4DKCA

Crystal structure of human interleukin-34
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
161
structure length
161
Chain Sequence
NEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.
pubmed doi rcsb
molecule tags Cytokine
source organism Homo sapiens
molecule keywords Interleukin-34
total genus 59
structure length 161
sequence length 161
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15036 IL34 Interleukin 34
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.80 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 4dkcA00
4DKEA 4EXPA 4DKCA 4EXNA 4DKDA 4DKFA
chains in the Genus database with same CATH superfamily
1IARA 1M49A 3Q1SI 3DI3A 2C35A 1WU3I 4IKYA 4U4WA 1PGRA 2LAGA 3QWRB 3D87A 2ERJD 1M4CA 5D59A 3HOUD 1HGUA 2LMSA 2JA6D 1HZIA 1Y6ML 4ZYRA 1CYLA 3QB7A 2CYKA 1V7MV 1A22A 4BBRD 1A7MA 3NCFA 3OQ3A 1LKIA 2XQBA 1ITFA 3I4ND 3QB1A 1B5LA 4BXXD 5L6YC 4J4LC 4BY1D 5EQHA 4DOHA 1PY2A 4GBZA 4D2DA 1HIJA 3WCYI 4ZW9A 4TPGA 4YUEC 1PW6A 1FYHA 1BUYA 4NEJA 1CD9A 3O7QA 1PW4A 1RFBA 4YDYI 4D2BA 4LDSA 4XNIA 5EQIA 2HYMB 3N06A 2CFQA 4ZWCA 3AYHA 4A3JD 1Y14A 5IYBD 4A3MD 3G6DA 1Y6NL 1AXIA 5D72A 5A2OA 4ZF7A 1D9CA 4GS7A 3D85C 3LB6B 2D48A 1PV7A 4PS4A 1PV6A 4OAAA 2ILKA 1ALUA 3H0GD 2B90A 4BBSD 4IU9A 2JA7D 4OH3A 1IJZA 4IKXA 2B91A 2PSMA 2CFPA 2JA5D 4A3DD 4D2CA 3IRHA 4NKQC 1VLKA 3G9VB 4GRWA 4DKDA 4A93D 1EXZA 2B8UA 1HULA 5D71A 5IP7D 3HOYD 1Z7CA 5E4EA 1NBPA 1HWGA 3HMXB 3I4MD 3PO2D 3BPOA 1QVNA 4CNIC 2O27A 1INRA 3WDOA 2OQPA 1M4BA 3DI2A 4TPHA 3HOXD 5C7XA 3L5XA 4ZS7A 3PO3D 1ITLA 1M48A 1N1FA 2L3OA 1M47A 4MHLA 3UEZE 2E9WC 4NI9A 2GMFA 1HUWA 3N0PA 4A3ED 5C3ED 4A3LD 2B8YA 1IRLA 4ZWBA 2H24A 4IKVA 4NN6A 1AX8A 1CSGA 5IYDD 2R92D 3EJJA 3PIWA 4DKFA 1GNCA 1PVHB 5D6KA 2B8ZA 4A3GD 5D70A 4LRLA 1WCMD 4FA8E 3BPNA 4A3ID 4U4TA 1AU1A 4I77Z 3DLQI 1Y1VD 1Y6KL 3HOZD 1BGDA 3L5WI 2Q98A 1IK0A 4O6KA 1IL6A 1RHGA 1BCNA 1RCBA 4YPGC 3TGXB 4YQXA 2Z3QA 5FHXA 1ILKA 4BY7D 1I1RB 5GXBA 4NEMA 2V8NA 3NCEA 1M4AA 3VA2A 5KNHI 3NCCA 4JR9A 4XNJA 5LQBA 2B63D 4NN7A 4X51A 1LK3A 4A3KD 5TS9A 3QAZA 1V7NV 1ETEA 3PIVA 2Y5YA 2Q14A 1BP3A 1KF9A 4PYPA 3QT2C 4TPJA 1BBNA 4EXNA 2L3YA 3EW3A 3O7PA 1HIKA 3BPLA 1CN4C 