4NN5A

Cytokine receptor complex - crystal form 1a
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
121
structure length
109
Chain Sequence
YNFSNCNFTSITKIYCNIIFHDLTGDLKGAKFEQIEDCESKPACLLKIEYYTLNPIPGCPSLPDKTFARRTREALNDHCPGYPQEVQNICLQQTSQILRLWYSFMQSPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of the proinflammatory signaling complex mediated by TSLP.
pubmed doi rcsb
molecule tags Cytokine/cytokine receptor
source organism Mus musculus
molecule keywords Thymic stromal lymphopoietin
total genus 45
structure length 109
sequence length 121
ec nomenclature
pdb deposition date 2013-11-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15216 TSLP Thymic stromal lymphopoietin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.90 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 4nn5A00
4NN5A 4NN7A 4NN6A
chains in the Genus database with same CATH superfamily
4A3ID 4BBSD 3D48P 5IP7D 1EERA 5FUCA 3DUHC 3LB6A 4IU8A 4BY7D 5D70A 1EVSA 1CSGA 2GMFA 3OQ3A 4EXNA 1IRLA 1CYLA 2D48A 3BESL 1EMRA 2Z3QA 3QB1A 4XNJA 1LK3A 1N1FA 2Q14A 2Z3RA 2C35A 2ILKA 4A3GD 2ERJD 3DI2A 2XQBA 4QIQA 3D85C 3I4MD 1JLIA 1PW6A 1BGDA 2B8UA 1PGRA 4A3LD 1HULA 3UF5A 3UF2A 2CFQA 2XUTA 4A3JD 4W6VA 4A3KD 3OG4A 4A3CD 3PIWA 4XNIA 4ZS7A 1IK0A 5C44D 3UEZE 3O7QA 1LKIA 1PW4A 1BCNA 4OAAA 4I77Z 4D2CA 2B8XA 5C7XA 3EJJA 2Q98A 3L5XA 4A3BD 2LAGA 1M4BA 4ZWCA 3H3VE 1HZIA 4YUEC 1WCMD 3HOYD 4IU9A 1V7MV 3QB7A 4ZF7A 1ITMA 3WCYI 5KNHI 4D2BA 4PS4A 1PV6A 3MZGA 4LRLA 4ZWBA 4NN6A 1QVNA 1BGEA 3QT2C 4IKYA 1ITIA 3SE3B 4O9HA 1IJZA 2L3YA 3L5WI 4U4TA 1I1RB 3NPZA 3TGXB 4YDYI 1PVHB 4NKQC 1D9CA 1A7MA 4A3DD 1FG9A 1IARA 5TS9A 1HWHA 3DLQI 1M47A 2O27A 1M4AA 1FYHA 2JA5D 1M49A 2LMSA 1A22A 3BPNA 5EQHA 4DOHA 4APSA 4GS7A 1BBNA 4UVMA 1F6FA 4WRLB 1VLKA 2JA8D 4EXPA 5FHXA 1P9MB 4IKXA 1D9GA 1Y6ML 4FA8E 1CNT1 4Q65A 2O6IA 4O6KA 4NN5A 4GRWA 2PSMA 1SCFA 3HMXB 4IKWA 5D59A 4TPHA 1B5LA 1F45B 4A3MD 2H24A 4NEMA 1ITFA 1HIJA 1PV7A 1RHGA 4DKEA 4RS1A 3B5KA 2R92D 4A93D 1ILKA 1IL6A 1CD9A 4YPGC 4ZW9A 2R7ZD 3O7PA 3NCFA 3H0GD 5IYCD 3IRHA 5D28B 4BBRD 1Z7CA 2Q7NB 1Y1VD 2Y5YA 3HHRA 4MHLA 2CYKA 5C4XD 3LB6B 1BP3A 3PIVA 4TPJA 4IKVA 2CFPA 1BUYA 1GNCA 1HWGA 3OG6A 5IYBD 1HIKA 1ALUA 4J4LC 