E9W C;  2JA8 D;  4EXP A;  5L6Y C;  4NI9 A;  1IK0 A;  3VA2 A;  3TGX B;  4LEP A;  1HUL A;  2D9Q A;  5EQH A;  4NEJ A;  1BCN A;  4A93 D;  4J4L C;  4YB9 D;  3QT2 C;  1AX8 A;  5IYB D;  4FA8 E;  4A3E D;  3QAZ A;  1D9G A;  3D48 P;  3UX9 A;  4ZWC A;  3HOU D;  1EXZ A;  3PIV A;  1RFB A;  1LQS L;  4QIQ A;  2Z3R A;  4MHL A;  2LMS A;  3I4N D;  3BPO A;  4ZS7 A;  1HIJ A;  4IKV A;  4A3F D;  1CN4 C;  5D22 A;  3SE4 B;  2VUM D;  3HMX B;  1ETE A;  1Y6M L;  3FKI D;  3IRH A;  3WCY I;  4U4V A;  1YKB A;  4EXN A;  4YBQ A;  1AXI A;  3NCC A;  2JA5 D;  5TS9 A;  1D9C A;  1LK3 A;  1N1F A;  2Q14 A;  1VLK A;  1IL6 A;  3O7P A;  3OG4 A;  3HOV D;  4YDY I;  3S9D A;  2HYM B;  1CD9 A;  5D58 A;  3HHC A;  4TPJ A;  1ALU A;  3EW3 A;  2JA7 D;  1P9M B;  1PW4 A;  1B5L A;  4JRE A;  3DLQ I;  4A3K D;  1Y1W D;  4NN7 A;  1RHG A;  5C65 A;  3MZG A;  4NI7 A;  4J05 A;  2Y5Y A;  3UEZ E;  5GXB A;  5KNH I;  2XUT A;  4O6K A;  3PIW A;  4PYP A;  5EQI A;  1Y6K L;  3BPN A;  3OG6 A;  4OH3 A;  1A22 A;  2L3Y A;  3D87 A;  1EVS A;  4BY1 D;  4GBZ A;  3NCF A;  4ZW9 A;  1M4B A;  1PV6 A;  4IKY A;  2B91 A;  5LQB A;  3OQ3 A;  2B8Z A;  2CYK A;  1M47 A;  4OAA A;  3QWR B;  1IJZ A;  2V8N A;  3LB6 B;  1PV7 A;  4XNI A;  5E4E A;  2B5I A;  5A2N A;  4BY7 D;  4BXX D;  3AYH A;  1WCM D;  1SCF A;  3N0P A;  4XNJ A;  3N06 A;  1IRL A;  3LB6 A;  1HWG A;  1ITI A;  5C4X D;  1EER A;  4Z5R D;  5FHX A;  4LRL A;  4A3G D;  4LDS A;  2B63 D;  1HZI A;  2R7Z D;  2ERJ D;  2O6I A;  5D71 A;  2CFQ A;  3B5K A;  1CNT 1;  2B8U A;  2Q7N B;  4NEM A;  1JLI A;  1QVN A;  4TPH A;  3QB1 A;  3QB7 A;  4A3M D;  1HWH A;  4U4W A;  3BPL A;  1HIK A;  4A3I D;  4ZF7 A;  4JR9 A;  4O9H A;  1INR A;  1RW5 A;  3NCB A;  1GA3 A;  5FLM D;  3HOX D;  3WDO A;  5IP9 D;  1CSG A;  1ITM A;  1HUW A;  2H24 A;  1FG9 A;  3INK C;  4D2D A;  3PO2 D;  3UF2 A;  3L5X A;  5IP7 D;  1BGE A;  4YQX A;  3HOW D;  1FYH A;  1NBP A;  4A3L D;  4DKF A;  1Z7C A;  5D28 B;  1M4R A;  3NPZ A;  2GMF A;  3PO3 D;  1Y6N L;  3H0G D;  1PGR A;  2L3O A;  3D85 C;  4NN6 A;  4DOH A;  2CFP A;  3SE3 B;  4D2B A;  2B90 A;  2JA6 D;  1ITL A;  1PW6 A;  2LAG A;  1J7V L;  1M4A A;  3L5W I;  5D6K A;  1M49 A;  3I4M D;  1PVH B;  4YPG C;  4TPG A;  3BES L;  2B8X A;  2Z3Q A;  4JA3 A;  3DUH C;  2O26 A;  4NN5 A;  1F6F A;  3G6D A;  3H3V E;  2O27 A;  2PSM A;  5IYC D;  5D59 A;  4RS1 A;  1EKU A;  1V7N V;  4IKW A;  4I77 Z;  3HOY D;  4APS A;  2Q98 A; 
#chains in the Genus database with same CATH homology
