1SJ8 | Genus

Total Genus 119

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	119
sequence length	297
structure length	297
Chain Sequence	PPLTSAQQALTGTINSSMQAVQAAQATLDDFETLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGNGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDVLMQLANAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELL

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 297 atoms

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1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

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297 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Structural protein
source organism	Mus musculus
publication title	Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle pubmed doi rcsb
molecule keywords	Talin 1
total genus	119
structure length	297
sequence length	297
ec nomenclature
pdb deposition date	2004-03-03

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF09141	Talin_middle	Talin, middle domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.1420.10	Mainly Alpha	Up-down Bundle	A middle domain of Talin 1	Talin, central domain	1sj8A01
1.20.1440.10	Mainly Alpha	Up-down Bundle	de novo design (two linked rop proteins)	de novo design (two linked rop proteins)	1sj8A02

2KGXA 3FYQA 3DYJA 1SJ8A 4W8PA 2L7NA 1SJ7A 1YO7A 3AY5A 2X0CA 4F7GB 2L10A 5FZTA 2KVPA 2KBBA
chains in the Genus database with same CATH superfamily

3AJFA 4G75A 3FVVA 2YFAA 5HWYA 3DA4A 4JCVE 4Z7HA 2K19A 3DYJA 1JQOA 3AT7A 2L7NA 2ZRRA 2LQUA 2JB1A 4F7GB 3FBVA 1U5KA 4GXTA 2A2CA 3VJZA 2QZGA 2JAEA 3SDJA 5JDLA 2FUG1 5HXEA 2XTQA 5HGIA 2GSCA 2QGMA 4U6RA 3L0IA 4Q9VA 4PL4A 1TDPA 2A2DA 5HXHA 4ECGA 3DO9A 2HGKA 5HXSA 4PL5A 4OAUC 2BL8A 4NV5A 3VA9A 5LNK1 2JBWA 3M1CA 2QSBA 3V5SA 3FYQA 3WURA 4O1OA 2YFBA 2L1LB 2ETDA 4DWLA 3I9V1 4HFVA 4I1TA 1SJ7A 3B55A 3AY5A 3UITA 2L10A 5JDFA 2V1CC 3F4MA 1SJ8A 2KKMA 1YO7A 4BGOA 3V5UA 3P23A 2KVPA 4G76A 4YZDA 5HXCA 2XQYA 5JDHA 5JDNA 2CAZB 3LJ0A 2P22B 2MJFB 3WSCA 3PF0A 5JDGA 3LJ1A 4PL3A 2ZW3A 3DA3A 4OAVB 2X0CA 2FU2A 2JB3A 1W3SA 2RIOA 4HEA1 4O1PA 4AS3A 2V6EA 5HYAA 2F6MB 2E8GA 4YZ9A 2XTRA 5FZTA 2JB2A 5HWXA 3JSBA 2F66B 5JDQA 3PHF1 2KBBA 2XMXA 2MTCA 5T1DA 5JDMA 2BL7A 3KP9A 3IAS1 3LJ2A 4Z7GA 3FNBA 4YZCA 2IP6A 2KGXA 2RADA 4W8PA 3IAM1 4AS2A 4ONRA 4NV2A 5HXRA 3Q8DA 2RLDA 2FEFA
chains in the Genus database with same CATH topology

