4ZYRA

Crystal structure of e. coli lactose permease g46w/g262w bound to p-nitrophenyl alpha-d-galactopyranoside (alpha-npg)
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
403
structure length
387
Chain Sequence
NTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTWIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFWYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of LacY with an alpha-substituted galactoside: Connecting the binding site to the protonation site.
pubmed doi rcsb
molecule tags Transport protein
source organism Escherichia coli (strain k12)
molecule keywords Lactose permease
total genus 136
structure length 387
sequence length 403
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01306 LacY_symp LacY proton/sugar symporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 4zyrA02
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 4zyrA01
5EQGA 4J05A 4IKVA 4IKZA 3O7QA 4OAAA 5EQHA 2CFPA 1PV6A 4PYPA 4IKXA 4D2CA 4GBYA 2Y5YA 4YBQA 4IU9A 4IKWA 4TPGA 5EQIA 3O7PA 4JA3A 4U4TA 5D6KA 4XNJA 3WDOA 2XUTA 4ZWCA 5C65A 4LDSA 5D58A 4D2BA 5GXBA 1PW4A 2V8NA 4Q65A 4U4WA 4W6VA 4OH3A 4U4VA 5A2OA 4UVMA 2CFQA 4JR9A 4XNIA 4ZW9A 5D59A 4D2DA 4TPHA 4GC0A 1PV7A 4ZWBA 4GBZA 4IU8A 4IKYA 4QIQA 4LEPA 4TPJA 4YB9D 4APSA 4ZYRA 5A2NA 4JREA
chains in the Genus database with same CATH superfamily
4J4LC 4J05A 4A3LD 3O7QA 1M4CA 1IJZA 4Z5RD 4PYPA 5IP9D 2Y5YA 2JA6D 4BY7D 1INRA 2E9WC 3PIVA 5D72A 5D58A 4D2BA 1M49A 4A3CD 3BPOA 3DLQI 1M47A 3I4ND 3EJJA 4A3MD 2C35A 2IL6A 3WCYI 3NCCA 4IU9A 5EQIA 2V8NA 2VUMD 3SE3B 2CFQA 1CN4C 3I4MD 2PSMA 1V7MV 4ZS7A 4DKFA 2CFPA 5C44D 4A3GD 1BGDA 5D6KA 1M4AA 5TS9A 2D48A 5D28B 2LAGA 1IARA 4ZF7A 4PS4A 3UX9A 3HOWD 1BGCA 3H3VE 4FA8E 2R7ZD 4OAAA 5D70A 2JA8D 3SE4B 4NN5A 1HULA 3MZGA 4JA3A 4LDSA 1ITIA 1ITLA 4NN7A 5A2OA 4UVMA 3NCBA 4YQXA 2B8YA 1RHGA 5GXBA 3TGXB 1AX8A 3PO3D 2KZ1A 4A3ED 2Q7NB 4CNIC 3FKID 3O7PA 5IYBD 4U4WA 1RFBA 4DOHA 4XNIA 5D59A 4D2DA 2B8UA 4GBZA 1B5LA 4QIQA 3HMXB 1PY2A 1NBPA 4XNJA 1EERA 2B8ZA 1HUWA 4NEJA 1Y6NL 4A3DD 4GC0A 3LB6B 2B63D 5C7XA 4IKXA 4GBYA 1BCNA 1LK3A 5FLMD 1BBNA 1N1FA 3OQ3A 2B91A 3S9DA 2B90A 