1Y14A 1GA3A 3VA2A 4U4WA 1M48A 4IKZA 3NCBA 4BY1D 1NBPA 1WU3I 4J05A 3QAZA 3DI3A 2B8ZA 3NCEA 1HGUA 1RW5A 4OH3A 1Y1WD 1LQSL 2D9QA 2INTA 5D58A 2B5IA 2JA7D 1YKBA 5GXBA 4CNIC 4TPGA 1KF9A 5IYDD 1ETEA 1EXZA 1M4RA 1AX8A 4GBZA 3N0PA 1AU1A 1Y6KL 5IP9D 3DGCL 5D72A 3HOVD 5A2OA 2B91A 2V8NA 2R93D 2O26A 1RFBA 2OQPA 3I4ND 2HYMB 3HOZD 2JA6D 4JREA 4DKCA 4GBYA 3INKC 4NEJA 1M4CA 4NN7A 4D2DA 4DKDA 2L3OA 5D71A 5EQGA 1EKUA 4NI9A 3N06A 5A2NA 4JA3A 5EQIA 4PYPA 4YB9D 4DKFA 3UX9A 3HOWD 4ZYRA 3WDOA 5D22A 4X51A 2B90A 2IL6A 2B63D 1V7NV 3BPLA 3HHCA 3SE4B 1Y6NL 5C3ED 2E9WC 4U4VA 1RCBA 1INRA 3PO3D 1AXIA 2VUMD 1HUWA 3D87A 2B8YA 1Z92A 2KZ1A 4NI7A 5FLMD 3QWRB 5L6YC 5C65A 3G6DA 3HOXD 1BGCA 3G9VB 4YQXA 1PY2A 1J7VL 3PO2D 4GC0A 3FKID 5LQBA 4YBQA 4LEPA 3BPOA 3Q1SI 3EW3A 5E4EA 5D6KA 3NCCA 4A3ED 4Z5RD 4A3FD 4LDSA 3AYHA 3S9DA 4JR9A 1CN4C 4BXXD 1ITLA 3HOUD
chains in the Genus database with same CATH topology
3HHRA 1ITIA 3SE3B 4O9HA 1IJZA 4MHLA 4DKDA 4A3ID 2CYKA 2L3YA 5C4XD 2L3OA 3LB6B 5D71A 4BBSD 3L5WI 1EKUA 1BP3A 4NI9A 1I1RB 3NPZA 3TGXB 4YDYI 3D48P 3PIVA 5IP7D 1EERA 3N06A 5FUCA 1PVHB 3DUHC 1D9CA 3LB6A 4NKQC 4BY7D 5D70A 1EVSA 1CSGA 1A7MA 4A3DD 1FG9A 2GMFA 3OQ3A 1IARA 4DKFA 3UX9A 4EXNA 5TS9A 3HOWD 1IRLA 1CYLA 2D48A 1HWHA 1BUYA 3DLQI 1M47A 5D22A 2O27A 4X51A 1GNCA 3BESL 1EMRA 1M4AA 1HWGA 2B90A 2Z3QA 3OG6A 3QB1A 1LK3A 1N1FA 2IL6A 2Q14A 2B63D 2Z3RA 1FYHA 2C35A 1V7NV 2ILKA 2JA5D 1M49A 5IYBD 2LMSA 1HIKA 2ERJD 4A3GD 3DI2A 2XQBA 1A22A 3BPNA 3D85C 3BPLA 4DOHA 1ALUA 4J4LC 3I4MD 3HHCA 1Y14A 1JLIA 3SE4B 1PW6A 1BGDA 4GS7A 1GA3A 1BBNA 1Y6NL 3VA2A 2B8UA 1PGRA 4A3LD 1HULA 1M48A 3UF5A 3NCBA 3UF2A 4BY1D 1NBPA 1WU3I 5C3ED 1F6FA 2E9WC 4A3JD 3QAZA 1RCBA 1INRA 3DI3A 1VLKA 4WRLB 2JA8D 2B8ZA 4EXPA 3PO3D 4A3KD 3NCEA 1P9MB 5FHXA 3OG4A 4A3CD 1D9GA 3PIWA 1Y6ML 1HGUA 1AXIA 1RW5A 4ZS7A 2VUMD 4FA8E 1HUWA 1Y1WD 1LQSL 2D9QA 1IK0A 5C44D 3UEZE 3D87A 2B8YA 1CNT1 2INTA 2O6IA 1Z92A 4O6KA 1LKIA 2B5IA 2JA7D 2KZ1A 4NI7A 5FLMD 1BCNA 1YKBA 3QT2C 3QWRB 4NN5A 5L6YC 4I77Z 4CNIC 4GRWA 2PSMA 3G6DA 1KF9A 5IYDD 1SCFA 2B8XA 3HMXB 3HOXD 1ETEA 1B5LA 1F45B 4A3MD 1EXZA 5C7XA 1BGCA 3G9VB 1M4RA 4YQXA 1AX8A 1PY2A 3EJJA 2H24A 1J7VL 3PO2D 4NEMA 3N0PA 1AU1A 1HIJA 2Q98A 1ITFA 3L5XA 1RHGA 