4DKFA

Crystal structure of human interleukin-34 bound to fab2
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
161
structure length
161
Chain Sequence
NEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.
pubmed doi rcsb
molecule tags Cytokine/immune system
source organism Homo sapiens
molecule keywords Interleukin-34
total genus 57
structure length 161
sequence length 161
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15036 IL34 Interleukin 34
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.80 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 4dkfA00
4EXNA 4EXPA 4DKFA 4DKDA 4DKEA 4DKCA
chains in the Genus database with same CATH superfamily
1PV6A 1BCNA 4D2CA 1CNT1 1YKBA 4EXPA 2Z3QA 4BY1D 4A3GD 4GRWA 5D71A 1RW5A 3TGXB 4GS7A 2R92D 4W6VA 3EW3A 1Y1WD 3UF2A 4YPGC 1HGUA 2CFPA 1JLIA 1D9GA 4YBQA 1N1FA 5EQIA 3PIVA 3HHCA 5D28B 4IKVA 5A2NA 3UEZE 2LMSA 3I4ND 3INKC 2INTA 3FKID 1Z92A 4A3ED 1ALUA 4MHLA 3IRHA 4BXXD 3H0GD 4GC0A 5L6YC 2B8UA 4PS4A 1ITIA 4BBRD 2C35A 5IP7D 1CYLA 3HOXD 2ILKA 3N06A 2B8ZA 1Y6KL 4GBYA 1IRLA 4BY7D 4O6KA 5A2OA 1A7MA 4A3FD 1A22A 4YDYI 5D72A 4GBZA 4IKXA 4A3MD 1SCFA 3PO3D 2JA6D 2B90A 4IKWA 1J7VL 4NKQC 1M48A 3NCBA 4IKYA 5TS9A 1HWGA 3AYHA 1ITLA 2Y5YA 3OG6A 2GMFA 4TPHA 1IL6A 4QIQA 4Z5RD 4NN6A 4XNJA 1PVHB 1I1RB 1FYHA 3G9VB 4YQXA 1M4CA 1VLKA 2CFQA 1EERA 1HZIA 3QT2C 1WCMD 1IARA 4EXNA 1AXIA 1WU3I 1RCBA 1AU1A 3OG4A 3UF5A 4IU9A 1LK3A 3DLQI 3Q1SI 5C44D 1V7NV 4A3LD 1PY2A 1HULA 2CYKA 3S9DA 1KF9A 1NBPA 2O26A 5FLMD 1BUYA 1CSGA 2E9WC 1CN4C 2B8YA 5C65A 3G6DA 5FHXA 4OH3A 4Q65A 2O6IA 5C3ED 1B5LA 1M4RA 4ZWCA 4DKCA 3VA2A 2JA5D 4X51A 3D85C 1GA3A 2R93D 1RHGA 1EVSA 4IKZA 3SE4B 1BGEA 1GNCA 1HIKA 2V8NA 3NCCA 1M4AA 3PO2D 4A3ID 3HOYD 3NCFA 4NEMA 3SE3B 2Z3RA 4YB9D 1ITFA 2OQPA 4APSA 4JR9A 2KZ1A 1EKUA 4LDSA 3QB1A 3L5WI 4ZW9A 1INRA 3EJJA 1P9MB 5C7XA 2Q7NB 1M47A 1Y1VD 3O7PA 4A93D 2B63D 1Y6ML 4A3KD 1RFBA 1M49A 4NI7A 1ILKA 3OQ3A 1HIJA 4D2DA 2LAGA 5E4EA 4UVMA 4RS1A 4PYPA 1Y14A 4LRLA 4FA8E 1ITMA 4ZS7A 4A3JD 2L3YA 3HOUD 3DUHC 5IYDD 1EXZA 2B8XA 5D58A 1FG9A 1HUWA 4A3BD 3QB7A 2JA8D 2O27A 1V7MV 4A3CD 4NEJA 1F6FA 1AX8A 4DKDA 3LB6B 1Y6NL 5KNHI 4ZF7A 4TPJA 