5C44D

Crystal structure of a transcribing rna polymerase ii complex reveals a complete transcription bubble
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
218
structure length
178
Chain Sequence
STSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIKEALVERRRAFKRSQKKETREKELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQLGSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
pubmed doi rcsb
molecule tags Transferase/dna/rna
source organism Saccharomyces cerevisiae (strain atcc 204508 / s288c)
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 39
structure length 178
sequence length 218
ec nomenclature
pdb deposition date 2015-06-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF03874 RNA_pol_Rpb4 RNA polymerase Rpb4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.40 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 5c44D02
3H3VE 3AYHA 3H0GD 4A93D 4BBSD 4A3DD 5IYDD 4A3ID 5IYBD 4A3LD 1Y1VD 2R93D 4A3KD 4A3FD 1Y14A 3HOVD 4A3ED 3HOWD 2R92D 2VUMD 1WCMD 2JA8D 3PO3D 4A3BD 3HOYD 5IYCD 3I4ND 2R7ZD 4BY7D 5IP7D 4BXXD 1Y1WD 2JA6D 4A3JD 4A3MD 3FKID 3HOZD 3I4MD 2C35A 5C3ED 2JA5D 3HOUD 4BY1D 2B63D 5C44D 4A3CD 5C4XD 3HOXD 2JA7D 5IP9D 4A3GD 3PO2D 4BBRD 5FLMD
chains in the Genus database with same CATH superfamily
3OG6A 3SE3B 3S9DA 2ERJD 2JA8D 3O7PA 4NN7A 4FA8E 4QIQA 2B90A 1GA3A 1A7MA 3DI3A 4BXXD 2B8ZA 2E9WC 2O27A 4DKCA 2JA5D 5TS9A 1IRLA 1P9MB 4UVMA 4I77Z 1VLKA 4PS4A 4WRLB 4APSA 3NCFA 1AU1A 2GMFA 4XNJA 1J7VL 3HOZD 5C4XD 2OQPA 1RHGA 1F45B 5IYBD 1IARA 1PGRA 3HOVD 3O7QA 2R92D 5C65A 4YPGC 3N0PA 1EERA 2Z3RA 1IJZA 3PIVA 1NBPA 2D48A 2C35A 2KZ1A 5D72A 3H3VE 2CFQA 3H0GD 2B8UA 4O9HA 5FHXA 4EXPA 1YKBA 4A3ED 2VUMD 2B8XA 2HYMB 1BP3A 5A2OA 1Y6NL 1PV7A 1LKIA 4ZWCA 4RS1A 1AXIA 1F6FA 4JA3A 3SE4B 1ETEA 1HIKA 5A2NA 1INRA 1AX8A 3AYHA 1SCFA 5D59A 1PVHB 4NI9A 3EJJA 4MHLA 3PO3D 5IYCD 1KF9A 1EMRA 1RFBA 5GXBA 1LQSL 1HGUA 1BGDA 3N06A 3QB1A 5EQIA 3NPZA 3HHCA 3OG4A 3HOUD 5D70A 4IKYA 