3FKID 1Y6KL 4DKEA 5IP9D 5LQBA 4A3BD 4RS1A 3DGCL 2LAGA 1M4BA 5D72A 3H3VE 3B5KA 3BPOA 3HOVD 1HZIA 3Q1SI 3EW3A 5E4EA 4YUEC 1WCMD 2R92D 3HOYD 4A93D 3NCCA 2R93D 2B91A 1ILKA 1V7MV 4A3ED 1IL6A 1CD9A 1RFBA 2O26A 2OQPA 4YPGC 4Z5RD 3I4ND 2R7ZD 2HYMB 3QB7A 3NCFA 3HOZD 4ZF7A 1ITMA 3WCYI 5KNHI 3H0GD 5IYCD 3IRHA 4A3FD 2JA6D 4PS4A 5D28B 4DKCA 3MZGA 4LRLA 3AYHA 4BBRD 3S9DA 4NN6A 3INKC 1CN4C 1Z7CA 1Y1VD 2Q7NB 1QVNA 4NEJA 4BXXD 1BGEA 1ITLA 3HOUD 1M4CA 4NN7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NN5 A;  4NN7 A;  4NN6 A; 
#chains in the Genus database with same CATH topology
 4A3I D;  4BBS D;  3D48 P;  5IP7 D;  1EER A;  5FUC A;  3DUH C;  3LB6 A;  4IU8 A;  4BY7 D;  5D70 A;  1EVS A;  1CSG A;  2GMF A;  3OQ3 A;  4EXN A;  1IRL A;  1CYL A;  2D48 A;  3BES L;  1EMR A;  2Z3Q A;  3QB1 A;  4XNJ A;  1LK3 A;  1N1F A;  2Q14 A;  2Z3R A;  2C35 A;  2ILK A;  4A3G D;  2ERJ D;  3DI2 A;  2XQB A;  4QIQ A;  3D85 C;  3I4M D;  1JLI A;  1PW6 A;  1BGD A;  2B8U A;  1PGR A;  4A3L D;  1HUL A;  3UF5 A;  3UF2 A;  2CFQ A;  2XUT A;  4A3J D;  4W6V A;  4A3K D;  3OG4 A;  4A3C D;  3PIW A;  4XNI A;  4ZS7 A;  1IK0 A;  5C44 D;  3UEZ E;  3O7Q A;  1LKI A;  1PW4 A;  1BCN A;  4OAA A;  4I77 Z;  4D2C A;  2B8X A;  5C7X A;  3EJJ A;  2Q98 A;  3L5X A;  4A3B D;  2LAG A;  1M4B A;  4ZWC A;  3H3V E;  1HZI A;  4YUE C;  1WCM D;  3HOY D;  4IU9 A;  1V7M V;  3QB7 A;  4ZF7 A;  1ITM A;  3WCY I;  5KNH I;  4D2B A;  4PS4 A;  1PV6 A;  3MZG A;  4LRL A;  4ZWB A;  4NN6 A;  1QVN A;  1BGE A;  3QT2 C;  4IKY A;  1ITI A;  3SE3 B;  4O9H A;  1IJZ A;  2L3Y A;  3L5W I;  4U4T A;  1I1R B;  3NPZ A;  3TGX B;  4YDY I;  1PVH B;  4NKQ C;  1D9C A;  1A7M A;  4A3D D;  1FG9 A;  1IAR A;  5TS9 A;  1HWH A;  3DLQ I;  1M47 A;  2O27 A;  1M4A A;  1FYH A;  2JA5 D;  1M49 A;  2LMS A;  1A22 A;  3BPN A;  5EQH A;  4DOH A;  4APS A;  4GS7 A;  1BBN A;  4UVM A;  1F6F A;  4WRL B;  1VLK A;  2JA8 D;  4EXP A;  5FHX A;  1P9M B;  4IKX A;  1D9G A;  1Y6M L;  4FA8 E;  1CNT 1;  4Q65 A;  2O6I A;  4O6K A;  4NN5 A;  4GRW A;  2PSM A;  1SCF A;  3HMX B;  4IKW A;  5D59 A;  4TPH A;  1B5L A;  1F45 B;  4A3M D;  2H24 A;  4NEM A;  1ITF A;  1HIJ A;  1PV7 A;  1RHG A;  4DKE A;  4RS1 A;  3B5K A;  2R92 D;  4A93 D;  