4YTMD

Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with n-biphenyl-3-yl-2-(trifluoromethyl)benzamide
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
129
structure length
129
Chain Sequence
TSAAVTGAAPPQFDPIAAEKGFKPLHSHGTLFKIERYFAAAMVPLIPAAYFIHGREMDLCLALALTLHVHWGVWGVVNDYGRPFVLGDTLAAAVRVGAYIFTACLLAGLLYFNEHDVGLTRAFEMVWEL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
molecule keywords Succinate dehydrogenase flavoprotein
total genus 37
structure length 129
sequence length 129
chains with identical sequence H
ec nomenclature
pdb deposition date 2015-03-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF05328 CybS CybS, succinate dehydrogenase cytochrome B small subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunit 4ytmD00
4YXDC 2WDQC 3AEGC 3VR8D 1QLBC 3AE2D 3AEAC 3VR9C 3VRAC 3AE5C 3P4PC 3AEFC 3CIRD 3AECD 2WU2D 3SFDD 4YXDD 4KX6D 4YSZD 3AEGD 1ZOYC 3P4SC 2H89C 3AEAD 3VR9D 4YSXC 3VRAD 1YQ4C 3P4QC 3AE5D 3P4PD 3AEFD 1ZP0C 3P4SD 4YTPC 2H89D 2WDVC 3SFEC 4YSXD 3VR8C 3AE2C 1ZP0D 3AE7C 2BS4C 4YTPD 3AECC 2WU5D 3AEBD 2WDVD 3P4RC 4KX6C 3SFED 3SFDC 4YSZC 2WS3D 1NEKC 1KF6C 3AE7D 3P4RD 2FBWC 2WDRC 1NEKD 1KF6D 1YQ3C 3AE8C 3AE4C 4YTMC 2FBWD 2H88D 2WDRD 1YQ3D 2WU5C 3AE8D 3AEBC 3AE4D 3AE6C 2WS3C 2BS2C 3VRBC 4YTMD 2WP9D 4YTNC 4YT0C 3AE1D 3AE6D 2WQYC 3VRBD 5C2TC 3ABVD 4YTND 4YT0D 2H88C 2WQYD 5C2TD 2ACZD 2B76C 1NENC 3AEED 2WP9C 3AE1C 3AE9C 2B76D 1NEND 3AEDC 4YSYC 3ABVC 3AE9D 1L0VD 2WDQD 1KFYC 3AEDD 4YSYD 2ACZC 2BS3C 3AEEC 3AE3C 5C3JC 1ZOYD 1KFYD 1YQ4D 3P4QD 3AE3D 1E7PC 5C3JD 3CIRC 1L0VC 2WU2C
chains in the Genus database with same CATH superfamily
4YXDC 2WDQC 3AEGC 3VR8D 3VONA 4LDTA 1QLBC 3AE2D 3AEAC 3VR9C 3VRAC 3AE5C 3P4PC 3AEFC 3CIRD 3AECD 2WU2D 1TFFA 3SFDD 4YXDD 4KX6D 4YSZD 3AEGD 1ZOYC 3P4SC 2H89C 3AEAD 3VR9D 4YSXC 3VRAD 1YQ4C 3P4QC 3AE5D 3P4PD 3AEFD 1ZP0C 3P4SD 4YTPC 2H89D 2WDVC 3SFEC 4YSXD 3VR8C 3AE2C 1ZP0D 2ZFYA 3AE7C 2BS4C 4YTPD 3AECC 2WU5D 3AEBD 2WDVD 3P4RC 4KX6C 3SFED 3SFDC 4YSZC 2WS3D 1NEKC 1KF6C 3AE7D 3P4RD 2FBWC 2WDRC 1NEKD 1KF6D 1YQ3C 3AE8C 3AE4C 4YTMC 2FBWD 2H88D 2WDRD 1YQ3D 2WU5C 3AE8D 3AEBC 3AE4D 3AE6C 2WS3C 2BS2C 3VRBC 4YTMD 4DDIA 2WP9D 4YTNC 4DHIB 4YT0C 3AE1D 3AE6D 2WQYC 3VRBD 5C2TC 3ABVD 4YTND 4YT0D 2H88C 4FJVA 2WQYD 5C2TD 2ACZD 2B76C 1NENC 3AEED 2WP9C 3AE1C 3AE9C 2B76D 1NEND 4I6LA 3AEDC 4YSYC 3ABVC 3AE9D 1L0VD 2WDQD 4DHJA 1KFYC 3AEDD 4YSYD 2ACZC 2BS3C 3AEEC 3AE3C 4DDGA 1ZOYD 1KFYD 5C3JC 1YQ4D 3P4QD 4DHZA 3AE3D 1E7PC 5C3JD 3CIRC 1L0VC 2WU2C