3SE3B 1F45B 1F6FA 4NI7A 4Z5RD 4A3FD 3S9DA 4DKEA 5A2NA 4IKZA 4WRLB 2O26A 1EVSA 5D58A 2O6IA 2Q7NB 3HOVD 4IU8A 3UF2A 1EMRA 4U4VA 2B5IA 3HOWD 4IKWA 1J7VL 1Z92A 2JA8D 3SE4B 1GA3A 2KZ1A 3HHRA 4NN5A 3NCBA 3FKID 1JLIA 1BGCA 5EQGA 5IYCD 4LEPA 4UVMA 1EERA 1M4RA 2B8XA 3UX9A 4A3CD 2VUMD 3INKC 3UF5A 1BGEA 1LQSL 3DUHC 2R7ZD 1RW5A 4J05A 3NPZA 4Q65A 3LB6A 3B5KA 1P9MB 4A3BD 2INTA 1D9GA 4JA3A 4GC0A 2R93D 4GBYA 4QIQA 3D48P 1Y1WD 5C44D 4DKCA 3H3VE 3OG4A 1YKBA 4RS1A 2Z3RA 5D28B 1ITMA 1EKUA 3BESL 3MZGA 5C4XD 4YB9D 5FUCA 2IL6A 1SCFA 5IP9D 4JREA 4EXPA 5D22A 4YBQA 1CNT1 3DGCL 2XUTA 1ITIA 1HWHA 4O9HA 1FG9A 2D9QA 4W6VA 3OG6A 5C65A 5FLMD 3HHCA 4APSA
chains in the Genus database with same CATH topology
1JLIA 1IARA 1BGCA 1M49A 1Y1VD 3Q1SI 5IYCD 1Y6KL 3DI3A 2C35A 1BGDA 1WU3I 2ILKA 3HOZD 1ALUA 3H0GD 2B90A 1EERA 3L5WI 1M4RA 2Q98A 1PGRA 2LAGA 1IK0A 4O6KA 2B8XA 4BBSD 1IL6A 3UX9A 3QWRB 3D87A 2JA7D 1IJZA 2ERJD 4A3CD 1M4CA 1RHGA 2VUMD 1BCNA 3INKC 3UF5A 3HOUD 1BGEA 1HGUA 2LMSA 1LQSL 1RCBA 2JA6D 1HZIA 2B91A 2PSMA 1Y6ML 4YPGC 4YQXA 3TGXB 2Z3QA 2JA5D 3DUHC 5FHXA 4A3DD 1ILKA 2R7ZD 4BY7D 1CYLA 3QB7A 1I1RB 2CYKA 1V7MV 3NCEA 4NEMA 3IRHA 1A22A 4NKQC 1VLKA 1RW5A 4BBRD 1A7MA 3NPZA 3NCFA 1M4AA 3OQ3A 3G9VB 4GRWA 3VA2A 4DKDA 1LKIA 3LB6A 3B5KA 1EXZA 3NCCA 5KNHI 2B8UA 1HULA 2XQBA 5LQBA 1P9MB 2B63D 5D71A 4A3BD 1ITFA 5IP7D 3I4ND 4NN7A 1Z7CA 2INTA 5E4EA 3HOYD 1D9GA 3QB1A 4A93D 1B5LA 1NBPA 4X51A 1LK3A 4BXXD 1HWGA 5L6YC 2R93D 4A3KD 5TS9A 4J4LC 3QAZA 1V7NV 3HMXB 3I4MD 1ETEA 3PIVA 3PO2D 3D48P 2Q14A 1BP3A 1Y1WD 4BY1D 3BPOA 1QVNA 4DOHA 4CNIC 1PY2A 1KF9A 5C44D 1HIJA 2O27A 1INRA 3QT2C 2OQPA 3WCYI 1BBNA 4DKCA 4EXNA 3OG4A 1M4BA 1YKBA 3H3VE 2L3YA 4RS1A 3DI2A 2Z3RA 4YUEC 3HOXD 5C7XA 3L5XA 1PW6A 4ZS7A 1FYHA 3NCBA 5D28B 3PO3D 1BUYA 1ITMA 1ITLA 1EKUA 3EW3A 1M48A 4NEJA 1HIKA 1CD9A 3BPLA 3BESL 1N1FA 2L3OA 1M47A 1CN4C 3MZGA 1RFBA 4YDYI 5C4XD 3SE3B 4MHLA 1F45B 3UEZE 1F6FA 2E9WC 4NI9A 4NI7A 4Z5RD 4A3FD 3S9DA 5FUCA 2IL6A 2GMFA 4DKEA 4WRLB 2O26A 2HYMB 1EVSA 1HUWA 1SCFA 2O6IA 3N0PA 2Q7NB 5IP9D 4A3ED 3HOVD 3N06A 5C3ED 4A3LD 2B8YA 4A3JD 3AYHA 1IRLA 4EXPA 5D22A 2H24A 4NN6A 5IYDD 1AX8A 1CSGA 2R92D 1Y14A 1CNT1 3UF2A 3DGCL 3EJJA 5IYBD 1EMRA 3PIWA 4DKFA 4A3MD 1PVHB 1ITIA 1GNCA 1HWHA 3G6DA 1Y6NL 2B8ZA 1AXIA 5D72A 2B5IA 4ZF7A 4O9HA 1D9CA 3HOWD 4A3GD 4GS7A 5D70A 4LRLA 3D85C 1WCMD 3LB6B 4FA8E 2D48A 1FG9A 2D9QA 3BPNA 4A3ID 1J7VL 3OG6A 1Z92A 4PS4A 2JA8D 5FLMD 3HHCA 3SE4B 1AU1A 1GA3A 4I77Z 2KZ1A 3HHRA 4NN5A 3DLQI 3FKID
