4YTNC

Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with n-[3-(pentafluorophenoxy)phenyl]-2-(trifluoromethyl)benzamide
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
153
structure length
153
Chain Sequence
EKTPIQVWGWDYLMRQRALKRPIAPHLTIYKPQMTWMVSGLHRVTGCAMAGTLLIGGVGFSVLPLDFTTFVEFIRGLGIPWVILDTFKFIIAFPIAFHTLNGIRFIGFDMAKGTDIPSIYRGAYLVLGLAALISLAVVVYPRWERHKKATLPT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title New Insights into the Design of Inhibitors Targeted for Parasitic Anaerobic Energy Metabolism
rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
molecule keywords Succinate dehydrogenase flavoprotein
total genus 54
structure length 153
sequence length 153
chains with identical sequence G
ec nomenclature
pdb deposition date 2015-03-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01127 Sdh_cyt Succinate dehydrogenase/Fumarate reductase transmembrane subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunit 4ytnC00
2H88D 3AEBC 4YTPC 3P4RC 4YSXD 3AE9D 1NEKD 3AE9C 1NEKC 4YT0C 4YT0D 1ZP0C 3AE3D 3AEDD 3AEDC 3VRBD 3VRBC 2ACZC 1L0VD 2WU5D 1L0VC 2WU5C 2BS3C 5C2TC 5C3JD 4YTND 4YTNC 2WDRC 3ABVC 4YSZD 3AE2C 1KF6D 2WDQD 1KF6C 2WDQC 3AEBD 4YTPD 3P4RD 2WU2D 2WU2C 1ZP0D 4YSYD 4YSYC 3P4PC 2ACZD 2FBWD 2FBWC 1ZOYD 1ZOYC 5C2TD 2B76D 2WQYD 2B76C 2WQYC 3VR8D 3VR8C 3AEGC 2WDRD 3ABVD 1E7PC 3AE2D 3AE8C 3AEED 3AEEC 3AEFD 3AEFC 3P4SC 3AECD 3SFED 3AECC 3SFEC 1KFYD 1KFYC 2BS4C 3VRAD 3VRAC 3AE5D 3AEAC 3AE5C 3AE6C 3P4PD 3AE1D 3AE1C 4YTMD 4YTMC 1NEND 1YQ3C 1NENC 3AEGD 3P4QC 4YXDD 4YXDC 1QLBC 3AE8D 2H88C 4YSXC 3P4SD 1YQ4D 1YQ4C 3AE4D 3AE4C 3AE3C 3AE7D 3AE7C 3SFDD 3SFDC 3CIRD 3CIRC 3AEAD 3AE6D 3VR9D 3VR9C 5C3JC 1YQ3D 2H89D 2H89C 2WDVC 2WDVD 2BS2C 4KX6D 4KX6C 2WP9D 2WP9C 4YSZC 3P4QD 2WS3D 2WS3C
chains in the Genus database with same CATH superfamily
4DHZA 2H88D 3AEBC 4YTPC 3P4RC 4YSXD 3AE9D 4DHIB 1NEKD 3AE9C 1NEKC 4YT0C 4YT0D 4LDTA 1ZP0C 3AE3D 3AEDD 3AEDC 3VRBD 3VRBC 2ACZC 1L0VD 2WU5D 1L0VC 2WU5C 2BS3C 5C2TC 5C3JD 4YTND 4YTNC 2WDRC 3ABVC 4YSZD 3AE2C 1KF6D 2WDQD 1KF6C 2WDQC 2ZFYA 3AEBD 4YTPD 3P4RD 2WU2D 2WU2C 1ZP0D 4YSYD 4YSYC 3P4PC 4DDIA 2ACZD 2FBWD 2FBWC 1ZOYD 1ZOYC 5C2TD 2B76D 2WQYD 2B76C 2WQYC 3VR8D 3VR8C 3AEGC 2WDRD 3ABVD 1E7PC 3AE2D 3AE8C 3AEED 3AEEC 3AEFD 3AEFC 3P4SC 3AECD 3SFED 3AECC 3SFEC 1KFYD 1KFYC 2BS4C 3VRAD 3VRAC 4DDGA 3AE5D 3AEAC 3AE5C 3AE6C 3P4PD 3AE1D 3AE1C 4YTMD 4YTMC 1NEND 1YQ3C 1NENC 4DHJA 3AEGD 4I6LA 3P4QC 4YXDD 4YXDC 3VONA 1QLBC 3AE8D 2H88C 4YSXC 3P4SD 1YQ4D 1YQ4C 3AE4D 1TFFA 3AE4C 3AE3C 4FJVA 3AE7D 3AE7C 3SFDD 3SFDC 3CIRD 3CIRC 3AEAD 3AE6D 3VR9D 3VR9C 5C3JC 1YQ3D 2H89D 2H89C 2WDVC 2WDVD 2BS2C 4KX6D 4KX6C 2WP9D 2WP9C 4YSZC 3P4QD 2WS3D 2WS3C