5LQBA 4ZS7A 1CYLA 4A3KD 4U4WA 3UEZE 5D22A 5D6KA 3UX9A 5IP7D 2V8NA 5KNHI 4GBZA 2Q7NB 4IU9A 4NEJA 5C3ED 4A3CD 1EVSA 2CFPA 4IKWA 4DKFA 5EQGA 4LRLA 1WCMD 3D87A 4GS7A 3MZGA 4TPHA 4ZW9A 4JREA 1CSGA 3LB6A 4NEMA 4DOHA 1BCNA 4YQXA 4U4TA 4A93D 4IKVA 3L5WI 1LK3A 3G9VB 4TPGA 3HOYD 2LMSA 2B8YA 3DUHC 1FYHA 2Q98A 4A3JD 1HWHA 2L3YA 4PYPA 4A3GD 4A3DD 5FLMD 1V7NV 1HZIA 1M47A 2D9QA 3HOWD 1BUYA 4IKZA 3WDOA 4YUEC 1RCBA 2IL6A 5FUCA 1GNCA 3G6DA 1HULA 3BPNA 1FG9A 1M4RA 1ILKA 3IRHA 3PIWA 4IKXA 2O26A 5D28B 5IYDD 3BPOA 3LB6B 3D48P 1Y14A 1ITFA 3VA2A 4GBYA 1PW4A 1ITMA 5EQHA 1HIJA 4NKQC 4CNIC 5D58A 4J4LC 5D71A 1BBNA 1QVNA 1CNT1 2LAGA 1ITLA 3UF2A 1HWGA 3PO2D 2XUTA 1IK0A 1Y1VD 4D2BA 4YB9D 4IU8A 2R7ZD 1EKUA 1M4AA 3BESL 5L6YC 1D9CA 4BY1D 2INTA 2PSMA 4NN5A 1CN4C 1PY2A 4A3BD 3Q1SI 4BY7D 4NI7A 1BGCA 4GC0A 3DLQI 2CYKA 4GRWA 3WCYI 1BGEA 1JLIA 4TPJA 3HHRA 4BBRD 1EXZA 4LEPA 4BBSD 1A22A 4OH3A 3D85C 1Z92A 3TGXB 2B91A 1ITIA 5C7XA 3I4ND 1PV6A 2Q14A 1Y1WD 2JA6D 1PW6A 4A3MD 3QWRB 3NCBA 2Y5YA 4EXNA 4O6KA 5C44D 5IP9D 3INKC 3DI2A 2XQBA 3EW3A 3QB7A 1Z7CA 4A3ID 2R93D 4YBQA 4A3FD 4D2DA 1Y6KL 4J05A 2B5IA 3NCEA 4Z5RD 4DKDA 1RW5A 1M4CA 1M48A 1V7MV 3QAZA 3I4MD 1N1FA 1M49A 3OQ3A 1Y6ML 3HOXD 4OAAA 4U4VA 1M4BA 4DKEA 3DGCL 3L5XA 2H24A 1HUWA 3HMXB 3NCCA 4W6VA 4X51A 4YDYI 1IL6A 4JR9A 3QT2C 4ZYRA 4XNIA 1D9GA 4Q65A 2Z3QA 2JA7D 1I1RB 2B63D 4ZWBA 4A3LD 3B5KA 3UF5A 4D2CA 4NN6A 1CD9A 1ALUA 2ILKA 2L3OA 1B5LA 3BPLA 3FKID 4LDSA 1WU3I 2O6IA 5E4EA 4ZF7A
chains in the Genus database with same CATH topology
1V7NV 3OG6A 3SE3B 1EXZA 3AYHA 1HZIA 4BBSD 1A22A 1M47A 1SCFA 2D9QA 3D85C 3S9DA 1PVHB 2ERJD 4NI9A 1Z92A 3EJJA 3HOWD 4MHLA 3TGXB 1BUYA 2B91A 3PO3D 2JA8D 4NN7A 1ITIA 4FA8E 5C7XA 5IYCD 3I4ND 4YUEC 2B90A 1GA3A 1RCBA 2IL6A 1A7MA 1KF9A 3DI3A 1EMRA 4BXXD 2B8ZA 1RFBA 5FUCA 1LQSL 2Q14A 1Y1WD 1HGUA 3G6DA 1BGDA 1PW6A 2E9WC 2O27A 3N06A 2JA6D 3QB1A 4A3MD 1HULA 3QWRB 3BPNA 3NPZA 3NCBA 1FG9A 1M4RA 1ILKA 3HHCA 3OG4A 4DKCA 4EXNA 2JA5D 3HOUD 3IRHA 4O6KA 5C44D 