1ITMA 1M4RA 1EKUA 1VLKA 1HWGA 3NCFA 2O26A 3DI3A 1WU3I 1HWHA 4DKCA 4IKYA 1ILKA 3N06A 1D9GA 3EW3A 3QT2C 5L6YC 2B8XA 1ALUA 3HHRA 1BUYA 3UF2A 3D48P 2Z3QA 4U4VA 2Q98A 1A7MA 2Z3RA 5A2NA 3AYHA 1JLIA 3G6DA 1Y14A 1PVHB 2R93D 1PV6A 3HOYD 1LQSL 1RW5A 1PGRA 3NPZA 2XQBA 3HHCA 3QWRB 4OH3A 5FHXA 2HYMB 2LMSA 1SCFA 3OG6A 1IRLA 2L3YA 3QAZA 4IKVA 3INKC 1BGEA 3UF5A 2H24A 5E4EA 4X51A 5IYDD 3PO2D 3OG4A 4NKQC 2L3OA 1M4BA 1Y6KL 1CD9A 1V7NV 4YUEC 1PV7A 1WCMD 5EQGA 5LQBA 1CSGA 4A3BD 1RCBA 4A93D 4I77Z 1Y6ML 1HIKA 4LRLA 2XUTA 5D71A 1M48A 1Z92A 1GNCA 1YKBA 2JA7D 1EXZA 4NI9A 4ZW9A 2INTA 1EMRA 1P9MB 4IU8A 4ZYRA 1IK0A 4APSA 3N0PA 2O27A 3VA2A 4O9HA 5C4XD 1F6FA 4D2CA 1CYLA 2R92D 4YBQA 4IKWA 5IP7D 4U4TA 1AXIA 1KF9A 4RS1A 4NI7A 4BY1D 4JR9A 3BPNA 4YB9D 4TPHA 4MHLA 2Q14A 4YDYI 1PW6A 4ZWCA 2D9QA 4YPGC 4GS7A 4A3ID 3BESL 1I1RB 4BBRD 4LEPA 1F45B 3LB6A 2B5IA 4WRLB 4IKZA 4A3JD 3B5KA 3L5WI 3Q1SI 3IRHA 1D9CA 1J7VL 3UEZE 1FG9A 1HGUA 3D87A 3L5XA 3PIWA 4Q65A 4NN6A 4A3KD 3QB7A 2ILKA 3QB1A 4A3FD 1IL6A 2JA5D 3DI2A 3DUHC 1CNT1 1EVSA 4DKEA 1ITFA 1BP3A 2O6IA 1A22A 5FUCA 5IYCD 3HOZD 4BBSD 5C65A 1PW4A 3HOXD 4EXPA 4BXXD 1FYHA 2ERJD 4ZWBA 1GA3A 1AU1A 2CYKA 3D85C 4GRWA 5C3ED 1QVNA 5EQHA 1ETEA 3H0GD 3DGCL 4TPGA 4NEMA 1Y1WD 3WDOA 5D22A 4EXNA 1Z7CA 1HZIA 3NCEA 1LKIA 4W6VA 2GMFA 1Y1VD 4O6KA 1HIJA 2OQPA 3HOVD 3BPLA 3G9VB 4TPJA 5KNHI 4JREA 3HOUD 4DKDA
chains in the Genus database with same CATH topology
5EQGA 4J05A 4IKVA 4IKZA 3O7QA 4OAAA 5EQHA 2CFPA 1PV6A 4PYPA 4IKXA 4D2CA 4GBYA 2Y5YA 4YBQA 4IU9A 4IKWA 4TPGA 5EQIA 3O7PA 4JA3A 4U4TA 5D6KA 4XNJA 3WDOA 2XUTA 4ZWCA 5C65A 4LDSA 5D58A 4D2BA 5GXBA 1PW4A 2V8NA 4Q65A 4U4WA 4W6VA 4OH3A 4U4VA 5A2OA 4UVMA 2CFQA 4JR9A 4XNIA 4ZW9A 5D59A 4D2DA 4TPHA 4GC0A 1PV7A 4ZWBA 4GBZA 4IU8A 4IKYA 4QIQA 4LEPA 4TPJA 4YB9D 4APSA 4ZYRA 5A2NA 4JREA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EQG A;  4J05 A;  4IKV A;  4IKZ A;  3O7Q A;  4OAA A;  5EQH A;  2CFP A;  1PV6 A;  4PYP A;  4IKX A;  4D2C A;  4GBY A;  2Y5Y A;  4YBQ A;  4IU9 A;  4IKW A;  4TPG A;  5EQI A;  3O7P A;  4JA3 A;  4U4T A;  5D6K A;  4XNJ A;  3WDO A;  2XUT A;  4ZWC A;  5C65 A;  4LDS A;  5D58 A;  4D2B A;  5GXB A;  1PW4 A;  2V8N A;  4Q65 A;  4U4W A;  4W6V A;  4OH3 A;  4U4V A;  5A2O A;  4UVM A;  2CFQ A;  4JR9 A;  4XNI A;  4ZW9 A;  5D59 A;  4D2D A;  4TPH A;  4GC0 A;  1PV7 A;  4ZWB A;  4GBZ A;  4IU8 A;  4IKY A;  4QIQ A;  4LEP A;  4TPJ A;  4YB9 D;  4APS A;  4ZYR A;  5A2N A;  4JRE A; 