chains in the Genus database with same CATH topology
4YXDC 2WDQC 3AEGC 3VR8D 1QLBC 3AE2D 3AEAC 3VR9C 3VRAC 3AE5C 3P4PC 3AEFC 3CIRD 3AECD 2WU2D 3SFDD 4YXDD 4KX6D 4YSZD 3AEGD 1ZOYC 3P4SC 2H89C 3AEAD 3VR9D 4YSXC 3VRAD 1YQ4C 3P4QC 3AE5D 3P4PD 3AEFD 1ZP0C 3P4SD 4YTPC 2H89D 2WDVC 3SFEC 4YSXD 3VR8C 3AE2C 1ZP0D 3AE7C 2BS4C 4YTPD 3AECC 2WU5D 3AEBD 2WDVD 3P4RC 4KX6C 3SFED 3SFDC 4YSZC 2WS3D 1NEKC 1KF6C 3AE7D 3P4RD 2FBWC 2WDRC 1NEKD 1KF6D 1YQ3C 3AE8C 3AE4C 4YTMC 2FBWD 2H88D 2WDRD 1YQ3D 2WU5C 3AE8D 3AEBC 3AE4D 3AE6C 2WS3C 2BS2C 3VRBC 4YTMD 2WP9D 4YTNC 4YT0C 3AE1D 3AE6D 2WQYC 3VRBD 5C2TC 3ABVD 4YTND 4YT0D 2H88C 2WQYD 5C2TD 2ACZD 2B76C 1NENC 3AEED 2WP9C 3AE1C 3AE9C 2B76D 1NEND 3AEDC 4YSYC 3ABVC 3AE9D 1L0VD 2WDQD 1KFYC 3AEDD 4YSYD 2ACZC 2BS3C 3AEEC 3AE3C 5C3JC 1ZOYD 1KFYD 1YQ4D 3P4QD 3AE3D 1E7PC 5C3JD 3CIRC 1L0VC 2WU2C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YXD C;  2WDQ C;  3AEG C;  3VR8 D;  1QLB C;  3AE2 D;  3AEA C;  3VR9 C;  3VRA C;  3AE5 C;  3P4P C;  3AEF C;  3CIR D;  3AEC D;  2WU2 D;  3SFD D;  4YXD D;  4KX6 D;  4YSZ D;  3AEG D;  1ZOY C;  3P4S C;  2H89 C;  3AEA D;  3VR9 D;  4YSX C;  3VRA D;  1YQ4 C;  3P4Q C;  3AE5 D;  3P4P D;  3AEF D;  1ZP0 C;  3P4S D;  4YTP C;  2H89 D;  2WDV C;  3SFE C;  4YSX D;  3VR8 C;  3AE2 C;  1ZP0 D;  3AE7 C;  2BS4 C;  4YTP D;  3AEC C;  2WU5 D;  3AEB D;  2WDV D;  3P4R C;  4KX6 C;  3SFE D;  3SFD C;  4YSZ C;  2WS3 D;  1NEK C;  1KF6 C;  3AE7 D;  3P4R D;  2FBW C;  2WDR C;  1NEK D;  1KF6 D;  1YQ3 C;  3AE8 C;  3AE4 C;  4YTM C;  2FBW D;  2H88 D;  2WDR D;  1YQ3 D;  2WU5 C;  3AE8 D;  3AEB C;  3AE4 D;  3AE6 C;  2WS3 C;  2BS2 C;  3VRB C;  4YTM D;  2WP9 D;  4YTN C;  4YT0 C;  3AE1 D;  3AE6 D;  2WQY C;  3VRB D;  5C2T C;  3ABV D;  4YTN D;  4YT0 D;  2H88 C;  2WQY D;  5C2T D;  2ACZ D;  2B76 C;  1NEN C;  3AEE D;  2WP9 C;  3AE1 C;  3AE9 C;  2B76 D;  1NEN D;  3AED C;  4YSY C;  3ABV C;  3AE9 D;  1L0V D;  2WDQ D;  1KFY C;  3AED D;  4YSY D;  2ACZ C;  2BS3 C;  3AEE C;  3AE3 C;  5C3J C;  1ZOY D;  1KFY D;  1YQ4 D;  3P4Q D;  3AE3 D;  1E7P C;  5C3J D;  3CIR C;  1L0V C;  2WU2 C; 
#chains in the Genus database with same CATH topology
 4YXD C;  2WDQ C;  3AEG C;  3VR8 D;  3VON A;  4LDT A;  1QLB C;  3AE2 D;  3AEA C;  3VR9 C;  3VRA C;  3AE5 C;  3P4P C;  3AEF C;  3CIR D;  3AEC D;  2WU2 D;  1TFF A;  3SFD D;  4YXD D;  4KX6 D;  4YSZ D;  3AEG D;  1ZOY C;  3P4S C;  2H89 C;  3AEA D;  3VR9 D;  4YSX C;  3VRA D;  1YQ4 C;  3P4Q C;  3AE5 D;  3P4P D;  3AEF D;  1ZP0 C;  3P4S D;  4YTP C;  2H89 D;  2WDV C;  3SFE C;  4YSX D;  3VR8 C;  3AE2 C;  1ZP0 D;  2ZFY A;  3AE7 C;  2BS4 C;  4YTP D;  3AEC C;  2WU5 D;  3AEB D;  2WDV D;  3P4R C;  4KX6 C;  3SFE D;  3SFD C;  4YSZ C;  2WS3 D;  1NEK C;  1KF6 C;  3AE7 D;  3P4R D;  2FBW C;  2WDR C;  1NEK D;  1KF6 D;  1YQ3 C;  3AE8 C;  3AE4 C;  4YTM C;  2FBW D;  2H88 D;  2WDR D;  1YQ3 D;  2WU5 C;  3AE8 D;  3AEB C;  3AE4 D;  3AE6 C;  2WS3 C;  2BS2 C;  3VRB C;  4YTM D;  4DDI A;  2WP9 D;  4YTN C;  4DHI B;  4YT0 C;  3AE1 D;  3AE6 D;  2WQY C;  3VRB D;  5C2T C;  3ABV D;  4YTN D;  4YT0 D;  2H88 C;  4FJV A;  2WQY D;  5C2T D;  2ACZ D;  2B76 C;  1NEN C;  3AEE D;  2WP9 C;  3AE1 C;  3AE9 C;  2B76 D;  1NEN D;  4I6L A;  3AED C;  4YSY C;  3ABV C;  3AE9 D;  1L0V D;  2WDQ D;  4DHJ A;  1KFY C;  3AED D;  4YSY D;  2ACZ C;  2BS3 C;  3AEE C;  3AE3 C;  4DDG A;  1ZOY D;  1KFY D;  5C3J C;  1YQ4 D;  3P4Q D;  4DHZ A;  3AE3 D;  1E7P C;  5C3J D;  3CIR C;  1L0V C;  2WU2 C; 
#chains in the Genus database with same CATH homology
 4YXD C;  2WDQ C;  3AEG C;  3VR8 D;  1QLB C;  3AE2 D;  3AEA C;  3VR9 C;  3VRA C;  3AE5 C;  3P4P C;  3AEF C;  3CIR D;  3AEC D;  2WU2 D;  3SFD D;  4YXD D;  4KX6 D;  4YSZ D;  3AEG D;  1ZOY C;  3P4S C;  2H89 C;  3AEA D;  3VR9 D;  4YSX C;  3VRA D;  1YQ4 C;  3P4Q C;  3AE5 D;  3P4P D;  3AEF D;  1ZP0 C;  3P4S D;  4YTP C;  2H89 D;  2WDV C;  3SFE C;  4YSX D;  3VR8 C;  3AE2 C;  1ZP0 D;  3AE7 C;  2BS4 C;  4YTP D;  3AEC C;  2WU5 D;  3AEB D;  2WDV D;  3P4R C;  4KX6 C;  3SFE D;  3SFD C;  4YSZ C;  2WS3 D;  1NEK C;  1KF6 C;  3AE7 D;  3P4R D;  2FBW C;  2WDR C;  1NEK D;  1KF6 D;  1YQ3 C;  3AE8 C;  3AE4 C;  4YTM C;  2FBW D;  2H88 D;  2WDR D;  1YQ3 D;  2WU5 C;  3AE8 D;  3AEB C;  3AE4 D;  3AE6 C;  2WS3 C;  2BS2 C;  3VRB C;  4YTM D;  2WP9 D;  4YTN C;  4YT0 C;  3AE1 D;  3AE6 D;  2WQY C;  3VRB D;  5C2T C;  3ABV D;  4YTN D;  4YT0 D;  2H88 C;  2WQY D;  5C2T D;  2ACZ D;  2B76 C;  1NEN C;  3AEE D;  2WP9 C;  3AE1 C;  3AE9 C;  2B76 D;  1NEN D;  3AED C;  4YSY C;  3ABV C;  3AE9 D;  1L0V D;  2WDQ D;  1KFY C;  3AED D;  4YSY D;  2ACZ C;  2BS3 C;  3AEE C;  3AE3 C;  5C3J C;  1ZOY D;  1KFY D;  1YQ4 D;  3P4Q D;  3AE3 D;  1E7P C;  5C3J D;  3CIR C;  1L0V C;  2WU2 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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