4DKEA

Crystal structure of human interleukin-34 bound to fab1.1
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
159
structure length
157
Chain Sequence
ECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.
pubmed doi rcsb
molecule tags Cytokine/immune system
source organism Homo sapiens
molecule keywords Interleukin-34
total genus 49
structure length 157
sequence length 159
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15036 IL34 Interleukin 34
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.80 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 4dkeA00
4EXPA 4DKDA 4DKEA 4DKCA 4EXNA 4DKFA
chains in the Genus database with same CATH superfamily
1IL6A 3QWRB 3WCYI 1N1FA 2XQBA 2B8UA 4PS4A 3DI3A 3B5KA 4ZWCA 1Y14A 4ZYRA 2R92D 5EQHA 3N06A 4A3MD 1FG9A 3BPNA 2HYMB 5A2NA 4ZWBA 4DKCA 2VUMD 1M4CA 4MHLA 5IP9D 4PYPA 4BBRD 2GMFA 1P9MB 5D28B 1M49A 1BCNA 1PY2A 1Z92A 3QB1A 5IYDD 5FUCA 4JREA 2LAGA 3D87A 1EKUA 1CYLA 2B8YA 3VA2A 1D9GA 1GNCA 1CD9A 1PV6A 3TGXB 4U4TA 1ETEA 3NPZA 2O26A 5EQIA 1PGRA 3D48P 2R93D 3UEZE 2B8XA 2B90A 1Y6KL 1PW4A 4W6VA 1CSGA 2JA7D 4QIQA 5L6YC 4A93D 5D71A 4A3ID 5D6KA 5TS9A 4CNIC 5A2OA 3O7QA 1Y1VD 3UF2A 5C4XD 1GA3A 3I4MD 4DOHA 3G6DA 1J7VL 3LB6B 1RHGA 5KNHI 1HUWA 4WRLB 3PO3D 4UVMA 3L5WI 3AYHA 1V7NV 4U4VA 1EXZA 1B5LA 4ZF7A 2Z3RA 3HOUD 5FHXA 1ALUA 2INTA 2XUTA 5C7XA 3PIVA 3DGCL 4GS7A 1F45B 2E9WC 3WDOA 4ZS7A 1Z7CA 2D9QA 4TPGA 4NEJA 3BPLA 4TPHA 4DKFA 1EMRA 4YQXA 4D2DA 2C35A 4OH3A 3QAZA 1HWGA 2IL6A 4NN7A 1BGEA 2V8NA 3H3VE 4JR9A 4APSA 3BESL 3HOZD 1AXIA 1ITFA 1EVSA 4LRLA 1M48A 3FKID 2O27A 3DI2A 1IRLA 3DUHC 4YB9D 4NN5A 4O9HA 1ITIA 1BP3A 5FLMD 1HULA 3HOWD 3UF5A 1BGDA 3I4ND 4GRWA 1IARA 4NI7A 5D58A 2B91A 2B63D 4IU8A 2Q98A 4NN6A 4IKXA 5D59A 4D2CA 5LQBA 5IYCD 4U4WA 4A3JD 3Q1SI 4A3DD 4EXPA 1KF9A 2KZ1A 5EQGA 2ILKA 1RCBA 4GBZA 1IJZA 1LQSL 3D85C 1EERA 3N0PA 1QVNA 4NI9A 4DKDA 1JLIA 4OAAA 4XNJA 1INRA 1PVHB 2B5IA 2PSMA 1M47A 4O6KA 3UX9A 4YDYI 1HIKA 4BY1D 3O7PA 1RFBA 1HZIA 4NEMA 2LMSA 4I77Z 1NBPA 3EJJA 4LEPA 4NKQC 1I1RB 1AX8A 3IRHA 1A7MA 1HGUA 2L3OA 1Y1WD 2O6IA 1BBNA 4EXNA 1A22A 4GC0A 4Z5RD 4J05A 4A3LD 1CN4C 4A3BD 2Q7NB 4FA8E 3H0GD 5C44D 1Y6NL 