4ZYRA

Crystal structure of e. coli lactose permease g46w/g262w bound to p-nitrophenyl alpha-d-galactopyranoside (alpha-npg)
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
403
structure length
387
Chain Sequence
NTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTWIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFWYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of LacY with an alpha-substituted galactoside: Connecting the binding site to the protonation site.
pubmed doi rcsb
molecule tags Transport protein
source organism Escherichia coli (strain k12)
molecule keywords Lactose permease
total genus 136
structure length 387
sequence length 403
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01306 LacY_symp LacY proton/sugar symporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 4zyrA02
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 4zyrA01
4OH3A 4GBZA 2CFPA 5GXBA 4UVMA 4GC0A 4D2BA 4IKXA 4LEPA 4J05A 4JR9A 4LDSA 5A2OA 2V8NA 4QIQA 4IKYA 4IKWA 4YBQA 3O7PA 5D58A 5EQHA 4TPJA 4D2CA 2Y5YA 4U4VA 4IKZA 4ZWCA 4ZW9A 4OAAA 4IU8A 4GBYA 4YB9D 4W6VA 5A2NA 5C65A 3O7QA 4U4WA 1PW4A 4U4TA 4XNJA 4D2DA 1PV6A 4XNIA 1PV7A 4TPHA 2XUTA 5D59A 5EQIA 4JA3A 4TPGA 5D6KA 3WDOA 5EQGA 4IU9A 4JREA 4PYPA 4IKVA 4Q65A 2CFQA 4ZYRA 4APSA 4ZWBA
chains in the Genus database with same CATH superfamily
1EERA 1BGCA 1EKUA 3BPNA 3D87A 1Y1WD 3OQ3A 2B8UA 4A3CD 1NBPA 1Y1VD 1Z7CA 1I1RB 5C4XD 5C44D 4JA3A 3S9DA 4ZWBA 2LAGA 4DKFA 2B91A 4LDSA 3H3VE 4NN7A 2HYMB 3DGCL 1M48A 1FYHA 1HGUA 1LKIA 4O9HA 1PW4A 1IARA 4PS4A 1HZIA 4BY7D 2PSMA 3OG6A 3D85C 4Z5RD 4D2BA 2R7ZD 3WCYI 2JA5D 2D48A 3HHCA 3HOUD 1F6FA 4OAAA 2JA7D 4A3KD 1AXIA 2B63D 2L3OA 1AU1A 3UF2A 3QAZA 1RCBA 1HWHA 5IYBD 1D9GA 5FUCA 4FA8E 4BXXD 1M4AA 4YB9D 2B8ZA 2Q7NB 3FKID 3LB6A 3WDOA 4JREA 1J7VL 4NI9A 2R93D 1BGEA 4IKXA 1ITMA 5D70A 4QIQA 4IKWA 2ILKA 3UF5A 1CNT1 3PO3D 5EQHA 4A3MD 3BPLA 4IKZA 4GBYA 1V7NV 3NCCA 2JA6D 4XNIA 2R92D 4I77Z 4PYPA 5TS9A 4JR9A 3HOZD 3PIVA 3N06A 1M4BA 4DKDA 3SE4B 1ALUA 1M47A 4ZW9A 5FLMD 3O7QA 3OG4A 4XNJA 4YQXA 3H0GD 1ITLA 5D59A 4Q65A 3NPZA 3NCFA 2CFPA 4LEPA 3VA2A 3I4ND 1EMRA 3PIWA 