5D70A 3QAZA 5D59A 1CD9A 3HHRA 5GXBA 4U4WA 1PW6A 1BGCA 3L5XA 1PGRA 2D48A 1D9CA 4JA3A 4XNIA 2JA7D 3BPNA 2B5IA 3DI2A 2Q98A 3WDOA 5IP9D 3D48P 2ERJD 3I4MD 4WRLB 4DKFA 3HOZD 1F45B 2H24A 4TPGA 3BPLA 1BGDA 4ZYRA 1QVNA 5IYBD 3D87A 4U4TA 4J05A 3NPZA 5EQHA 1PV7A 1IJZA 2VUMD 2R7ZD 3BESL 2IL6A 4I77Z 4ZWBA 2HYMB 1Z7CA 5C4XD 4OAAA 1EMRA 2XQBA 3UX9A 3MZGA 4U4VA 3HMXB 3DI3A 4NN5A 2XUTA 3QWRB 3O7QA 5LQBA 3HOWD 5IYCD 5FUCA 3HOVD 4D2BA 4CNIC 2Q14A 3WCYI 1LQSL 1IK0A 4IU8A 1HWHA 4DKEA 1M4BA 3BPOA 3N0PA 4YUEC 5D22A 3LB6A 2L3OA 1BBNA 1LKIA 4LEPA 2PSMA 5D6KA 4J4LC 4DOHA 1ETEA 4NI9A 2D9QA 1BP3A 3NCEA 4NN7A 3H3VE 5EQGA 1PW4A 3PIWA 3DGCL 3B5KA 4O9HA 4JREA 4A3DD 2B91A 4BBSD
chains in the Genus database with same CATH topology
3OG6A 5IP9D 3D48P 2ERJD 2KZ1A 1EKUA 3I4MD 2GMFA 4WRLB 4DKFA 1IL6A 3HOZD 1BCNA 3QB1A 1F45B 4Z5RD 2H24A 3L5WI 1CNT1 1INRA 3EJJA 1P9MB 1YKBA 2Q7NB 5C7XA 4EXPA 2Z3QA 4NN6A 4BY1D 1M47A 4A3GD 4GRWA 1Y1VD 3BPLA 5D71A 1BGDA 1PVHB 4A93D 1I1RB 1QVNA 5IYBD 2B63D 3D87A 1Y6ML 4A3KD 1RW5A 3TGXB 1FYHA 4GS7A 3G9VB 1RFBA 1M49A 4YQXA 3NPZA 4NI7A 3EW3A 1ILKA 2R92D 1IJZA 3OQ3A 1M4CA 1ITFA 1HIJA 2VUMD 1VLKA 1Y1WD 2R7ZD 1EERA 2LAGA 3BESL 2IL6A 1HZIA 5E4EA 3UF2A 3QT2C 4I77Z 4YPGC 4RS1A 1HGUA 1WCMD 1Y14A 2HYMB 1JLIA 1IARA 4LRLA 4EXNA 1D9GA 1Z7CA 1AXIA 1N1FA 3PIVA 5C4XD 1WU3I 3HHCA 1EMRA 1RCBA 2XQBA 5D28B 3UX9A 4FA8E 3MZGA 1ITMA 1AU1A 3OG4A 3UF5A 3HMXB 4ZS7A 4A3JD 3UEZE 1LK3A 2L3YA 2LMSA 3DLQI 3Q1SI 3I4ND 5C44D 3DI3A 3INKC 1V7NV 3DUHC 3HOUD 4NN5A 2INTA 3FKID 4A3LD 1PY2A 1Z92A 1HULA 3QWRB 4A3ED 5LQBA 1EXZA 2B8XA 5IYDD 3HOWD 1ALUA 2CYKA 3S9DA 5IYCD 1FG9A 1KF9A 1HUWA 4MHLA 5FUCA 3HOVD 3IRHA 4A3BD 1NBPA 4CNIC 4BXXD 3H0GD 2Q14A 3QB7A 3WCYI 1LQSL 1IK0A 2JA8D 2O27A 1HWHA 4DKEA 1M4BA 2O26A 5L6YC 5FLMD 2B8UA 1BUYA 1V7MV 4PS4A 3BPOA 3N0PA 4A3CD 1ITIA 1CSGA 4YUEC 2E9WC 1CN4C 4NEJA 2B8YA 2C35A 5D22A 5IP7D 4BBRD 3G6DA 3LB6A 2L3OA 1F6FA 1CYLA 1AX8A 5FHXA 1BBNA 3HOXD 4DKDA 2ILKA 1LKIA 3LB6B 3N06A 2B8ZA 1Y6NL 2O6IA 1Y6KL 5C3ED 1B5LA 2PSMA 1IRLA 5KNHI 1M4RA 4ZF7A 4DKCA 4BY7D 4J4LC 4O6KA 1A7MA 4DOHA 5D70A 3QAZA 1A22A 3VA2A 4A3FD 2JA5D 1ETEA 4X51A 4YDYI 1CD9A 4NI9A 3D85C 1GA3A 2D9QA 1BP3A 3HHRA 