3BPOA 1M4BA 3OG4A 1M4RA 2Z3QA 4BY7D 5D22A 3DLQI 2H24A 3NCBA 3INKC 3PIWA 4J4LC 2D48A 3OG6A 1AU1A 4GBYA 4A3CD 1YKBA 2CYKA 1PW6A 3QT2C 1CNT1 5D72A 3HOXD 5IYBD 3G9VB 4DKEA 2Q14A 1HWHA 5C65A 5D70A 4BXXD 1BUYA 3NCFA 3PO2D 4A3ED 1Y6ML 2L3YA 2CFQA 3NCCA 1HIJA 2OQPA 4IKVA 4XNIA 1BGCA 3HMXB 4ZW9A 3HHCA 3S9DA 1VLKA 2Y5YA 3QB7A 4RS1A 2JA5D 4YPGC 4JA3A 1ILKA 4IKYA 3LB6A 1LKIA 3MZGA 3NCEA 4YBQA 1PV7A 1WU3I 3EW3A 1RW5A 4X51A 1D9CA 4D2BA 1FYHA 4BBSD 5IP7D 4YUEC 4Q65A 2R7ZD 1LK3A 3L5XA 1V7MV 3SE3B 3HOVD 5GXBA 4IKWA 1SCFA 1WCMD 4A3GD 4TPJA 5C3ED 4LDSA 1IK0A 2B8ZA 3OQ3A 1ITLA 2ERJD 2JA8D 3HHRA 2JA6D 5E4EA 1M4AA 3SE4B 1ITMA 1F6FA 4IU9A 4A3FD 4A3KD 4IKZA 2CFPA 3HOYD
chains in the Genus database with same CATH topology
1IL6A 3QT2C 3N0PA 3QWRB 3WCYI 1N1FA 2XQBA 2B8UA 5C7XA 4PS4A 3DI3A 1CNT1 3B5KA 3PIVA 1QVNA 3DGCL 4GS7A 5D72A 4NI9A 1F45B 1Y14A 4DKDA 2E9WC 4ZS7A 3HOXD 1Z7CA 2D9QA 2R92D 1JLIA 3N06A 4A3MD 1INRA 4NEJA 1PVHB 3BPLA 3G9VB 4DKFA 1EMRA 2B5IA 5IYBD 4YQXA 1FG9A 4DKEA 3BPNA 2HYMB 2Q14A 1HWHA 2C35A 4DKCA 5D70A 2PSMA 1M4CA 2VUMD 4BXXD 1BUYA 1M47A 4MHLA 3NCFA 5IP9D 4O6KA 3UX9A 4YDYI 1HIKA 3QAZA 4A3ED 1Y6ML 4BBRD 2L3YA 3PO2D 3NCCA 1HWGA 1HIJA 2OQPA 2IL6A 2GMFA 4BY1D 1P9MB 5D28B 4NN7A 1BGEA 1RFBA 3H3VE 1BGCA 1HZIA 1M49A 3BESL 1AXIA 3HOZD 4NEMA 1BCNA 1ITFA 1PY2A 2LMSA 4I77Z 3HMXB 1NBPA 3EJJA 1EVSA 3HHCA 4NKQC 4LRLA 1Z92A 1M48A 3QB1A 3S9DA 1VLKA 3FKID 5IYDD 3QB7A 2O27A 5FUCA 4RS1A 3DI2A 2JA5D 1I1RB 1AX8A 3IRHA 1IRLA 1ILKA 4YPGC 2LAGA 3D87A 1EKUA 1LKIA 3LB6A 3DUHC 3MZGA 1CYLA 3NCEA 2B8YA 1WU3I 3EW3A 3VA2A 1RW5A 1D9GA 4NN5A 4X51A 1GNCA 1A7MA 1HGUA 4O9HA 1D9CA 2L3OA 1Y1WD 1CD9A 2O6IA 3TGXB 1BBNA 4EXNA 1ETEA 1ITIA 3NPZA 2O26A 1FYHA 4BBSD 5IP7D 1BP3A 4YUEC 1PGRA 3D48P 5FLMD 1A22A 2R93D 2R7ZD 4Z5RD 3UEZE 4A3LD 1HULA 1LK3A 2B8XA 3L5XA 2B90A 1V7MV 1Y6KL 3SE3B 1CN4C 3HOVD 3HOWD 4A3BD 3UF5A 1BGDA 2Q7NB 3H0GD 4GRWA 4FA8E 3I4ND 1IARA 1CSGA 5C44D 1SCFA 1WCMD 1Y6NL 3BPOA 2JA7D 4A3GD 1M4BA 3OG4A 4NI7A 5C3ED 1M4RA 2Z3QA 5L6YC 4A93D 5D71A 4BY7D 4A3ID 2B91A 2B63D 5D22A 5TS9A 1IK0A 4CNIC 3DLQI 2B8ZA 1Y1VD 3OQ3A 1ITLA 2H24A 2Q98A 2ERJD 4NN6A 3UF2A 5C4XD 1GA3A 3I4MD 4DOHA 5LQBA 5IYCD 4A3JD 2JA8D 3Q1SI 4A3DD 3G6DA 4EXPA 1J7VL 3NCBA 3HHRA 3INKC 1KF9A 3LB6B 3PIWA 1RHGA 4J4LC 2D48A 3OG6A 5E4EA 1M4AA 5KNHI 1AU1A 2JA6D 1HUWA 4WRLB 3SE4B 2KZ1A 3PO3D 3L5WI 2ILKA 1RCBA 3AYHA 1IJZA 1ITMA 4A3CD 1F6FA 1V7NV 1YKBA 1EXZA 1LQSL 1B5LA 3D85C 2Z3RA 4ZF7A 3HOUD 4A3FD 5FHXA 2CYKA 4A3KD 1PW6A 1EERA 1ALUA 2INTA 3HOYD