3SE3B 2E9WC 3G9VB 4TPJA 3AYHA 1INRA 3HOWD 4WRLB 3HOXD 4MHLA 5C65A 4W6VA 4DKEA 4D2DA 5KNHI 3DLQI 4BBSD 1PV7A 3DUHC 3HHRA 1Z92A 1B5LA 2O27A 3NCEA 2L3YA 5GXBA 4J05A 4YBQA 4J4LC 3N0PA 4A3BD 4ZWCA 3QB1A 1CSGA 2Z3RA 4GS7A 5D6KA 4A3LD 2O6IA 2LMSA 4ZS7A 1HIJA 1IRLA 2GMFA 3IRHA 3QB7A 4D2CA 4NEMA 3EW3A 1HIKA 3BESL 5A2NA 1LQSL 4U4WA 3I4MD 1A22A 1CN4C 1Y6KL 1N1FA 4A3JD 5FHXA 5D22A 1HWGA 1EVSA 2CYKA 2C35A 4O6KA 1RHGA 5D28B 4BY1D 4LRLA 3EJJA 3HOYD 3HMXB 1AX8A 4A3ED 4BBRD 1LK3A 1Y6NL 2ERJD 4A93D 2OQPA 4ZF7A 1QVNA 4DOHA 5A2OA 3NCBA 3G6DA 3O7PA 1VLKA 1M4RA 2Y5YA 4U4VA 1SCFA 3MZGA 1WU3I 3HOVD 1A7MA 3PO2D 4NI7A 1CD9A 1GNCA 2Z3QA 4CNIC 4RS1A 1D9CA 4IKVA 5C3ED 1IK0A 4GBZA 4YUEC 5C7XA 3TGXB 3BPOA 2O26A 2Q98A 2INTA 3UX9A 3INKC 1BCNA 5IYCD 1GA3A 4NKQC 5E4EA 5LQBA 4TPHA 2H24A 1PVHB 1JLIA 5IYDD 5EQGA 4EXPA 4OH3A 1BGDA 4UVMA 3LB6B 2V8NA 1Y6ML 4IKYA 4YPGC 1WCMD 1ITIA 3QT2C 1V7MV 4NN5A 4YDYI 2B90A 1BUYA 4IU9A 1BP3A 1ETEA 4ZYRA 1PGRA 5IP9D 4A3FD 4GC0A 2D9QA 1P9MB 1IL6A 1ITFA 1PW6A 5IP7D 5D58A 3QWRB 2B5IA 1KF9A 4IU8A 1FG9A 1PV6A 2KZ1A 2XUTA 4DKCA 1IJZA 3L5WI 2B8YA 3Q1SI 1EXZA 1HUWA 1CYLA 5D71A 2XQBA 2IL6A 3DI2A 1Y14A 4U4TA 4NN6A 1PY2A 4A3ID 2Q14A 4GRWA 5EQIA 4EXNA 1M4CA 3D48P 1RW5A 2B8XA 2CFQA 4APSA 4X51A 2VUMD 1BBNA 1M49A 1YKBA 3L5XA 4A3GD 4NEJA 1HULA 1RFBA 3B5KA 1F45B 5D72A 4TPGA 3DI3A 2JA8D 4A3DD 3UEZE 1ILKA 5L6YC
chains in the Genus database with same CATH topology
4OH3A 4GBZA 2CFPA 5GXBA 4UVMA 4GC0A 4D2BA 4IKXA 4LEPA 4J05A 4JR9A 4LDSA 5A2OA 2V8NA 4QIQA 4IKYA 4IKWA 4YBQA 3O7PA 5D58A 5EQHA 4TPJA 4D2CA 2Y5YA 4U4VA 4IKZA 4ZWCA 4ZW9A 4OAAA 4IU8A 4GBYA 4YB9D 4W6VA 5A2NA 5C65A 3O7QA 4U4WA 1PW4A 4U4TA 4XNJA 4D2DA 1PV6A 4XNIA 1PV7A 4TPHA 2XUTA 5D59A 5EQIA 4JA3A 4TPGA 5D6KA 3WDOA 5EQGA 4IU9A 4JREA 4PYPA 4IKVA 4Q65A 2CFQA 4ZYRA 4APSA 4ZWBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OH3 A;  4GBZ A;  2CFP A;  5GXB A;  4UVM A;  4GC0 A;  4D2B A;  4IKX A;  4LEP A;  4J05 A;  4JR9 A;  4LDS A;  5A2O A;  2V8N A;  4QIQ A;  4IKY A;  4IKW A;  4YBQ A;  3O7P A;  5D58 A;  5EQH A;  4TPJ A;  4D2C A;  2Y5Y A;  4U4V A;  4IKZ A;  4ZWC A;  4ZW9 A;  4OAA A;  4IU8 A;  4GBY A;  4YB9 D;  4W6V A;  5A2N A;  5C65 A;  3O7Q A;  4U4W A;  1PW4 A;  4U4T A;  4XNJ A;  4D2D A;  1PV6 A;  4XNI A;  1PV7 A;  4TPH A;  2XUT A;  5D59 A;  5EQI A;  4JA3 A;  4TPG A;  5D6K A;  3WDO A;  5EQG A;  4IU9 A;  4JRE A;  4PYP A;  4IKV A;  4Q65 A;  2CFQ A;  4ZYR A;  4APS A;  4ZWB A; 