5D72A 3NCEA 2R93D 1PW6A 4NN7A 1RHGA 1EVSA 3H3VE 4A3MD 3PO3D 1SCFA 2JA6D 1BGCA 2B90A 3L5XA 1PGRA 3SE4B 2D48A 1J7VL 1BGEA 1GNCA 1D9CA 1HIKA 1M48A 1M4AA 3DGCL 3NCCA 3NCBA 3PIWA 4NKQC 3B5KA 4O9HA 3PO2D 5TS9A 4A3ID 3HOYD 1HWGA 3BPNA 3NCFA 2JA7D 4NEMA 3SE3B 2Z3RA 2B5IA 3AYHA 4A3DD 2B91A 4BBSD 1ITLA 3DI2A 2OQPA 2Q98A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EXN A;  4EXP A;  4DKF A;  4DKD A;  4DKE A;  4DKC A; 
#chains in the Genus database with same CATH topology
 1PV6 A;  1BCN A;  4D2C A;  1CNT 1;  1YKB A;  4EXP A;  2Z3Q A;  4BY1 D;  4A3G D;  4GRW A;  5D71 A;  1RW5 A;  3TGX B;  4GS7 A;  2R92 D;  4W6V A;  3EW3 A;  1Y1W D;  3UF2 A;  4YPG C;  1HGU A;  2CFP A;  1JLI A;  1D9G A;  4YBQ A;  1N1F A;  5EQI A;  3PIV A;  3HHC A;  5D28 B;  4IKV A;  5A2N A;  3UEZ E;  2LMS A;  3I4N D;  3INK C;  2INT A;  3FKI D;  1Z92 A;  4A3E D;  1ALU A;  4MHL A;  3IRH A;  4BXX D;  3H0G D;  4GC0 A;  5L6Y C;  2B8U A;  4PS4 A;  1ITI A;  4BBR D;  2C35 A;  5IP7 D;  1CYL A;  3HOX D;  2ILK A;  3N06 A;  2B8Z A;  1Y6K L;  4GBY A;  1IRL A;  4BY7 D;  4O6K A;  5A2O A;  1A7M A;  4A3F D;  1A22 A;  4YDY I;  5D72 A;  4GBZ A;  4IKX A;  4A3M D;  1SCF A;  3PO3 D;  2JA6 D;  2B90 A;  4IKW A;  1J7V L;  4NKQ C;  1M48 A;  3NCB A;  4IKY A;  5TS9 A;  1HWG A;  3AYH A;  1ITL A;  2Y5Y A;  3OG6 A;  2GMF A;  4TPH A;  1IL6 A;  4QIQ A;  4Z5R D;  4NN6 A;  4XNJ A;  1PVH B;  1I1R B;  1FYH A;  3G9V B;  4YQX A;  1M4C A;  1VLK A;  2CFQ A;  1EER A;  1HZI A;  3QT2 C;  1WCM D;  1IAR A;  4EXN A;  1AXI A;  1WU3 I;  1RCB A;  1AU1 A;  3OG4 A;  3UF5 A;  4IU9 A;  1LK3 A;  3DLQ I;  3Q1S I;  5C44 D;  1V7N V;  4A3L D;  1PY2 A;  1HUL A;  2CYK A;  3S9D A;  1KF9 A;  1NBP A;  2O26 A;  5FLM D;  1BUY A;  1CSG A;  2E9W C;  1CN4 C;  2B8Y A;  5C65 A;  3G6D A;  5FHX A;  4OH3 A;  4Q65 A;  2O6I A;  5C3E D;  1B5L A;  1M4R A;  4ZWC A;  4DKC A;  3VA2 A;  2JA5 D;  4X51 A;  3D85 C;  1GA3 A;  2R93 D;  1RHG A;  1EVS A;  4IKZ A;  3SE4 B;  1BGE A;  1GNC A;  1HIK A;  2V8N A;  3NCC A;  1M4A A;  3PO2 D;  4A3I D;  3HOY D;  3NCF A;  4NEM A;  3SE3 B;  2Z3R A;  4YB9 D;  1ITF A;  2OQP A;  4APS A;  4JR9 A;  2KZ1 A;  1EKU A;  4LDS A;  3QB1 A;  3L5W I;  