5D70A 5TS9A 1IRLA 3PIWA 5LQBA 5IP9D 4ZS7A 1P9MB 3INKC 2O26A 3DI2A 2XQBA 1CYLA 5D28B 3EW3A 4I77Z 5IYDD 3QB7A 1Z7CA 3BPOA 4A3ID 3LB6B 2R93D 1VLKA 4A3KD 3D48P 1Y14A 4PS4A 1Y6KL 4WRLB 3UEZE 4A3FD 2B5IA 1ITFA 3VA2A 3NCFA 3NCEA 5D22A 4Z5RD 3UX9A 5IP7D 1ITMA 4DKDA 1AU1A 1RW5A 2GMFA 5KNHI 1M4CA 2Q7NB 1HIJA 1J7VL 4NKQC 4CNIC 1M48A 1V7MV 3QAZA 3HOZD 3I4MD 4J4LC 1N1FA 4NEJA 5D71A 1BBNA 5C3ED 1M49A 1QVNA 1CNT1 3OQ3A 1Y6ML 2LAGA 1ITLA 4A3CD 5C4XD 3HOXD 3UF2A 1HWGA 1EVSA 3PO2D 2OQPA 1RHGA 1M4BA 1F45B 4DKEA 3DGCL 3L5XA 5IYBD 1IK0A 4DKFA 1Y1VD 1IARA 1PGRA 3HOVD 2H24A 2R92D 4LRLA 1WCMD 1HUWA 3HMXB 3NCCA 3D87A 4YPGC 4X51A 2R7ZD 4YDYI 1IL6A 1GNCA 1EKUA 3N0PA 1EERA 1M4AA 3BESL 2Z3RA 1IJZA 4GS7A 3MZGA 3QT2C 3PIVA 1NBPA 2D48A 5L6YC 1D9CA 1D9GA 2C35A 1CSGA 2KZ1A 3LB6A 4BY1D 4NEMA 5D72A 4DOHA 2Z3QA 1BCNA 2JA7D 4YQXA 1I1RB 2B63D 3H3VE 4A93D 3H0GD 2B8UA 4A3DD 4O9HA 4A3LD 5FHXA 2INTA 3B5KA 3L5WI 1YKBA 3UF5A 1LK3A 2B8XA 2HYMB 2PSMA 4NN5A 4EXPA 4A3ED 1BP3A 1CN4C 1PY2A 1Y6NL 3G9VB 3Q1SI 4A3BD 1LKIA 4NN6A 1CD9A 3HOYD 1ALUA 2LMSA 4BY7D 2B8YA 3DUHC 4NI7A 1BGCA 1FYHA 4RS1A 2Q98A 1AXIA 2ILKA 1F6FA 3DLQI 4A3JD 2L3OA 2CYKA 4GRWA 1B5LA 1ETEA 3SE4B 3BPLA 3FKID 3WCYI 1BGEA 1HIKA 1WU3I 1HWHA 1INRA 2VUMD 2L3YA 2O6IA 1AX8A 1JLIA 5E4EA 3HHRA 4A3GD 4ZF7A 4BBRD 5FLMD
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3H3V E;  3AYH A;  3H0G D;  4A93 D;  4BBS D;  4A3D D;  5IYD D;  4A3I D;  5IYB D;  4A3L D;  1Y1V D;  2R93 D;  4A3K D;  4A3F D;  1Y14 A;  3HOV D;  4A3E D;  3HOW D;  2R92 D;  2VUM D;  1WCM D;  2JA8 D;  3PO3 D;  4A3B D;  3HOY D;  5IYC D;  3I4N D;  2R7Z D;  4BY7 D;  5IP7 D;  4BXX D;  1Y1W D;  2JA6 D;  4A3J D;  4A3M D;  3FKI D;  3HOZ D;  3I4M D;  2C35 A;  5C3E D;  2JA5 D;  3HOU D;  4BY1 D;  2B63 D;  5C44 D;  4A3C D;  5C4X D;  3HOX D;  2JA7 D;  5IP9 D;  4A3G D;  3PO2 D;  4BBR D;  5FLM D; 
#chains in the Genus database with same CATH topology