#chains in the Genus database with same CATH topology
 4J4L C;  4J05 A;  4A3L D;  3O7Q A;  1M4C A;  1IJZ A;  4Z5R D;  4PYP A;  5IP9 D;  2Y5Y A;  2JA6 D;  4BY7 D;  1INR A;  2E9W C;  3PIV A;  5D72 A;  5D58 A;  4D2B A;  1M49 A;  4A3C D;  3BPO A;  3DLQ I;  1M47 A;  3I4N D;  3EJJ A;  4A3M D;  2C35 A;  2IL6 A;  3WCY I;  3NCC A;  4IU9 A;  5EQI A;  2V8N A;  2VUM D;  3SE3 B;  2CFQ A;  1CN4 C;  3I4M D;  2PSM A;  1V7M V;  4ZS7 A;  4DKF A;  2CFP A;  5C44 D;  4A3G D;  1BGD A;  5D6K A;  1M4A A;  5TS9 A;  2D48 A;  5D28 B;  2LAG A;  1IAR A;  4ZF7 A;  4PS4 A;  3UX9 A;  3HOW D;  1BGC A;  3H3V E;  4FA8 E;  2R7Z D;  4OAA A;  5D70 A;  2JA8 D;  3SE4 B;  4NN5 A;  1HUL A;  3MZG A;  4JA3 A;  4LDS A;  1ITI A;  1ITL A;  4NN7 A;  5A2O A;  4UVM A;  3NCB A;  4YQX A;  2B8Y A;  1RHG A;  5GXB A;  3TGX B;  1AX8 A;  3PO3 D;  2KZ1 A;  4A3E D;  2Q7N B;  4CNI C;  3FKI D;  3O7P A;  5IYB D;  4U4W A;  1RFB A;  4DOH A;  4XNI A;  5D59 A;  4D2D A;  2B8U A;  4GBZ A;  1B5L A;  4QIQ A;  3HMX B;  1PY2 A;  1NBP A;  4XNJ A;  1EER A;  2B8Z A;  1HUW A;  4NEJ A;  1Y6N L;  4A3D D;  4GC0 A;  3LB6 B;  2B63 D;  5C7X A;  4IKX A;  4GBY A;  1BCN A;  1LK3 A;  5FLM D;  1BBN A;  1N1F A;  3OQ3 A;  2B91 A;  3S9D A;  2B90 A;  1ITM A;  1M4R A;  1EKU A;  1VLK A;  1HWG A;  3NCF A;  2O26 A;  3DI3 A;  1WU3 I;  1HWH A;  4DKC A;  4IKY A;  1ILK A;  3N06 A;  1D9G A;  3EW3 A;  3QT2 C;  5L6Y C;  2B8X A;  1ALU A;  3HHR A;  1BUY A;  3UF2 A;  3D48 P;  2Z3Q A;  4U4V A;  2Q98 A;  1A7M A;  2Z3R A;  5A2N A;  3AYH A;  1JLI A;  3G6D A;  1Y14 A;  1PVH B;  2R93 D;  1PV6 A;  3HOY D;  1LQS L;  1RW5 A;  1PGR A;  3NPZ A;  2XQB A;  3HHC A;  3QWR B;  4OH3 A;  5FHX A;  2HYM B;  2LMS A;  1SCF A;  3OG6 A;  1IRL A;  2L3Y A;  3QAZ A;  4IKV A;  3INK C;  1BGE A;  3UF5 A;  2H24 A;  5E4E A;  4X51 A;  5IYD D;  3PO2 D;  3OG4 A;  4NKQ C;  2L3O A;  1M4B A;  1Y6K