chains in the Genus database with same CATH topology
2H88D 3AEBC 4YTPC 3P4RC 4YSXD 3AE9D 1NEKD 3AE9C 1NEKC 4YT0C 4YT0D 1ZP0C 3AE3D 3AEDD 3AEDC 3VRBD 3VRBC 2ACZC 1L0VD 2WU5D 1L0VC 2WU5C 2BS3C 5C2TC 5C3JD 4YTND 4YTNC 2WDRC 3ABVC 4YSZD 3AE2C 1KF6D 2WDQD 1KF6C 2WDQC 3AEBD 4YTPD 3P4RD 2WU2D 2WU2C 1ZP0D 4YSYD 4YSYC 3P4PC 2ACZD 2FBWD 2FBWC 1ZOYD 1ZOYC 5C2TD 2B76D 2WQYD 2B76C 2WQYC 3VR8D 3VR8C 3AEGC 2WDRD 3ABVD 1E7PC 3AE2D 3AE8C 3AEED 3AEEC 3AEFD 3AEFC 3P4SC 3AECD 3SFED 3AECC 3SFEC 1KFYD 1KFYC 2BS4C 3VRAD 3VRAC 3AE5D 3AEAC 3AE5C 3AE6C 3P4PD 3AE1D 3AE1C 4YTMD 4YTMC 1NEND 1YQ3C 1NENC 3AEGD 3P4QC 4YXDD 4YXDC 1QLBC 3AE8D 2H88C 4YSXC 3P4SD 1YQ4D 1YQ4C 3AE4D 3AE4C 3AE3C 3AE7D 3AE7C 3SFDD 3SFDC 3CIRD 3CIRC 3AEAD 3AE6D 3VR9D 3VR9C 5C3JC 1YQ3D 2H89D 2H89C 2WDVC 2WDVD 2BS2C 4KX6D 4KX6C 2WP9D 2WP9C 4YSZC 3P4QD 2WS3D 2WS3C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2H88 D;  3AEB C;  4YTP C;  3P4R C;  4YSX D;  3AE9 D;  1NEK D;  3AE9 C;  1NEK C;  4YT0 C;  4YT0 D;  1ZP0 C;  3AE3 D;  3AED D;  3AED C;  3VRB D;  3VRB C;  2ACZ C;  1L0V D;  2WU5 D;  1L0V C;  2WU5 C;  2BS3 C;  5C2T C;  5C3J D;  4YTN D;  4YTN C;  2WDR C;  3ABV C;  4YSZ D;  3AE2 C;  1KF6 D;  2WDQ D;  1KF6 C;  2WDQ C;  3AEB D;  4YTP D;  3P4R D;  2WU2 D;  2WU2 C;  1ZP0 D;  4YSY D;  4YSY C;  3P4P C;  2ACZ D;  2FBW D;  2FBW C;  1ZOY D;  1ZOY C;  5C2T D;  2B76 D;  2WQY D;  2B76 C;  2WQY C;  3VR8 D;  3VR8 C;  3AEG C;  2WDR D;  3ABV D;  1E7P C;  3AE2 D;  3AE8 C;  3AEE D;  3AEE C;  3AEF D;  3AEF C;  3P4S C;  3AEC D;  3SFE D;  3AEC C;  3SFE C;  1KFY D;  1KFY C;  2BS4 C;  3VRA D;  3VRA C;  3AE5 D;  3AEA C;  3AE5 C;  3AE6 C;  3P4P D;  3AE1 D;  3AE1 C;  4YTM D;  4YTM C;  1NEN D;  1YQ3 C;  1NEN C;  3AEG D;  3P4Q C;  4YXD D;  4YXD C;  1QLB C;  3AE8 D;  2H88 C;  4YSX C;  3P4S D;  1YQ4 D;  1YQ4 C;  3AE4 D;  3AE4 C;  3AE3 C;  3AE7 D;  3AE7 C;  3SFD D;  3SFD C;  3CIR D;  3CIR C;  3AEA D;  3AE6 D;  3VR9 D;  3VR9 C;  5C3J C;  1YQ3 D;  2H89 D;  2H89 C;  2WDV C;  2WDV D;  2BS2 C;  4KX6 D;  4KX6 C;  2WP9 D;  2WP9 C;  4YSZ C;  3P4Q D;  2WS3 D;  2WS3 C; 
#chains in the Genus database with same CATH topology
 4DHZ A;  2H88 D;  3AEB C;  4YTP C;  3P4R C;  4YSX D;  3AE9 D;  4DHI B;  1NEK D;  3AE9 C;  1NEK C;  4YT0 C;  4YT0 D;  4LDT A;  1ZP0 C;  3AE3 D;  3AED D;  3AED C;  3VRB D;  3VRB C;  2ACZ C;  1L0V D;  2WU5 D;  1L0V C;  2WU5 C;  2BS3 C;  5C2T C;  5C3J D;  4YTN D;  4YTN C;  2WDR C;  3ABV C;  4YSZ D;  3AE2 C;  1KF6 D;  2WDQ D;  1KF6 C;  2WDQ C;  2ZFY A;  3AEB D;  4YTP D;  3P4R D;  2WU2 D;  2WU2 C;  1ZP0 D;  4YSY D;  4YSY C;  3P4P C;  4DDI A;  2ACZ D;  2FBW D;  2FBW C;  1ZOY D;  1ZOY C;  5C2T D;  2B76 D;  2WQY D;  2B76 C;  2WQY C;  3VR8 D;  3VR8 C;  3AEG C;  2WDR D;  3ABV D;  1E7P C;  3AE2 D;  3AE8 C;  3AEE D;  3AEE C;  3AEF D;  3AEF C;  3P4S C;  3AEC D;  3SFE D;  3AEC C;  3SFE C;  1KFY D;  1KFY C;  2BS4 C;  3VRA D;  3VRA C;  4DDG A;  3AE5 D;  3AEA C;  3AE5 C;  3AE6 C;  3P4P D;  3AE1 D;  3AE1 C;  4YTM D;  4YTM C;  1NEN D;  1YQ3 C;  1NEN C;  4DHJ A;  3AEG D;  4I6L A;  3P4Q C;  4YXD D;  4YXD C;  3VON A;  1QLB C;  3AE8 D;  2H88 C;  4YSX C;  3P4S D;  1YQ4 D;  1YQ4 C;  3AE4 D;  1TFF A;  3AE4 C;  3AE3 C;  4FJV A;  3AE7 D;  3AE7 C;  3SFD D;  3SFD C;  3CIR D;  3CIR C;  3AEA D;  3AE6 D;  3VR9 D;  3VR9 C;  5C3J C;  1YQ3 D;  2H89 D;  2H89 C;  2WDV C;  2WDV D;  2BS2 C;  4KX6 D;  4KX6 C;  2WP9 D;  2WP9 C;  4YSZ C;  3P4Q D;  2WS3 D;  2WS3 C; 
#chains in the Genus database with same CATH homology
 2H88 D;  3AEB C;  4YTP C;  3P4R C;  4YSX D;  3AE9 D;  1NEK D;  3AE9 C;  1NEK C;  4YT0 C;  4YT0 D;  1ZP0 C;  3AE3 D;  3AED D;  3AED C;  3VRB D;  3VRB C;  2ACZ C;  1L0V D;  2WU5 D;  1L0V C;  2WU5 C;  2BS3 C;  5C2T C;  5C3J D;  4YTN D;  4YTN C;  2WDR C;  3ABV C;  4YSZ D;  3AE2 C;  1KF6 D;  2WDQ D;  1KF6 C;  2WDQ C;  3AEB D;  4YTP D;  3P4R D;  2WU2 D;  2WU2 C;  1ZP0 D;  4YSY D;  4YSY C;  3P4P C;  2ACZ D;  2FBW D;  2FBW C;  1ZOY D;  1ZOY C;  5C2T D;  2B76 D;  2WQY D;  2B76 C;  2WQY C;  3VR8 D;  3VR8 C;  3AEG C;  2WDR D;  3ABV D;  1E7P C;  3AE2 D;  3AE8 C;  3AEE D;  3AEE C;  3AEF D;  3AEF C;  3P4S C;  3AEC D;  3SFE D;  3AEC C;  3SFE C;  1KFY D;  1KFY C;  2BS4 C;  3VRA D;  3VRA C;  3AE5 D;  3AEA C;  3AE5 C;  3AE6 C;  3P4P D;  3AE1 D;  3AE1 C;  4YTM D;  4YTM C;  1NEN D;  1YQ3 C;  1NEN C;  3AEG D;  3P4Q C;  4YXD D;  4YXD C;  1QLB C;  3AE8 D;  2H88 C;  4YSX C;  3P4S D;  1YQ4 D;  1YQ4 C;  3AE4 D;  3AE4 C;  3AE3 C;  3AE7 D;  3AE7 C;  3SFD D;  3SFD C;  3CIR D;  3CIR C;  3AEA D;  3AE6 D;  3VR9 D;  3VR9 C;  5C3J C;  1YQ3 D;  2H89 D;  2H89 C;  2WDV C;  2WDV D;  2BS2 C;  4KX6 D;  4KX6 C;  2WP9 D;  2WP9 C;  4YSZ C;  3P4Q D;  2WS3 D;  2WS3 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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