1YHQE

Crystal structure of azithromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
172
structure length
172
Chain Sequence
PRVELEIPEDVDAEQDHLDITVEGDNGSVTRRLWYPDIDVSVDGDTVVIESDEDNAKTMSTIGTFQSHIENMFHGVTEGWEYGMEVFYSHFPMQVNVEGDEVVIENFLGEKAPRRTTIHGDTDVEIDGEELTVSGPDIEAVGQTAADIEQLTRINDKDVRVFQDGVYITRKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S Ribosomal RNA
total genus 37
structure length 172
sequence length 172
ec nomenclature
pdb deposition date 2005-01-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF00347 Ribosomal_L6 Ribosomal protein L6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 1yhqE02
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 1yhqE01
4WF9E 1RL6A 5JVGE 5DM6E 3CMAE 3PIOE 3CCEE 1VQNE 1QVGE 5HL7E 5GAEG 1YHQE 3I56E 5DM7E 4WFNE 1YJWE 1VQOE 1YJ9E 2OTJE 4IO9E 3G4SE 2CQLA 1N8RG 4WFBE 5H1SI 1K9MG 2QEXE 3CCVE 1VQLE 1KC8G 1NJIG 1M1KG 3CC2E 2ZJQE 2QA4E 4IOCE 3CCRE 3CC4E 3CCME 2ZJPE 4WFAE 1YIJE 1K8AG 3CCUE 1YITE 1VQME 3CC7E 5MLCH 3CMEE 3G71E 4U67E 1KQSE 3CCLE 1Q81G 1VQ9E 3CF5E 1S72E 1VQKE 3CCQE 3DLLE 1YI2E 1VQ7E 3J7ZG 1K73G 1Q86G 1VQ4E 1VQ5E 3CCJE 3CD6E 1M90G 3CPWE 3I55E 3CCSE 1YJNE 3PIPE 1VQ6E 1VQPE 4WCEE 1KD1G 5JVHE 2OTLE 1Q7YG 2ZJRE 5AN9B 1Q82G 3G6EE 4UY8G 1JJ2E 3CXCE 1VQ8E 5GAHG 4IOAE 5GADG 5GAGG 3OW2E 1W2BE 1QVFE
chains in the Genus database with same CATH superfamily
2FKJA 4WF9E 1RL6A 5JVGE 2AF5A 5DM6E 2FKGA 3CMAE 3PIOE 3CCEE 1VQNE 1QVGE 5HL7E 5GAEG 1YHQE 2I5VO 3I56E 5DM7E 4WFNE 1YJWE 1VQOE 1YJ9E 2OTJE 4IO9E 3CKFA 2OL7A 2CQLA 3G4SE 1N8RG 4WFBE 1RJLC 3IGEA 5H1SI 1K9MG 2QEXE 2I5ZO 3CCVE 1VQLE 3EC5A 1KC8G 1NJIG 1M1KG 5B2AO 3CC2E 2ZJQE 2QA4E 4IOCE 3CCRE 3CC4E 3CCME 2ZJPE 5B11O 4WFAE 1OSPO 1YIJE 1K8AG 5B3MO 1QVFE 3CCUE 1YITE 1VQME 2HKDA 3CC7E 2G8CO 5MLCH 3CMEE 3G71E 2OL8O 2PI3O 2OY5O 4U67E 1KQSE 3CCLE 1Q81G 1VQ9E 3CF5E 2OY7A 1S72E 1VQKE 3CCQE 3DLLE 1YI2E 1VQ7E 5B10O 3J7ZG 1K73G 1Q86G 1VQ4E 1VQ5E 2OL6O 3CCJE 3CD6E 1M90G 3CPWE 3I55E 3CCSE 1YJNE 3PIPE 1VQ6E 3CKGA 1VQPE 4WCEE 2OY1O 1KD1G 5JVHE 2OTLE 1Q7YG 2ZJRE 5AN9B 1Q82G 3G6EE 4UY8G 1JJ2E 3AUMO 1FJ1E 1P4PA 3CXCE 3IG9A 2OYBO 1VQ8E 5GAHG 4IOAE 5GADG 5GAGG 3OW2E 1W2BE 2OY8A
