5C3ED

Crystal structure of a transcribing rna polymerase ii complex reveals a complete transcription bubble
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
218
structure length
178
Chain Sequence
STSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIKEALVERRRAFKRSQKKETREKELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQLGSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
pubmed doi rcsb
molecule tags Transferase/dna/rna
source organism Saccharomyces cerevisiae (strain atcc 204508 / s288c)
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 43
structure length 178
sequence length 218
ec nomenclature
pdb deposition date 2015-06-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF03874 RNA_pol_Rpb4 RNA polymerase Rpb4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.40 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 5c3eD02
5C4XD 1Y14A 4A3KD 2R92D 4A3ID 3H3VE 2R7ZD 3H0GD 2JA6D 1WCMD 5IP9D 4A3JD 2JA5D 3PO3D 3HOZD 5IYCD 4BY1D 3I4MD 3FKID 4A3CD 5IYBD 3HOUD 3HOWD 2R93D 3AYHA 2VUMD 4A3ED 5C3ED 5FLMD 1Y1WD 4A3BD 3HOYD 2JA8D 2B63D 4BBRD 4BXXD 3PO2D 4BY7D 4A93D 2JA7D 3I4ND 4A3GD 3HOXD 5IP7D 5IYDD 4A3FD 2C35A 3HOVD 4A3DD 5C44D 4A3LD 4BBSD 4A3MD 1Y1VD
chains in the Genus database with same CATH superfamily
1Y6NL 4LRLA 1HWHA 3BPNA 4IKVA 2XUTA 1GNCA 1PVHB 4A93D 3BPLA 4FA8E 2R92D 1CNT1 3G9VB 4A3JD 3EW3A 3DUHC 4QIQA 1VLKA 1EERA 4JREA 1M4AA 2L3YA 5A2NA 1Z7CA 3NCBA 5C44D 4D2CA 1QVNA 1RHGA 1B5LA 1IARA 1Y1WD 3HOYD 3HMXB 4TPJA 3D87A 4JA3A 2O6IA 4NN5A 2Y5YA 5L6YC 1V7NV 2E9WC 4OH3A 5EQGA 3MZGA 5D71A 1BGEA 4PYPA 4NEJA 4Q65A 3FKID 2VUMD 3VA2A 1LQSL 1M4CA 4YB9D 5KNHI 1HGUA 2IL6A 2C35A 4D2BA 4D2DA 2D48A 4ZWBA 5D28B 1CD9A 3HOZD 5D58A 2ILKA 3LB6B 3O7PA 3BESL 4BBRD 4BY7D 1ILKA 1P9MB 3OG6A 4DKCA 2L3OA 1F6FA 4W6VA 5C4XD 2V8NA 3PO3D 4YPGC 4TPHA 1IK0A 4UVMA 2OQPA 4PS4A 3S9DA 4YUEC 2D9QA 2PSMA 2JA7D 3HOXD 2Q14A 4MHLA 4A3DD 1PW4A 5D70A 2O26A 2LMSA 3NPZA 3UF2A 3H3VE 3UF5A 