1ILK A;  1IL6 A;  1CD9 A;  4YPG C;  4ZW9 A;  2R7Z D;  3O7P A;  3NCF A;  3H0G D;  5IYC D;  3IRH A;  5D28 B;  4BBR D;  1Z7C A;  2Q7N B;  1Y1V D;  2Y5Y A;  3HHR A;  4MHL A;  2CYK A;  5C4X D;  3LB6 B;  1BP3 A;  3PIV A;  4TPJ A;  4IKV A;  2CFP A;  1BUY A;  1GNC A;  1HWG A;  3OG6 A;  5IYB D;  1HIK A;  1ALU A;  4J4L C;  1Y14 A;  1GA3 A;  3VA2 A;  4U4W A;  1M48 A;  4IKZ A;  3NCB A;  4BY1 D;  1NBP A;  1WU3 I;  4J05 A;  3QAZ A;  3DI3 A;  2B8Z A;  3NCE A;  1HGU A;  1RW5 A;  4OH3 A;  1Y1W D;  1LQS L;  2D9Q A;  2INT A;  5D58 A;  2B5I A;  2JA7 D;  1YKB A;  5GXB A;  4CNI C;  4TPG A;  1KF9 A;  5IYD D;  1ETE A;  1EXZ A;  1M4R A;  1AX8 A;  4GBZ A;  3N0P A;  1AU1 A;  1Y6K L;  5IP9 D;  3DGC L;  5D72 A;  3HOV D;  5A2O A;  2B91 A;  2V8N A;  2R93 D;  2O26 A;  1RFB A;  2OQP A;  3I4N D;  2HYM B;  3HOZ D;  2JA6 D;  4JRE A;  4DKC A;  4GBY A;  3INK C;  4NEJ A;  1M4C A;  4NN7 A;  4D2D A;  4DKD A;  2L3O A;  5D71 A;  5EQG A;  1EKU A;  4NI9 A;  3N06 A;  5A2N A;  4JA3 A;  5EQI A;  4PYP A;  4YB9 D;  4DKF A;  3UX9 A;  3HOW D;  4ZYR A;  3WDO A;  5D22 A;  4X51 A;  2B90 A;  2IL6 A;  2B63 D;  1V7N V;  3BPL A;  3HHC A;  3SE4 B;  1Y6N L;  5C3E D;  2E9W C;  4U4V A;  1RCB A;  1INR A;  3PO3 D;  1AXI A;  2VUM D;  1HUW A;  3D87 A;  2B8Y A;  1Z92 A;  2KZ1 A;  4NI7 A;  5FLM D;  3QWR B;  5L6Y C;  5C65 A;  3G6D A;  3HOX D;  1BGC A;  3G9V B;  4YQX A;  1PY2 A;  1J7V L;  3PO2 D;  4GC0 A;  3FKI D;  5LQB A;  4YBQ A;  4LEP A;  3BPO A;  3Q1S I;  3EW3 A;  5E4E A;  5D6K A;  3NCC A;  4A3E D;  4Z5R D;  4A3F D;  4LDS A;  3AYH A;  3S9D A;  4JR9 A;  1CN4 C;  4BXX D;  1ITL A;  3HOU D; 
#chains in the Genus database with same CATH homology
 3HHR A;  1ITI A;  3SE3 B;  4O9H A;  1IJZ A;  4MHL A;  4DKD A;  4A3I D;  2CYK A;  2L3Y A;  5C4X D;  2L3O A;  3LB6 B;  5D71 A;  4BBS D;  3L5W I;  1EKU A;  1BP3 A;  4NI9 A;  1I1R B;  3NPZ A;  3TGX B;  4YDY I;  3D48 P;  3PIV A;  5IP7 D;  1EER A;  3N06 A;  5FUC A;  1PVH B;  3DUH C;  1D9C A;  3LB6 A;  4NKQ C;  4BY7 D;  5D70 A;  1EVS A;  1CSG A;  1A7M A;  4A3D D;  1FG9 A;  2GMF A;  3OQ3 A;  1IAR A;  4DKF A;  3UX9 A;  4EXN A;  5TS9 A;  3HOW D;  1IRL A;  1CYL A;  2D48 A;  1HWH A;  1BUY A;  3DLQ I;  1M47 A;  5D22 A;  