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EXP A;  4DKD A;  4DKE A;  4DKC A;  4EXN A;  4DKF A; 
#chains in the Genus database with same CATH topology
 1IL6 A;  3QWR B;  3WCY I;  1N1F A;  2XQB A;  2B8U A;  4PS4 A;  3DI3 A;  3B5K A;  4ZWC A;  1Y14 A;  4ZYR A;  2R92 D;  5EQH A;  3N06 A;  4A3M D;  1FG9 A;  3BPN A;  2HYM B;  5A2N A;  4ZWB A;  4DKC A;  2VUM D;  1M4C A;  4MHL A;  5IP9 D;  4PYP A;  4BBR D;  2GMF A;  1P9M B;  5D28 B;  1M49 A;  1BCN A;  1PY2 A;  1Z92 A;  3QB1 A;  5IYD D;  5FUC A;  4JRE A;  2LAG A;  3D87 A;  1EKU A;  1CYL A;  2B8Y A;  3VA2 A;  1D9G A;  1GNC A;  1CD9 A;  1PV6 A;  3TGX B;  4U4T A;  1ETE A;  3NPZ A;  2O26 A;  5EQI A;  1PGR A;  3D48 P;  2R93 D;  3UEZ E;  2B8X A;  2B90 A;  1Y6K L;  1PW4 A;  4W6V A;  1CSG A;  2JA7 D;  4QIQ A;  5L6Y C;  4A93 D;  5D71 A;  4A3I D;  5D6K A;  5TS9 A;  4CNI C;  5A2O A;  3O7Q A;  1Y1V D;  3UF2 A;  5C4X D;  1GA3 A;  3I4M D;  4DOH A;  3G6D A;  1J7V L;  3LB6 B;  1RHG A;  5KNH I;  1HUW A;  4WRL B;  3PO3 D;  4UVM A;  3L5W I;  3AYH A;  1V7N V;  4U4V A;  1EXZ A;  1B5L A;  4ZF7 A;  2Z3R A;  3HOU D;  5FHX A;  1ALU A;  2INT A;  2XUT A;  5C7X A;  3PIV A;  3DGC L;  4GS7 A;  1F45 B;  2E9W C;  3WDO A;  4ZS7 A;  1Z7C A;  2D9Q A;  4TPG A;  4NEJ A;  3BPL A;  4TPH A;  4DKF A;  1EMR A;  4YQX A;  4D2D A;  2C35 A;  4OH3 A;  3QAZ A;  1HWG A;  2IL6 A;  4NN7 A;  1BGE A;  2V8N A;  3H3V E;  4JR9 A;  4APS A;  3BES L;  3HOZ D;  1AXI A;  1ITF A;  1EVS A;  4LRL A;  1M48 A;  3FKI D;  2O27 A;  3DI2 A;  1IRL A;  3DUH C;  4YB9 D;  4NN5 A;  4O9H A;  1ITI A;  1BP3 A;  5FLM D;  1HUL A;  3HOW D;  3UF5 A;  1BGD A;  3I4N D;  4GRW A;  1IAR A;  4NI7 A;  5D58 A;  2B91 A;  2B63 D;  4IU8 A;  2Q98 A;  4NN6 A;  4IKX A;  5D59 A;  4D2C A;  5LQB A;  5IYC D;  4U4W A;  4A3J D;  3Q1S I;  4A3D D;  4EXP A;  1KF9 A;  2KZ1 A;  5EQG A;  2ILK A;  