4ZW9 A;  1INR A;  3EJJ A;  1P9M B;  5C7X A;  2Q7N B;  1M47 A;  1Y1V D;  3O7P A;  4A93 D;  2B63 D;  1Y6M L;  4A3K D;  1RFB A;  1M49 A;  4NI7 A;  1ILK A;  3OQ3 A;  1HIJ A;  4D2D A;  2LAG A;  5E4E A;  4UVM A;  4RS1 A;  4PYP A;  1Y14 A;  4LRL A;  4FA8 E;  1ITM A;  4ZS7 A;  4A3J D;  2L3Y A;  3HOU D;  3DUH C;  5IYD D;  1EXZ A;  2B8X A;  5D58 A;  1FG9 A;  1HUW A;  4A3B D;  3QB7 A;  2JA8 D;  2O27 A;  1V7M V;  4A3C D;  4NEJ A;  1F6F A;  1AX8 A;  4DKD A;  3LB6 B;  1Y6N L;  5KNH I;  4ZF7 A;  4TPJ A;  5D70 A;  3QAZ A;  5D59 A;  1CD9 A;  3HHR A;  5GXB A;  4U4W A;  1PW6 A;  1BGC A;  3L5X A;  1PGR A;  2D48 A;  1D9C A;  4JA3 A;  4XNI A;  2JA7 D;  3BPN A;  2B5I A;  3DI2 A;  2Q98 A;  3WDO A;  5IP9 D;  3D48 P;  2ERJ D;  3I4M D;  4WRL B;  4DKF A;  3HOZ D;  1F45 B;  2H24 A;  4TPG A;  3BPL A;  1BGD A;  4ZYR A;  1QVN A;  5IYB D;  3D87 A;  4U4T A;  4J05 A;  3NPZ A;  5EQH A;  1PV7 A;  1IJZ A;  2VUM D;  2R7Z D;  3BES L;  2IL6 A;  4I77 Z;  4ZWB A;  2HYM B;  1Z7C A;  5C4X D;  4OAA A;  1EMR A;  2XQB A;  3UX9 A;  3MZG A;  4U4V A;  3HMX B;  3DI3 A;  4NN5 A;  2XUT A;  3QWR B;  3O7Q A;  5LQB A;  3HOW D;  5IYC D;  5FUC A;  3HOV D;  4D2B A;  4CNI C;  2Q14 A;  3WCY I;  1LQS L;  1IK0 A;  4IU8 A;  1HWH A;  4DKE A;  1M4B A;  3BPO A;  3N0P A;  4YUE C;  5D22 A;  3LB6 A;  2L3O A;  1BBN A;  1LKI A;  4LEP A;  2PSM A;  5D6K A;  4J4L C;  4DOH A;  1ETE A;  4NI9 A;  2D9Q A;  1BP3 A;  3NCE A;  4NN7 A;  3H3V E;  5EQG A;  1PW4 A;  3PIW A;  3DGC L;  3B5K A;  4O9H A;  4JRE A;  4A3D D;  2B91 A;  4BBS D; 
#chains in the Genus database with same CATH homology
 3OG6 A;  5IP9 D;  3D48 P;  2ERJ D;  2KZ1 A;  1EKU A;  3I4M D;  2GMF A;  4WRL B;  4DKF A;  1IL6 A;  3HOZ D;  1BCN A;  3QB1 A;  1F45 B;  4Z5R D;  2H24 A;  3L5W I;  1CNT 1;  1INR A;  3EJJ A;  1P9M B;  1YKB A;  2Q7N B;  5C7X A;  4EXP A;  2Z3Q A;  4NN6 A;  4BY1 D;  1M47 A;  4A3G D;  4GRW A;  1Y1V D;  3BPL A;  5D71 A;  1BGD A;  1PVH B;  4A93 D;  1I1R B;  1QVN A;  5IYB D;  2B63 D;  3D87 A;  1Y6M L;  4A3K D;  1RW5 A;  3TGX B;  1FYH A;  4GS7 A;  3G9V B;  1RFB A;  1M49 A;  4YQX A;  3NPZ A;  4NI7 A;  3EW3 A;  1ILK A;  2R92 D;  1IJZ A;  3OQ3 A;  1M4C A;  