2O27 A;  4X51 A;  1GNC A;  3BES L;  1EMR A;  1M4A A;  1HWG A;  2B90 A;  2Z3Q A;  3OG6 A;  3QB1 A;  1LK3 A;  1N1F A;  2IL6 A;  2Q14 A;  2B63 D;  2Z3R A;  1FYH A;  2C35 A;  1V7N V;  2ILK A;  2JA5 D;  1M49 A;  5IYB D;  2LMS A;  1HIK A;  2ERJ D;  4A3G D;  3DI2 A;  2XQB A;  1A22 A;  3BPN A;  3D85 C;  3BPL A;  4DOH A;  1ALU A;  4J4L C;  3I4M D;  3HHC A;  1Y14 A;  1JLI A;  3SE4 B;  1PW6 A;  1BGD A;  4GS7 A;  1GA3 A;  1BBN A;  1Y6N L;  3VA2 A;  2B8U A;  1PGR A;  4A3L D;  1HUL A;  1M48 A;  3UF5 A;  3NCB A;  3UF2 A;  4BY1 D;  1NBP A;  1WU3 I;  5C3E D;  1F6F A;  2E9W C;  4A3J D;  3QAZ A;  1RCB A;  1INR A;  3DI3 A;  1VLK A;  4WRL B;  2JA8 D;  2B8Z A;  4EXP A;  3PO3 D;  4A3K D;  3NCE A;  1P9M B;  5FHX A;  3OG4 A;  4A3C D;  1D9G A;  3PIW A;  1Y6M L;  1HGU A;  1AXI A;  1RW5 A;  4ZS7 A;  2VUM D;  4FA8 E;  1HUW A;  1Y1W D;  1LQS L;  2D9Q A;  1IK0 A;  5C44 D;  3UEZ E;  3D87 A;  2B8Y A;  1CNT 1;  2INT A;  2O6I A;  1Z92 A;  4O6K A;  1LKI A;  2B5I A;  2JA7 D;  2KZ1 A;  4NI7 A;  5FLM D;  1BCN A;  1YKB A;  3QT2 C;  3QWR B;  4NN5 A;  5L6Y C;  4I77 Z;  4CNI C;  4GRW A;  2PSM A;  3G6D A;  1KF9 A;  5IYD D;  1SCF A;  2B8X A;  3HMX B;  3HOX D;  1ETE A;  1B5L A;  1F45 B;  4A3M D;  1EXZ A;  5C7X A;  1BGC A;  3G9V B;  1M4R A;  4YQX A;  1AX8 A;  1PY2 A;  3EJJ A;  2H24 A;  1J7V L;  3PO2 D;  4NEM A;  3N0P A;  1AU1 A;  1HIJ A;  2Q98 A;  1ITF A;  3L5X A;  1RHG A;  3FKI D;  1Y6K L;  4DKE A;  5IP9 D;  5LQB A;  4A3B D;  4RS1 A;  3DGC L;  2LAG A;  1M4B A;  5D72 A;  3H3V E;  3B5K A;  3BPO A;  3HOV D;  1HZI A;  3Q1S I;  3EW3 A;  5E4E A;  4YUE C;  1WCM D;  2R92 D;  3HOY D;  4A93 D;  3NCC A;  2R93 D;  2B91 A;  1ILK A;  1V7M V;  4A3E D;  1IL6 A;  1CD9 A;  1RFB A;  2O26 A;  2OQP A;  4YPG C;  4Z5R D;  3I4N D;  2R7Z D;  2HYM B;  3QB7 A;  3NCF A;  3HOZ D;  4ZF7 A;  1ITM A;  3WCY I;  5KNH I;  3H0G D;  5IYC D;  3IRH A;  4A3F D;  2JA6 D;  4PS4 A;  5D28 B;  4DKC A;  3MZG A;  4LRL A;  3AYH A;  4BBR D;  3S9D A;  4NN6 A;  3INK C;  1CN4 C;  1Z7C A;  1Y1V D;  2Q7N B;  1QVN A;  4NEJ A;  4BXX D;  1BGE A;  1ITL A;  3HOU D;  1M4C A;  4NN7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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