5C3ED

Crystal structure of a transcribing rna polymerase ii complex reveals a complete transcription bubble
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
218
structure length
178
Chain Sequence
STSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIKEALVERRRAFKRSQKKETREKELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQLGSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
pubmed doi rcsb
molecule tags Transferase/dna/rna
source organism Saccharomyces cerevisiae (strain atcc 204508 / s288c)
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 43
structure length 178
sequence length 218
ec nomenclature
pdb deposition date 2015-06-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF03874 RNA_pol_Rpb4 RNA polymerase Rpb4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.40 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 5c3eD02
4A3LD 5C4XD 1WCMD 3AYHA 5IP9D 4BXXD 5IYCD 4BBRD 3HOUD 3H3VE 4BBSD 4A3GD 2R92D 3H0GD 4A3CD 5IYBD 4A3BD 4BY1D 5IP7D 4A3FD 5C3ED 4A3JD 4A3MD 1Y1WD 2C35A 2JA5D 2R7ZD 3PO3D 4A93D 3I4ND 4A3ED 3I4MD 2VUMD 5C44D 3HOXD 3HOZD 2JA6D 4BY7D 3HOVD 5FLMD 1Y1VD 4A3ID 3HOYD 3FKID 4A3KD 1Y14A 3PO2D 4A3DD 2JA7D 2R93D 2B63D 5IYDD 2JA8D 3HOWD
chains in the Genus database with same CATH superfamily
4JR9A 1HGUA 4ZW9A 4IU9A 4NI7A 4IU8A 1LQSL 3EJJA 3UX9A 1PGRA 5GXBA 1FG9A 4NEMA 3WDOA 2B5IA 5D22A 3G9VB 2XQBA 3HOYD 2B91A 4O9HA 3QAZA 5E4EA 2LAGA 4YUEC 1ETEA 1HZIA 5IP9D 4CNIC 1EXZA 2H24A 4OAAA 5IYBD 4A3BD 4YPGC 1HIKA 1I1RB 4GBYA 1Y6KL 1PVHB 3MZGA 1ITLA 1IJZA 4A3ID 1GA3A 4I77Z 4OH3A 4YB9D 2B8YA 2V8NA 1ITIA 1AU1A 4DOHA 3BPNA 1PW6A 4A3JD 1CN4C 1F45B 3UF5A 4BXXD 3SE3B 1CD9A 3PIWA 1M4AA 4X51A 1HIJA 2IL6A 1Y1VD 3NPZA 5C65A 4QIQA 5D72A 1BGCA 2Q14A 4RS1A 2KZ1A 3BPLA 4FA8E 1WU3I 3IRHA 3HHRA 5D59A 3QB7A 1YKBA 2PSMA 1AXIA 1CSGA 3TGXB 2VUMD 3HOXD 4LRLA 1EKUA 2JA7D 2Q98A 4ZWCA 4IKYA 4YQXA 4A3GD 4YBQA 1J7VL 5C3ED 3Q1SI 2ILKA 4NEJA 3FKID 4IKXA 1VLKA 1Y6ML 4A3LD 5C4XD 1M4CA 3WCYI 4BBSD 3QT2C 4A3CD 5C7XA 5IP7D 5EQHA 1BCNA 1M49A 3VA2A 3PO3D 3D48P 2O27A 5D6KA 1IL6A 2CFQA 5D28B 1Y6NL 2JA8D 2CYKA 5D58A 2Y5YA 3H0GD 4TPGA 4IKVA 1M4RA 4MHLA 5D70A 4Z5RD 2GMFA 5C44D 2JA6D 1N1FA 3BPOA 1IRLA 4UVMA 1RHGA 4A3KD 4TPHA 1HUWA 3BESL 3UF2A 4BBRD 3H3VE 1P9MB 2R92D 1IK0A 1ITMA 4J4LC 1V7MV 4NN6A 4U4TA 1SCFA 4GRWA 4A3ED 3I4ND 4WRLB 1A7MA 1INRA 4GS7A 4ZYRA 4JA3A 2R93D 5IYDD 4IKZA 4W6VA 4D2DA 1M47A 1ITFA 4APSA 2OQPA 4NN7A 4DKDA 1BUYA 5A2OA 1HULA 2XUTA 3DLQI 1LKIA 4GBZA 2Z3QA 1FYHA 4EXPA 4J05A 2LMSA 4IKWA 3AYHA 5D71A 1BGEA 3NCEA 3D87A 5KNHI 1A22A 4A3FD 1Y1WD 3EW3A 2B8UA 3L5XA 3HHCA 3OG4A 3S9DA 3NCCA 1WCMD 3DUHC 3N0PA 2CFPA 4NN5A 2ERJD 4NKQC 1PV7A 3SE4B 1Z7CA 4JREA 3N06A 3O7PA 3I4MD 3LB6B 3D85C 2D48A 1Y14A 2B8ZA 5IYCD 2B8XA 2INTA 4YDYI 4EXNA 2O6IA 1AX8A 1M48A 1IARA 1BBNA 2JA5D 5EQIA 3HOVD 1HWHA 5FLMD 1ALUA 3O7QA 1PW4A 2B90A 1F6FA 1M4BA 4D2CA 1JLIA 2O26A 4LDSA 4PS4A 1RFBA 4ZWBA 5LQBA 1QVNA 5TS9A 2R7ZD 5FHXA 4DKEA 4BY7D 3OG6A 3DI3A 3PIVA 1D9GA 2E9WC 4LEPA 2B63D 3INKC 3UEZE 1BP3A 1GNCA 3B5KA 1NBPA 1BGDA 4DKCA 4XNIA 1EMRA 3L5WI 3HOZD 3OQ3A 1B5LA 2L3YA 4NI9A 4TPJA 4U4VA 1CYLA 3DI2A 4DKFA 4PYPA 3HOWD 4XNJA 1HWGA 1V7NV 3HOUD 4D2BA 1ILKA 2Q7NB 5L6YC 5FUCA 3DGCL 4ZS7A 2C35A 1LK3A 4A93D 5A2NA 4GC0A 3QB1A 3G6DA 1KF9A 3NCBA 5EQGA 2HYMB 3LB6A 1EVSA 3QWRB 4A3DD 3NCFA 4ZF7A 1D9CA 4BY1D 4A3MD 2Z3RA 4O6KA 3HMXB 1RW5A 1EERA 4U4WA 1PY2A 2L3OA 1CNT1 1PV6A 3PO2D 1RCBA 1Z92A 2D9QA 4Q65A
chains in the Genus database with same CATH topology
1HGUA 2O26A 4PS4A 4NI7A 2Q98A 1M47A 1ITFA 1RFBA 4YQXA 4A3GD 1LQSL 3EJJA 5LQBA 1QVNA 1PGRA 3UX9A 5TS9A 2OQPA 1J7VL 4NN7A 4DKDA 1BUYA 1FG9A 5C3ED 1HULA 4NEMA 5FHXA 2R7ZD 3DLQI 1LKIA 3Q1SI 4DKEA 2B5IA 5D22A 2Z3QA 1FYHA 4BY7D 3OG6A 3DI3A 2ILKA 3G9VB 2XQBA 3FKID 4NEJA 3HOYD 1VLKA 3PIVA 4EXPA 2B91A 4O9HA 1D9GA 2E9WC 1Y6ML 3QAZA 2B63D 3INKC 2LMSA 2LAGA 4YUEC 5E4EA 4A3LD 1M4CA 3AYHA 1ETEA 1HZIA 3UEZE 5IP9D 5D71A 5C4XD 4CNIC 1BGEA 3WCYI 1BP3A 4BBSD 1GNCA 3QT2C 1EXZA 2H24A 3NCEA 3D87A 5KNHI 1A22A 4A3CD 3B5KA 1NBPA 5IYBD 4A3BD 4YPGC 5C7XA 1BGDA 1HIKA 5IP7D 4A3FD 1BCNA 1M49A 4DKCA 1I1RB 1Y1WD 3VA2A 3PO3D 3EW3A 1Y6KL 1PVHB 3MZGA 1EMRA 3L5WI 1ITLA 2B8UA 3L5XA 3HOZD 3OQ3A 1IJZA 3HHCA 3D48P 1B5LA 3OG4A 3S9DA 2L3YA 4I77Z 4A3ID 1GA3A 2B8YA 4NI9A 2O27A 1CYLA 3NCCA 1IL6A 3DI2A 1AU1A 1ITIA 5D28B 4DOHA 1Y6NL 3BPNA 4DKFA 1PW6A 4A3JD 1CN4C 2JA8D 3HOWD 1F45B 3UF5A 1WCMD 3DUHC 4BXXD 3N0PA 1HWGA 1V7NV 2CYKA 3SE3B 3HOUD 4NN5A 1ILKA 2Q7NB 2ERJD 3H0GD 1CD9A 3PIWA 4NKQC 5L6YC 3SE4B 5FUCA 1M4AA 3DGCL 4ZS7A 1M4RA 1Z7CA 2C35A 3N06A 4MHLA 1LK3A 5D70A 4Z5RD 4A93D 4X51A 1HIJA 3I4MD 2GMFA 3QB1A 3G6DA 5C44D 2JA6D 1N1FA 3BPOA 1IRLA 2IL6A 1KF9A 1Y1VD 3LB6B 3NPZA 1RHGA 3NCBA 5D72A 2HYMB 1BGCA 3D85C 3LB6A 4A3KD 1EVSA 2D48A 3QWRB 1Y14A 4A3DD 1HUWA 2Q14A 3NCFA 4RS1A 2KZ1A 3BESL 3BPLA 4FA8E 4ZF7A 2B8ZA 3UF2A 5IYCD 4BBRD 1WU3I 2B8XA 3H3VE 2INTA 4YDYI 4EXNA 1P9MB 2R92D 3IRHA 1D9CA 1IK0A 2O6IA 1AX8A 1M48A 3HHRA 1ITMA 4J4LC 4BY1D 3QB7A 2Z3RA 1V7MV 1IARA 4A3MD 1BBNA 4NN6A 4O6KA 1YKBA 2JA5D 3HMXB 1RW5A 2PSMA 1SCFA 4GRWA 4A3ED 3I4ND 4WRLB 1A7MA 1AXIA 1CSGA 1EERA 3TGXB 2VUMD 3HOXD 3HOVD 1HWHA 5FLMD 1PY2A 1ALUA 2L3OA 1CNT1 2B90A 1INRA 4GS7A 1F6FA 1M4BA 4LRLA 1EKUA 3PO2D 2R93D 2JA7D 1RCBA 1Z92A 1JLIA 5IYDD 2D9QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A3L D;  5C4X D;  1WCM D;  3AYH A;  5IP9 D;  4BXX D;  5IYC D;  4BBR D;  3HOU D;  3H3V E;  4BBS D;  4A3G D;  2R92 D;  3H0G D;  4A3C D;  5IYB D;  4A3B D;  4BY1 D;  5IP7 D;  4A3F D;  5C3E D;  4A3J D;  4A3M D;  1Y1W D;  2C35 A;  2JA5 D;  2R7Z D;  3PO3 D;  4A93 D;  3I4N D;  4A3E D;  3I4M D;  2VUM D;  5C44 D;  3HOX D;  3HOZ D;  2JA6 D;  4BY7 D;  3HOV D;  5FLM D;  1Y1V D;  4A3I D;  3HOY D;  3FKI D;  4A3K D;  1Y14 A;  3PO2 D;  4A3D D;  2JA7 D;  2R93 D;  2B63 D;  5IYD D;  2JA8 D;  3HOW D; 
#chains in the Genus database with same CATH topology