4A3BD 1FYHA 1PY2A 1Y6KL 3SE4B 4YDYI 1BP3A 4U4TA 1M4BA 4DKDA 2B8UA 2B8XA 2Q98A 3Q1SI 2B5IA 2B8ZA 3QB7A 1WU3I 1EVSA 3H0GD 1JLIA 2B90A 5C7XA 1BGDA 1IL6A 1PGRA 2ERJD 4GC0A 1ITFA 1RCBA 1I1RB 4U4VA 2B8YA 3L5XA 3NCCA 1LKIA 4IKXA 4XNJA 4BBSD 1KF9A 2JA6D 1WCMD 2Q7NB 5IP9D 4RS1A 5EQIA 1V7MV 2R93D 3AYHA 1AXIA 5D72A 1Z92A 2Z3RA 1A7MA 1IJZA 1M49A 5LQBA 4O6KA 2CFPA 4A3LD 1AX8A 1HZIA 2JA5D 1AU1A 2XQBA 3B5KA 4BY1D 5TS9A 1EMRA 4WRLB 4DOHA 1BUYA 1M4RA 5GXBA 4BXXD 3IRHA 4ZW9A 4NI9A 5D6KA 5IP7D 2CFQA 5D22A 4ZF7A 2H24A 1BGCA 4A3KD 4GRWA 1A22A 1BCNA 4IKWA 4A3CD 4IKZA 2GMFA 1D9CA 1PW6A 1HWGA 3BPOA 4ZWCA 4NI7A 3DGCL 4IU8A 1M47A 1Y6ML 1HIJA 3QT2C 4TPGA 1ETEA 5FHXA 1EXZA 3O7QA 4A3FD 1D9GA 1YKBA 4A3ID 4CNIC 1F45B 1ITIA 4EXNA 3WDOA 4X51A 4U4WA 1HIKA 1HUWA 5C65A 4A3ED 4LEPA 1RFBA 5C3ED 4EXPA 3D85C 5EQHA 4DKEA 4Z5RD 3D48P 4ZYRA 1ALUA 3N06A 1CSGA 5D59A 1LK3A 3PIWA 2INTA 1CYLA 4IKYA 5IYCD 3HHCA 5FUCA 3EJJA 4YQXA 4GBYA 1SCFA 1GA3A 1HULA 4A3GD 1N1FA 4NN7A 5IYDD 4O9HA 1EKUA 3QAZA 4APSA 4ZS7A 3NCEA 1Y14A 2R7ZD 1NBPA 3INKC 4GS7A 4NKQC 4JR9A 1J7VL 2Z3QA 3OG4A 5FLMD 4YBQA 2B63D 4NN6A 3I4ND 5A2OA 1BBNA 4I77Z 3HOVD 5E4EA 4A3MD 1Y1VD 3G6DA 3L5WI 3DI3A 4DKFA 2O27A 1INRA 1RW5A 3I4MD 3QWRB 3DI2A 3HOWD 1IRLA 4LDSA 4J05A 2KZ1A 3TGXB 1FG9A 3OQ3A 3QB1A 2HYMB 1CN4C 4OAAA 4J4LC 2B91A 1PV7A 3HHRA 3UX9A 3LB6A 1ITMA 5IYBD 1ITLA 3HOUD 4GBZA 2CYKA 3UEZE 4XNIA 2JA8D 3DLQI 2LAGA 3PO2D 1PV6A 4NEMA 1M48A 3WCYI 3NCFA 3N0PA 3SE3B 4IU9A 3PIVA
chains in the Genus database with same CATH topology
3PIWA 1Y6NL 2D48A 2INTA 4LRLA 1HWHA 3BPNA 1WCMD 2Q7NB 5IP9D 2JA6D 5D28B 1CYLA 1CD9A 4RS1A 3HOZD 5IYCD 2ILKA 3LB6B 1V7MV 3HHCA 2R93D 3AYHA 5FUCA 1AXIA 5D72A 3BESL 3EJJA 1PVHB 1Z92A 4YQXA 4BBRD 4BY7D 1SCFA 1GNCA 4A93D 2Z3RA 1GA3A 1HULA 1A7MA 1IJZA 1ILKA 1M49A 1N1FA 1P9MB 4O6KA 3BPLA 5LQBA 4A3GD 3OG6A 4NN7A 4O9HA 5IYDD 1EKUA 4DKCA 4A3LD 3QAZA 2L3OA 1AX8A 1F6FA 1HZIA 4ZS7A 3NCEA 5C4XD 4FA8E 1Y14A 2R92D 1CNT1 3G9VB 2R7ZD 4A3JD 1NBPA 3INKC 4GS7A 