 1WU3 I;  5FUC A;  4YUE C;  3B5K A;  1CNT 1;  2B8U A;  5D70 A;  2IL6 A;  2INT A;  4NEM A;  2Q7N B;  1JLI A;  1QVN A;  4BBS D;  1LKI A;  2E9W C;  1I1R B;  2JA8 D;  3UEZ E;  4EXP A;  3QB1 A;  1Z92 A;  5L6Y C;  3UF5 A;  4NI9 A;  3QB7 A;  4A3M D;  1HWH A;  1IK0 A;  3VA2 A;  3TGX B;  1Y1V D;  3BPL A;  1HIK A;  4A3I D;  4NKQ C;  4ZF7 A;  1CYL A;  5D72 A;  1Y14 A;  1HUL A;  5KNH I;  2D9Q A;  4O6K A;  3PIW A;  5C7X A;  1M4C A;  1BBN A;  4O9H A;  4NEJ A;  1BCN A;  4CNI C;  4A93 D;  1KF9 A;  4J4L C;  2KZ1 A;  3QT2 C;  1Y6K L;  1AX8 A;  5IYB D;  1INR A;  4FA8 E;  3BPN A;  1RW5 A;  3OG6 A;  4A3E D;  3QAZ A;  3NCB A;  4A3D D;  1GA3 A;  1D9G A;  1V7M V;  5FLM D;  3HOX D;  2R93 D;  1RCB A;  1A22 A;  3D48 P;  3UX9 A;  5IP9 D;  3HOU D;  1EXZ A;  1CSG A;  2L3Y A;  1ITM A;  3D87 A;  1RFB A;  3PIV A;  4GRW A;  1EVS A;  3DGC L;  1LQS L;  1HUW A;  2Z3R A;  4BY1 D;  1ILK A;  4MHL A;  3HOZ D;  2LMS A;  4X51 A;  3I4N D;  2H24 A;  4DKE A;  1BP3 A;  1FG9 A;  3INK C;  3NCF A;  3BPO A;  1AU1 A;  3PO2 D;  1IAR A;  3UF2 A;  4ZS7 A;  3L5X A;  5IP7 D;  5C44 D;  1BGE A;  1HIJ A;  1M4B A;  4YQX A;  4A3F D;  3HOW D;  1FYH A;  1CN4 C;  1NBP A;  5D22 A;  3SE4 B;  2VUM D;  3HMX B;  4WRL B;  4A3L D;  1ETE A;  1Y6M L;  2B91 A;  4DKC A;  5LQB A;  3DI3 A;  3OQ3 A;  4DKF A;  1Z7C A;  2B8Z A;  2D48 A;  3FKI D;  3HHR A;  2CYK A;  3IRH A;  4PS4 A;  5D28 B;  1M4R A;  1M47 A;  3NPZ A;  2GMF A;  3WCY I;  2C35 A;  3PO3 D;  3QWR B;  1A7M A;  1IJZ A;  1YKB A;  4EXN A;  1Y6N L;  3DI2 A;  3H0G D;  3LB6 B;  4GS7 A;  1PGR A;  2XQB A;  1F45 B;  1PY2 A;  1AXI A;  2L3O A;  3D85 C;  3NCC A;  4NN6 A;  3G9V B;  2OQP A;  5E4E A;  5TS9 A;  4BBR D;  4DOH A;  2JA5 D;  1D9C A;  3SE3 B;  4A3C D;  1LK3 A;  1N1F A;  2B5I A;  2ILK A;  2B90 A;  2Q14 A;  2JA6 D;  1GNC A;  4BY7 D;  1ITL A;  3Q1S I;  1BUY A;  1PW6 A;  1VLK A;  2LAG A;  4BXX D;  1J7V L;  1M4A A;  3AYH A;  3L5W I;  1IL6 A;  1WCM D;  1M49 A;  3I4M D;  1SCF A;  1PVH B;  3N0P A;  4YPG C;  3N06 A;  1IRL A;  3OG4 A;  3BES L;  4A3J D;  5C3E D;  2B8X A;  4DKD A;  3LB6 A;  3HOV D;  4YDY I;  1HWG A;  1ITI A;  2Z3Q A;  3DUH C;  2O26 A;  5C4X D;  3S9D A;  5IYD D;  2HYM B;  1EER A;  4NN5 A;  1CD9 A;  1F6F A;  4Z5R D;  3HHC A;  3G6D A;  5FHX A;  1ALU A;  3EW3 A;  1EMR A;  4LRL A;  4A3G D;  2JA7 D;  3H3V E;  1HGU A;  1P9M B;  2B63 D;  1HZI A;  2R7Z D;  2ERJ D;  1B5L A;  2O27 A;  2O6I A;  2PSM A;  1ITF A;  3DLQ I;  5IYC D;  1BGD A;  4A3B D;  1BGC A;  4A3K D;  3EJJ A;  3NCE A;  2R92 D;  4RS1 A;  1EKU A;  1V7N V;  5D71 A;  4I77 Z;  1Y1W D;  2B8Y A;  1M48 A;  1RHG A;  4NN7 A;  3HOY D;  3MZG A;  4NI7 A;  2Q98 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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