4EXNA

Crystal structure of mouse interleukin-34
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
172
structure length
172
Chain Sequence
NLEIWTLTQDKECDLTGYLRGKLQYKNRLQYMKHYFPINYRIAVPYEGVLRVANITRLQKAHVSERELRYLWVLVSLNATESVMDVLLEGHPSWKYLQEVQTLLENVQRSLMDVEIGPHVEAVLSLLSTPGLSLKLVRPKALLDNCFRVMELLYCSCCKQSPILKWQDCELP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
pubmed doi rcsb
molecule tags Cytokine
source organism Mus musculus
molecule keywords Interleukin-34
total genus 57
structure length 172
sequence length 172
chains with identical sequence B, E, F
ec nomenclature
pdb deposition date 2012-04-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15036 IL34 Interleukin 34
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.80 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 4exnA00
4DKCA 4DKFA 4EXPA 4EXNA 4DKDA 4DKEA
chains in the Genus database with same CATH superfamily
1CYLA 5D59A 3I4ND 1Y1VD 1BP3A 5EQHA 1HZIA 4O9HA 4YUEC 4A3ED 4OH3A 3HOXD 1V7NV 5D70A 3FKID 3I4MD 4ZWBA 3O7PA 1CN4C 2R92D 1F6FA 5A2OA 4IU9A 4EXNA 3N0PA 5D22A 5D72A 4O6KA 2B8UA 3HHRA 3PO3D 4ZW9A 1HIKA 1I1RB 5KNHI 4D2BA 1M48A 1PGRA 2B90A 1IRLA 2VUMD 3DGCL 4DKCA 3SE4B 5FUCA 2JA6D 4GS7A 4NN7A 1GNCA 1CSGA 1A22A 4A3ID 2V8NA 1M49A 4DKFA 4GRWA 4NI7A 3LB6B 3WCYI 3PIWA 4I77Z 1INRA 1V7MV 5IP7D 1F45B 5E4EA 3TGXB 1EERA 3DUHC 5GXBA 2B91A 3BPLA 3NCBA 3PIVA 4NN6A 4J4LC 4YB9D 1RCBA 3O7QA 4A3JD 3DI3A 2PSMA 1M4AA 3DLQI 4XNIA 1ALUA 3NCEA 1BGEA 2Z3QA 2L3OA 4D2CA 4A3MD 1PW6A 3QB7A 4A3LD 2B8YA 1NBPA 4APSA 4YBQA 2ILKA 1B5LA 1BGDA 1BCNA 4RS1A 1KF9A 4ZF7A 2B5IA 1D9CA 1ITFA 1A7MA 1CD9A 1RW5A 4ZWCA 4JREA 4IKWA 1PV7A 4X51A 1IARA 1N1FA 1AX8A 4GC0A 1CNT1 5IYDD 4U4WA 4BBRD 2Q14A 1J7VL 2HYMB 5TS9A 1QVNA 4MHLA 2R7ZD 5IP9D 4ZYRA 1RFBA 2XUTA 1VLKA 2LMSA 4FA8E 3HOUD 1EMRA 4IKXA 4UVMA 3SE3B 1SCFA 4BXXD 3IRHA 1LQSL 2CYKA 3G9VB 2CFPA 4NKQC 3UF2A 4JR9A 3D87A 4IU8A 5L6YC 1M4RA 4NEJA 4BY1D 1ITLA 4W6VA 5FHXA 1AXIA 1IK0A 5C65A 1ITMA 1Y6KL 1M47A 1Z7CA 1YKBA 2IL6A 4PS4A 4PYPA 4NN5A 4YDYI 4BY7D 2R93D 1RHGA 5C7XA 4LEPA 1PW4A 4TPHA 4LDSA 3NCCA 5FLMD 4LRLA 1BGCA 3DI2A 5C3ED 1M4BA 3QWRB 2H24A 4U4VA 2XQBA 1ILKA 2JA5D 4YQXA 4QIQA 4CNIC 2Q98A 1EVSA 1HULA 3N06A 