L;  1CD9 A;  1V7N V;  4YUE C;  1PV7 A;  1WCM D;  5EQG A;  5LQB A;  1CSG A;  4A3B D;  1RCB A;  4A93 D;  4I77 Z;  1Y6M L;  1HIK A;  4LRL A;  2XUT A;  5D71 A;  1M48 A;  1Z92 A;  1GNC A;  1YKB A;  2JA7 D;  1EXZ A;  4NI9 A;  4ZW9 A;  2INT A;  1EMR A;  1P9M B;  4IU8 A;  4ZYR A;  1IK0 A;  4APS A;  3N0P A;  2O27 A;  3VA2 A;  4O9H A;  5C4X D;  1F6F A;  4D2C A;  1CYL A;  2R92 D;  4YBQ A;  4IKW A;  5IP7 D;  4U4T A;  1AXI A;  1KF9 A;  4RS1 A;  4NI7 A;  4BY1 D;  4JR9 A;  3BPN A;  4YB9 D;  4TPH A;  4MHL A;  2Q14 A;  4YDY I;  1PW6 A;  4ZWC A;  2D9Q A;  4YPG C;  4GS7 A;  4A3I D;  3BES L;  1I1R B;  4BBR D;  4LEP A;  1F45 B;  3LB6 A;  2B5I A;  4WRL B;  4IKZ A;  4A3J D;  3B5K A;  3L5W I;  3Q1S I;  3IRH A;  1D9C A;  1J7V L;  3UEZ E;  1FG9 A;  1HGU A;  3D87 A;  3L5X A;  3PIW A;  4Q65 A;  4NN6 A;  4A3K D;  3QB7 A;  2ILK A;  3QB1 A;  4A3F D;  1IL6 A;  2JA5 D;  3DI2 A;  3DUH C;  1CNT 1;  1EVS A;  4DKE A;  1ITF A;  1BP3 A;  2O6I A;  1A22 A;  5FUC A;  5IYC D;  3HOZ D;  4BBS D;  5C65 A;  1PW4 A;  3HOX D;  4EXP A;  4BXX D;  1FYH A;  2ERJ D;  4ZWB A;  1GA3 A;  1AU1 A;  2CYK A;  3D85 C;  4GRW A;  5C3E D;  1QVN A;  5EQH A;  1ETE A;  3H0G D;  3DGC L;  4TPG A;  4NEM A;  1Y1W D;  3WDO A;  5D22 A;  4EXN A;  1Z7C A;  1HZI A;  3NCE A;  1LKI A;  4W6V A;  2GMF A;  1Y1V D;  4O6K A;  1HIJ A;  2OQP A;  3HOV D;  3BPL A;  3G9V B;  4TPJ A;  5KNH I;  4JRE A;  3HOU D;  4DKD A; 
#chains in the Genus database with same CATH homology
 5EQG A;  4J05 A;  4IKV A;  4IKZ A;  3O7Q A;  4OAA A;  5EQH A;  2CFP A;  1PV6 A;  4PYP A;  4IKX A;  4D2C A;  4GBY A;  2Y5Y A;  4YBQ A;  4IU9 A;  4IKW A;  4TPG A;  5EQI A;  3O7P A;  4JA3 A;  4U4T A;  5D6K A;  4XNJ A;  3WDO A;  2XUT A;  4ZWC A;  5C65 A;  4LDS A;  5D58 A;  4D2B A;  5GXB A;  1PW4 A;  2V8N A;  4Q65 A;  4U4W A;  4W6V A;  4OH3 A;  4U4V A;  5A2O A;  4UVM A;  2CFQ A;  4JR9 A;  4XNI A;  4ZW9 A;  5D59 A;  4D2D A;  4TPH A;  4GC0 A;  1PV7 A;  4ZWB A;  4GBZ A;  4IU8 A;  4IKY A;  4QIQ A;  4LEP A;  4TPJ A;  4YB9 D;  4APS A;  4ZYR A;  5A2N A;  4JRE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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