 4JR9 A;  1HGU A;  4ZW9 A;  4IU9 A;  4NI7 A;  4IU8 A;  1LQS L;  3EJJ A;  3UX9 A;  1PGR A;  5GXB A;  1FG9 A;  4NEM A;  3WDO A;  2B5I A;  5D22 A;  3G9V B;  2XQB A;  3HOY D;  2B91 A;  4O9H A;  3QAZ A;  5E4E A;  2LAG A;  4YUE C;  1ETE A;  1HZI A;  5IP9 D;  4CNI C;  1EXZ A;  2H24 A;  4OAA A;  5IYB D;  4A3B D;  4YPG C;  1HIK A;  1I1R B;  4GBY A;  1Y6K L;  1PVH B;  3MZG A;  1ITL A;  1IJZ A;  4A3I D;  1GA3 A;  4I77 Z;  4OH3 A;  4YB9 D;  2B8Y A;  2V8N A;  1ITI A;  1AU1 A;  4DOH A;  3BPN A;  1PW6 A;  4A3J D;  1CN4 C;  1F45 B;  3UF5 A;  4BXX D;  3SE3 B;  1CD9 A;  3PIW A;  1M4A A;  4X51 A;  1HIJ A;  2IL6 A;  1Y1V D;  3NPZ A;  5C65 A;  4QIQ A;  5D72 A;  1BGC A;  2Q14 A;  4RS1 A;  2KZ1 A;  3BPL A;  4FA8 E;  1WU3 I;  3IRH A;  3HHR A;  5D59 A;  3QB7 A;  1YKB A;  2PSM A;  1AXI A;  1CSG A;  3TGX B;  2VUM D;  3HOX D;  4LRL A;  1EKU A;  2JA7 D;  2Q98 A;  4ZWC A;  4IKY A;  4YQX A;  4A3G D;  4YBQ A;  1J7V L;  5C3E D;  3Q1S I;  2ILK A;  4NEJ A;  3FKI D;  4IKX A;  1VLK A;  1Y6M L;  4A3L D;  5C4X D;  1M4C A;  3WCY I;  4BBS D;  3QT2 C;  4A3C D;  5C7X A;  5IP7 D;  5EQH A;  1BCN A;  1M49 A;  3VA2 A;  3PO3 D;  3D48 P;  2O27 A;  5D6K A;  1IL6 A;  2CFQ A;  5D28 B;  1Y6N L;  2JA8 D;  2CYK A;  5D58 A;  2Y5Y A;  3H0G D;  4TPG A;  4IKV A;  1M4R A;  4MHL A;  5D70 A;  4Z5R D;  2GMF A;  5C44 D;  2JA6 D;  1N1F A;  3BPO A;  1IRL A;  4UVM A;  1RHG A;  4A3K D;  4TPH A;  1HUW A;  3BES L;  3UF2 A;  4BBR D;  3H3V E;  1P9M B;  2R92 D;  1IK0 A;  1ITM A;  4J4L C;  1V7M V;  4NN6 A;  4U4T A;  1SCF A;  4GRW A;  4A3E D;  3I4N D;  4WRL B;  1A7M A;  1INR A;  4GS7 A;  4ZYR A;  4JA3 A;  2R93 D;  5IYD D;  4IKZ A;  4W6V A;  4D2D A;  1M47 A;  1ITF A;  4APS A;  2OQP A;  4NN7 A;  4DKD A;  1BUY A;  5A2O A;  1HUL A;  2XUT A;  3DLQ I;  1LKI A;  4GBZ A;  2Z3Q A;  1FYH A;  4EXP A;  4J05 A;  2LMS A;  4IKW A;  3AYH A;  5D71 A;  1BGE A;  3NCE A;  3D87 A;  5KNH I;  1A22 A;  4A3F D;  1Y1W D;  3EW3 A;  2B8U A;  3L5X A;  3HHC A;  3OG4 A;  3S9D A;  3NCC A;  1WCM D;  3DUH C;  3N0P A;  2CFP A;  4NN5 A;  2ERJ D;  4NKQ C;  1PV7 A;  3SE4 B;  1Z7C A;  4JRE A;  3N06 A;  3O7P A;  3I4M D;  3LB6 B;  3D85 C;  2D48 A;  1Y14 A;  2B8Z A;  5IYC D;  2B8X A;  2INT A;  4YDY I;  4EXN A;  2O6I A;  1AX8 A;  1M48 A;  1IAR A;  1BBN A;  2JA5 D;  5EQI A;  3HOV D;  1HWH A;  5FLM D;  1ALU A;  3O7Q A;  1PW4 A;  2B90 A;  1F6F A;  1M4B A;  4D2C A;  1JLI A;  2O26 A;  4LDS A;  4PS4 A;  1RFB A;  4ZWB A;  5LQB A;  1QVN A;  5TS9 A;  2R7Z D;  5FHX A;  4DKE A;  4BY7 D;  3OG6 A;  3DI3 A;  3PIV A;  1D9G A;  2E9W C;  4LEP A;  2B63 D;  3INK C;  3UEZ E;  1BP3 A;  1GNC A;  3B5K A;  1NBP A;  1BGD A;  4DKC A;  4XNI A;  1EMR A;  3L5W I;  3HOZ D;  3OQ3 A;  1B5L A;  2L3Y A;  4NI9 A;  4TPJ A;  4U4V A;  1CYL A;  3DI2 A;  4DKF A;  4PYP A;  3HOW D;  4XNJ A;  1HWG A;  1V7N V;  3HOU D;  4D2B A;  1ILK A;  2Q7N B;  5L6Y C;  5FUC A;  3DGC L;  4ZS7 A;  2C35 A;  1LK3 A;  4A93 D;  5A2N A;  4GC0 A;  3QB1 A;  3G6D A;  1KF9 A;  3NCB A;  5EQG A;  2HYM B;  3LB6 A;  1EVS A;  3QWR B;  4A3D D;  3NCF A;  4ZF7 A;  1D9C A;  4BY1 D;  4A3M D;  2Z3R A;  4O6K A;  3HMX B;  1RW5 A;  1EER A;  4U4W A;  1PY2 A;  2L3O A;  1CNT 1;  1PV6 A;  3PO2 D;  1RCB A;  1Z92 A;  2D9Q A;  4Q65 A; 
#chains in the Genus database with same CATH homology
 1HGU A;  2O26 A;  4PS4 A;  4NI7 A;  2Q98 A;  1M47 A;  1ITF A;  1RFB A;  4YQX A;  4A3G D;  1LQS L;  3EJJ A;  5LQB A;  1QVN A;  1PGR A;  3UX9 A;  5TS9 A;  2OQP A;  1J7V L;  4NN7 A;  4DKD A;  1BUY A;  1FG9 A;  5C3E D;  1HUL A;  4NEM A;  5FHX A;  2R7Z D;  3DLQ I;  1LKI A;  3Q1S I;  4DKE A;  2B5I A;  5D22 A;  2Z3Q A;  1FYH A;  4BY7 D;  3OG6 A;  3DI3 A;  2ILK A;  3G9V B;  2XQB A;  3FKI D;  4NEJ A;  3HOY D;  1VLK A;  3PIV A;  4EXP A;  2B91 A;  4O9H A;  1D9G A;  2E9W C;  1Y6M L;  3QAZ A;  2B63 D;  3INK C;  2LMS A;  2LAG A;  4YUE C;  5E4E A;  4A3L D;  1M4C A;  3AYH A;  1ETE A;  1HZI A;  3UEZ E;  5IP9 D;  5D71 A;  5C4X D;  4CNI C;  1BGE A;  3WCY I;  1BP3 A;  4BBS D;  1GNC A;  3QT2 C;  1EXZ A;  2H24 A;  3NCE A;  3D87 A;  5KNH I;  1A22 A;  4A3C D;  3B5K A;  1NBP A;  5IYB D;  4A3B D;  4YPG C;  5C7X A;  1BGD A;  1HIK A;  5IP7 D;  4A3F D;  1BCN A;  1M49 A;  4DKC A;  1I1R B;  1Y1W D;  3VA2 A;  3PO3 D;  3EW3 A;  1Y6K L;  1PVH B;  3MZG A;  1EMR A;  3L5W I;  1ITL A;  2B8U A;  3L5X A;  3HOZ D;  3OQ3 A;  1IJZ A;  3HHC A;  3D48 P;  1B5L A;  3OG4 A;  3S9D A;  2L3Y A;  4I77 Z;  4A3I D;  1GA3 A;  2B8Y A;  4NI9 A;  2O27 A;  1CYL A;  3NCC A;  1IL6 A;  3DI2 A;  1AU1 A;  1ITI A;  5D28 B;  4DOH A;  1Y6N L;  3BPN A;  4DKF A;  1PW6 A;  4A3J D;  1CN4 C;  2JA8 D;  3HOW D;  1F45 B;  3UF5 A;  1WCM D;  3DUH C;  4BXX D;  3N0P A;  1HWG A;  1V7N V;  2CYK A;  3SE3 B;  3HOU D;  4NN5 A;  1ILK A;  2Q7N B;  2ERJ D;  3H0G D;  1CD9 A;  3PIW A;  4NKQ C;  5L6Y C;  3SE4 B;  5FUC A;  1M4A A;  3DGC L;  4ZS7 A;  1M4R A;  1Z7C A;  2C35 A;  3N06 A;  4MHL A;  1LK3 A;  5D70 A;  4Z5R D;  4A93 D;  4X51 A;  1HIJ A;  3I4M D;  2GMF A;  3QB1 A;  3G6D A;  5C44 D;  2JA6 D;  1N1F A;  3BPO A;  1IRL A;  2IL6 A;  1KF9 A;  1Y1V D;  3LB6 B;  3NPZ A;  1RHG A;  3NCB A;  5D72 A;  2HYM B;  1BGC A;  3D85 C;  3LB6 A;  4A3K D;  1EVS A;  2D48 A;  3QWR B;  1Y14 A;  4A3D D;  1HUW A;  2Q14 A;  3NCF A;  4RS1 A;  2KZ1 A;  3BES L;  3BPL A;  4FA8 E;  4ZF7 A;  2B8Z A;  3UF2 A;  5IYC D;  4BBR D;  1WU3 I;  2B8X A;  3H3V E;  2INT A;  4YDY I;  4EXN A;  1P9M B;  2R92 D;  3IRH A;  1D9C A;  1IK0 A;  2O6I A;  1AX8 A;  1M48 A;  3HHR A;  1ITM A;  4J4L C;  4BY1 D;  3QB7 A;  2Z3R A;  1V7M V;  1IAR A;  4A3M D;  1BBN A;  4NN6 A;  4O6K A;  1YKB A;  2JA5 D;  3HMX B;  1RW5 A;  2PSM A;  1SCF A;  4GRW A;  4A3E D;  3I4N D;  4WRL B;  1A7M A;  1AXI A;  1CSG A;  1EER A;  3TGX B;  2VUM D;  3HOX D;  3HOV D;  1HWH A;  5FLM D;  1PY2 A;  1ALU A;  2L3O A;  1CNT 1;  2B90 A;  1INR A;  4GS7 A;  1F6F A;  1M4B A;  4LRL A;  1EKU A;  3PO2 D;  2R93 D;  2JA7 D;  1RCB A;  1Z92 A;  1JLI A;  5IYD D;  2D9Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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