4YPGC 1AU1A 2XQBA 4NKQC 2JA5D 3PO3D 3B5KA 3EW3A 4BY1D 5TS9A 1IK0A 1EMRA 4WRLB 3DUHC 4DOHA 2OQPA 4PS4A 1J7VL 2Z3QA 3OG4A 1BUYA 3S9DA 5FLMD 3PIVA 1M4RA 4YUEC 2B63D 1VLKA 1EERA 2D9QA 4BXXD 2PSMA 3IRHA 4NN6A 2JA7D 3I4ND 4NI9A 1BBNA 1M4AA 2L3YA 1Z7CA 3HOXD 5IP7D 2Q14A 5D22A 4MHLA 4ZF7A 4I77Z 3NCBA 3HOVD 2H24A 5E4EA 4A3DD 5C44D 5D70A 1BGCA 4A3MD 1Y1VD 2O26A 2LMSA 3G6DA 3L5WI 3NPZA 3DI3A 3UF2A 1QVNA 4A3KD 3UF5A 3H3VE 4DKFA 4GRWA 2O27A 1INRA 1A22A 1RW5A 1BCNA 1RHGA 3I4MD 3QWRB 4A3CD 3DI2A 3HOWD 1IRLA 2GMFA 1B5LA 1D9CA 1PW6A 1FYHA 1IARA 1PY2A 1Y1WD 3HOYD 3HMXB 4A3BD 1Y6KL 3SE4B 1HWGA 3D87A 4YDYI 3BPOA 1BP3A 1M4BA 2KZ1A 3TGXB 2O6IA 1FG9A 4NI7A 4DKDA 2B8UA 4NN5A 2B8XA 3OQ3A 2Q98A 3DGCL 1M47A 2B5IA 3Q1SI 5L6YC 1Y6ML 1HIJA 1V7NV 3QB1A 1ETEA 2E9WC 3QT2C 1EXZA 5FHXA 2HYMB 4A3FD 1CN4C 4J4LC 1D9GA 2B91A 2B8ZA 3QB7A 1WU3I 3HHRA 1YKBA 3UX9A 1EVSA 3MZGA 4A3ID 3H0GD 4CNIC 1JLIA 5D71A 1F45B 1ITIA 1BGEA 4EXNA 3LB6A 2B90A 4NEJA 1ITMA 3FKID 4X51A 5IYBD 1ITLA 3HOUD 5C7XA 1HIKA 1HUWA 2VUMD 4A3ED 3VA2A 1RFBA 5C3ED 2CYKA 1BGDA 3UEZE 4EXPA 2JA8D 1LQSL 3DLQI 1M4CA 2LAGA 3D85C 1IL6A 1PGRA 4DKEA 4Z5RD 5KNHI 2ERJD 3D48P 3PO2D 4NEMA 1ALUA 1M48A 3N06A 3WCYI 3NCFA 1CSGA 1HGUA 3N0PA 1ITFA 1RCBA 2IL6A 1I1RB 2C35A 3SE3B 2B8YA 3L5XA 3NCCA 1LKIA 4BBSD 1LK3A 1KF9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C4X D;  1Y14 A;  4A3K D;  2R92 D;  4A3I D;  3H3V E;  2R7Z D;  3H0G D;  2JA6 D;  1WCM D;  5IP9 D;  4A3J D;  2JA5 D;  3PO3 D;  3HOZ D;  5IYC D;  4BY1 D;  3I4M D;  3FKI D;  4A3C D;  5IYB D;  3HOU D;  3HOW D;  2R93 D;  3AYH A;  2VUM D;  4A3E D;  5C3E D;  5FLM D;  1Y1W D;  4A3B D;  3HOY D;  2JA8 D;  2B63 D;  4BBR D;  4BXX D;  3PO2 D;  4BY7 D;  4A93 D;  2JA7 D;  3I4N D;  4A3G D;  3HOX D;  5IP7 D;  5IYD D;  4A3F D;  2C35 A;  3HOV D;  4A3D D;  5C44 D;  4A3L D;  4BBS D;  4A3M D;  1Y1V D; 
#chains in the Genus database with same CATH topology