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DKE A;  4EXP A;  4DKC A;  4EXN A;  4DKD A;  4DKF A; 
#chains in the Genus database with same CATH topology
 1IAR A;  1M49 A;  3Q1S I;  3DI3 A;  2C35 A;  1WU3 I;  4IKY A;  4U4W A;  1PGR A;  2LAG A;  3QWR B;  3D87 A;  2ERJ D;  1M4C A;  5D59 A;  3HOU D;  1HGU A;  2LMS A;  2JA6 D;  1HZI A;  1Y6M L;  4ZYR A;  1CYL A;  3QB7 A;  2CYK A;  1V7M V;  1A22 A;  4BBR D;  1A7M A;  3NCF A;  3OQ3 A;  1LKI A;  2XQB A;  1ITF A;  3I4N D;  3QB1 A;  1B5L A;  4BXX D;  5L6Y C;  4J4L C;  4BY1 D;  5EQH A;  4DOH A;  1PY2 A;  4GBZ A;  4D2D A;  1HIJ A;  3WCY I;  4ZW9 A;  4TPG A;  4YUE C;  1PW6 A;  1FYH A;  1BUY A;  4NEJ A;  1CD9 A;  3O7Q A;  1PW4 A;  1RFB A;  4YDY I;  4D2B A;  4LDS A;  4XNI A;  5EQI A;  2HYM B;  3N06 A;  2CFQ A;  4ZWC A;  3AYH A;  4A3J D;  1Y14 A;  5IYB D;  4A3M D;  3G6D A;  1Y6N L;  1AXI A;  5D72 A;  5A2O A;  4ZF7 A;  1D9C A;  4GS7 A;  3D85 C;  3LB6 B;  2D48 A;  1PV7 A;  4PS4 A;  1PV6 A;  4OAA A;  2ILK A;  1ALU A;  3H0G D;  2B90 A;  4BBS D;  4IU9 A;  2JA7 D;  4OH3 A;  1IJZ A;  4IKX A;  2B91 A;  2PSM A;  2CFP A;  2JA5 D;  4A3D D;  4D2C A;  3IRH A;  4NKQ C;  1VLK A;  3G9V B;  4GRW A;  4DKD A;  4A93 D;  1EXZ A;  2B8U A;  1HUL A;  5D71 A;  5IP7 D;  3HOY D;  1Z7C A;  5E4E A;  1NBP A;  1HWG A;  3HMX B;  3I4M D;  3PO2 D;  3BPO A;  1QVN A;  4CNI C;  2O27 A;  1INR A;  3WDO A;  2OQP A;  1M4B A;  3DI2 A;  4TPH A;  3HOX D;  5C7X A;  3L5X A;  4ZS7 A;  3PO3 D;  1ITL A;  1M48 A;  1N1F A;  2L3O A;  1M47 A;  4MHL A;  3UEZ E;  2E9W C;  4NI9 A;  2GMF A;  1HUW A;  3N0P A;  4A3E D;  5C3E D;  4A3L D;  2B8Y A;  1IRL A;  4ZWB A;  2H24 A;  4IKV A;  4NN6 A;  1AX8 A;  1CSG A;  5IYD D;  2R92 D;  3EJJ A;  3PIW A;  4DKF A;  1GNC A;  1PVH B;  5D6K A;  2B8Z A;  4A3G D;  5D70 A;  4LRL A;  1WCM D;  4FA8 E;  3BPN A;  4A3I D;  4U4T A;  1AU1 A;  