chains in the Genus database with same CATH topology
4WF9E 1RL6A 5JVGE 5DM6E 3CMAE 3PIOE 3CCEE 1VQNE 1QVGE 5HL7E 5GAEG 1YHQE 3I56E 5DM7E 4WFNE 1YJWE 1VQOE 1YJ9E 2OTJE 4IO9E 3G4SE 2CQLA 1N8RG 4WFBE 5H1SI 1K9MG 2QEXE 3CCVE 1VQLE 1KC8G 1NJIG 1M1KG 3CC2E 2ZJQE 2QA4E 4IOCE 3CCRE 3CC4E 3CCME 2ZJPE 4WFAE 1YIJE 1K8AG 3CCUE 1YITE 1VQME 3CC7E 5MLCH 3CMEE 3G71E 4U67E 1KQSE 3CCLE 1Q81G 1VQ9E 3CF5E 1S72E 1VQKE 3CCQE 3DLLE 1YI2E 1VQ7E 3J7ZG 1K73G 1Q86G 1VQ4E 1VQ5E 3CCJE 3CD6E 1M90G 3CPWE 3I55E 3CCSE 1YJNE 3PIPE 1VQ6E 1VQPE 4WCEE 1KD1G 5JVHE 2OTLE 1Q7YG 2ZJRE 5AN9B 1Q82G 3G6EE 4UY8G 1JJ2E 3CXCE 1VQ8E 5GAHG 4IOAE 5GADG 5GAGG 3OW2E 1W2BE 1QVFE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WF9 E;  1RL6 A;  5JVG E;  5DM6 E;  3CMA E;  3PIO E;  3CCE E;  1VQN E;  1QVG E;  5HL7 E;  5GAE G;  1YHQ E;  3I56 E;  5DM7 E;  4WFN E;  1YJW E;  1VQO E;  1YJ9 E;  2OTJ E;  4IO9 E;  3G4S E;  2CQL A;  1N8R G;  4WFB E;  5H1S I;  1K9M G;  2QEX E;  3CCV E;  1VQL E;  1KC8 G;  1NJI G;  1M1K G;  3CC2 E;  2ZJQ E;  2QA4 E;  4IOC E;  3CCR E;  3CC4 E;  3CCM E;  2ZJP E;  4WFA E;  1YIJ E;  1K8A G;  3CCU E;  1YIT E;  1VQM E;  3CC7 E;  5MLC H;  3CME E;  3G71 E;  4U67 E;  1KQS E;  3CCL E;  1Q81 G;  1VQ9 E;  3CF5 E;  1S72 E;  1VQK E;  3CCQ E;  3DLL E;  1YI2 E;  1VQ7 E;  3J7Z G;  1K73 G;  1Q86 G;  1VQ4 E;  1VQ5 E;  3CCJ E;  3CD6 E;  1M90 G;  3CPW E;  3I55 E;  3CCS E;  1YJN E;  3PIP E;  1VQ6 E;  1VQP E;  4WCE E;  1KD1 G;  5JVH E;  2OTL E;  1Q7Y G;  2ZJR E;  5AN9 B;  1Q82 G;  3G6E E;  4UY8 G;  1JJ2 E;  3CXC E;  1VQ8 E;  5GAH G;  4IOA E;  5GAD G;  5GAG G;  3OW2 E;  1W2B E;  1QVF E; 
#chains in the Genus database with same CATH topology