 1Y6N L;  4LRL A;  1HWH A;  3BPN A;  4IKV A;  2XUT A;  1GNC A;  1PVH B;  4A93 D;  3BPL A;  4FA8 E;  2R92 D;  1CNT 1;  3G9V B;  4A3J D;  3EW3 A;  3DUH C;  4QIQ A;  1VLK A;  1EER A;  4JRE A;  1M4A A;  2L3Y A;  5A2N A;  1Z7C A;  3NCB A;  5C44 D;  4D2C A;  1QVN A;  1RHG A;  1B5L A;  1IAR A;  1Y1W D;  3HOY D;  3HMX B;  4TPJ A;  3D87 A;  4JA3 A;  2O6I A;  4NN5 A;  2Y5Y A;  5L6Y C;  1V7N V;  2E9W C;  4OH3 A;  5EQG A;  3MZG A;  5D71 A;  1BGE A;  4PYP A;  4NEJ A;  4Q65 A;  3FKI D;  2VUM D;  3VA2 A;  1LQS L;  1M4C A;  4YB9 D;  5KNH I;  1HGU A;  2IL6 A;  2C35 A;  4D2B A;  4D2D A;  2D48 A;  4ZWB A;  5D28 B;  1CD9 A;  3HOZ D;  5D58 A;  2ILK A;  3LB6 B;  3O7P A;  3BES L;  4BBR D;  4BY7 D;  1ILK A;  1P9M B;  3OG6 A;  4DKC A;  2L3O A;  1F6F A;  4W6V A;  5C4X D;  2V8N A;  3PO3 D;  4YPG C;  4TPH A;  1IK0 A;  4UVM A;  2OQP A;  4PS4 A;  3S9D A;  4YUE C;  2D9Q A;  2PSM A;  2JA7 D;  3HOX D;  2Q14 A;  4MHL A;  4A3D D;  1PW4 A;  5D70 A;  2O26 A;  2LMS A;  3NPZ A;  3UF2 A;  3H3V E;  3UF5 A;  4A3B D;  1FYH A;  1PY2 A;  1Y6K L;  3SE4 B;  4YDY I;  1BP3 A;  4U4T A;  1M4B A;  4DKD A;  2B8U A;  2B8X A;  2Q98 A;  3Q1S I;  2B5I A;  2B8Z A;  3QB7 A;  1WU3 I;  1EVS A;  3H0G D;  1JLI A;  2B90 A;  5C7X A;  1BGD A;  1IL6 A;  1PGR A;  2ERJ D;  4GC0 A;  1ITF A;  1RCB A;  1I1R B;  4U4V A;  2B8Y A;  3L5X A;  3NCC A;  1LKI A;  4IKX A;  4XNJ A;  4BBS D;  1KF9 A;  2JA6 D;  1WCM D;  2Q7N B;  5IP9 D;  4RS1 A;  5EQI A;  1V7M V;  2R93 D;  3AYH A;  1AXI A;  5D72 A;  1Z92 A;  2Z3R A;  1A7M A;  1IJZ A;  1M49 A;  5LQB A;  4O6K A;  2CFP A;  4A3L D;  1AX8 A;  1HZI A;  2JA5 D;  1AU1 A;  2XQB A;  3B5K A;  4BY1 D;  5TS9 A;  1EMR A;  4WRL B;  4DOH A;  1BUY A;  1M4R A;  5GXB A;  4BXX D;  3IRH A;  4ZW9 A;  4NI9 A;  5D6K A;  5IP7 D;  2CFQ A;  5D22 A;  4ZF7 A;  2H24 A;  1BGC A;  4A3K D;  4GRW A;  1A22 A;  1BCN A;  4IKW A;  4A3C D;  4IKZ A;  2GMF A;  1D9C A;  1PW6 A;  1HWG A;  3BPO A;  4ZWC A;  4NI7 A;  3DGC L;  4IU8 A;  1M47 A;  1Y6M L;  1HIJ A;  3QT2 C;  4TPG A;  1ETE A;  5FHX A;  1EXZ A;  3O7Q A;  