 3OG6 A;  3SE3 B;  3S9D A;  2ERJ D;  2JA8 D;  3O7P A;  4NN7 A;  4FA8 E;  4QIQ A;  2B90 A;  1GA3 A;  1A7M A;  3DI3 A;  4BXX D;  2B8Z A;  2E9W C;  2O27 A;  4DKC A;  2JA5 D;  5TS9 A;  1IRL A;  1P9M B;  4UVM A;  4I77 Z;  1VLK A;  4PS4 A;  4WRL B;  4APS A;  3NCF A;  1AU1 A;  2GMF A;  4XNJ A;  1J7V L;  3HOZ D;  5C4X D;  2OQP A;  1RHG A;  1F45 B;  5IYB D;  1IAR A;  1PGR A;  3HOV D;  3O7Q A;  2R92 D;  5C65 A;  4YPG C;  3N0P A;  1EER A;  2Z3R A;  1IJZ A;  3PIV A;  1NBP A;  2D48 A;  2C35 A;  2KZ1 A;  5D72 A;  3H3V E;  2CFQ A;  3H0G D;  2B8U A;  4O9H A;  5FHX A;  4EXP A;  1YKB A;  4A3E D;  2VUM D;  2B8X A;  2HYM B;  1BP3 A;  5A2O A;  1Y6N L;  1PV7 A;  1LKI A;  4ZWC A;  4RS1 A;  1AXI A;  1F6F A;  4JA3 A;  3SE4 B;  1ETE A;  1HIK A;  5A2N A;  1INR A;  1AX8 A;  3AYH A;  1SCF A;  5D59 A;  1PVH B;  4NI9 A;  3EJJ A;  4MHL A;  3PO3 D;  5IYC D;  1KF9 A;  1EMR A;  1RFB A;  5GXB A;  1LQS L;  1HGU A;  1BGD A;  3N06 A;  3QB1 A;  5EQI A;  3NPZ A;  3HHC A;  3OG4 A;  3HOU D;  5D70 A;  4IKY A;  5LQB A;  4ZS7 A;  1CYL A;  4A3K D;  4U4W A;  3UEZ E;  5D22 A;  5D6K A;  3UX9 A;  5IP7 D;  2V8N A;  5KNH I;  4GBZ A;  2Q7N B;  4IU9 A;  4NEJ A;  5C3E D;  4A3C D;  1EVS A;  2CFP A;  4IKW A;  4DKF A;  5EQG A;  4LRL A;  1WCM D;  3D87 A;  4GS7 A;  3MZG A;  4TPH A;  4ZW9 A;  4JRE A;  1CSG A;  3LB6 A;  4NEM A;  4DOH A;  1BCN A;  4YQX A;  4U4T A;  4A93 D;  4IKV A;  3L5W I;  1LK3 A;  3G9V B;  4TPG A;  3HOY D;  2LMS A;  2B8Y A;  3DUH C;  1FYH A;  2Q98 A;  4A3J D;  1HWH A;  2L3Y A;  4PYP A;  4A3G D;  4A3D D;  5FLM D;  1V7N V;  1HZI A;  1M47 A;  2D9Q A;  3HOW D;  1BUY A;  4IKZ A;  3WDO A;  4YUE C;  1RCB A;  2IL6 A;  5FUC A;  1GNC A;  3G6D A;  1HUL A;  3BPN A;  1FG9 A;  1M4R A;  1ILK A;  3IRH A;  3PIW A;  4IKX A;  2O26 A;  5D28 B;  5IYD D;  3BPO A;  3LB6 B;  3D48 P;  1Y14 A;  1ITF A;  3VA2 A;  4GBY A;  1PW4 A;  1ITM A;  5EQH A;  1HIJ A;  4NKQ C;  4CNI C;  5D58 A;  4J4L C;  5D71 A;  1BBN A;  1QVN A;  1CNT 1;  2LAG A;  1ITL A;  3UF2 A;  1HWG A;  3PO2 D;  2XUT A;  1IK0 A;  1Y1V D;  4D2B A;  