1M4CA 4A93D 2ERJD 3G6DA 1Z92A 5D28B 1FYHA 2JA8D 1IJZA 2B63D 2D9QA 4DKEA 3OG6A 1ITIA 3OQ3A 1HGUA 1WU3I 1PY2A 2O6IA 4A3CD 5EQIA 3L5WI 4YPGC 3AYHA 5D6KA 4JA3A 3UEZE 1Y14A 2E9WC 3BPOA 2O27A 4XNJA 4GBYA 4DKDA 5LQBA 3EW3A 4D2DA 2INTA 5IYCD 1LK3A 3BESL 1JLIA 3S9DA 4TPJA 2KZ1A 4BBSD 3INKC 1Y6ML 1HWGA 1PV6A 2B8XA 3Q1SI 4A3FD 4NEMA 4WRLB 1HIJA 4U4TA 4A3BD 5C44D 3BPNA 5IYBD 4A3DD 1WCMD 3QB1A 2Z3RA 1FG9A 1BBNA 2D48A 3HOYD 1ETEA 2OQPA 3D85C 4EXPA 1Y6NL 3HMXB 2GMFA 4TPGA 5D71A 4DOHA 2L3YA 3HOVD 3NCFA 3OG4A 1LKIA 1P9MB 3D48P 1BUYA 4GBZA 4IKYA 1Y1WD 1EXZA 5D58A 1HWHA 3PO2D 4OAAA 3EJJA 3NPZA 4A3KD 2LAGA 4A3GD 1GA3A 1IL6A 1AU1A 5C4XD 5EQGA 3B5KA 2CFQA 3H0GD 4J05A 4Q65A 1HUWA 1D9GA 2Q7NB 2Y5YA 3HHCA 4NI9A 3WDOA 3LB6A 2O26A 3UF5A 3L5XA 3HOWD 1EKUA 2JA7D 2B8ZA 4IKVA 2C35A 3UX9A 3HOZD 3H3VE 1PVHB 4IKZA 4ZS7A 4Z5RD 3QT2C 3QAZA 3VA2A 5A2NA 3MZGA
chains in the Genus database with same CATH topology
1AXIA 3BESL 1JLIA 3S9DA 1CYLA 3NCEA 1IK0A 1BGEA 3I4ND 1ITMA 2Z3QA 1Y1VD 2KZ1A 3INKC 1BP3A 4BBSD 1Y6ML 1HWGA 2L3OA 1HZIA 2B8XA 3Q1SI 1Y6KL 4O9HA 4YUEC 4NEMA 4A3FD 4WRLB 1PW6A 3QB7A 1M47A 1Z7CA 4A3ED 1YKBA 4A3MD 1HIJA 4A3BD 2IL6A 4PS4A 5C44D 3HOXD 4A3LD 1V7NV 3BPNA 4NN5A 4YDYI 5IYBD 2B8YA 1WCMD 1NBPA 3QB1A 5D70A 4A3DD 4BY7D 2R93D 1RHGA 2Z3RA 3FKID 5C7XA 1FG9A 1BBNA 2D48A 3I4MD 3HOYD 1ETEA 2ILKA 1CN4C 2OQPA 3D85C 4EXPA 1Y6NL 3HMXB 1B5LA 2R92D 3WCYI 3NCCA 2GMFA 1BGDA 5D71A 1F6FA 5FLMD 1BCNA 4RS1A 4LRLA 4DOHA 4EXNA 1BGCA 3N0PA 1KF9A 4ZF7A 2L3YA 5D22A 5D72A 3HOVD 2B5IA 2B8UA 3HHRA 3NCFA 4O6KA 3DI2A 1D9CA 3PO3D 3OG4A 5C3ED 1LKIA 1P9MB 1ITFA 3D48P 1A7MA 1M4BA 3QWRB 1BUYA 2H24A 1CD9A 1RW5A 1ILKA 2XQBA 2JA5D 1Y1WD 4YQXA 1HIKA 4CNIC 4X51A 1I1RB 5KNHI 1IARA 2Q98A 1N1FA 1EVSA 1EXZA 1HULA 1AX8A 1HWHA 3PO2D 3EJJA 3NPZA 1M48A 3N06A 1CNT1 1PGRA 2B90A 5IYDD 1M4CA 4A3KD 4BBRD 2Q14A 1IRLA 2LAGA 3DGCL 2VUMD 4A3GD 1J7VL 2HYMB 4DKCA 3SE4B 1GA3A 1IL6A 5FUCA 2JA6D 4GS7A 4NN7A 5TS9A 1GNCA 1AU1A 1QVNA 4MHLA 2R7ZD 1CSGA 5IP9D 1A22A 4A3ID 5C4XD 1RFBA 4A93D 2ERJD 3B5KA 3H0GD 1VLKA 1M49A 4DKFA 3G6DA 1Z92A 2LMSA 3LB6B 3PIWA 4GRWA 5D28B 1HUWA 1FYHA 1D9GA 4I77Z 1IJZA 1INRA 4FA8E 2JA8D 2Q7NB 2B63D 1V7MV 2D9QA 4DKEA 3OG6A 3HOUD 5IP7D 1ITIA 1F45B 3HHCA 3OQ3A 