4A3F D;  1D9G A;  1YKB A;  4A3I D;  4CNI C;  1F45 B;  1ITI A;  4EXN A;  3WDO A;  4X51 A;  4U4W A;  1HIK A;  1HUW A;  5C65 A;  4A3E D;  4LEP A;  1RFB A;  5C3E D;  4EXP A;  3D85 C;  5EQH A;  4DKE A;  4Z5R D;  3D48 P;  4ZYR A;  1ALU A;  3N06 A;  1CSG A;  5D59 A;  1LK3 A;  3PIW A;  2INT A;  1CYL A;  4IKY A;  5IYC D;  3HHC A;  5FUC A;  3EJJ A;  4YQX A;  4GBY A;  1SCF A;  1GA3 A;  1HUL A;  4A3G D;  1N1F A;  4NN7 A;  5IYD D;  4O9H A;  1EKU A;  3QAZ A;  4APS A;  4ZS7 A;  3NCE A;  1Y14 A;  2R7Z D;  1NBP A;  3INK C;  4GS7 A;  4NKQ C;  4JR9 A;  1J7V L;  2Z3Q A;  3OG4 A;  5FLM D;  4YBQ A;  2B63 D;  4NN6 A;  3I4N D;  5A2O A;  1BBN A;  4I77 Z;  3HOV D;  5E4E A;  4A3M D;  1Y1V D;  3G6D A;  3L5W I;  3DI3 A;  4DKF A;  2O27 A;  1INR A;  1RW5 A;  3I4M D;  3QWR B;  3DI2 A;  3HOW D;  1IRL A;  4LDS A;  4J05 A;  2KZ1 A;  3TGX B;  1FG9 A;  3OQ3 A;  3QB1 A;  2HYM B;  1CN4 C;  4OAA A;  4J4L C;  2B91 A;  1PV7 A;  3HHR A;  3UX9 A;  3LB6 A;  1ITM A;  5IYB D;  1ITL A;  3HOU D;  4GBZ A;  2CYK A;  3UEZ E;  4XNI A;  2JA8 D;  3DLQ I;  2LAG A;  3PO2 D;  1PV6 A;  4NEM A;  1M48 A;  3WCY I;  3NCF A;  3N0P A;  3SE3 B;  4IU9 A;  3PIV A; 
#chains in the Genus database with same CATH homology
 3PIW A;  1Y6N L;  2D48 A;  2INT A;  4LRL A;  1HWH A;  3BPN A;  1WCM D;  2Q7N B;  5IP9 D;  2JA6 D;  5D28 B;  1CYL A;  1CD9 A;  4RS1 A;  3HOZ D;  5IYC D;  2ILK A;  3LB6 B;  1V7M V;  3HHC A;  2R93 D;  3AYH A;  5FUC A;  1AXI A;  5D72 A;  3BES L;  3EJJ A;  1PVH B;  1Z92 A;  4YQX A;  4BBR D;  4BY7 D;  1SCF A;  1GNC A;  4A93 D;  2Z3R A;  1GA3 A;  1HUL A;  1A7M A;  1IJZ A;  1ILK A;  1M49 A;  1N1F A;  1P9M B;  4O6K A;  3BPL A;  5LQB A;  4A3G D;  3OG6 A;  4NN7 A;  4O9H A;  5IYD D;  1EKU A;  4DKC A;  4A3L D;  3QAZ A;  2L3O A;  1AX8 A;  1F6F A;  1HZI A;  4ZS7 A;  3NCE A;  5C4X D;  4FA8 E;  1Y14 A;  2R92 D;  1CNT 1;  3G9V B;  2R7Z D;  4A3J D;  1NBP A;  3INK C;  4GS7 A;  4YPG C;  1AU1 A;  2XQB A;  4NKQ C;  2JA5 D;  3PO3 D;  3B5K A;  