#chains in the Genus database with same CATH topology
 1EER A;  1BGC A;  1EKU A;  3BPN A;  3D87 A;  1Y1W D;  3OQ3 A;  2B8U A;  4A3C D;  1NBP A;  1Y1V D;  1Z7C A;  1I1R B;  5C4X D;  5C44 D;  4JA3 A;  3S9D A;  4ZWB A;  2LAG A;  4DKF A;  2B91 A;  4LDS A;  3H3V E;  4NN7 A;  2HYM B;  3DGC L;  1M48 A;  1FYH A;  1HGU A;  1LKI A;  4O9H A;  1PW4 A;  1IAR A;  4PS4 A;  1HZI A;  4BY7 D;  2PSM A;  3OG6 A;  3D85 C;  4Z5R D;  4D2B A;  2R7Z D;  3WCY I;  2JA5 D;  2D48 A;  3HHC A;  3HOU D;  1F6F A;  4OAA A;  2JA7 D;  4A3K D;  1AXI A;  2B63 D;  2L3O A;  1AU1 A;  3UF2 A;  3QAZ A;  1RCB A;  1HWH A;  5IYB D;  1D9G A;  5FUC A;  4FA8 E;  4BXX D;  1M4A A;  4YB9 D;  2B8Z A;  2Q7N B;  3FKI D;  3LB6 A;  3WDO A;  4JRE A;  1J7V L;  4NI9 A;  2R93 D;  1BGE A;  4IKX A;  1ITM A;  5D70 A;  4QIQ A;  4IKW A;  2ILK A;  3UF5 A;  1CNT 1;  3PO3 D;  5EQH A;  4A3M D;  3BPL A;  4IKZ A;  4GBY A;  1V7N V;  3NCC A;  2JA6 D;  4XNI A;  2R92 D;  4I77 Z;  4PYP A;  5TS9 A;  4JR9 A;  3HOZ D;  3PIV A;  3N06 A;  1M4B A;  4DKD A;  3SE4 B;  1ALU A;  1M47 A;  4ZW9 A;  5FLM D;  3O7Q A;  3OG4 A;  4XNJ A;  4YQX A;  3H0G D;  1ITL A;  5D59 A;  4Q65 A;  3NPZ A;  3NCF A;  2CFP A;  4LEP A;  3VA2 A;  3I4N D;  1EMR A;  3PIW A;  3SE3 B;  2E9W C;  3G9V B;  4TPJ A;  3AYH A;  1INR A;  3HOW D;  4WRL B;  3HOX D;  4MHL A;  5C65 A;  4W6V A;  4DKE A;  4D2D A;  5KNH I;  3DLQ I;  4BBS D;  1PV7 A;  3DUH C;  3HHR A;  1Z92 A;  1B5L A;  2O27 A;  3NCE A;  2L3Y A;  5GXB A;  4J05 A;  4YBQ A;  4J4L C;  3N0P A;  4A3B D;  4ZWC A;  3QB1 A;  1CSG A;  2Z3R A;  4GS7 A;  5D6K A;  4A3L D;  2O6I A;  2LMS A;  4ZS7 A;  1HIJ A;  1IRL A;  2GMF A;  3IRH A;  3QB7 A;  4D2C A;  4NEM A;  3EW3 A;  1HIK A;  3BES L;  5A2N A;  1LQS L;  4U4W A;  3I4M D;  1A22 A;  1CN4 C;  1Y6K L;  1N1F A;  4A3J D;  5FHX A;  5D22 A;  1HWG A;  1EVS A;  2CYK A;  2C35 A;  4O6K A;  1RHG