5E4EA 4NI9A 1HGUA 1WU3I 1EMRA 3TGXB 1EERA 1PY2A 2O6IA 3DUHC 4A3CD 3L5WI 2B91A 4YPGC 3SE3B 3LB6A 2O26A 3AYHA 3UF5A 3UEZE 1Y14A 3L5XA 3HOWD 2E9WC 3BPLA 3NCBA 3BPOA 1SCFA 1EKUA 3PIVA 4NN6A 4BXXD 4NI7A 2O27A 3IRHA 1LQSL 2CYKA 3G9VB 2JA7D 2B8ZA 4J4LC 4NKQC 2C35A 3UF2A 3UX9A 3HOZD 1RCBA 3D87A 3H3VE 4DKDA 5L6YC 4A3JD 5LQBA 1M4RA 1PVHB 3DI3A 2PSMA 4ZS7A 3EW3A 4Z5RD 4NEJA 3QT2C 1M4AA 2INTA 3DLQI 4BY1D 5IYCD 3QAZA 1ITLA 3VA2A 1ALUA 5FHXA 1LK3A 3MZGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DKC A;  4DKF A;  4EXP A;  4EXN A;  4DKD A;  4DKE A; 
#chains in the Genus database with same CATH topology
 1CYL A;  5D59 A;  3I4N D;  1Y1V D;  1BP3 A;  5EQH A;  1HZI A;  4O9H A;  4YUE C;  4A3E D;  4OH3 A;  3HOX D;  1V7N V;  5D70 A;  3FKI D;  3I4M D;  4ZWB A;  3O7P A;  1CN4 C;  2R92 D;  1F6F A;  5A2O A;  4IU9 A;  4EXN A;  3N0P A;  5D22 A;  5D72 A;  4O6K A;  2B8U A;  3HHR A;  3PO3 D;  4ZW9 A;  1HIK A;  1I1R B;  5KNH I;  4D2B A;  1M48 A;  1PGR A;  2B90 A;  1IRL A;  2VUM D;  3DGC L;  4DKC A;  3SE4 B;  5FUC A;  2JA6 D;  4GS7 A;  4NN7 A;  1GNC A;  1CSG A;  1A22 A;  4A3I D;  2V8N A;  1M49 A;  4DKF A;  4GRW A;  4NI7 A;  3LB6 B;  3WCY I;  3PIW A;  4I77 Z;  1INR A;  1V7M V;  5IP7 D;  1F45 B;  5E4E A;  3TGX B;  1EER A;  3DUH C;  5GXB A;  2B91 A;  3BPL A;  3NCB A;  3PIV A;  4NN6 A;  4J4L C;  4YB9 D;  1RCB A;  3O7Q A;  4A3J D;  3DI3 A;  2PSM A;  1M4A A;  3DLQ I;  4XNI A;  1ALU A;  3NCE A;  1BGE A;  2Z3Q A;  2L3O A;  4D2C A;  4A3M D;  1PW6 A;  3QB7 A;  4A3L D;  2B8Y A;  1NBP A;  4APS A;  4YBQ A;  2ILK A;  1B5L A;  1BGD A;  1BCN A;  4RS1 A;  1KF9 A;  4ZF7 A;  2B5I A;  1D9C A;  1ITF A;  1A7M A;  1CD9 A;  1RW5 A;  4ZWC A;  4JRE A;  4IKW A;  1PV7 A;  4X51 A;  1IAR A;  1N1F A;  1AX8 A;  4GC0 A;  1CNT 1;  5IYD D;  4U4W A;  4BBR D;  2Q14 A;  1J7V L;  2HYM B;  5TS9 A;  1QVN A;  4MHL A;  2R7Z D;  5IP9 D;  4ZYR A;  1RFB A;  2XUT A;  1VLK A;  2LMS A;  4FA8 E;  3HOU D;  1EMR A;  4IKX A;  4UVM A;  3SE3 B;  1SCF A;  4BXX D;  3IRH A;  1LQS L;  2CYK A;  3G9V B;  2CFP A;  4NKQ C;  3UF2 A;  4JR9 A;  3D87 A;  4IU8 A;  5L6Y C;  1M4R A;  4NEJ A;  4BY1 D;  1ITL A;  4W6V A;  5FHX A;  1AXI A;  1IK0 A;  5C65 A;  1ITM A;  1Y6K L;  1M47 A;  