3EW3 A;  4BY1 D;  5TS9 A;  1IK0 A;  1EMR A;  4WRL B;  3DUH C;  4DOH A;  2OQP A;  4PS4 A;  1J7V L;  2Z3Q A;  3OG4 A;  1BUY A;  3S9D A;  5FLM D;  3PIV A;  1M4R A;  4YUE C;  2B63 D;  1VLK A;  1EER A;  2D9Q A;  4BXX D;  2PSM A;  3IRH A;  4NN6 A;  2JA7 D;  3I4N D;  4NI9 A;  1BBN A;  1M4A A;  2L3Y A;  1Z7C A;  3HOX D;  5IP7 D;  2Q14 A;  5D22 A;  4MHL A;  4ZF7 A;  4I77 Z;  3NCB A;  3HOV D;  2H24 A;  5E4E A;  4A3D D;  5C44 D;  5D70 A;  1BGC A;  4A3M D;  1Y1V D;  2O26 A;  2LMS A;  3G6D A;  3L5W I;  3NPZ A;  3DI3 A;  3UF2 A;  1QVN A;  4A3K D;  3UF5 A;  3H3V E;  4DKF A;  4GRW A;  2O27 A;  1INR A;  1A22 A;  1RW5 A;  1BCN A;  1RHG A;  3I4M D;  3QWR B;  4A3C D;  3DI2 A;  3HOW D;  1IRL A;  2GMF A;  1B5L A;  1D9C A;  1PW6 A;  1FYH A;  1IAR A;  1PY2 A;  1Y1W D;  3HOY D;  3HMX B;  4A3B D;  1Y6K L;  3SE4 B;  1HWG A;  3D87 A;  4YDY I;  3BPO A;  1BP3 A;  1M4B A;  2KZ1 A;  3TGX B;  2O6I A;  1FG9 A;  4NI7 A;  4DKD A;  2B8U A;  4NN5 A;  2B8X A;  3OQ3 A;  2Q98 A;  3DGC L;  1M47 A;  2B5I A;  3Q1S I;  5L6Y C;  1Y6M L;  1HIJ A;  1V7N V;  3QB1 A;  1ETE A;  2E9W C;  3QT2 C;  1EXZ A;  5FHX A;  2HYM B;  4A3F D;  1CN4 C;  4J4L C;  1D9G A;  2B91 A;  2B8Z A;  3QB7 A;  1WU3 I;  3HHR A;  1YKB A;  3UX9 A;  1EVS A;  3MZG A;  4A3I D;  3H0G D;  4CNI C;  1JLI A;  5D71 A;  1F45 B;  1ITI A;  1BGE A;  4EXN A;  3LB6 A;  2B90 A;  4NEJ A;  1ITM A;  3FKI D;  4X51 A;  5IYB D;  1ITL A;  3HOU D;  5C7X A;  1HIK A;  1HUW A;  2VUM D;  4A3E D;  3VA2 A;  1RFB A;  5C3E D;  2CYK A;  1BGD A;  3UEZ E;  4EXP A;  2JA8 D;  1LQS L;  3DLQ I;  1M4C A;  2LAG A;  3D85 C;  1IL6 A;  1PGR A;  4DKE A;  4Z5R D;  5KNH I;  2ERJ D;  3D48 P;  3PO2 D;  4NEM A;  1ALU A;  1M48 A;  3N06 A;  3WCY I;  3NCF A;  1CSG A;  1HGU A;  3N0P A;  1ITF A;  1RCB A;  2IL6 A;  1I1R B;  2C35 A;  3SE3 B;  2B8Y A;  3L5X A;  3NCC A;  1LKI A;  4BBS D;  1LK3 A;  1KF9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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