A;  5D28 B;  4BY1 D;  4LRL A;  3EJJ A;  3HOY D;  3HMX B;  1AX8 A;  4A3E D;  4BBR D;  1LK3 A;  1Y6N L;  2ERJ D;  4A93 D;  2OQP A;  4ZF7 A;  1QVN A;  4DOH A;  5A2O A;  3NCB A;  3G6D A;  3O7P A;  1VLK A;  1M4R A;  2Y5Y A;  4U4V A;  1SCF A;  3MZG A;  1WU3 I;  3HOV D;  1A7M A;  3PO2 D;  4NI7 A;  1CD9 A;  1GNC A;  2Z3Q A;  4CNI C;  4RS1 A;  1D9C A;  4IKV A;  5C3E D;  1IK0 A;  4GBZ A;  4YUE C;  5C7X A;  3TGX B;  3BPO A;  2O26 A;  2Q98 A;  2INT A;  3UX9 A;  3INK C;  1BCN A;  5IYC D;  1GA3 A;  4NKQ C;  5E4E A;  5LQB A;  4TPH A;  2H24 A;  1PVH B;  1JLI A;  5IYD D;  5EQG A;  4EXP A;  4OH3 A;  1BGD A;  4UVM A;  3LB6 B;  2V8N A;  1Y6M L;  4IKY A;  4YPG C;  1WCM D;  1ITI A;  3QT2 C;  1V7M V;  4NN5 A;  4YDY I;  2B90 A;  1BUY A;  4IU9 A;  1BP3 A;  1ETE A;  4ZYR A;  1PGR A;  5IP9 D;  4A3F D;  4GC0 A;  2D9Q A;  1P9M B;  1IL6 A;  1ITF A;  1PW6 A;  5IP7 D;  5D58 A;  3QWR B;  2B5I A;  1KF9 A;  4IU8 A;  1FG9 A;  1PV6 A;  2KZ1 A;  2XUT A;  4DKC A;  1IJZ A;  3L5W I;  2B8Y A;  3Q1S I;  1EXZ A;  1HUW A;  1CYL A;  5D71 A;  2XQB A;  2IL6 A;  3DI2 A;  1Y14 A;  4U4T A;  4NN6 A;  1PY2 A;  4A3I D;  2Q14 A;  4GRW A;  5EQI A;  4EXN A;  1M4C A;  3D48 P;  1RW5 A;  2B8X A;  2CFQ A;  4APS A;  4X51 A;  2VUM D;  1BBN A;  1M49 A;  1YKB A;  3L5X A;  4A3G D;  4NEJ A;  1HUL A;  1RFB A;  3B5K A;  1F45 B;  5D72 A;  4TPG A;  3DI3 A;  2JA8 D;  4A3D D;  3UEZ E;  1ILK A;  5L6Y C; 
#chains in the Genus database with same CATH homology
 4OH3 A;  4GBZ A;  2CFP A;  5GXB A;  4UVM A;  4GC0 A;  4D2B A;  4IKX A;  4LEP A;  4J05 A;  4JR9 A;  4LDS A;  5A2O A;  2V8N A;  4QIQ A;  4IKY A;  4IKW A;  4YBQ A;  3O7P A;  5D58 A;  5EQH A;  4TPJ A;  4D2C A;  2Y5Y A;  4U4V A;  4IKZ A;  4ZWC A;  4ZW9 A;  4OAA A;  4IU8 A;  4GBY A;  4YB9 D;  4W6V A;  5A2N A;  5C65 A;  3O7Q A;  4U4W A;  1PW4 A;  4U4T A;  4XNJ A;  4D2D A;  1PV6 A;  4XNI A;  1PV7 A;  4TPH A;  2XUT A;  5D59 A;  5EQI A;  4JA3 A;  4TPG A;  5D6K A;  3WDO A;  5EQG A;  4IU9 A;  4JRE A;  4PYP A;  4IKV A;  4Q65 A;  2CFQ A;  4ZYR A;  4APS A;  4ZWB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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