1Z7C A;  1YKB A;  2IL6 A;  4PS4 A;  4PYP A;  4NN5 A;  4YDY I;  4BY7 D;  2R93 D;  1RHG A;  5C7X A;  4LEP A;  1PW4 A;  4TPH A;  4LDS A;  3NCC A;  5FLM D;  4LRL A;  1BGC A;  3DI2 A;  5C3E D;  1M4B A;  3QWR B;  2H24 A;  4U4V A;  2XQB A;  1ILK A;  2JA5 D;  4YQX A;  4QIQ A;  4CNI C;  2Q98 A;  1EVS A;  1HUL A;  3N06 A;  1M4C A;  4A93 D;  2ERJ D;  3G6D A;  1Z92 A;  5D28 B;  1FYH A;  2JA8 D;  1IJZ A;  2B63 D;  2D9Q A;  4DKE A;  3OG6 A;  1ITI A;  3OQ3 A;  1HGU A;  1WU3 I;  1PY2 A;  2O6I A;  4A3C D;  5EQI A;  3L5W I;  4YPG C;  3AYH A;  5D6K A;  4JA3 A;  3UEZ E;  1Y14 A;  2E9W C;  3BPO A;  2O27 A;  4XNJ A;  4GBY A;  4DKD A;  5LQB A;  3EW3 A;  4D2D A;  2INT A;  5IYC D;  1LK3 A;  3BES L;  1JLI A;  3S9D A;  4TPJ A;  2KZ1 A;  4BBS D;  3INK C;  1Y6M L;  1HWG A;  1PV6 A;  2B8X A;  3Q1S I;  4A3F D;  4NEM A;  4WRL B;  1HIJ A;  4U4T A;  4A3B D;  5C44 D;  3BPN A;  5IYB D;  4A3D D;  1WCM D;  3QB1 A;  2Z3R A;  1FG9 A;  1BBN A;  2D48 A;  3HOY D;  1ETE A;  2OQP A;  3D85 C;  4EXP A;  1Y6N L;  3HMX B;  2GMF A;  4TPG A;  5D71 A;  4DOH A;  2L3Y A;  3HOV D;  3NCF A;  3OG4 A;  1LKI A;  1P9M B;  3D48 P;  1BUY A;  4GBZ A;  4IKY A;  1Y1W D;  1EXZ A;  5D58 A;  1HWH A;  3PO2 D;  4OAA A;  3EJJ A;  3NPZ A;  4A3K D;  2LAG A;  4A3G D;  1GA3 A;  1IL6 A;  1AU1 A;  5C4X D;  5EQG A;  3B5K A;  2CFQ A;  3H0G D;  4J05 A;  4Q65 A;  1HUW A;  1D9G A;  2Q7N B;  2Y5Y A;  3HHC A;  4NI9 A;  3WDO A;  3LB6 A;  2O26 A;  3UF5 A;  3L5X A;  3HOW D;  1EKU A;  2JA7 D;  2B8Z A;  4IKV A;  2C35 A;  3UX9 A;  3HOZ D;  3H3V E;  1PVH B;  4IKZ A;  4ZS7 A;  4Z5R D;  3QT2 C;  3QAZ A;  3VA2 A;  5A2N A;  3MZG A; 
#chains in the Genus database with same CATH homology
 1AXI A;  3BES L;  1JLI A;  3S9D A;  1CYL A;  3NCE A;  1IK0 A;  1BGE A;  3I4N D;  1ITM A;  2Z3Q A;  1Y1V D;  2KZ1 A;  3INK C;  1BP3 A;  4BBS D;  1Y6M L;  1HWG A;  2L3O A;  1HZI A;  2B8X A;  3Q1S I;  1Y6K L;  4O9H A;  4YUE C;  4NEM A;  4A3F D;  4WRL B;  1PW6 A;  3QB7 A;  1M47 A;  1Z7C A;  4A3E D;  1YKB A;  4A3M D;  1HIJ A;  4A3B D;  2IL6 A;  4PS4 A;  5C44 D;  3HOX D;  4A3L D;  1V7N V;  3BPN A;  4NN5 A;  4YDY I;  5IYB D;  2B8Y A;  1WCM D;  1NBP A;  3QB1 A;  5D70 A;  4A3D D;  4BY7 D;  2R93 D;  1RHG A;  