1ITF A;  1HIJ A;  2VUM D;  1VLK A;  1Y1W D;  2R7Z D;  1EER A;  2LAG A;  3BES L;  2IL6 A;  1HZI A;  5E4E A;  3UF2 A;  3QT2 C;  4I77 Z;  4YPG C;  4RS1 A;  1HGU A;  1WCM D;  1Y14 A;  2HYM B;  1JLI A;  1IAR A;  4LRL A;  4EXN A;  1D9G A;  1Z7C A;  1AXI A;  1N1F A;  3PIV A;  5C4X D;  1WU3 I;  3HHC A;  1EMR A;  1RCB A;  2XQB A;  5D28 B;  3UX9 A;  4FA8 E;  3MZG A;  1ITM A;  1AU1 A;  3OG4 A;  3UF5 A;  3HMX B;  4ZS7 A;  4A3J D;  3UEZ E;  1LK3 A;  2L3Y A;  2LMS A;  3DLQ I;  3Q1S I;  3I4N D;  5C44 D;  3DI3 A;  3INK C;  1V7N V;  3DUH C;  3HOU D;  4NN5 A;  2INT A;  3FKI D;  4A3L D;  1PY2 A;  1Z92 A;  1HUL A;  3QWR B;  4A3E D;  5LQB A;  1EXZ A;  2B8X A;  5IYD D;  3HOW D;  1ALU A;  2CYK A;  3S9D A;  5IYC D;  1FG9 A;  1KF9 A;  1HUW A;  4MHL A;  5FUC A;  3HOV D;  3IRH A;  4A3B D;  1NBP A;  4CNI C;  4BXX D;  3H0G D;  2Q14 A;  3QB7 A;  3WCY I;  1LQS L;  1IK0 A;  2JA8 D;  2O27 A;  1HWH A;  4DKE A;  1M4B A;  2O26 A;  5L6Y C;  5FLM D;  2B8U A;  1BUY A;  1V7M V;  4PS4 A;  3BPO A;  3N0P A;  4A3C D;  1ITI A;  1CSG A;  4YUE C;  2E9W C;  1CN4 C;  4NEJ A;  2B8Y A;  2C35 A;  5D22 A;  5IP7 D;  4BBR D;  3G6D A;  3LB6 A;  2L3O A;  1F6F A;  1CYL A;  1AX8 A;  5FHX A;  1BBN A;  3HOX D;  4DKD A;  2ILK A;  1LKI A;  3LB6 B;  3N06 A;  2B8Z A;  1Y6N L;  2O6I A;  1Y6K L;  5C3E D;  1B5L A;  2PSM A;  1IRL A;  5KNH I;  1M4R A;  4ZF7 A;  4DKC A;  4BY7 D;  4J4L C;  4O6K A;  1A7M A;  4DOH A;  5D70 A;  3QAZ A;  1A22 A;  3VA2 A;  4A3F D;  2JA5 D;  1ETE A;  4X51 A;  4YDY I;  1CD9 A;  4NI9 A;  3D85 C;  1GA3 A;  2D9Q A;  1BP3 A;  3HHR A;  5D72 A;  3NCE A;  2R93 D;  1PW6 A;  4NN7 A;  1RHG A;  1EVS A;  3H3V E;  4A3M D;  3PO3 D;  1SCF A;  2JA6 D;  1BGC A;  2B90 A;  3L5X A;  1PGR A;  3SE4 B;  2D48 A;  1J7V L;  1BGE A;  1GNC A;  1D9C A;  1HIK A;  1M48 A;  1M4A A;  3DGC L;  3NCC A;  3NCB A;  3PIW A;  4NKQ C;  3B5K A;  4O9H A;  3PO2 D;  5TS9 A;  4A3I D;  3HOY D;  1HWG A;  3BPN A;  3NCF A;  2JA7 D;  4NEM A;  3SE3 B;  2Z3R A;  2B5I A;  3AYH A;  4A3D D;  2B91 A;  4BBS D;  1ITL A;  3DI2 A;  2OQP A;  2Q98 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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