4I77 Z;  3DLQ I;  1Y1V D;  1Y6K L;  3HOZ D;  1BGD A;  3L5W I;  2Q98 A;  1IK0 A;  4O6K A;  1IL6 A;  1RHG A;  1BCN A;  1RCB A;  4YPG C;  3TGX B;  4YQX A;  2Z3Q A;  5FHX A;  1ILK A;  4BY7 D;  1I1R B;  5GXB A;  4NEM A;  2V8N A;  3NCE A;  1M4A A;  3VA2 A;  5KNH I;  3NCC A;  4JR9 A;  4XNJ A;  5LQB A;  2B63 D;  4NN7 A;  4X51 A;  1LK3 A;  4A3K D;  5TS9 A;  3QAZ A;  1V7N V;  1ETE A;  3PIV A;  2Y5Y A;  2Q14 A;  1BP3 A;  1KF9 A;  4PYP A;  3QT2 C;  4TPJ A;  1BBN A;  4EXN A;  2L3Y A;  3EW3 A;  3O7P A;  1HIK A;  3BPL A;  1CN4 C;  3SE3 B;  1F45 B;  1F6F A;  4NI7 A;  4Z5R D;  4A3F D;  3S9D A;  4DKE A;  5A2N A;  4IKZ A;  4WRL B;  2O26 A;  1EVS A;  5D58 A;  2O6I A;  2Q7N B;  3HOV D;  4IU8 A;  3UF2 A;  1EMR A;  4U4V A;  2B5I A;  3HOW D;  4IKW A;  1J7V L;  1Z92 A;  2JA8 D;  3SE4 B;  1GA3 A;  2KZ1 A;  3HHR A;  4NN5 A;  3NCB A;  3FKI D;  1JLI A;  1BGC A;  5EQG A;  5IYC D;  4LEP A;  4UVM A;  1EER A;  1M4R A;  2B8X A;  3UX9 A;  4A3C D;  2VUM D;  3INK C;  3UF5 A;  1BGE A;  1LQS L;  3DUH C;  2R7Z D;  1RW5 A;  4J05 A;  3NPZ A;  4Q65 A;  3LB6 A;  3B5K A;  1P9M B;  4A3B D;  2INT A;  1D9G A;  4JA3 A;  4GC0 A;  2R93 D;  4GBY A;  4QIQ A;  3D48 P;  1Y1W D;  5C44 D;  4DKC A;  3H3V E;  3OG4 A;  1YKB A;  4RS1 A;  2Z3R A;  5D28 B;  1ITM A;  1EKU A;  3BES L;  3MZG A;  5C4X D;  4YB9 D;  5FUC A;  2IL6 A;  1SCF A;  5IP9 D;  4JRE A;  4EXP A;  5D22 A;  4YBQ A;  1CNT 1;  3DGC L;  2XUT A;  1ITI A;  1HWH A;  4O9H A;  1FG9 A;  2D9Q A;  4W6V A;  3OG6 A;  5C65 A;  5FLM D;  3HHC A;  4APS A; 
#chains in the Genus database with same CATH homology
 1JLI A;  1IAR A;  1BGC A;  1M49 A;  1Y1V D;  3Q1S I;  5IYC D;  1Y6K L;  3DI3 A;  2C35 A;  1BGD A;  1WU3 I;  2ILK A;  3HOZ D;  1ALU A;  3H0G D;  2B90 A;  1EER A;  3L5W I;  1M4R A;  2Q98 A;  1PGR A;  2LAG A;  1IK0 A;  4O6K A;  2B8X A;  4BBS D;  1IL6 A;  3UX9 A;  3QWR B;  3D87 A;  2JA7 D;  1IJZ A;  2ERJ D;  4A3C D;  1M4C A;  1RHG A;  2VUM D;  1BCN A;  3INK C;  3UF5 A;  3HOU D;  1BGE A;  1HGU A;  2LMS A;  1LQS L;  1RCB A;  2JA6 D;  1HZI A;  2B91 A;  2PSM A;  1Y6M L;  4YPG C;  4YQX A;  3TGX B;  2Z3Q A;  2JA5 D;  3DUH C;  5FHX A;  4A3D D;  1ILK A;  2R7Z D;  