3AJFA 4G75A 2YFAA 3DA4A 4JCVE 4Z7HA 2K19A 3DYJA 2L7NA 2ZRRA 2JB1A 4F7GB 3FBVA 1U5KA 4GXTA 2A2CA 3SDJA 2JAEA 2FUG1 2XTQA 5HGIA 4U6RA 3L0IA 4Q9VA 4PL4A 2A2DA 3DO9A 4PL5A 4OAUC 4NV5A 3VA9A 5LNK1 3FYQA 4O1OA 2YFBA 2L1LB 4DWLA 3I9V1 4HFVA 4I1TA 1SJ7A 3AY5A 3UITA 2L10A 2V1CC 3F4MA 1SJ8A 2KKMA 1YO7A 4G76A 3P23A 2KVPA 4YZDA 2CAZB 3LJ0A 2P22B 2MJFB 3LJ1A 4PL3A 3DA3A 4OAVB 2X0CA 2JB3A 1W3SA 2RIOA 4HEA1 4O1PA 4AS3A 2V6EA 2F6MB 2E8GA 4YZ9A 2XTRA 5FZTA 2JB2A 3JSBA 2F66B 2KBBA 2XMXA 3KP9A 3IAS1 3LJ2A 4Z7GA 4YZCA 2IP6A 2KGXA 4W8PA 3IAM1 4AS2A 4NV2A 3Q8DA
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 2KGX A;  3FYQ A;  3DYJ A;  1SJ8 A;  4W8P A;  2L7N A;  1SJ7 A;  1YO7 A;  3AY5 A;  2X0C A;  4F7G B;  2L10 A;  5FZT A;  2KVP A;  2KBB A; 
#chains in the Genus database with same CATH topology
 3AJF A;  4G75 A;  3FVV A;  2YFA A;  5HWY A;  3DA4 A;  4JCV E;  4Z7H A;  2K19 A;  3DYJ A;  1JQO A;  3AT7 A;  2L7N A;  2ZRR A;  2LQU A;  2JB1 A;  4F7G B;  3FBV A;  1U5K A;  4GXT A;  2A2C A;  3VJZ A;  2QZG A;  2JAE A;  3SDJ A;  5JDL A;  2FUG 1;  5HXE A;  2XTQ A;  5HGI A;  2GSC A;  2QGM A;  4U6R A;  3L0I A;  4Q9V A;  4PL4 A;  1TDP A;  2A2D A;  5HXH A;  4ECG A;  3DO9 A;  2HGK A;  5HXS A;  4PL5 A;  4OAU C;  2BL8 A;  4NV5 A;  3VA9 A;  5LNK 1;  2JBW A;  3M1C A;  2QSB A;  3V5S A;  3FYQ A;  3WUR A;  4O1O A;  2YFB A;  2L1L B;  2ETD A;  4DWL A;  3I9V 1;  4HFV A;  4I1T A;  1SJ7 A;  3B55 A;  3AY5 A;  3UIT A;  2L10 A;  5JDF A;  2V1C C;  3F4M A;  1SJ8 A;  2KKM A;  1YO7 A;  4BGO A;  3V5U A;  3P23 A;  2KVP A;  4G76 A;  4YZD A;  5HXC A;  2XQY A;  5JDH A;  5JDN A;  2CAZ B;  3LJ0 A;  2P22 B;  2MJF B;  3WSC A;  3PF0 A;  5JDG A;  3LJ1 A;  4PL3 A;  2ZW3 A;  3DA3 A;  4OAV B;  2X0C A;  2FU2 A;  2JB3 A;  1W3S A;  2RIO A;  4HEA 1;  4O1P A;  4AS3 A;  2V6E A;  5HYA A;  2F6M B;  2E8G A;  4YZ9 A;  2XTR A;  5FZT A;  2JB2 A;  5HWX A;  3JSB A;  2F66 B;  5JDQ A;  3PHF 1;  2KBB A;  2XMX A;  2MTC A;  5T1D A;  5JDM A;  2BL7 A;  3KP9 A;  3IAS 1;  3LJ2 A;  4Z7G A;  3FNB A;  4YZC A;  2IP6 A;  2KGX A;  2RAD A;  4W8P A;  3IAM 1;  4AS2 A;  4ONR A;  4NV2 A;  5HXR A;  3Q8D A;  2RLD A;  2FEF A; 
#chains in the Genus database with same CATH homology
 3AJF A;  4G75 A;  2YFA A;  3DA4 A;  4JCV E;  4Z7H A;  2K19 A;  3DYJ A;  2L7N A;  2ZRR A;  2JB1 A;  4F7G B;  3FBV A;  1U5K A;  4GXT A;  2A2C A;  3SDJ A;  2JAE A;  2FUG 1;  2XTQ A;  5HGI A;  4U6R A;  3L0I A;  4Q9V A;  4PL4 A;  2A2D A;  3DO9 A;  4PL5 A;  4OAU C;  4NV5 A;  3VA9 A;  5LNK 1;  3FYQ A;  4O1O A;  2YFB A;  2L1L B;  4DWL A;  3I9V 1;  4HFV A;  4I1T A;  1SJ7 A;  3AY5 A;  3UIT A;  2L10 A;  2V1C C;  3F4M A;  1SJ8 A;  2KKM A;  1YO7 A;  4G76 A;  3P23 A;  2KVP A;  4YZD A;  2CAZ B;  3LJ0 A;  2P22 B;  2MJF B;  3LJ1 A;  4PL3 A;  3DA3 A;  4OAV B;  2X0C A;  2JB3 A;  1W3S A;  2RIO A;  4HEA 1;  4O1P A;  4AS3 A;  2V6E A;  2F6M B;  2E8G A;  4YZ9 A;  2XTR A;  5FZT A;  2JB2 A;  3JSB A;  2F66 B;  2KBB A;  2XMX A;  3KP9 A;  3IAS 1;  3LJ2 A;  4Z7G A;  4YZC A;  2IP6 A;  2KGX A;  4W8P A;  3IAM 1;  4AS2 A;  4NV2 A;  3Q8D A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1SJ8A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations