5C44D

Crystal structure of a transcribing rna polymerase ii complex reveals a complete transcription bubble
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
218
structure length
178
Chain Sequence
STSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIKEALVERRRAFKRSQKKETREKELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQLGSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
pubmed doi rcsb
molecule tags Transferase/dna/rna
source organism Saccharomyces cerevisiae (strain atcc 204508 / s288c)
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 39
structure length 178
sequence length 218
ec nomenclature
pdb deposition date 2015-06-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF03874 RNA_pol_Rpb4 RNA polymerase Rpb4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.40 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 5c44D02
1Y14A 4A3ED 5IYBD 2R92D 4A3BD 2JA7D 3I4MD 2JA8D 4BBSD 2JA6D 4A3LD 2C35A 3HOXD 5C44D 3FKID 4A3JD 4A3DD 4BY7D 4A3FD 5IYDD 3H3VE 5C4XD 3HOUD 5IP7D 4BBRD 2VUMD 4A3GD 1Y1VD 4A3MD 2R7ZD 3HOZD 4A93D 3H0GD 5IYCD 5IP9D 5C3ED 2B63D 3I4ND 3HOWD 4A3ID 3PO2D 3HOYD 3HOVD 4A3CD 1Y1WD 2JA5D 3PO3D 1WCMD 4BXXD 4BY1D 5FLMD 3AYHA 4A3KD 2R93D
chains in the Genus database with same CATH superfamily
2B8YA 2L3OA 4IU8A 1CNT1 5IYDD 4J05A 5IP7D 4GBYA 1LKIA 1Z7CA 3LB6A 1N1FA 1PV7A 4DOHA 3QB1A 1ETEA 4PYPA 1HWHA 1IK0A 3UX9A 4ZW9A 5EQIA 1BGCA 1Y14A 2LAGA 4LDSA 4TPJA 1IARA 2Q7NB 3O7PA 4CNIC 3L5WI 1BGEA 4YQXA 4A3MD 2B91A 1RW5A 5D59A 1HIKA 4A93D 4U4TA 3WDOA 5FUCA 5D58A 4Z5RD 2Q14A 5L6YC 3H3VE 5TS9A 2HYMB 4EXNA 4IKXA 1A7MA 2B90A 1ITFA 2INTA 5C65A 3SE3B 2XQBA 1BBNA 1D9CA 4X51A 3PIWA 4UVMA 4FA8E 4IKWA 3EJJA 4YBQA 4NN7A 1LQSL 3QWRB 3HOUD 2IL6A 3HMXB 3INKC 4DKCA 3NPZA 5IYCD 1HUWA 2GMFA 1M4AA 3WCYI 2D48A 4MHLA 4BBSD 3HOXD 4A3JD 1AX8A 4BY7D 1CD9A 4LRLA 4EXPA 4A3GD 1IRLA 1BUYA 2B5IA 3UF2A 3DLQI 4RS1A 1F45B 3I4ND 1Y6NL 3BPLA 4YUEC 3OG4A 3VA2A 1I1RB 3O7QA 4IKZA 4YB9D 2E9WC 2KZ1A 1V7NV 4ZWBA 2Z3RA 2LMSA 4A3FD 1JLIA 1F6FA 3UF5A 1EERA 3D85C 3PO2D 1AXIA 1PV6A 3PO3D 2CFQA 4DKDA 1HULA 2R93D 2JA7D 2V8NA 4O9HA 2Q98A 4ZYRA 5LQBA 5E4EA 1NBPA 2R7ZD 3QB7A 3DI3A 4ZWCA 2Z3QA 3B5KA 2JA5D 2O27A 4BXXD 3QT2C 4W6VA 2B8XA 3BESL 5D70A 2JA6D 1EKUA 3FKID 1M49A 2VUMD 1SCFA 3HOZD 4A3ID 1GA3A 4JA3A 4GBZA 2Y5YA 1WCMD 1Y6KL 4QIQA 3Q1SI 3EW3A 4A3ED 4XNJA 2L3YA 3PIVA 1ALUA 1ITMA 1RCBA 1PW6A 5EQHA 3BPOA 4NEMA 4IKYA 5C4XD 5A2OA 1Y1VD 4NI9A 1Y6ML 3QAZA 1FYHA 1HWGA 2O6IA 4JR9A 5GXBA 1HIJA 4A3CD 4GRWA 3SE4B 3HHRA 1EVSA 4ZF7A 4YPGC 1LK3A 1B5LA 5A2NA 4A3LD 1BGDA 4J4LC 1CSGA 2ERJD 1PVHB 3H0GD 1GNCA 5D22A 3HOYD 4APSA 3D48P 3NCFA 3G6DA 5FLMD 4U4VA 1AU1A 3IRHA 3OQ3A 1HGUA 4BBRD 1D9GA 4PS4A 4Q65A 5C3ED 5FHXA 4U4WA 3DI2A 1ILKA 4A3KD 1YKBA 2R92D 4A3BD 4NI7A 1EMRA 4D2CA 1M48A 3DGCL 2OQPA 5C7XA 4JREA 3TGXB 4D2BA 3N06A 5IP9D 1BCNA 3HHCA 3L5XA 5D72A 1WU3I 4OAAA 3UEZE 3NCBA 4OH3A 3NCCA 1FG9A 1CYLA 1RFBA 3BPNA 4TPHA 1HZIA 5D28B 2B8ZA 4GS7A 1ITIA 2JA8D 2D9QA 4I77Z 1CN4C 1PY2A 2PSMA 2CFPA 3S9DA 2B63D 4TPGA 4WRLB 3MZGA 4BY1D 1ITLA 5EQGA 3G9VB 2H24A 3I4MD 3D87A 3LB6B 1P9MB 4NN5A 4NN6A 4GC0A 1M4RA 1EXZA 2O26A 1Y1WD 1PW4A 1BP3A 4D2DA 3N0PA 1Z92A 2XUTA 4DKEA 5KNHI 2B8UA 4XNIA 1PGRA 1KF9A 4A3DD 3NCEA 1QVNA 4ZS7A 4YDYI 4NKQC 4NEJA 1INRA 4IKVA 1M4CA 3HOWD 3HOVD 3OG6A 2ILKA 1VLKA 1A22A 3AYHA 3DUHC 4O6KA 5IYBD 5D71A 5D6KA 2C35A 5C44D 4DKFA 1J7VL 1IL6A 1IJZA 1V7MV 4LEPA 4IU9A 2CYKA 1M4BA 1RHGA 1M47A
chains in the Genus database with same CATH topology
4A3ED 1HZIA 2B8YA 2L3YA 1ALUA 3PIVA 5D28B 2B8ZA 4GS7A 2L3OA 4MHLA 2JA8D 4BBSD 1ITIA 3HOXD 1ITMA 1RCBA 1PW6A 4A3JD 1AX8A 1CNT1 3BPOA 4NEMA 2D9QA 4BY7D 5IYDD 1CD9A 4I77Z 5C4XD 4LRLA 1CN4C 5IP7D 1PY2A 2PSMA 4EXPA 4A3GD 1Y1VD 1LKIA 1IRLA 1Z7CA 3S9DA 4NI9A 1BUYA 2B5IA 1Y6ML 1N1FA 3DLQI 3LB6A 3QAZA 4RS1A 3UF2A 2B63D 4DOHA 1F45B 3I4ND 1Y6NL 3BPLA 1FYHA 1HWGA 2O6IA 4WRLB 4YUEC 3OG4A 3QB1A 3VA2A 1HIJA 4A3CD 1I1RB 4GRWA 1ETEA 3SE4B 1HWHA 3MZGA 2E9WC 3HHRA 1IK0A 3UX9A 4BY1D 1EVSA 4ZF7A 4YPGC 1BGCA 1ITLA 1LK3A 1Y14A 2H24A 1B5LA 2LAGA 3G9VB 1IARA 2Q7NB 4CNIC 3I4MD 4A3LD 2KZ1A 1V7NV 2Z3RA 3D87A 2LMSA 1BGDA 4J4LC 3L5WI 3LB6B 4A3FD 1JLIA 1P9MB 1BGEA 4YQXA 4NN5A 1F6FA 4NN6A 1CSGA 1EERA 3UF5A 2B91A 3D85C 1RW5A 2ERJD 1HIKA 4A3MD 4A93D 1M4RA 1PVHB 1RFBA 3H0GD 1GNCA 5FUCA 1AXIA 3PO2D 1EXZA 3EW3A 5D22A 3HOYD 2O26A 3D48P 3NCFA 1Y1WD 3G6DA 4Z5RD 3PO3D 4DKDA 1HULA 1BP3A 2Q14A 5FLMD 5L6YC 3H3VE 2R93D 3N0PA 1Z92A 5TS9A 2HYMB 2JA7D 4DKEA 5KNHI 4O9HA 2B8UA 2Q98A 1AU1A 3IRHA 1PGRA 1KF9A 3OQ3A 4EXNA 5LQBA 4A3DD 1A7MA 5E4EA 1NBPA 3NCEA 1HGUA 2B90A 1QVNA 4BBRD 4ZS7A 1ITFA 4YDYI 4NKQC 1D9GA 2INTA 2R7ZD 3SE3B 3QB7A 4NEJA 1INRA 2XQBA 3DI3A 4PS4A 5C3ED 1M4CA 1BBNA 2Z3QA 1D9CA 3HOWD 5FHXA 3HOVD 4X51A 3OG6A 3B5KA 2JA5D 2ILKA 1VLKA 3PIWA 2O27A 4BXXD 1A22A 3AYHA 1ILKA 3DI2A 1YKBA 3DUHC 3QT2C 4O6KA 4A3KD 5IYBD 5D71A 4FA8E 3BPNA 2R92D 4A3BD 4NI7A 2B8XA 3BESL 1EMRA 5D70A 2JA6D 1EKUA 1M48A 2C35A 3DGCL 3EJJA 4DKFA 5C44D 2OQPA 3FKID 5C7XA 1J7VL 1IL6A 4NN7A 1IJZA 1LQSL 3QWRB 1V7MV 3HOUD 1M49A 2IL6A 3HMXB 2VUMD 3INKC 3TGXB 1SCFA 4DKCA 3HOZD 3NPZA 5IYCD 3N06A 1HUWA 5IP9D 1BCNA 3HHCA 3L5XA 4A3ID 5D72A 1WU3I 2CYKA 2GMFA 3UEZE 1GA3A 3NCBA 3NCCA 1M4BA 1M4AA 1WCMD 1RHGA 1FG9A 3WCYI 1Y6KL 1CYLA 1M47A 3Q1SI 2D48A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Y14 A;  4A3E D;  5IYB D;  2R92 D;  4A3B D;  2JA7 D;  3I4M D;  2JA8 D;  4BBS D;  2JA6 D;  4A3L D;  2C35 A;  3HOX D;  5C44 D;  3FKI D;  4A3J D;  4A3D D;  4BY7 D;  4A3F D;  5IYD D;  3H3V E;  5C4X D;  3HOU D;  5IP7 D;  4BBR D;  2VUM D;  4A3G D;  1Y1V D;  4A3M D;  2R7Z D;  3HOZ D;  4A93 D;  3H0G D;  5IYC D;  5IP9 D;  5C3E D;  2B63 D;  3I4N D;  3HOW D;  4A3I D;  3PO2 D;  3HOY D;  3HOV D;  4A3C D;  1Y1W D;  2JA5 D;  3PO3 D;  1WCM D;  4BXX D;  4BY1 D;  5FLM D;  3AYH A;  4A3K D;  2R93 D; 
#chains in the Genus database with same CATH topology
 2B8Y A;  2L3O A;  4IU8 A;  1CNT 1;  5IYD D;  4J05 A;  5IP7 D;  4GBY A;  1LKI A;  1Z7C A;  3LB6 A;  1N1F A;  1PV7 A;  4DOH A;  3QB1 A;  1ETE A;  4PYP A;  1HWH A;  1IK0 A;  3UX9 A;  4ZW9 A;  5EQI A;  1BGC A;  1Y14 A;  2LAG A;  4LDS A;  4TPJ A;  1IAR A;  2Q7N B;  3O7P A;  4CNI C;  3L5W I;  1BGE A;  4YQX A;  4A3M D;  2B91 A;  1RW5 A;  5D59 A;  1HIK A;  4A93 D;  4U4T A;  3WDO A;  5FUC A;  5D58 A;  4Z5R D;  2Q14 A;  5L6Y C;  3H3V E;  5TS9 A;  2HYM B;  4EXN A;  4IKX A;  1A7M A;  2B90 A;  1ITF A;  2INT A;  5C65 A;  3SE3 B;  2XQB A;  1BBN A;  1D9C A;  4X51 A;  3PIW A;  4UVM A;  4FA8 E;  4IKW A;  3EJJ A;  4YBQ A;  4NN7 A;  1LQS L;  3QWR B;  3HOU D;  2IL6 A;  3HMX B;  3INK C;  4DKC A;  3NPZ A;  5IYC D;  1HUW A;  2GMF A;  1M4A A;  3WCY I;  2D48 A;  4MHL A;  4BBS D;  3HOX D;  4A3J D;  1AX8 A;  4BY7 D;  1CD9 A;  4LRL A;  4EXP A;  4A3G D;  1IRL A;  1BUY A;  2B5I A;  3UF2 A;  3DLQ I;  4RS1 A;  1F45 B;  3I4N D;  1Y6N L;  3BPL A;  4YUE C;  3OG4 A;  3VA2 A;  1I1R B;  3O7Q A;  4IKZ A;  4YB9 D;  2E9W C;  2KZ1 A;  1V7N V;  4ZWB A;  2Z3R A;  2LMS A;  4A3F D;  1JLI A;  1F6F A;  3UF5 A;  1EER A;  3D85 C;  3PO2 D;  1AXI A;  1PV6 A;  3PO3 D;  2CFQ A;  4DKD A;  1HUL A;  2R93 D;  2JA7 D;  2V8N A;  4O9H A;  2Q98 A;  4ZYR A;  5LQB A;  5E4E A;  1NBP A;  2R7Z D;  3QB7 A;  3DI3 A;  4ZWC A;  2Z3Q A;  3B5K A;  2JA5 D;  2O27 A;  4BXX D;  3QT2 C;  4W6V A;  2B8X A;  3BES L;  5D70 A;  2JA6 D;  1EKU A;  3FKI D;  1M49 A;  2VUM D;  1SCF A;  3HOZ D;  4A3I D;  1GA3 A;  4JA3 A;  4GBZ A;  2Y5Y A;  1WCM D;  1Y6K L;  4QIQ A;  3Q1S I;  3EW3 A;  4A3E D;  4XNJ A;  2L3Y A;  3PIV A;  1ALU A;  1ITM A;  1RCB A;  1PW6 A;  5EQH A;  3BPO A;  4NEM A;  4IKY A;  5C4X D;  5A2O A;  1Y1V D;  4NI9 A;  1Y6M L;  3QAZ A;  1FYH A;  1HWG A;  2O6I A;  4JR9 A;  5GXB A;  1HIJ A;  4A3C D;  4GRW A;  3SE4 B;  3HHR A;  1EVS A;  4ZF7 A;  4YPG C;  1LK3 A;  1B5L A;  5A2N A;  4A3L D;  1BGD A;  4J4L C;  1CSG A;  2ERJ D;  1PVH B;  3H0G D;  1GNC A;  5D22 A;  3HOY D;  4APS A;  3D48 P;  3NCF A;  3G6D A;  5FLM D;  4U4V A;  1AU1 A;  3IRH A;  3OQ3 A;  1HGU A;  4BBR D;  1D9G A;  4PS4 A;  4Q65 A;  5C3E D;  5FHX A;  4U4W A;  3DI2 A;  1ILK A;  4A3K D;  1YKB A;  2R92 D;  4A3B D;  4NI7 A;  1EMR A;  4D2C A;  1M48 A;  3DGC L;  2OQP A;  5C7X A;  4JRE A;  3TGX B;  4D2B A;  3N06 A;  5IP9 D;  1BCN A;  3HHC A;  3L5X A;  5D72 A;  1WU3 I;  4OAA A;  3UEZ E;  3NCB A;  4OH3 A;  3NCC A;  1FG9 A;  1CYL A;  1RFB A;  3BPN A;  4TPH A;  1HZI A;  5D28 B;  2B8Z A;  4GS7 A;  1ITI A;  2JA8 D;  2D9Q A;  4I77 Z;  1CN4 C;  1PY2 A;  2PSM A;  2CFP A;  3S9D A;  2B63 D;  4TPG A;  4WRL B;  3MZG A;  4BY1 D;  1ITL A;  5EQG A;  3G9V B;  2H24 A;  3I4M D;  3D87 A;  3LB6 B;  1P9M B;  4NN5 A;  4NN6 A;  4GC0 A;  1M4R A;  1EXZ A;  2O26 A;  1Y1W D;  1PW4 A;  1BP3 A;  4D2D A;  3N0P A;  1Z92 A;  2XUT A;  4DKE A;  5KNH I;  2B8U A;  4XNI A;  1PGR A;  1KF9 A;  4A3D D;  3NCE A;  1QVN A;  4ZS7 A;  4YDY I;  4NKQ C;  4NEJ A;  1INR A;  4IKV A;  1M4C A;  3HOW D;  3HOV D;  3OG6 A;  2ILK A;  1VLK A;  1A22 A;  3AYH A;  3DUH C;  4O6K A;  5IYB D;  5D71 A;  5D6K A;  2C35 A;  5C44 D;  4DKF A;  1J7V L;  1IL6 A;  1IJZ A;  1V7M V;  4LEP A;  4IU9 A;  2CYK A;  1M4B A;  1RHG A;  1M47 A; 
#chains in the Genus database with same CATH homology
 4A3E D;  1HZI A;  2B8Y A;  2L3Y A;  1ALU A;  3PIV A;  5D28 B;  2B8Z A;  4GS7 A;  2L3O A;  4MHL A;  2JA8 D;  4BBS D;  1ITI A;  3HOX D;  1ITM A;  1RCB A;  1PW6 A;  4A3J D;  1AX8 A;  1CNT 1;  3BPO A;  4NEM A;  2D9Q A;  4BY7 D;  5IYD D;  1CD9 A;  4I77 Z;  5C4X D;  4LRL A;  1CN4 C;  5IP7 D;  1PY2 A;  2PSM A;  4EXP A;  4A3G D;  1Y1V D;  1LKI A;  1IRL A;  1Z7C A;  3S9D A;  4NI9 A;  1BUY A;  2B5I A;  1Y6M L;  1N1F A;  3DLQ I;  3LB6 A;  3QAZ A;  4RS1 A;  3UF2 A;  2B63 D;  4DOH A;  1F45 B;  3I4N D;  1Y6N L;  3BPL A;  1FYH A;  1HWG A;  2O6I A;  4WRL B;  4YUE C;  3OG4 A;  3QB1 A;  3VA2 A;  1HIJ A;  4A3C D;  1I1R B;  4GRW A;  1ETE A;  3SE4 B;  1HWH A;  3MZG A;  2E9W C;  3HHR A;  1IK0 A;  3UX9 A;  4BY1 D;  1EVS A;  4ZF7 A;  4YPG C;  