 2FKJ A;  4WF9 E;  1RL6 A;  5JVG E;  2AF5 A;  5DM6 E;  2FKG A;  3CMA E;  3PIO E;  3CCE E;  1VQN E;  1QVG E;  5HL7 E;  5GAE G;  1YHQ E;  2I5V O;  3I56 E;  5DM7 E;  4WFN E;  1YJW E;  1VQO E;  1YJ9 E;  2OTJ E;  4IO9 E;  3CKF A;  2OL7 A;  2CQL A;  3G4S E;  1N8R G;  4WFB E;  1RJL C;  3IGE A;  5H1S I;  1K9M G;  2QEX E;  2I5Z O;  3CCV E;  1VQL E;  3EC5 A;  1KC8 G;  1NJI G;  1M1K G;  5B2A O;  3CC2 E;  2ZJQ E;  2QA4 E;  4IOC E;  3CCR E;  3CC4 E;  3CCM E;  2ZJP E;  5B11 O;  4WFA E;  1OSP O;  1YIJ E;  1K8A G;  5B3M O;  1QVF E;  3CCU E;  1YIT E;  1VQM E;  2HKD A;  3CC7 E;  2G8C O;  5MLC H;  3CME E;  3G71 E;  2OL8 O;  2PI3 O;  2OY5 O;  4U67 E;  1KQS E;  3CCL E;  1Q81 G;  1VQ9 E;  3CF5 E;  2OY7 A;  1S72 E;  1VQK E;  3CCQ E;  3DLL E;  1YI2 E;  1VQ7 E;  5B10 O;  3J7Z G;  1K73 G;  1Q86 G;  1VQ4 E;  1VQ5 E;  2OL6 O;  3CCJ E;  3CD6 E;  1M90 G;  3CPW E;  3I55 E;  3CCS E;  1YJN E;  3PIP E;  1VQ6 E;  3CKG A;  1VQP E;  4WCE E;  2OY1 O;  1KD1 G;  5JVH E;  2OTL E;  1Q7Y G;  2ZJR E;  5AN9 B;  1Q82 G;  3G6E E;  4UY8 G;  1JJ2 E;  3AUM O;  1FJ1 E;  1P4P A;  3CXC E;  3IG9 A;  2OYB O;  1VQ8 E;  5GAH G;  4IOA E;  5GAD G;  5GAG G;  3OW2 E;  1W2B E;  2OY8 A; 
#chains in the Genus database with same CATH homology
 4WF9 E;  1RL6 A;  5JVG E;  5DM6 E;  3CMA E;  3PIO E;  3CCE E;  1VQN E;  1QVG E;  5HL7 E;  5GAE G;  1YHQ E;  3I56 E;  5DM7 E;  4WFN E;  1YJW E;  1VQO E;  1YJ9 E;  2OTJ E;  4IO9 E;  3G4S E;  2CQL A;  1N8R G;  4WFB E;  5H1S I;  1K9M G;  2QEX E;  3CCV E;  1VQL E;  1KC8 G;  1NJI G;  1M1K G;  3CC2 E;  2ZJQ E;  2QA4 E;  4IOC E;  3CCR E;  3CC4 E;  3CCM E;  2ZJP E;  4WFA E;  1YIJ E;  1K8A G;  3CCU E;  1YIT E;  1VQM E;  3CC7 E;  5MLC H;  3CME E;  3G71 E;  4U67 E;  1KQS E;  3CCL E;  1Q81 G;  1VQ9 E;  3CF5 E;  1S72 E;  1VQK E;  3CCQ E;  3DLL E;  1YI2 E;  1VQ7 E;  3J7Z G;  1K73 G;  1Q86 G;  1VQ4 E;  1VQ5 E;  3CCJ E;  3CD6 E;  1M90 G;  3CPW E;  3I55 E;  3CCS E;  1YJN E;  3PIP E;  1VQ6 E;  1VQP E;  4WCE E;  1KD1 G;  5JVH E;  2OTL E;  1Q7Y G;  2ZJR E;  5AN9 B;  1Q82 G;  3G6E E;  4UY8 G;  1JJ2 E;  3CXC E;  1VQ8 E;  5GAH G;  4IOA E;  5GAD G;  5GAG G;  3OW2 E;  1W2B E;  1QVF E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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