2Z3R A;  3FKI D;  5C7X A;  1FG9 A;  1BBN A;  2D48 A;  3I4M D;  3HOY D;  1ETE A;  2ILK A;  1CN4 C;  2OQP A;  3D85 C;  4EXP A;  1Y6N L;  3HMX B;  1B5L A;  2R92 D;  3WCY I;  3NCC A;  2GMF A;  1BGD A;  5D71 A;  1F6F A;  5FLM D;  1BCN A;  4RS1 A;  4LRL A;  4DOH A;  4EXN A;  1BGC A;  3N0P A;  1KF9 A;  4ZF7 A;  2L3Y A;  5D22 A;  5D72 A;  3HOV D;  2B5I A;  2B8U A;  3HHR A;  3NCF A;  4O6K A;  3DI2 A;  1D9C A;  3PO3 D;  3OG4 A;  5C3E D;  1LKI A;  1P9M B;  1ITF A;  3D48 P;  1A7M A;  1M4B A;  3QWR B;  1BUY A;  2H24 A;  1CD9 A;  1RW5 A;  1ILK A;  2XQB A;  2JA5 D;  1Y1W D;  4YQX A;  1HIK A;  4CNI C;  4X51 A;  1I1R B;  5KNH I;  1IAR A;  2Q98 A;  1N1F A;  1EVS A;  1EXZ A;  1HUL A;  1AX8 A;  1HWH A;  3PO2 D;  3EJJ A;  3NPZ A;  1M48 A;  3N06 A;  1CNT 1;  1PGR A;  2B90 A;  5IYD D;  1M4C A;  4A3K D;  4BBR D;  2Q14 A;  1IRL A;  2LAG A;  3DGC L;  2VUM D;  4A3G D;  1J7V L;  2HYM B;  4DKC A;  3SE4 B;  1GA3 A;  1IL6 A;  5FUC A;  2JA6 D;  4GS7 A;  4NN7 A;  5TS9 A;  1GNC A;  1AU1 A;  1QVN A;  4MHL A;  2R7Z D;  1CSG A;  5IP9 D;  1A22 A;  4A3I D;  5C4X D;  1RFB A;  4A93 D;  2ERJ D;  3B5K A;  3H0G D;  1VLK A;  1M49 A;  4DKF A;  3G6D A;  1Z92 A;  2LMS A;  3LB6 B;  3PIW A;  4GRW A;  5D28 B;  1HUW A;  1FYH A;  1D9G A;  4I77 Z;  1IJZ A;  1INR A;  4FA8 E;  2JA8 D;  2Q7N B;  2B63 D;  1V7M V;  2D9Q A;  4DKE A;  3OG6 A;  3HOU D;  5IP7 D;  1ITI A;  1F45 B;  3HHC A;  3OQ3 A;  5E4E A;  4NI9 A;  1HGU A;  1WU3 I;  1EMR A;  3TGX B;  1EER A;  1PY2 A;  2O6I A;  3DUH C;  4A3C D;  3L5W I;  2B91 A;  4YPG C;  3SE3 B;  3LB6 A;  2O26 A;  3AYH A;  3UF5 A;  3UEZ E;  1Y14 A;  3L5X A;  3HOW D;  2E9W C;  3BPL A;  3NCB A;  3BPO A;  1SCF A;  1EKU A;  3PIV A;  4NN6 A;  4BXX D;  4NI7 A;  2O27 A;  3IRH A;  1LQS L;  2CYK A;  3G9V B;  2JA7 D;  2B8Z A;  4J4L C;  4NKQ C;  2C35 A;  3UF2 A;  3UX9 A;  3HOZ D;  1RCB A;  3D87 A;  3H3V E;  4DKD A;  5L6Y C;  4A3J D;  5LQB A;  1M4R A;  1PVH B;  3DI3 A;  2PSM A;  4ZS7 A;  3EW3 A;  4Z5R D;  4NEJ A;  3QT2 C;  1M4A A;  2INT A;  3DLQ I;  4BY1 D;  5IYC D;  3QAZ A;  1ITL A;  3VA2 A;  1ALU A;  5FHX A;  1LK3 A;  3MZG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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