1BGC A;  1ITL A;  1LK3 A;  1Y14 A;  2H24 A;  1B5L A;  2LAG A;  3G9V B;  1IAR A;  2Q7N B;  4CNI C;  3I4M D;  4A3L D;  2KZ1 A;  1V7N V;  2Z3R A;  3D87 A;  2LMS A;  1BGD A;  4J4L C;  3L5W I;  3LB6 B;  4A3F D;  1JLI A;  1P9M B;  1BGE A;  4YQX A;  4NN5 A;  1F6F A;  4NN6 A;  1CSG A;  1EER A;  3UF5 A;  2B91 A;  3D85 C;  1RW5 A;  2ERJ D;  1HIK A;  4A3M D;  4A93 D;  1M4R A;  1PVH B;  1RFB A;  3H0G D;  1GNC A;  5FUC A;  1AXI A;  3PO2 D;  1EXZ A;  3EW3 A;  5D22 A;  3HOY D;  2O26 A;  3D48 P;  3NCF A;  1Y1W D;  3G6D A;  4Z5R D;  3PO3 D;  4DKD A;  1HUL A;  1BP3 A;  2Q14 A;  5FLM D;  5L6Y C;  3H3V E;  2R93 D;  3N0P A;  1Z92 A;  5TS9 A;  2HYM B;  2JA7 D;  4DKE A;  5KNH I;  4O9H A;  2B8U A;  2Q98 A;  1AU1 A;  3IRH A;  1PGR A;  1KF9 A;  3OQ3 A;  4EXN A;  5LQB A;  4A3D D;  1A7M A;  5E4E A;  1NBP A;  3NCE A;  1HGU A;  2B90 A;  1QVN A;  4BBR D;  4ZS7 A;  1ITF A;  4YDY I;  4NKQ C;  1D9G A;  2INT A;  2R7Z D;  3SE3 B;  3QB7 A;  4NEJ A;  1INR A;  2XQB A;  3DI3 A;  4PS4 A;  5C3E D;  1M4C A;  1BBN A;  2Z3Q A;  1D9C A;  3HOW D;  5FHX A;  3HOV D;  4X51 A;  3OG6 A;  3B5K A;  2JA5 D;  2ILK A;  1VLK A;  3PIW A;  2O27 A;  4BXX D;  1A22 A;  3AYH A;  1ILK A;  3DI2 A;  1YKB A;  3DUH C;  3QT2 C;  4O6K A;  4A3K D;  5IYB D;  5D71 A;  4FA8 E;  3BPN A;  2R92 D;  4A3B D;  4NI7 A;  2B8X A;  3BES L;  1EMR A;  5D70 A;  2JA6 D;  1EKU A;  1M48 A;  2C35 A;  3DGC L;  3EJJ A;  4DKF A;  5C44 D;  2OQP A;  3FKI D;  5C7X A;  1J7V L;  1IL6 A;  4NN7 A;  1IJZ A;  1LQS L;  3QWR B;  1V7M V;  3HOU D;  1M49 A;  2IL6 A;  3HMX B;  2VUM D;  3INK C;  3TGX B;  1SCF A;  4DKC A;  3HOZ D;  3NPZ A;  5IYC D;  3N06 A;  1HUW A;  5IP9 D;  1BCN A;  3HHC A;  3L5X A;  4A3I D;  5D72 A;  1WU3 I;  2CYK A;  2GMF A;  3UEZ E;  1GA3 A;  3NCB A;  3NCC A;  1M4B A;  1M4A A;  1WCM D;  1RHG A;  1FG9 A;  3WCY I;  1Y6K L;  1CYL A;  1M47 A;  3Q1S I;  2D48 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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