1RCB A;  4GBZ A;  1IJZ A;  1LQS L;  3D85 C;  1EER A;  3N0P A;  1QVN A;  4NI9 A;  4DKD A;  1JLI A;  4OAA A;  4XNJ A;  1INR A;  1PVH B;  2B5I A;  2PSM A;  1M47 A;  4O6K A;  3UX9 A;  4YDY I;  1HIK A;  4BY1 D;  3O7P A;  1RFB A;  1HZI A;  4NEM A;  2LMS A;  4I77 Z;  1NBP A;  3EJJ A;  4LEP A;  4NKQ C;  1I1R B;  1AX8 A;  3IRH A;  1A7M A;  1HGU A;  2L3O A;  1Y1W D;  2O6I A;  1BBN A;  4EXN A;  1A22 A;  4GC0 A;  4Z5R D;  4J05 A;  4A3L D;  1CN4 C;  4A3B D;  2Q7N B;  4FA8 E;  3H0G D;  5C44 D;  1Y6N L;  3BPO A;  1M4B A;  3OG4 A;  1M4R A;  2Z3Q A;  4BY7 D;  5D22 A;  3DLQ I;  2H24 A;  3NCB A;  3INK C;  3PIW A;  4J4L C;  2D48 A;  3OG6 A;  1AU1 A;  4GBY A;  4A3C D;  1YKB A;  2CYK A;  1PW6 A;  3QT2 C;  1CNT 1;  5D72 A;  3HOX D;  5IYB D;  3G9V B;  4DKE A;  2Q14 A;  1HWH A;  5C65 A;  5D70 A;  4BXX D;  1BUY A;  3NCF A;  3PO2 D;  4A3E D;  1Y6M L;  2L3Y A;  2CFQ A;  3NCC A;  1HIJ A;  2OQP A;  4IKV A;  4XNI A;  1BGC A;  3HMX B;  4ZW9 A;  3HHC A;  3S9D A;  1VLK A;  2Y5Y A;  3QB7 A;  4RS1 A;  2JA5 D;  4YPG C;  4JA3 A;  1ILK A;  4IKY A;  3LB6 A;  1LKI A;  3MZG A;  3NCE A;  4YBQ A;  1PV7 A;  1WU3 I;  3EW3 A;  1RW5 A;  4X51 A;  1D9C A;  4D2B A;  1FYH A;  4BBS D;  5IP7 D;  4YUE C;  4Q65 A;  2R7Z D;  1LK3 A;  3L5X A;  1V7M V;  3SE3 B;  3HOV D;  5GXB A;  4IKW A;  1SCF A;  1WCM D;  4A3G D;  4TPJ A;  5C3E D;  4LDS A;  1IK0 A;  2B8Z A;  3OQ3 A;  1ITL A;  2ERJ D;  2JA8 D;  3HHR A;  2JA6 D;  5E4E A;  1M4A A;  3SE4 B;  1ITM A;  1F6F A;  4IU9 A;  4A3F D;  4A3K D;  4IKZ A;  2CFP A;  3HOY D; 
#chains in the Genus database with same CATH homology
 1IL6 A;  3QT2 C;  3N0P A;  3QWR B;  3WCY I;  1N1F A;  2XQB A;  2B8U A;  5C7X A;  4PS4 A;  3DI3 A;  1CNT 1;  3B5K A;  3PIV A;  1QVN A;  3DGC L;  4GS7 A;  5D72 A;  4NI9 A;  1F45 B;  1Y14 A;  4DKD A;  2E9W C;  4ZS7 A;  3HOX D;  1Z7C A;  2D9Q A;  2R92 D;  1JLI A;  3N06 A;  4A3M D;  1INR A;  4NEJ A;  1PVH B;  3BPL A;  3G9V B;  4DKF A;  1EMR A;  2B5I A;  5IYB D;  4YQX A;  1FG9 A;  4DKE A;  3BPN A;  2HYM B;  2Q14 A;  1HWH A;  2C35 A;  4DKC A;  5D70 A;  2PSM A;  1M4C A;  2VUM D;  4BXX D;  1BUY A;  1M47 A;  4MHL A;  3NCF A;  5IP9 D;  4O6K A;  3UX9 A;  