4BY7 D;  1CYL A;  3QB7 A;  1I1R B;  2CYK A;  1V7M V;  3NCE A;  4NEM A;  3IRH A;  1A22 A;  4NKQ C;  1VLK A;  1RW5 A;  4BBR D;  1A7M A;  3NPZ A;  3NCF A;  1M4A A;  3OQ3 A;  3G9V B;  4GRW A;  3VA2 A;  4DKD A;  1LKI A;  3LB6 A;  3B5K A;  1EXZ A;  3NCC A;  5KNH I;  2B8U A;  1HUL A;  2XQB A;  5LQB A;  1P9M B;  2B63 D;  5D71 A;  4A3B D;  1ITF A;  5IP7 D;  3I4N D;  4NN7 A;  1Z7C A;  2INT A;  5E4E A;  3HOY D;  1D9G A;  3QB1 A;  4A93 D;  1B5L A;  1NBP A;  4X51 A;  1LK3 A;  4BXX D;  1HWG A;  5L6Y C;  2R93 D;  4A3K D;  5TS9 A;  4J4L C;  3QAZ A;  1V7N V;  3HMX B;  3I4M D;  1ETE A;  3PIV A;  3PO2 D;  3D48 P;  2Q14 A;  1BP3 A;  1Y1W D;  4BY1 D;  3BPO A;  1QVN A;  4DOH A;  4CNI C;  1PY2 A;  1KF9 A;  5C44 D;  1HIJ A;  2O27 A;  1INR A;  3QT2 C;  2OQP A;  3WCY I;  1BBN A;  4DKC A;  4EXN A;  3OG4 A;  1M4B A;  1YKB A;  3H3V E;  2L3Y A;  4RS1 A;  3DI2 A;  2Z3R A;  4YUE C;  3HOX D;  5C7X A;  3L5X A;  1PW6 A;  4ZS7 A;  1FYH A;  3NCB A;  5D28 B;  3PO3 D;  1BUY A;  1ITM A;  1ITL A;  1EKU A;  3EW3 A;  1M48 A;  4NEJ A;  1HIK A;  1CD9 A;  3BPL A;  3BES L;  1N1F A;  2L3O A;  1M47 A;  1CN4 C;  3MZG A;  1RFB A;  4YDY I;  5C4X D;  3SE3 B;  4MHL A;  1F45 B;  3UEZ E;  1F6F A;  2E9W C;  4NI9 A;  4NI7 A;  4Z5R D;  4A3F D;  3S9D A;  5FUC A;  2IL6 A;  2GMF A;  4DKE A;  4WRL B;  2O26 A;  2HYM B;  1EVS A;  1HUW A;  1SCF A;  2O6I A;  3N0P A;  2Q7N B;  5IP9 D;  4A3E D;  3HOV D;  3N06 A;  5C3E D;  4A3L D;  2B8Y A;  4A3J D;  3AYH A;  1IRL A;  4EXP A;  5D22 A;  2H24 A;  4NN6 A;  5IYD D;  1AX8 A;  1CSG A;  2R92 D;  1Y14 A;  1CNT 1;  3UF2 A;  3DGC L;  3EJJ A;  5IYB D;  1EMR A;  3PIW A;  4DKF A;  4A3M D;  1PVH B;  1ITI A;  1GNC A;  1HWH A;  3G6D A;  1Y6N L;  2B8Z A;  1AXI A;  5D72 A;  2B5I A;  4ZF7 A;  4O9H A;  1D9C A;  3HOW D;  4A3G D;  4GS7 A;  5D70 A;  4LRL A;  3D85 C;  1WCM D;  3LB6 B;  4FA8 E;  2D48 A;  1FG9 A;  2D9Q A;  3BPN A;  4A3I D;  1J7V L;  3OG6 A;  1Z92 A;  4PS4 A;  2JA8 D;  5FLM D;  3HHC A;  3SE4 B;  1AU1 A;  1GA3 A;  4I77 Z;  2KZ1 A;  3HHR A;  4NN5 A;  3DLQ I;  3FKI D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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