4YB9 D;  4IU8 A;  2R7Z D;  1EKU A;  1M4A A;  3BES L;  5L6Y C;  1D9C A;  4BY1 D;  2INT A;  2PSM A;  4NN5 A;  1CN4 C;  1PY2 A;  4A3B D;  3Q1S I;  4BY7 D;  4NI7 A;  1BGC A;  4GC0 A;  3DLQ I;  2CYK A;  4GRW A;  3WCY I;  1BGE A;  1JLI A;  4TPJ A;  3HHR A;  4BBR D;  1EXZ A;  4LEP A;  4BBS D;  1A22 A;  4OH3 A;  3D85 C;  1Z92 A;  3TGX B;  2B91 A;  1ITI A;  5C7X A;  3I4N D;  1PV6 A;  2Q14 A;  1Y1W D;  2JA6 D;  1PW6 A;  4A3M D;  3QWR B;  3NCB A;  2Y5Y A;  4EXN A;  4O6K A;  5C44 D;  5IP9 D;  3INK C;  3DI2 A;  2XQB A;  3EW3 A;  3QB7 A;  1Z7C A;  4A3I D;  2R93 D;  4YBQ A;  4A3F D;  4D2D A;  1Y6K L;  4J05 A;  2B5I A;  3NCE A;  4Z5R D;  4DKD A;  1RW5 A;  1M4C A;  1M48 A;  1V7M V;  3QAZ A;  3I4M D;  1N1F A;  1M49 A;  3OQ3 A;  1Y6M L;  3HOX D;  4OAA A;  4U4V A;  1M4B A;  4DKE A;  3DGC L;  3L5X A;  2H24 A;  1HUW A;  3HMX B;  3NCC A;  4W6V A;  4X51 A;  4YDY I;  1IL6 A;  4JR9 A;  3QT2 C;  4ZYR A;  4XNI A;  1D9G A;  4Q65 A;  2Z3Q A;  2JA7 D;  1I1R B;  2B63 D;  4ZWB A;  4A3L D;  3B5K A;  3UF5 A;  4D2C A;  4NN6 A;  1CD9 A;  1ALU A;  2ILK A;  2L3O A;  1B5L A;  3BPL A;  3FKI D;  4LDS A;  1WU3 I;  2O6I A;  5E4E A;  4ZF7 A; 
#chains in the Genus database with same CATH homology
 1V7N V;  3OG6 A;  3SE3 B;  1EXZ A;  3AYH A;  1HZI A;  4BBS D;  1A22 A;  1M47 A;  1SCF A;  2D9Q A;  3D85 C;  3S9D A;  1PVH B;  2ERJ D;  4NI9 A;  1Z92 A;  3EJJ A;  3HOW D;  4MHL A;  3TGX B;  1BUY A;  2B91 A;  3PO3 D;  2JA8 D;  4NN7 A;  1ITI A;  4FA8 E;  5C7X A;  5IYC D;  3I4N D;  4YUE C;  2B90 A;  1GA3 A;  1RCB A;  2IL6 A;  1A7M A;  1KF9 A;  3DI3 A;  1EMR A;  4BXX D;  2B8Z A;  1RFB A;  5FUC A;  1LQS L;  2Q14 A;  1Y1W D;  1HGU A;  3G6D A;  1BGD A;  1PW6 A;  2E9W C;  2O27 A;  3N06 A;  2JA6 D;  3QB1 A;  4A3M D;  1HUL A;  3QWR B;  3BPN A;  3NPZ A;  3NCB A;  1FG9 A;  1M4R A;  1ILK A;  3HHC A;  3OG4 A;  4DKC A;  4EXN A;  2JA5 D;  3HOU D;  3IRH A;  4O6K A;  5C44 D;  5D70 A;  5TS9 A;  1IRL A;  3PIW A;  5LQB A;  5IP9 D;  4ZS7 A;  1P9M B;  3INK C;  2O26 A;  3DI2 A;  2XQB A;  1CYL A;  5D28 B;  3EW3 A;  4I77 Z;  5IYD D;  3QB7 A;  1Z7C A;  3BPO A;  4A3I D;  3LB6 B;  2R93 D;  1VLK A;  4A3K D;  3D48 P;  1Y14 A;  4PS4 A;  1Y6K L;  4WRL B;  3UEZ E;  4A3F D;  2B5I A;  1ITF A;  3VA2 A;  3NCF A;  3NCE A;  5D22 A;  4Z5R D;  3UX9 A;  5IP7 D;  1ITM A;  4DKD A;  1AU1 A;  1RW5 A;  2GMF A;  5KNH I;  1M4C A;  2Q7N B;  1HIJ A;  1J7V L;  4NKQ C;  4CNI C;  1M48 A;  1V7M V;  3QAZ A;  3HOZ D;  3I4M D;  4J4L C;  1N1F A;  4NEJ A;  5D71 A;  1BBN A;  5C3E D;  1M49 A;  1QVN A;  1CNT 1;  3OQ3 A;  1Y6M L;  2LAG A;  1ITL A;  4A3C D;  5C4X D;  3HOX D;  3UF2 A;  1HWG A;  1EVS A;  3PO2 D;  2OQP A;  1RHG A;  1M4B A;  1F45 B;  4DKE A;  3DGC L;  3L5X A;  5IYB D;  1IK0 A;  4DKF A;  1Y1V D;  1IAR A;  1PGR A;  3HOV D;  2H24 A;  2R92 D;  4LRL A;  1WCM D;  1HUW A;  3HMX B;  3NCC A;  3D87 A;  4YPG C;  4X51 A;  2R7Z D;  4YDY I;  1IL6 A;  1GNC A;  1EKU A;  3N0P A;  1EER A;  1M4A A;  3BES L;  2Z3R A;  1IJZ A;  4GS7 A;  3MZG A;  3QT2 C;  3PIV A;  1NBP A;  2D48 A;  5L6Y C;  1D9C A;  1D9G A;  2C35 A;  1CSG A;  2KZ1 A;  3LB6 A;  4BY1 D;  4NEM A;  5D72 A;  4DOH A;  2Z3Q A;  1BCN A;  2JA7 D;  4YQX A;  1I1R B;  2B63 D;  3H3V E;  4A93 D;  3H0G D;  2B8U A;  4A3D D;  4O9H A;  4A3L D;  5FHX A;  2INT A;  3B5K A;  3L5W I;  1YKB A;  3UF5 A;  1LK3 A;  2B8X A;  2HYM B;  2PSM A;  4NN5 A;  4EXP A;  4A3E D;  1BP3 A;  1CN4 C;  1PY2 A;  1Y6N L;  3G9V B;  3Q1S I;  4A3B D;  1LKI A;  4NN6 A;  1CD9 A;  3HOY D;  1ALU A;  2LMS A;  4BY7 D;  2B8Y A;  3DUH C;  4NI7 A;  1BGC A;  1FYH A;  4RS1 A;  2Q98 A;  1AXI A;  2ILK A;  1F6F A;  3DLQ I;  4A3J D;  2L3O A;  2CYK A;  4GRW A;  1B5L A;  1ETE A;  3SE4 B;  3BPL A;  3FKI D;  3WCY I;  1BGE A;  1HIK A;  1WU3 I;  1HWH A;  1INR A;  2VUM D;  2L3Y A;  2O6I A;  1AX8 A;  1JLI A;  5E4E A;  3HHR A;  4A3G D;  4ZF7 A;  4BBR D;  5FLM D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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