4YDY I;  1HIK A;  3QAZ A;  4A3E D;  1Y6M L;  4BBR D;  2L3Y A;  3PO2 D;  3NCC A;  1HWG A;  1HIJ A;  2OQP A;  2IL6 A;  2GMF A;  4BY1 D;  1P9M B;  5D28 B;  4NN7 A;  1BGE A;  1RFB A;  3H3V E;  1BGC A;  1HZI A;  1M49 A;  3BES L;  1AXI A;  3HOZ D;  4NEM A;  1BCN A;  1ITF A;  1PY2 A;  2LMS A;  4I77 Z;  3HMX B;  1NBP A;  3EJJ A;  1EVS A;  3HHC A;  4NKQ C;  4LRL A;  1Z92 A;  1M48 A;  3QB1 A;  3S9D A;  1VLK A;  3FKI D;  5IYD D;  3QB7 A;  2O27 A;  5FUC A;  4RS1 A;  3DI2 A;  2JA5 D;  1I1R B;  1AX8 A;  3IRH A;  1IRL A;  1ILK A;  4YPG C;  2LAG A;  3D87 A;  1EKU A;  1LKI A;  3LB6 A;  3DUH C;  3MZG A;  1CYL A;  3NCE A;  2B8Y A;  1WU3 I;  3EW3 A;  3VA2 A;  1RW5 A;  1D9G A;  4NN5 A;  4X51 A;  1GNC A;  1A7M A;  1HGU A;  4O9H A;  1D9C A;  2L3O A;  1Y1W D;  1CD9 A;  2O6I A;  3TGX B;  1BBN A;  4EXN A;  1ETE A;  1ITI A;  3NPZ A;  2O26 A;  1FYH A;  4BBS D;  5IP7 D;  1BP3 A;  4YUE C;  1PGR A;  3D48 P;  5FLM D;  1A22 A;  2R93 D;  2R7Z D;  4Z5R D;  3UEZ E;  4A3L D;  1HUL A;  1LK3 A;  2B8X A;  3L5X A;  2B90 A;  1V7M V;  1Y6K L;  3SE3 B;  1CN4 C;  3HOV D;  3HOW D;  4A3B D;  3UF5 A;  1BGD A;  2Q7N B;  3H0G D;  4GRW A;  4FA8 E;  3I4N D;  1IAR A;  1CSG A;  5C44 D;  1SCF A;  1WCM D;  1Y6N L;  3BPO A;  2JA7 D;  4A3G D;  1M4B A;  3OG4 A;  4NI7 A;  5C3E D;  1M4R A;  2Z3Q A;  5L6Y C;  4A93 D;  5D71 A;  4BY7 D;  4A3I D;  2B91 A;  2B63 D;  5D22 A;  5TS9 A;  1IK0 A;  4CNI C;  3DLQ I;  2B8Z A;  1Y1V D;  3OQ3 A;  1ITL A;  2H24 A;  2Q98 A;  2ERJ D;  4NN6 A;  3UF2 A;  5C4X D;  1GA3 A;  3I4M D;  4DOH A;  5LQB A;  5IYC D;  4A3J D;  2JA8 D;  3Q1S I;  4A3D D;  3G6D A;  4EXP A;  1J7V L;  3NCB A;  3HHR A;  3INK C;  1KF9 A;  3LB6 B;  3PIW A;  1RHG A;  4J4L C;  2D48 A;  3OG6 A;  5E4E A;  1M4A A;  5KNH I;  1AU1 A;  2JA6 D;  1HUW A;  4WRL B;  3SE4 B;  2KZ1 A;  3PO3 D;  3L5W I;  2ILK A;  1RCB A;  3AYH A;  1IJZ A;  1ITM A;  4A3C D;  1F6F A;  1V7N V;  1YKB A;  1EXZ A;  1LQS L;  1B5L A;  3D85 C;  2Z3R A;  4ZF7 A;  3HOU D;  4A3F D;  5FHX A;  2CYK A;  4A3K D;  1PW6 A;  1EER A;  1ALU A;  2INT A;  3HOY D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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